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Growth and development of the tibia, fibula, and ankle joint.

Deformities of the leg and ankle may result from growth abnormalities of the tibia and fibula. Measurements of the distance between the proximal tibial and fibular physes, the distal tibial and fibular physes, and the angle between the long axis of the tibia and the distal tibial physis and talar dome were made to determine the changes that occur during normal skeletal development. These measurements demonstrate that early detection of growth discrepancy is possible.

Ankle Joint↗

Tissue engineered ceramic artificial joint--ex vivo osteogenic differentiation of patient mesenchymal cells on total ankle joints for treatment of osteoarthritis.

Total joint arthroplasty is the common treatment of severe cases of osteoarthritis. However, complications involving failure of the bone-prosthesis interface are significant, especially in ankle arthroplasty. To prevent this complication, we attempted a tissue engineering approach using the mesenchymal cells of the patient. We collected a small amount of fresh bone marrow cells from the patient's iliac crest and expanded the number of mesenchymal cells. We then applied the mesenchymal cells to a ceramic ankle prosthesis and cultured them to form an osteoblasts/bone matrix on the prosthesis. We used tissue engineered prostheses on three patients suffering from ankle arthritis and followed their progress for at least 2 years. Follow-up X-ray examinations revealed early radiodense appearance (bone formation) around the cell-seeded areas of the prostheses about 2 months after the operation after which a stable host bone-prosthesis interface was established. All patients showed high clinical scores after the operation and did not exhibit inflammatory reactions. These preliminary results indicate that the tissue engineering approach using autologous cultured marrow mesenchymal cells might prevent aseptic loosening of the total ankle arthroplasty.

Ankle Joint↗

Is range of motion of the hip and ankle joint related to running injuries? A case control study.

This study concerns a case-control study on the relation between range of motion (ROM) of the hip and ankle joints and running injuries. Sixteen male runners who had sustained a medically treated running injury during the year prior to the ROM measurements were matched for weekly running distance and age with sixteen male runners who had not sustained such an injury. All subjects were fit at the time of measurement. ROM was measured by standardized goniometry after a warm-up on a cycle-ergometer. Within non-injured subjects all goniometric measurements showed no significant (p > 0.05) differences between the left and right side of the body. Within injured subjects all goniometric measurements showed no significant (p > 0.05) differences between the injured and non-injured side of the body. Runners who had sustained a running injury showed a significant (p > 0.001) more restricted ROM of the hip joints (average ROM value 59.4 degrees +/- 8.0 degrees) in comparison to runners who had no been injured during the same period (average value ROM 68.1 degrees +/- 5.2 degrees). No such differences (p > 0.05) were found with regard to ankle ROM (average ROM value injured 12.8 degrees +/- 3.4 degrees and average ROM value non injured 14.0 degrees +/- 2.7 degrees). These findings suggest that ROM can be characterized as a more or less stable anthropometric trait.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

Differences in ankle joint complex range of motion as a function of age.

The purpose of this study was to determine whether gender- and age-related differences in ankle joint complex (AJC) range of motion (ROM) exist in children (range 9-13 years), adolescents (14-16 years), and young adults (17-20 years), and to compare these data with those published for older subjects (21-79 years) using the same protocol. A total of 120 subjects (58 males and 62 females) ranging in age from 9 to 20 years were tested for AJC ROM using a specifically designed 6 degrees of freedom fixture. All measurements were made with respect to a laboratory coordinate system, and represented assessment of active AJC ROM. Angular displacements for plantarflexion, dorsiflexion, inversion, eversion, abduction, and adduction were digitally recorded and compared. AJC ROMs of females aged 9 to 20 years were generally greater than those for males about all three orthogonal axes. Within each gender, there was a consistent trend for AJC ROM to decrease from a maximum at 14 to 16 or 17 to 20 years to a minimum after age 60 years. The average decrement was greater for females than for males. This study provided evidence to support the contention that age-related and gender differences in AJC ROM do exist. The possibility of minimizing the decline in AJC ROM with age requires further investigation.

Adolescent↗

Primary leiomyosarcoma affecting the ankle joint.

In a 50-year-old patient with a malignant tumor of the left distal tibia (stage la, according to Enneking) undermining the cartilage of the ankle joint, an extremely rare primary leiomyosarcoma of bone was diagnosed. The diagnosis of a primary leiomyosarcoma of bone is possible only after a secondary (metastatic) leiomyosarcoma has been excluded. Furthermore, typical histopathological features, including immunohistochemical staining results, are required for the diagnosis. Surgery is the therapy of choice. An R0 resection should always be attempted.

