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PubMed1992

Spatial frequency mechanisms with short-wavelength-sensitive cone inputs.

We have estimated the minimum number and frequency tuning of spatial mechanisms with Short-Wavelength-Sensitive (SWS)-cone inputs. This was accomplished by isolating SWS cones with intense, long-wavelength (yellow) adaptation, and measuring threshold elevation functions for short-wavelength, spatially localized test stimuli masked by obliquely oriented, short-wavelength, cosine gratings. Peak spatial frequency of the cosine gratings and test stimuli varied from 0.25 to 2.83 cpd in 0.5 octave steps. Results derived in this manner demonstrate that SWS cones input to at least two orientation selective mechanisms with peak spatial frequencies of approx. 0.7 and 1.4 cpd, respectively. The frequency tuning of the isolated-SWS-cone, spatial frequency mechanisms resemble closely the lowest two mechanisms measured with luminance modulation (i.e. normal viewing conditions where all cones contribute to the response).

Contrast Sensitivity↗
PubMed1994

Color contrast induction.

We report the results of psychophysical experiments on the intensive, spatial, temporal and chromatic properties of color contrast induction. Modulating the contrast of an annulus induces an apparent modulation of the color contrast of a central disk, at isoluminance. Results of varying the size of the annulus suggest that mechanisms which control contrast gain are spatially localized. Results of varying the orientations of disk and annulus patterns, with peak spatial frequencies at about 2 c/deg, suggest that the mechanisms are spatially isotropic. Results of varying the rate at which annulus contrast is modulated shows that mechanisms which mediate contrast induction have a low-pass temporal sensitivity that cuts off at about 8 Hz. Results of an experiment on the interocular transfer of color contrast induction suggest that the induction has a cortical locus. Finally, the results of varying the chromatic properties of disk and annulus suggest that the underlying mechanisms are partially, but not fully, chromatically selective.

Color Perception↗
PubMed2001

Information limitations in perception of shape from texture.

Li and Zaidi (Li, A., and Zaidi, Q. (2000) Vision Research, 40, 217-242) showed that the veridical perception of the 3-dimensional (3D) shape of a corrugated surface from texture cues is entirely dependent on the visibility of critical patterns of oriented energy. These patterns are created by perspective projection of surface markings oriented along lines of maximum 3D curvature. In images missing these orientation modulations, observers confused concavities with convexities, and leftward slants with rightward slants. In this paper, it is shown that these results were a direct consequence of the physical information conveyed by different oriented components of the texture pattern. For texture patterns consisting of single gratings of arbitrary spatial frequency and orientation, equations are derived from perspective geometry that describe the local spatial frequency and orientation for any slant at any height above and below eye level. The analysis shows that only gratings oriented within a few degrees of the axis of maximum curvature exhibit distinct patterns of orientation modulations for convex, concave, and leftward and rightward slanted portions of a corrugated surface. All other gratings exhibit patterns of frequency and orientation modulations that are distinct for curvatures on the one hand and slants on the other, but that are nearly identical for curvatures of different sign, and nearly identical for slants of different direction. The perceived shape of surfaces was measured in a 5AFC paradigm (concave, convex, leftward slant, rightward slant, and flat-frontoparallel). Observers perceived all five shapes correctly only for gratings oriented within a few degrees of the axis of maximum curvature. For all other oriented gratings, observers could distinguish curvatures from slants, but could not distinguish signs of curvature or directions of slant. These results demonstrate that human observers utilize the shape information provided by texture components along both critical and non-critical orientations.

Form Perception↗
PubMed2001

Erratum to "Information limitations in perception of shape from texture". [Vision Research 41 (2001) 1519-1534].

