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PubMedDate not supplied

Calcinosis cutis following extravasation of calcium gluconate in neonates.

Neonatal hypocalcemia is not an uncommon condition, especially in the premature neonate. It is effectively treated by intravenous infusion with calcium gluconate. We treated nine neonates with subcutaneous calcium deposition following calcium replacement with calcium gluconate from Jan. 1997 to Dec. 1997. Three of the infants were born to diabetic mothers, two had perinatal asphyxia and four were born prematurity. The average dosing number was 7.4 (5 to 9 doses). The onset of calcinosis cutis was 5 to 11 days after the first dose. The replacement of calcium gluconate caused amorphous masses at the site of extravasation and contracture of joint movement. A radiographic study was performed to determine the extent and course of extravasation, and areas remote from the infusion site also showed calcification. There is no specific mode of treatment except supportive management and a skin graft. The patient could functionally recover with cosmetic residue. In our follow-up clinics, all infants completely recovered without functional limitations.

Calcinosis↗
PubMed2000

[Strategy of treatment of aortic stenosis complicated by total calcinosis].

The authors made an analysis of problems of strategy of surgical treatment of 132 patients with aortal stenosis complicated by calcinosis. Detailed indications to surgical treatment for stenosis of the aortal valve are given depending on the stage of the disease and complications. The nuances of the technique of performing the operation of prosthesis of the aortic valve are described.

Adult↗
PubMed1975

Hypercalcemia and calcinosis in Florida horses: implication of the shrub, Cestrum diurnum, as the causative agent.

A chronic debilitating disease is described in Florida horses. There is progress weight loss and lameness of increasing severity. Plasma calcium is elevated to moderate or severe degree. Anatomical changes include dystrophic calcinosis of elastic tissues, viz. major arteries, tendons and ligaments. A generalized osteopetrosis is present and may be related to hypoparathyroidsim and hypercalcitoninism. The presence of Cestrum diurnum (day-blooming jessamine, day cestrum, wild jasmin) in areas accessible to affected animals, the observation that leaves of the plant were stripped in these areas, and the finding of a potent, active vitamin D-like substance in this plant constitute strong evidence that Cestrum diurnum is the agent causing the abnormalities of mineral metabolism.

Animals↗
PubMed2001

Treatment of calcinosis in juvenile dermatomyositis with probenecid: the role of phosphorus metabolism in the development of calcifications.

OBJECTIVE: To report the efficacy of probenecid for calcinosis of juvenile dermatomyositis (JDM) and assess the changes in phosphorus metabolism during treatment. METHODS: Biochemical studies of calcium and phosphorus metabolism were performed in a 9-year-old girl with JDM and extensive calcifications before and during probenecid treatment. RESULTS: The calcifications resolved over 18 months of treatment. Probenecid was found to be effective in reducing calcifications by increasing renal phosphate clearance. CONCLUSIONS: The tendency for calcifications in some patients with JDM might be related to an increase in renal phosphate reclamation, and therefore, probenecid treatment may be effective in these patients.

Calcinosis↗
PubMed1975

[Role of excessive phosphorus consumption in the development of aortic calcinosis].

The calcium and phosphorus content was studied in the blood serum and in the aorta of rats fed with varying Ca:P ratio in their diets (2:1; 1:1; 1:2; 1:3). In rats kept on a 1:3 Ca:P diet hypocalcemia, hyperphosphotemia and intensive calcination of the aorta was observed. Some accumulation of calcium in the aorta was noted also with a 1:2 Ca:P diet. The possible role of excessive phosphorus consumption is discussed as a factor contributing to the development of aortic calcinosis, emphasizing the need to precise and carefully maintain an optimum Ca:P ratio in the diet of normal individuals and in that of cardiovascular patients.

Animal Feed↗
PubMed1975

[Effect of mitral valve calcinosis on the remote results of commissurotomy].

The results of 249 mitral commissurotomies in calcification of the mitral valve are analysed. The authors have differentiated three grades of calcification of the valve and two groups according to its functional state. Late results were followed up in 177 patients within the terms up to 10 years and longer. The persistant positive result was noted in 99 patients, in 11 cases it was regarded as poor, and in 37--unstable. Postoperatively 34 patients died. The analysis enabled the authors to state that the positive effect of closed mitral commissurotomy could be also gained in considerable calcification. Prosthetic replacement of the valve is indicated in the presence of massive calcinosis associated with the rigidity of cusps and marked regurgitation.

Calcinosis↗
PubMed2001

Acute carpal tunnel syndrome caused by idiopathic tumoral calcinosis.

We present a case of acute carpal tunnel syndrome due to compression of the median nerve within the carpal tunnel caused by tumoral calcinosis. Wrist immobilization and oral corticosteroids produced excellent clinical resolution. Radiologically, the calcific mass disappeared.

Acute Disease↗
PubMedDate not supplied

[Cutaneous calcinosis induced by topical calciphylaxis in rats. I. Ultrastructural aspcts].

Skin calcification induced by topical calciphylaxis was provoked by a subcutaneous injection of iron chloride in rats previously sensitized by D.H.T. and studied by electron microscope. The evolution of the calciphylatic response can be resumed as follows: -- early appearance of numberous granules in the mitochondria of the cells of the connective tissue; their inorganic nature was revealed by microincineration and it is highly probable that they are a reserve of mineral ions; -- between the 6 hr, and the 18 hr, stages the interfibrillar matrix contained rounded vesicular structures, enclosed by a triple mambrane, which must surely be of cellular origin; they progressively incorporated more and more mineral particles which confirm their primordial role in the initial phases of mineralization; -- from the 14 hr. stage onward, mineral rodlets composed of chains of little dots appeared in the intercellular matrix and then on the collagen fibrils, probably in contact with the mucopolysaccharides; -- starting at the 24 hr, stage, the mineralization progressed without a vesicular intermediary forming increasingly dense and widespread plaques; the presence of needles of homogenous aspect indicated the appearance of a crystalline mineral deposit; an intrafibrillar mineral deposit becomes visible later. These results are compared with those obtained previously in other studies of experimental or pathological calcinosis and of mineralization of skeletal tissues.

