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At least 487 records · Page 27Linked to original sources
PubMed2001

Measurement of anal sphincter muscles: endoanal US, endoanal MR imaging, or phased-array MR imaging? A study with healthy volunteers.

PURPOSE: To compare endoanal ultrasonography (US), endoanal magnetic resonance (MR) imaging, and phased-array MR imaging for anal sphincter muscle measurement. MATERIALS AND METHODS: Sixty healthy volunteers underwent 1.5-T phased-array MR, endoanal MR, and endoanal US examinations. Sphincter muscle thicknesses were measured. Measurement reliability was analyzed, and correlations among the imaging methods were calculated. Multivariate analysis was performed to assess the influence of age, weight, height, sex, parity, and obstetric trauma on sphincter dimensions. RESULTS: Both MR methods had good reliability for measurements of all sphincter components, whereas endoanal US was reliable for internal sphincter measurement only. There was little correlation between the techniques, except between the two MR techniques, with a strong correlation for total sphincter and perineal body thickness. The internal sphincter thickened significantly (P =.002) with age at endoanal US and endoanal MR imaging but not at phased-array MR imaging. There were small sex-based differences in sphincter muscle measurements at phased-array MR imaging only. CONCLUSION: Endoanal US enables reliable measurement of only internal sphincter thickness, whereas both MR imaging methods enable reliable measurement of all sphincter components. Sphincter measurement with phased-array MR imaging is as reliable as that with endoanal MR imaging.

Adult↗
PubMed2004

Automatic image registration of three-dimensional images of the head of cats and dogs by use of maximization of mutual information.

OBJECTIVE: To validate mutual information criterion as a ready-to-use technique for automated alignment (ie, registration) of 3-dimensional (3-D) multimodal image data of the head of cats and dogs. SAMPLE POPULATION: Corresponding 3-D magnetic resonance imaging (MRI) and computed tomography (CT) brain scans of a 6-month-old Doberman Pinscher with a brain cyst; CT images of the head of a European shorthair cat with a meningioma before and immediately, 3, and 6 months after surgical resection; and CT and corresponding stacked anatomic cryosection images of the entire head of a 2-year-old sexually intact female Beagle. PROCEDURE: All images were matched retrospectively by use of an in-house computer program developed on the basis of a mutual information image registration algorithm. Accuracy of the resulting registrations was evaluated by visual inspection. RESULTS: All registrations were judged to be highly accurate. Additional manual corrections were not necessary. CONCLUSIONS AND CLINICAL RELEVANCE: Mutual information registration criterion can by applied to 3-D multimodal head images of cats and dogs for full automatic rigid-body image registration. The combination of such aligned images would considerably facilitate efforts of veterinary clinicians as indicated by its widespread use in brain surgery and radiation therapy of humans.

Animals↗
PubMed2002

3D stereophotogrammetric image superimposition onto 3D CT scan images: the future of orthognathic surgery. A pilot study.

The aim of this study was to register and assess the accuracy of the superimposition method of a 3-dimensional (3D) soft tissue stereophotogrammetric image (C3D image) and a 3D image of the underlying skeletal tissue acquired by 3D spiral computerized tomography (CT). The study was conducted on a model head, in which an intact human skull was embedded with an overlying latex mask that reproduced anatomic features of a human face. Ten artificial radiopaque landmarks were secured to the surface of the latex mask. A stereophotogrammetric image of the mask and a 3D spiral CT image of the model head were captured. The C3D image and the CT images were registered for superimposition by 3 different methods: Procrustes superimposition using artificial landmarks, Procrustes analysis using anatomic landmarks, and partial Procrustes analysis using anatomic landmarks and then registration completion by HICP (a modified Iterative Closest Point algorithm) using a specified region of both images. The results showed that Procrustes superimposition using the artificial landmarks produced an error of superimposition on the order of 10 mm. Procrustes analysis using anatomic landmarks produced an error in the order of 2 mm. Partial Procrustes analysis using anatomic landmarks followed by HICP produced a superimposition accuracy of between 1.25 and 1.5 mm. It was concluded that a stereophotogrammetric and a 3D spiral CT scan image can be superimposed with an accuracy of between 1.25 and 1.5 mm using partial Procrustes analysis based on anatomic landmarks and then registration completion by HICP.