Li and Zaidi (Li, A., and Zaidi, Q. (2000) Vision Research, 40, 217-242) showed that the veridical perception of the 3-dimensional (3D) shape of a corrugated surface from texture cues is entirely dependent on the visibility of critical patterns of oriented energy. These patterns are created by perspective projection of surface markings oriented along lines of maximum 3D curvature. In images missing these orientation modulations, observers confused concavities with convexities, and leftward slants with rightward slants. In this paper, it is shown that these results were a direct consequence of the physical information conveyed by different oriented components of the texture pattern. For texture patterns consisting of single gratings of arbitrary spatial frequency and orientation, equations are derived from perspective geometry that describe the local spatial frequency and orientation for any slant at any height above and below eye level. The analysis shows that only gratings oriented within a few degrees of the axis of maximum curvature exhibit distinct patterns of orientation modulations for convex, concave, and leftward and rightward slanted portions of a corrugated surface. All other gratings exhibit patterns of frequency and orientation modulations that are distinct for curvatures on the one hand and slants on the other, but that are nearly identical for curvatures of different sign, and nearly identical for slants of different direction. The perceived shape of surfaces was measured in a 5AFC paradigm (concave, convex, leftward slant, rightward slant, and flat-frontoparallel). Observers perceived all five shapes correctly only for gratings oriented within a few degrees of the axis of maximum curvature. For all other oriented gratings, observers could distinguish curvatures from slants, but could not distinguish signs of curvature or directions of slant. These results demonstrate that human observers utilize the shape information provided by texture components along both critical and non-critical orientations.

Form Perception↗
PubMed1988

Localization of tactile stimuli and body parts in space: two dissociated perceptual experiences revealed by a lack of constancy in the presence of position sense and motor activity.

Two motor acts were analyzed at the level of tongue and fingers. These motor acts generated illusions. When subjects voluntarily rotated the tongue by 90 degrees, the perceived orientation of a tactile stimulus applied to the tongue did not covary with the perceived orientation of the tongue itself. Analogously, when subjects voluntarily crossed two adjacent fingers, the perceived position of two tactile stimuli applied to the fingers did not covary with the perceived position of the fingers themselves. Although tongue and fingers were positioned accurately in space, a lack of perceptual constancy occurred for tactile stimuli applied to these body parts. Therefore, whereas position sense was preserved, correct localization of objects was lost. The occurrence of this perceptual dissociation suggests that spatial localization of tactile stimuli may be independent both of knowledge of body part location and motor activity.

Attention↗
PubMed2001

Dynamic localization of a cytoplasmic signal transduction response regulator controls morphogenesis during the Caulobacter cell cycle.

We present evidence that a bacterial signal transduction cascade that couples morphogenesis with cell cycle progression is regulated by dynamic localization of its components. Previous studies have implicated two histidine kinases, DivJ and PleC, and the response regulator, DivK, in the regulation of morphogenesis in the dimorphic bacterium Caulobacter crescentus. Here, we show that the cytoplasmic response regulator, DivK, exhibits a dynamic, cyclical localization that culminates in asymmetric distribution of DivK within the two cell types that are characteristic of the Caulobacter cell cycle; DivK is dispersed throughout the cytoplasm of the progeny swarmer cell and is localized to the pole of the stalked cell. The membrane-bound DivJ and PleC histidine kinases, which are asymmetrically localized at the opposite poles of the predivisional cell, control the temporal and spatial localization of DivK. DivJ mediates DivK targeting to the poles whereas PleC controls its release from one of the poles at times and places that are consistent with the activities and location of DivJ and PleC in the late predivisional cell. Thus, dynamic changes in subcellular location of multiple components of a signal transduction cascade may constitute a novel mode of prokaryotic regulation to generate and maintain cellular asymmetry.

Bacterial Proteins↗
PubMed1997

Color constancy in variegated scenes: role of low-level mechanisms in discounting illumination changes.

For a visual system to possess color constancy across varying illumination, chromatic signals from a scene must remain constant at some neural stage. We found that photoreceptor and opponent-color signals from a large sample of natural and man-made objects under one kind of natural daylight were almost perfectly correlated with the signals from those objects under every other spectrally different phase of daylight. Consequently, in scenes consisting of many objects, the effect of illumination changes on specific color mechanisms can be simulated by shifting all chromaticities by an additive or multiplicative constant along a theoretical axis. When the effect of the illuminant change was restricted to specific color mechanisms, thresholds for detecting a change in the colors in a scene were significantly elevated in the presence of spatial variations along the same chromatic axis as the simulated chromaticity shift. In a variegated scene, correlations between spatially local chromatic signals across illuminants, and the desensitization caused by eye movements across spatial variations, help the visual system to attenuate the perceptual effects that are due to changes in illumination.

