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Results for “CESTODES”

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At least 505 records · Page 28Linked to original sources
PubMed1987

Isotype restriction during infection of mice with the cestode Mesocestoides corti: role of immune suppression.

Mice infected with the parasite Mesocestoides corti produce a vigorous antibody response that is restricted to the IgM and IgG1 heavy chain classes. The isotypic restriction observed is apparently associated with active infection and is not a unique characteristic of responses to M. corti antigens. Thus, animals immunized with intact but nonviable parasites respond with the production of a variety of antibody isotypes in addition to IgM and IgG1. To delineate immunoregulatory mechanisms involved in the isotypic restriction of antibody responses to M. corti, an in vitro lymphocyte suspension culture was established. The data indicate that there are two cell subsets in the spleens of infected mice that contribute to an overall suppression of the in vitro antibody response. Thus, both Lyt-2+ cells and G-10-adherent cells must be removed to maximize antibody production. However, the anti-parasite response obtained in vitro after depletion of Lyt-2+ cells and G-10-adherent cells is restricted to the IgM and IgG1 isotypes as observed in vivo, indicating that suppression is not actively involved in the IgM, IgG1 dominance of the response. The cellular regulation associated with this restriction was then studied by using isolated helper T cells derived from parasite-infected animals to stimulate B cells from uninfected animals. The antibody produced was again restricted to IgM and IgG1, indicating that the helper T cells were regulating the preferential expression of the IgM and IgG1 antibody classes.

Animals↗
PubMed1986

Albendazole, a broad-spectrum anthelmintic, in the treatment of intestinal nematode and cestode infection: a multicenter study in 480 patients.

The anthelmintic activity of and patient tolerance to albendazole, a broad-spectrum anthelmintic, were studied in a multicenter trial involving 480 patients ranging in age from 2 to 60 years. The patients had single or mixed infections caused by pinworms, roundworms, hookworms, whipworms, threadworms, or tapeworms. The stools were examined by the direct method, and ova were counted by means of the Kato-Katz technique. A Graham-Scotch test was also done in patients infected with Enterobius vermicularis. Most patients received a single 400-mg dose of albendazole; adults were given two tablets, and children were given a 2% suspension. All patients with Hymenolepis nana and about half of those with Taenia infections were treated for three successive days. Patients were carefully evaluated before and after treatment to assess the efficacy and safety of the drug. After a single dose of albendazole, the cure rate was 95.3% in ascariasis, 92.2% in ancylostomiasis, 90.5% in trichuriasis, 64.9% in taeniasis, and 100% in enterobiasis. Among patients receiving 400 mg of albendazole for three days, the cure rate was 63.4% in hymenolepiasis and 86.1% in taeniasis. The drug was well tolerated, and no significant side effects were reported.

Adolescent↗
PubMed1985

Rhinebothrium biorchidum n. sp., a tetraphyllidean cestode from a yellow-spotted stingray, Urolophus jamaicensis, in Jamaica.

Rhinebothrium biorchidum n. sp. (Tetraphyllidea: Phyllobothriidae) is described from the spiral valve of the yellow-spotted stingray, Urolophus jamaicensis, from Jamaica. It was most similar to R. spinicephalum Campbell 1970 but differed by having fewer proglottids (15 to 26 vs. 36 to 49), smaller peduncle (110 to 146 vs. 330 to 470) and pedicels (100 to 180 vs. 170 to 370), fewer transverse septa (6 to 8 vs. 16 to 17), fewer total loculi per bothridium (22 to 30 vs. 32 to 34) and larger ovarian lobes (148 to 310 vs. 88 to 176). A key to bitestate species of Rhinebothrium is included.

Animals↗