Algorithms↗
PubMed2005

Manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging of acute reperfused myocardial injury in a cat model: part II: comparison with cine magnetic resonance imaging.

RATIONALE AND OBJECTIVES: To compare manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging (MRI) with cine MRI for distinguishing the dysfunctional myocardium from the normal myocardium. MATERIALS AND METHODS: Seventeen cats were prepared for acute myocardial infarction with 90 minutes of occlusion followed by 120 minutes of reperfusion. In vivo inversion-recovery gradient-recalled echo MRI and cine MRI were performed. Two radiologists independently analyzed the MR images and recorded the size of the unenhanced area on the MnDPDP-enhanced MR images as well as that of the dysfunctional area on the cine MR images. Agreement between these abnormal areas was evaluated using Bland-Altman analysis. Interobserver agreement was assessed using Bland-Altman analysis. RESULTS: The sizes of the unenhanced area on the MnDPDP-enhanced MR images and the dysfunctional area on the cine MR images showed good agreement on Bland-Altman analysis (the limits of agreement: observer 1= 1.8% +/- 11.6, observer 2 = 0.1% +/- 9.9). The abnormal segments on both types of MR imaging showed a good interobserver agreement (the limits of agreement: MnDPDP-enhanced MRI = 0.3% +/- 7.6, cine MRI = -1.4% +/- 10.9). CONCLUSION: The size of the dysfunctional area on the cine MR images was well correlated with that of the unenhanced area on the MnDPDP-enhanced MR images.

Acute Disease↗
PubMed2006

Endovascular treatment of intracerebral arteriovenous malformations: procedural safety, complications, and results evaluated by MR imaging, including diffusion and perfusion imaging.

BACKGROUND AND PURPOSE: Endovascular embolization is an increasingly common method to treat intracerebral arteriovenous malformations (AVM). To date, however, published data are rather scarce, especially with regard to true procedure-related complications and their causes. The purpose of our study was to evaluate treatment safety and correlate anatomic results with clinical outcome by using MR imaging, including diffusion-weighted (DWI) and perfusion imaging (PI). METHODS: We performed 50 endovascular procedures in 21 patients. Most AVMs were supratentorial, Spetzler-Martin grades II-IV. MR imaging was scheduled within 1 week before and 3 days after each treatment. MR imaging findings were correlated to digital subtraction angiography, procedure reports, and the clinical course. Outcome was graded according to the modified Rankin scale (mRS) 3-6 months after treatment. RESULTS: In this study, 104 MR imaging examinations were performed; mean interval between the endovascular procedure and posttreatment MR imaging was 28 hours. Nine adverse events occurred in 7 patients during 8 procedures (16%), one causing a permanent deficit. New lesions were noted on MR imaging after 22/50 procedures. Ischemic lesions in 22% of the procedures, frequently located perinidally. Most lesions were small, frequently asymptomatic, and reversible (18/23). Four hematomas were found. Subacute hemorrhages developed from a vasogenic edema on 2 occasions. New lesions, including hematomas, developed between treatments in 4 patients, mainly because of progressive occlusion of the nidus or draining veins. PI overestimated the AVM nidus on most occasions, and transient worsening of the PI pattern was noted in 2 patients. Treatment-related mortality and morbidity were 0% and 14.2%, respectively (mRS 1-2). CONCLUSIONS: Endovascular procedures are rather safe but are associated with more ischemic events and followed by less hemodynamic disturbances than previously understood. Adverse procedural events and new MR imaging lesions were generally asymptomatic and most often transient, if symptomatic. Most lesions would not have been verified without MR imaging. DWI and PI were most useful to detect and understand the cause of various complications. The most clinically important complications were caused by late venous occlusions.

Adult↗
PubMedDate not supplied

Implementation of the T4/5 left ventricular functional image on a VAX-based Lexidata image processing station.

A VAX-based Lexidata image processing station has been used for the development and application of image processing and data analysis techniques in nuclear medicine. Within the area of cardiac multigated equilibrium blood-pool scintigraphy, the computational implementation of the T4/5 functional image, a new left ventricular functional image, is presented. This image reflects myocardial compliance. The versatility of the implementation is demonstrated. Examples of the T4/5 functional image are presented. The VAX-based Lexidata image processing station is a useful tool for parameter, feature, and image extraction from nuclear medicine images.