Color Perception↗
PubMed2001

Lyme disease in New York State: spatial pattern at a regional scale.

Lyme disease occurs commonly in New York State, but its geographic distribution is heterogeneous. Over each of nine consecutive years, incidence rates from 57 New York State counties were subjected to spatial autocorrelation analysis. Although the epidemic advanced during the study period, the analyses reveal a consistent pattern of spatial dependence. The correlation distance, the distance over which incidence rates covary positively, remained near 120 km over the nine years. A local spatial analysis around Westchester County, a major disease focus, indicated that the global correlation distance matched the extent of the most intense local clustering; statistically weaker clustering extended to 200 km from Westchester. Analyzing the spatial character of the epidemic may reveal the epizootic processes underlying patterns in human infection, and may help identify a spatial scale for regional control of disease.

Humans↗
PubMed2000

The hippocampus and flexible spatial knowledge in rats.

Lesions to the hippocampal system in rats result in a profound impairment of place or locale spatial learning although other learning strategies remain unaltered. The main objective of the present study was to investigate whether the spatial knowledge preserved in the hippocampal animals can be expressed flexibly under conditions different from those of the acquisition period. Rats with neurotoxic lesions to the dorsal hippocampus and sham-operated subjects were trained to reach the goal arm in a four-arm plus-shaped maze using a constant starting arm. During the training a transparent plexiglas barrier divided the maze in two equal halves in such a way that the animals could only travel from the starting arm to the goal arm, not having access to the remaining 50% of the maze. After seven days of training, a transfer test was used in which the starting arms were the two arms from which the animals had not started during the training phase. Results indicated that the lesioned rats made significantly more errors than the control subjects. But the most interesting results revealed that the kind of error made by the lesioned animals was congruent with the turn that they had to make during the acquisition phase in order to access the goal arm (reinforced). These results suggest that when the hippocampus is damaged a preserved highly inflexible egocentric strategy is employed to solve the spatial problem.

Animals↗
PubMed2001

Noninvasive localized MR quantification of creatine kinase metabolites in normal and infarcted canine myocardium.

PURPOSE: To develop image-guided spatially localized magnetic resonance (MR) spectroscopy to provide a noninvasive quantitative probe of myocardial creatine kinase (CK) metabolism, and to use it to determine the extent of changes in CK energy metabolism in nonviable infarcted canine myocardium. MATERIALS AND METHODS: Water-referenced localized phosphorus and proton MR spectroscopy were combined in a single protocol to noninvasively measure phosphocreatine (PCr), adenosine triphosphate (ATP), and total of phosphorylated and unphosphorylated creatine (CR) concentrations and pH in the myocardium in six normal dogs and six dogs with surgically induced myocardial infarction. Unphosphorylated creatine and adenosine diphosphate (ADP) levels were calculated. The results were compared with biochemical measurements at postmortem biopsy. RESULTS: Significant reductions in PCr-to-ATP ratios (1.7 +/- 0.3 [SD] vs 1 +/- 0.4; P <.001), PCr (10.3 +/- 2.1 vs 4.3 +/- 2.0 micromol/g wet weight; P <.0001), ATP (6.4 +/- 1.4 vs 3.7 +/- 1.4 micromol/g wet weight; P <.001), and CR (24.7 +/- 6.1 vs 6.3 +/- 3.7; P <.0001) were measured noninvasively in infarcted, as compared with normal, tissue. Biopsy measurements confirmed infarct-related reductions observed at MR spectroscopy, although high-energy phosphate concentrations were lower at biopsy. ADP calculated from noninvasive MR spectroscopic measurements was 0.11 +/- 0.07 micromol/g wet weight in normal myocardium. CONCLUSION: This combined phosphorus and proton MR spectroscopic approach provides a near-complete picture of in vivo myocardial CK metabolism in normal and diseased heart and a tool for noninvasively measuring metabolite reductions associated with the loss of viability.

Adenosine Triphosphate↗
PubMed1996

Evaluation of the non-invasive localization accuracy of cardiac arrhythmias attainable by multichannel magnetocardiography (MCG).