Adolescent↗

Six DOF in vivo kinematics of the ankle joint complex: Application of a combined dual-orthogonal fluoroscopic and magnetic resonance imaging technique.

Accurate knowledge of in vivo ankle joint complex (AJC) biomechanics is critical for understanding AJC disease states and for improvement of surgical treatments. This study investigated 6 degrees-of-freedom (DOF) in vivo kinematics of the human AJC using a combined dual-orthogonal fluoroscopic and magnetic resonance imaging (MRI) technique. Five healthy ankles of living subjects were studied during three in vivo activities of the foot, including maximum plantarflexion and dorsiflexion, maximum supination and pronation, and three weight-bearing positions in simulated stance phases of walking. A three-dimensional (3D) computer model of the AJC (including tibia, fibula, talus, and calcaneus) was constructed using 3D MR images of the foot. The in vivo AJC position at each selected position of the foot was captured using two orthogonally positioned fluoroscopes. In vivo AJC motion could then be reproduced by coupling the orthogonal images with the 3D AJC model in a virtual dual-orthogonal fluoroscopic system. From maximum dorsiflexion to plantarflexion, the arc of motion of the talocrural joint (47.5 +/- 2.2 degrees) was significantly larger than that of the subtalar joint (3.1 +/- 6.8 degrees). Both joints showed similar degrees of internal-external and inversion-eversion rotation. From maximum supination to pronation, all rotations and translations of the subtalar joint were significantly larger than those of the talocrural joint. From heel strike to midstance, the plantarflexion contribution from the talocrural joint (9.1 +/- 5.3 degrees) was significantly larger than that of the subtalar joint (-0.9 +/- 1.2 degrees). From midstance to toe off, internal rotation and inversion of the subtalar joint (12.3 +/- 8.3 degrees and -10.7 +/- 3.8 degrees, respectively) were significantly larger than those of the talocrural joint (-1.6 +/- 5.9 degrees and -1.7 +/- 2.7 degrees). Strong kinematic coupling between the talocrural and subtalar joints was observed during in vivo AJC activities. The contribution of the talocrural joint to active dorsi-plantarflexion was higher than that of the subtalar joint, whereas the contribution of the subtalar joint to active supination-pronation was higher than that of the talocrural joint. In addition, the talocrural joint demonstrated larger motion during the early part of stance phase while the subtalar joint contributes more motion during the later part of stance phase. The results add quantitative data to an in vivo database of normals that can be used in clinical diagnosis, treatment, and evaluation of the AJC after injuries.

Adult↗

Diabetic neuro-osteoarthropathy. Rehabilitation of a patient with both ankle joints involved and associated skin problems.

Neuro-osteoarthropathy in diabetes mellitus is not rare. The case of a 53-year-old diabetic with involvement of both ankle joints and multiple associated skin problems complicating rehabilitation management is discussed. By applying a team approach, closely monitoring the patient's skin and joint problems, and treating them at an early stage by adaptive shoes and orthoses, we found that function could be sustained at an optimal level for a prolonged period. In addition to prevention of ulceration, modifying the weight bearing or temporarily non-weight bearing is the treatment of choice. Amputation is to be considered only as a last resort.

Ankle Joint↗

Ankle joint range of motion measurements in spastic cerebral palsy children: intraobserver and interobserver reliability and reproducibility of goniometry and visual estimation.

The aim of this study was to assess the intra- and interobserver reliability and reproducibility of goniometry and visual estimation of ankle joint range of motion measurements in children with spastic cerebral palsy. Forty-six ankles of 24 spastic cerebral palsy children were measured under a strict protocol. The global mean measurement error was 5 degrees (SD, 5 degrees) for intra- and interobserver measurements and 3 degrees (SD, 3 degrees) for goniometry versus visual estimation. Statistical analysis showed a high reliability for intra- and interobserver measurements (r>0.75), between visual estimation and goniometry (correlation coefficient, r>0.967; concordance coefficient, r>0.957). Both visual estimation and goniometry ankle range-of-motion measurements are reliable and reproducible in spastic cerebral palsy children if a strict but simple protocol is applied.

Adolescent↗

[Pseudarthrosis of the proximal ankle joint].