Coronary Disease↗
PubMed1996

Optimization of linear image combination for segmentation in red-green-blue images.

OBJECTIVE: To present an iterative algorithm that selects the optimal pair of grey level image components of red-green-blue (RGB) and hue-luminance-saturation (HLS) color image models and the optimal weighting factor for automated segmentation of the structure of interest in color images. STUDY DESIGN: The method was based on a stepwise technique, searching for the image combination that yielded the maximum two-sample t value for the grey levels of the object of interest and of the background. As a result, a transformed grey level image providing a two-peak grey level histogram suitable for automated thresholding was provided. RESULTS: The segmentation of collagen bundles in hematoxylin and eosin-stained slides of cutaneous melanomas is presented as an example. Though each of the RGB and HLS grey level images showed extensive overlap of objects and background, the combined image facilitated clear-cut discrimination. CONCLUSION: The proposed algorithm permits the discrimination of specified objects in color images that are not characterized by grey level in any of the underlying grey level image components.

Diagnostic Imaging↗
PubMedDate not supplied

Motion related artifacts in spin-echo MR imaging: effects of sequence parameters on image quality at 1.5 Tesla.

PURPOSE: The purpose of this study was to evaluate the effects of selected parameters in a conventional spin-echo MRI sequence on image quality in a phantom undergoing periodic motion. METHODS: Images of a composite oil/copper sulfate phantom moving in a 1.5 Tesla magnet were acquired. The CuSO4 ghost signal-to-noise ratio (SNR) and distances between corresponding points on the phantom image and adjacent ghosts were evaluated. RESULTS: Increasing time to repeat (TR) and number of acquisitions (NAq) improved image quality. Ghost SNR was near unity at TR = 500 msec and at NAq around 4. Increasing TR and NAq resulted in increased distance between images. The effects of field of view (FOV) and matrix size on image quality were relatively less significant. CONCLUSION: Increasing NAq appeared to have a comparatively greater effect on ghost SNR and image quality under our experimental conditions. However, the effect of increasing NAq on image quality appeared to be definite since a saturation point was reached after a particular NAq. Increasing NAq above this point resulted in a relatively smaller improvement in image quality.

Artifacts↗
PubMedDate not supplied

Functional MR imaging using gradient-echo echo-planar imaging in the presence of large static field inhomogeneities.

At 1.5 T, the field strength of most clinical MR imagers, gradient-echo imaging is the primary imaging method for measuring brain activation, as such sequences are highly sensitive to changes in blood oxygenation or T2* effects. Unfortunately, gradient-echo sequences are also extremely sensitive to magnetic field inhomogeneities, and this sensitivity has precluded examination of regions of cortex near field inhomogeneities with functional MR imaging. This article presents a gradient-echo echo-planar imaging method that uses variable amplitude scaling on the slice-select refocusing lobe to generate images compensated for static field inhomogeneities. A technique for constructing composite images to be used in statistical tests for activation is also presented. The method is shown to produce clean activation maps in the presence of large static field inhomogeneities. The technique retains the sensitivity of gradient-echo imaging to changes in blood oxygenation while removing the sensitivity to large static field inhomogeneities.

Algorithms↗
PubMed1995

Intracranial assessment of incontinentia pigmenti using magnetic resonance imaging, angiography, and spectroscopic imaging.

OBJECTIVE: To evaluate patients with incontinentia pigmenti for evidence of cerebrovascular disease using magnetic resonance imaging techniques. DESIGN: A prospective case series of seven patients (four of whom were related) with incontinentia pigmenti using magnetic resonance imaging, magnetic resonance angiography, and multislice proton (1H) magnetic resonance spectroscopic imaging. SETTING: The Johns Hopkins Medical Institutions, Baltimore, Md, a tertiary, referred care center. PATIENTS: Seven patients with a diagnosis of incontinentia pigmenti. RESULTS: Five of the seven patients had abnormal magnetic resonance imaging consistent with small-vessel occlusions. Of these five patients, four had normal magnetic resonance angiography and spectroscopic imaging, and one patient had reduced middle cerebral artery flow on magnetic resonance angiography and increased lactate level in the cerebrospinal fluid on spectroscopic imaging. The remaining two patients had normal magnetic resonance imaging and spectroscopic imaging. Of these two patients, one had normal magnetic resonance angiography and the other had a right supraclinoid internal carotid aneurysm. There was substantial concordance between clinical (ophthalmic/neurologic) and imaging abnormalities. CONCLUSIONS: The central nervous system changes in patients with incontinentia pigmenti may represent the result of small-vessel occlusive phenomena in the brain. These central nervous system findings may share a common pathophysiologic state with the vascular occlusive disease seen in the retinas of these patients. The changes in the retinal vasculature may serve as a potential marker for central nervous system disease. Physicians should be aware of the systemic and debilitating nature of incontinentia pigmenti.