The accuracy of multichannel magnetocardiography (MCG) for the non-invasive localization of cardiac arrhythmias was investigated. A non-magnetic catheter was used in phantom studies and for cardiac pacing of 6 patients. In a clinical setting, 32 patients with WPW-syndrome, 37 patients with premature ventricular complexes and 12 patients with ventricular tachycardia were studied and the MCG results compared to reference methods, including invasive electrophysiological mapping. Phantom and pacing studies demonstrated the spatial localization accuracy to be better than 15 mm for a dipole-to-dewar distance below 15 cm. In all patients with structural cardiac disease, the ectopic focus was localized at the margin of the damaged area, serving as a proof of MCG localization. Invasive mapping confirmed the MCG result whenever performed (42 patients). In 11 patients (9 WPW, 2 VT) the MCG localization result was verified by successful HF catheter ablation as a gold standard. MCG permits the non-invasive localization of cardiac arrhythmias with high spatial accuracy. MCG guided HF catheter ablation constitutes a new concept of non-invasive localization and minimally invasive causal therapy.

Cardiac Pacing, Artificial↗
PubMed2003

Early targeting of Min proteins to the cell poles in germinated spores of Bacillus subtilis: evidence for division apparatus-independent recruitment of Min proteins to the division site.

The earliest event in bacterial cell division is the assembly of a tubulin-like protein, FtsZ, at mid-cell to form a ring. In rod-shaped bacteria, the Min system plays an important role in division site placement by inhibiting FtsZ ring formation specifically at the polar regions of the cell. The Min system comprises MinD and MinC, which form an inhibitor complex and, in Bacillus subtilis, DivIVA, which ensures that division is inhibited only in the polar regions. All three proteins localize to the division site at mid-cell and to cell poles. Their recruitment to the division site is dependent on localization of both 'early' and 'late' division proteins. We have examined the temporal and spatial localization of DivIVA relative to that of FtsZ during the first and second cell division after germination and outgrowth of B. subtilis spores. We show that, although the FtsZ ring assembles at mid-cell about halfway through the cell cycle, DivIVA assembles at this site immediately before cell division and persists there during Z-ring constriction and completion of division. We also show that both DivIVA and MinD localize to the cell poles immediately upon spore germination, well before a Z ring forms at mid-cell. Furthermore, these proteins were found to be present in mature, dormant spores. These results suggest that targeting of Min proteins to division sites does not depend directly on the assembly of the division apparatus, as suggested previously, and that potential polar division sites are blocked at the earliest possible stage in the cell cycle in germinated spores as a mechanism to ensure that equal-sized daughter cells are produced upon cell division.

Bacillus subtilis↗
PubMed2003

Three-dimensional localization of sentinel lymph nodes using combined emission and transmission SPECT data.

PURPOSE: With conventional planar imaging, preoperative anatomic localization of a sentinel lymph node is possible in only two dimensions. To improve spatial localization of sentinel lymph nodes, a dual-head camera equipped with a transmission source was used to create combined transmission-emission SPECT images in a patient with a malignant melanoma of the left forearm. METHODS: Lymph node scintigraphy was performed after injection of Tc-99m-labeled nanocolloid around the tumor site 1 day before operation. SPECT was performed using a gamma camera equipped with a transmission collimator system originally designed to correct attenuation. Transmission and emission images were created simultaneously, matched, and displayed in three dimensions. RESULTS: In the combined emission-transmission images, the sentinel lymph node was clearly located in the left axilla. The lymph nodes could be identified during operation at the same location as that detected by SPECT. Based on preoperative information, the sentinel lymph node was identified rapidly and the extent and duration of the operation were minimized. CONCLUSIONS: This method provides better anatomic information, especially in deep structures such as the axilla or pelvis. With accurate three-dimensional preoperative information, intraoperative access is quicker and less invasive for the patient.

Aged↗
PubMed2005

Local induction of acetylcholine receptor clustering in myotube cultures using microfluidic application of agrin.

