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[Foundations for differential cytology of cervical changes. 2. Benign changes (author's transl)].

Causative relationships between various benign changes of the uterine cervix are discussed with reference to literature, and resulting cytomorphological substrates are presented in illustrations. Cytomorphological pictures obtained from good preparation practice often have been helpful in drawing proper conclusions as to causes of benign changes and in clarifying clinical patterns or portio changes which escaped macroscopic elucidation. Such changes may include inflammatory or degenerative lesions of differentiated aetiology, metaplastic processes in so-called transformation zones or at squamocolumnar junctions or abnormal cornification. As a rule, benign changes may be delimitated from atypical cell changes by the examiner who is aware of all direct and indirect cytological criteria.

Atrophy↗

[Some epidemiological factors in the incidence of female genital cancer in the Azerbaijan SSR].

In the structure of cancer morbidity of the female genitalia in Azerbaijan SSR within a ten-year period (1957-1966) cervical cancer occupies the first place--86.6%, it is observed more frequently among Russian female population (46.4 per 100 000 wives) and more rarely among aboriginal female population (7.1 per 100 000 wives). Of 2488 patients with cervical cancer 24.5% showed previous lesions against which background cancer would arise. Patients with cervical ruptures, advanced erosions, polyps should be identified as high-risk groups of cervical cancer.

Adnexal Diseases↗

[Characteristics of the uterine mucosa in cervix dysplasia].

In dysplasia of the vaginal cervix every 7th patient (in 68 of 500) showed hyperplastic and metaplasic changes in the mucous membrane of the cervical canal and 1 per cent--Ca in situ of the cervical canal. Females with different forms of dysplasia of the vaginal portion of the cervix should be referred to the high risk groups in cancer. They should be subjected to separate curetting of the cervical canal and uterine cavity to avert intraepithelial or initial forms of the invasive cancer in this area.

Adult↗

Connective tissue changes and mast cell variations in benign and malignant lesions of the uterine cervix.

We have studied mast cell variations and stromal changes in 100 benign and 100 malignant lesions of the uterine cervix. Mast cells were found in close proximity to the cervical glands or young proliferating fibroblasts. Comparison of mast cell densities in benign and malignant conditions revealed an increase in inflammatory processes, while in cancers there is diminution in number or total absence of mast cells. There is no conclusive correlation between the age of the patients and the density of these cells. An inverse relationship existed between the mast cell population and degree of anaplasia as well as of mitotic figures.

Adult↗

[Relation between human papillomavirus (HPV) and cancer of uterine cervix].

HPV-DNA fragments were detected in biopsy specimens (29 cases of cancer of uterine cervix, 2 cervical dysplasia and 9 normal cervix) using DNA hybridization technique. It was demonstrated that 52% of biopsy specimens of the cancer of uterine cervix was positive for HPV 16 DNA probe, while 9% was positive for HPV 18 DNA probe. 11% of non-cancerous biopsy specimens had a positive result for HPV 16 DNA probe. It was also demonstrated that the positive rate of HPV 16 DNA was 75% in grossly cauliflower and nodular type tumors but only 25% in erosion type. It seems that the positive rate of HPV 16 DNA is correlated to gross appearance of the tumor. The positive rates of HPV 16 DNA were different in 6 provinces in China. It was 64% in Shanxi Province, a high incidence area but 36% in Sichuan Province, a low incidence area. These results suggest that the carcinogenesis of cancer of the uterine cervix, be related to HPV infection.

Aged↗