Animals↗
PubMed2002

Bullous systemic lupus erythematosus with milia and calcinosis.

Bullous systemic lupus erythematosus (SLE) is a rare skin manifestation of SLE. It shares many features with epidermolysis bullosa acquisita (EBA). We report on a patient with SLE who developed a vesiculobullous eruption followed by findings not typical in bullous SLE, namely milia, mild scarring, and calcinosis. We discuss the relationship between bullous SLE and EBA.

Adult↗
PubMedDate not supplied

[Surgical approach to a leg ulcer in areas of subcutaneous calcinosis].

The medical treatment of ulceration of the legs in areas with a subcutaneous plaque of calcinosis is often unsuccessful. The phlebologists then refer the patient to a surgeon. A patient aged 58 years, with a previous history of phlebitis, presented on two successive occasions with ulceration in the area of a large calcification in the lower third of the left leg. Cicatrization was obtained by a surgical treatment. Such surgery must be preceded by local and complete vascular assessment and by appropriate pre-operative care. It consists mainly of ablation of bone sequestration in order to obtain a suitable surface on which to apply thin skin graft in strips. It is often necessary to carry out an internal saphenous crossectomy as well to treat an associated venous insufficiency.

Aged↗
PubMedDate not supplied

[Various cases of calcinosis].

The authors report seven cases of calcinosis, two of which were intravenous (phlebolithiasis) and five subcutaneous. Radiography of the soft tissues revealed in some cases a truly calcareous shealth, the size of which would not have been suspected from a clinical examination. Extensive calcification may be surprisingly well tolerated and results only in torpid ulceration that heals with simple conservative methods. On the other hand, pain and secondary infections may necessitate surgical resection of the calcareous plaques after arteriography.

Aged↗
PubMed2003

[Scrotal calcinosis].

The authors report a case of scrotal calcinosis in a 56-year-old patient. In the light of a review of the literature, they discuss the aetiopathogenic, clinical and histological features of this rare disease.

Calcinosis↗
PubMed2000

Tumoral calcinosis: report of nine cases.

Radiological observations of nine cases of tumoral calcinosis are reported. CT appearances of intracranial lesions in one patient are described. All patients were confirmed by histopathology. After complete excision no recurrence was seen in eight of the patients after a mean follow up of 24 months. Incomplete excision led to recurrence in one case.

Adolescent↗
PubMed2000

Radiological presentation of pulmonary calcinosis: case report.

A 64-year old man presented to the Department of Radiology for evaluation. He had a seven year history of chronic cough. The chest x-ray (CXR) done showed high density diffuse cotton wool parenchymal opacities in both lungs sparing the pleura and broncho vascular bundles. These were also demonstrated on CT. This type of pulmonary calcinosis did not fit in with the classical appearances.

Calcinosis↗
PubMed1992

Beneficial effects of a calcium antagonist, nifedipine, on death and cardiovascular calcinosis induced by dietary magnesium deficiency in adult mice.

The effects of nifedipine on the survival rate and the cardiovascular calcinosis were investigated in dietary magnesium (Mg)-deficient mice. Male mice aged 8 to 10 weeks were fed with a diet which was either normal (0.07%) or deficient (0.007%) in Mg for 30 d. Nifedipine was added to the Mg-deficient diet for 30 d in a concentration of 1000 ppm. About 65% of Mg-deficient mice died within 30 d. In contrast, all the nifedipine-treated mice survived for 30 d. Mg-deficient mice showed hypomagnesaemia and hypocalcaemia which were not influenced by nifedipine treatment. Aortic and cardiac calcium contents increased in Mg-deficient mice, and these increments were normalized by nifedipine treatment. These results suggest that the life-saving effect of nifedipine in Mg-deficient mice might relate, at least in part, to the prevention of a deleterious increase in Ca in cardiovascular tissues.

Animals↗
PubMed2003

Tumoral calcinosis with unusual presentation. A case report.

A case of multiple para-articular calcific masses involving the elbow, hand, back, knee and the feet was encountered. Pathology after surgical excision of all the masses revealed tumoral calcinosis. The unusual feature was the huge size of the lumbar and knee masses, and the distal location of the swellings in the hand and the foot; there was no disturbance of calcium and phosphorus metabolism, which was an unusual feature of the condition in this patient.

Adult↗
PubMed2004

[Tumoral calcinosis in a Sardinian patient mimicking hydatid disease: a case report].

The aim of this study is to report on a case of tumoral calcinosis (TC) mimicking hydatid cyst, which was diagnosed in a 51-year-old Caucasian woman of Sardinian origin. This lady presented with two symmetrical enlarging masses of soft tissue in the hips. The CT findings were suggestive of hydatid cysts. Grossly the two lesions appeared as unencapsulated firm, rubbery masses extending into the surrounding muscles. On cut surface the two specimens were multiloculated and contained either calcareous material or milky fluid. At histology the main findings were represented by multiple foci of amorphous calcified material bordered by proliferating macrophages, fibroblasts and multinucleated giant cells, separated by fibrous septa. The following characteristics are worth of note: the presentation in adulthood (late onset); the Caucasian race of the patient; the radiological appearances indicative of hydatid cyst; the aggressive clinicopathologic course, with multifocal involvement, rapid growth, infiltrative pattern. Histologically the TC exhibited the typical pattern of stage II according to Slavin's classification of disease.

Calcinosis↗