Adult↗
PubMed1996

Advances in automated 3-D image analyses of cell populations imaged by confocal microscopy.

Automated three-dimensional (3-D) image analysis methods are presented for rapid and effective analysis of populations of fluorescently labeled cells or nuclei in thick tissue sections that have been imaged three dimensionally using a confocal microscope. The methods presented here greatly improve upon our earlier work (Roysam et al.:J Microsc 173: 115-126, 1994). The principal advances reported are: algorithms for efficient data pre-processing and adaptive segmentation, effective handling of image anisotrophy, and fast 3-D morphological algorithms for separating overlapping or connected clusters utilizing image gradient information whenever available. A particular feature of this method is its ability to separate densely packed and connected clusters of cell nuclei. Some of the challenges overcome in this work include the efficient and effective handling of imaging noise, anisotrophy, and large variations in image parameters such as intensity, object size, and shape. The method is able to handle significant inter-cell, intra-cell, inter-image, and intra-image variations. Studies indicate that this method is rapid, robust, and adaptable. Examples were presented to illustrate the applicability of this approach to analyzing images of nuclei from densely packed regions in thick sections of rat liver, and brain that were labeled with a fluorescent Schiff reagent.

Algorithms↗
PubMed2007

Retrospective cine 3He ventilation imaging under spontaneous breathing conditions: a non-invasive protocol for small-animal lung function imaging.

A non-invasive and free-breathing hyperpolarized (HP) (3)He imaging protocol for small animals was implemented and validated on rats for lung function imaging. Animals were allowed to breathe a mixture of air and (3)He from a mask and a gas reservoir fitted to their heads. Radial imaging sequences were used, and MRI signal intensity changes were monitored for retrospective cine image reconstruction. The ventilation cycle of the animals was imaged with a 100 ms temporal resolution. The sliding window imaging technique was applied to reconstruct 5 ms time-shifted image series covering the complete breathing cycle. Image series were processed to extract quantitative ventilation parameters such as the gas arrival time. The reproducibility and the non-invasiveness of this ventilation imaging protocol were evaluated by multiple acquisitions on the same animals.

Animals↗
PubMed2002

Effects of image resolution on autoradiographic measurements of posterior cingulate activity in PDAPP mice: implications for functional brain imaging studies of transgenic mouse models of Alzheimer's Disease.

Fluorodeoxyglucosepositron emission tomography (PET) studies find that persons with Alzheimer's disease have preferential reductions in posterior cingulate activity. Using fluorodeoxyglucose autoradiography, we found that transgenic mice overexpressing a mutant form of the human amyloid precursor protein have preferentially reduced activity in the same region, providing a potential brain imaging indicator of Alzheimer's disease in these animals. In this study, we considered the feasibility of using in vivo imaging techniques, such as PET, to detect this reduction despite their limitations in spatial resolution. Autoradiographic measurements of posterior cingulate activity were remeasured in the previously studied PDAPP transgenic and littermate control mice after the images were filtered to lower spatial resolutions. We continued to detect significantly lower cingulate activity in the transgenic mice when the images were blurred to 0.50 mm, failed to detect significantly abnormal activity when the images were blurred to 0.75 mm, and, indeed, found significantly higher activity when the images were blurred to 1.0 mm. Reversal in direction of the abnormality appears attributable to a previously observed truncation in the corpus callosum in PDAPP mice. With the possible exception of future in vivo imaging techniques that have a spatial resolution greater than or equal to 0.50 mm and high sensitivity, noninvasive functional brain imaging techniques like PET may not be suitable for detecting declines in regional activity in PDAPP mice. It remains possible that these imaging techniques will prove useful in transgenic mouse lines that do not exhibit the same morphological abnormalities in neighboring white matter regions.