Nonunion of the ankle malleoli is extremely rare these days. This is probably due to the fact that primary osteosynthesis is performed in ankle fractures instead of the conservative treatment given up to 20 years ago. Today nonunions of the malleoli are seen, if at all, is infected cases after surgical procedures. Noninfected, stable and painless nonunions usually do not need any surgical correction. In painful cases, small fragments, especially of the medial malleolus, should be resected; larger fragments should be stabilized with two 3.5-mm cancellous screws. Alternatively, the tension banding technique, especially after Weber A fracture, produces high compression in the area of nonunion. In cases of additional bony defects, a local upside down cortical-cancellous bone graft should be performed in addition. In summary, the therapeutic approach requires exact remodeling, bone-grafting and stabilization. Infected nonunions with loss of bone mass should be treated according to the guidelines for osteitis therapy.

Adult↗

[A new procedure for measuring displacement of the anterior ankle joint in the lateral projection].

Different methods are recommended for exploration of stress-radiographs of the ankle joint in lateral projection. After considering the geometric-mathematical propositions a new schedule is shown, which combines simple handling with tolerable error level and regards individual bone size. An index is derived from measurements of the tibia and the talus according to certain conditions. The limits for normal, borderline and pathological indices were statistically determined by measurement of 50 lateral stress-radiographs of uninjured ankle sprains. In comparison with the common measuring of an posterior tibio-talar distance better results were found with a higher score of discrimination for the new method. Additionally the new procedure allows exploration of radiographs which do not fulfill the demands to an exact lateral projection of the ankle sprain.

Ankle Injuries↗

Nonsurgical treatment of lateral ligament injury of the ankle joint.

Between 1986 and 1989, 40 patients with acute lateral ligament injury of the ankle joint were treated by immobilizing their affected feet in a plaster cast with a heel for 4 weeks, followed by a brace for the next 2 months. The average follow-up time was 29 months. Ninety-eight percent of the patients were rated as having satisfactory functional results. Stress radiographs at the latest follow-up showed good stability even in ankles that were severely unstable at injury. Posttreatment stress radiographs taken periodically showed that stability was maintained 6 months after treatment.

Adolescent↗

Visualization and in situ analysis of leukocyte trafficking into the ankle joint in a systemic murine model of rheumatoid arthritis.

OBJECTIVE: To describe the kinetics of leukocyte migration into a distal joint during the development of chronic inflammation in a murine model of rheumatoid arthritis (RA), to identify leukocyte subpopulations recruited in the synovial vessels, and to test in real time the effects of an antiinflammatory compound on leukocyte-endothelial cell interactions in the arthritic joint. METHODS: We used intravital video microscopy (IVM), which was adapted to the microcirculation of the mouse ankle, to monitor the kinetics of leukocyte-endothelium interactions (rolling and firm adhesion) during the onset and progression of proteoglycan-induced arthritis (PGIA), a chronic autoimmune model of RA. Subpopulations of rolling and adherent leukocytes were identified by in vivo immunostaining. Leukocyte extravasation into the ankle joint was verified histologically. RESULTS: Between the onset of arthritis and the beginning of the destructive phase of PGIA, we found a steady increase in the number of leukocytes that exhibited firm adherence to the endothelium of synovial vessels, which clearly underscores the chronic, self-perpetuating character of joint inflammation in this autoimmune model. We showed, however, that granulocytes, and not T cells, constituted the major cell population that was continuously recruited to the inflamed ankle. Using IVM, we could detect instant changes in leukocyte adhesion behavior in the synovial vessels of the arthritic joint upon administration of a compound that antagonizes leukocyte rolling. CONCLUSION: IVM of the microcirculation of the mouse ankle could become an essential tool for investigating the mechanisms that regulate leukocyte migration to the joint in systemic models of RA as well as for preclinical testing of antiinflammatory therapies.

Animals↗

Ankle joint arthroscopy.

The arthroscope has been used clinically on the knee for quite some time. The history of arthroscopy is reviewed. The technique of arthroscopic surgery on the knee is summarized. The applications of its use on the ankle joint is discussed as well as technique for arthroscopy. A case report is presented and experiences with arthroscope for diagnosis of ankle problems at Harrison Community Hospital are summarized.

Ankle Injuries↗

[Synovial chondromatosis of the ankle joint and elbow in two cases].

Two male patients, aged 44 and 88 years, presented with complaints of restricted joint movement, a growing swelling, and pain in the elbow and ankle joints, respectively. Radiographs showed cartilaginous nodules in the affected joints and minimal chondral damage. Magnetic resonance findings were consistent with synovial chondromatosis. Both patients underwent removal of loose bodies by open arthrotomy and partial synovectomy. Histopathologic examination confirmed the diagnosis. No recurrences were detected within a follow-up period of at least a year.

Adult↗