During neuromuscular synaptogenesis, the exchange of spatially localized signals between nerve and muscle initiates the coordinated focal accumulation of the acetylcholine (ACh) release machinery and the ACh receptors (AChRs). One of the key first steps is the release of the proteoglycan agrin focalized at the axon tip, which induces the clustering of AChRs on the postsynaptic membrane at the neuromuscular junction. The lack of a suitable method for focal application of agrin in myotube cultures has limited the majority of in vitro studies to the application of agrin baths. We used a microfluidic device and surface microengineering to focally stimulate muscle cells with agrin at a small portion of their membrane and at a time and position chosen by the user. The device is used to verify the hypothesis that focal application of agrin to the muscle cell membrane induces local aggregation of AChRs in differentiated C2C12 myotubes.

Agrin↗
PubMed1991

[Comparison of ultrasound, computed tomography and magnetic resonance imaging in diagnosis of orbital disorders].

16 cases of confirmed orbital disorders, comprising orbital tumor 11 cases, inflammation 2 cases, ophthalmic Graves' disease 2 cases and carotid-cavernous sinus fistula 1 case, were studied with ultrasound, CT, and magnetic resonance imaging (MRI) in regard to identification and localization of the lesions. MRI excelled CT and ultrasound in histologic contrast resolution and spatial localization. The technique of MRI was particularly discussed.

Adolescent↗
PubMed1993

Lateral interactions between spatial channels: suppression and facilitation revealed by lateral masking experiments.

We measured contrast detection thresholds for a foveal Gabor signal flanked by two high contrast Gabor signals. The spatially localized target and masks enabled investigation of space dependent lateral interactions between foveal and neighboring spatial channels. Our data show a suppressive region extending to a radius of two wavelengths, in which the presence of the masking signals have the effect of increasing target threshold. Beyond this range a much larger facilitatory region (up to a distance of ten wavelengths) is indicated, in which contrast thresholds were found to decrease by up to a factor of two. The interactions between the foveal target and the flanking Gabor signals are spatial-frequency and orientation specific in both regions, but less specific in the suppression region.

Contrast Sensitivity↗
PubMed2003

A versatile wavelet domain noise filtration technique for medical imaging.

In this paper, we propose a robust wavelet domain method for noise filtering in medical images. The proposed method adapts itself to various types of image noise as well as to the preference of the medical expert; a single parameter can be used to balance the preservation of (expert-dependent) relevant details against the degree of noise reduction. The algorithm exploits generally valid knowledge about the correlation of significant image features across the resolution scales to perform a preliminary coefficient classification. This preliminary coefficient classification is used to empirically estimate the statistical distributions of the coefficients that represent useful image features on the one hand and mainly noise on the other. The adaptation to the spatial context in the image is achieved by using a wavelet domain indicator of the local spatial activity. The proposed method is of low complexity, both in its implementation and execution time. The results demonstrate its usefulness for noise suppression in medical ultrasound and magnetic resonance imaging. In these applications, the proposed method clearly outperforms single-resolution spatially adaptive algorithms, in terms of quantitative performance measures as well as in terms of visual quality of the images.

Algorithms↗
PubMed2003

Perception of global facial geometry in the inversion effect and prosopagnosia.

We investigated how efficiently combinations of positional shifts in facial features were perceived and whether the effects of combinations on the overall geometry of the face were reflected in discriminative performance. We moved the eyes closer together or further apart, and moved the mouth up or down. Trials with combinations of changes to both the mouth and the eyes were contrasted with trials with single changes to either the mouth or the eyes. As a contrast, we also examined combinations of changes in eye colour (brightness) and the same spatial manipulations. In addition, we specifically contrasted spatial combinations that more severely distorted the original triangular relation of the mouth and eyes (e.g. eyes closer and mouth down) to those that better preserved the original aspect ratio (e.g. eyes farther and mouth down). This we termed the "geometric context effect". We found that combinations of two spatial changes were detected more quickly and accurately by normal subjects viewing upright faces but not when faces were inverted. In contrast, combinations of spatial shifts and eye colour changes showed no advantage over faces with only one type of change. Combinations of spatial changes that distorted overall facial geometry more were detected more efficiently than less distorting combinations, showing that the spatial shifts were perceived in the context of the global facial structure. Again, this was found for upright but not inverted faces. We also tested a prosopagnosic patient, who showed the advantage for two spatial changes over one but lacked this geometric context effect, implying that she did not integrate local spatial information into overall facial structure.

Adolescent↗