Alzheimer Disease↗
PubMed1994

Experimental study of a real-time corona discharge imaging system as a future biomedical imaging device.

In the paper, a preliminary real-time corona discharge imaging system is introduced, and the effects of the imaging parameters, such as electric field intensities and their frequencies, on the resulting images are investigated. From experiments using metal phantoms and plant leaves, it is found that no insulators can be captured by the corona discharge, and the effect of imaging parameters on the image quality is clearly demonstrated. For the future application of this real-time corona discharge imaging system, a composite phantom made of four different metal substances is investigated, along with the various combinations of imaging parameters, and the corona discharge images of a fresh plant leaf are captured as a test version of biomedical objects. The ionisation current, which is important in biomedical applications, is measured in each imaging procedure and estimated by curve-fitting the measured values to the previously known theory of ionisation.

Computer Systems↗
PubMed1998

[Improved endocardium imaging using modified transthoracic echocardiography with the second harmonic frequency (tissue harmonic imaging)].

UNLABELLED: In human tissue sound propagation is not linear resulting in a modification of the ultrasound waves. Therefore the received ultrasound frequencies are not just the transmitted frequencies of the transducer, but contain additional harmonic frequencies. These frequencies were not used by standard echocardiography. Harmonic imaging processes the second harmonic frequency. Distortion of the transmitted beam by shallow surface layers or reverberations between the skin surface and ribs impair image quality in conventional 2-dimensional echocardiography. Since harmonic components develop with propagation distance, the reverberations are almost entirely made up of ultrasound energy at the fundamental frequency. The exclusive processing of the second harmonic frequency provides an impressive improvement in image quality of 2-dimensional echocardiograms. Noise and clutter artifacts are reduced and endocardial borders are enhanced. Commercially available imagers provide tissue harmonic imaging using transmit frequencies from 1.7 to 2.1 MHz and second harmonic frequencies between 3.4 and 4.2 MHz. Several clinical studies have shown that harmonic imaging was superior to standard echocardiography in the assessment of left ventricular (LV) wall motion by LV wall motion analysis. In patients with poor acoustic windows the number of myocardial segments which could be evaluated was significantly higher using harmonic imaging than standard echocardiography. Tissue harmonic imaging particularly improves the delineation of the anterior wall using the 2-chamber view and the lateral wall using the 4-chamber view. CONCLUSION: Harmonic imaging is a clinically relevant improvement of echocardiography. We suggest that this new technology should be the method of choice in the evaluation of LV function.

Artifacts↗
PubMed2001

Angled oblique sagittal MR imaging of rotator cuff tears: comparison with standard oblique sagittal images.

OBJECTIVE: To compare the accuracy for diagnosing rotator cuff tears of oblique coronal images supplemented with standard oblique sagittal images versus thinner-section angled oblique sagittal images. DESIGN AND PATIENTS: The study included 75 consecutive patients who had a shoulder MR scan followed by arthroscopy. MR images included oblique coronal, oblique sagittal (4 mm thick, 1 mm interslice gap), and angled oblique sagittal (3 mm/0.2 mm) images perpendicular to the lateral cuff. A musculoskeletal staff radiologist and fellow separately evaluated the cuff for tears on the oblique coronal images supplemented with either the oblique sagittal or the angled sagittal images. RESULTS: For distinguishing a cuff tear from no tear, the staff radiologist had an accuracy of 0.76 (95% confidence interval: 0.67, 0.85) with the standard sagittal set, and 0.88 (0.80, 0.95) with the angled set (P=0.04). There was a nonsignificant improvement in accuracy for the fellow, calculated as 0.73 (0.63, 0.83) on the standard sagittal set and 0.76 (0.67, 0.85) on the angled set. Both readers also improved their diagnostic accuracy for partial-thickness tears with the angled set, although the improvement was statistically significant only for the staff radiologist. CONCLUSION: There is a slight improvement in accuracy for diagnosing rotator cuff tears, particularly partial-thickness tears, for the more experienced radiologist using thinner-section angled oblique sagittal images. These images may be useful as a supplemental sequence in patients where it is important to identify partial-thickness tears accurately.

Adult↗
PubMedDate not supplied

MR imaging of cervical carcinoma: comparison among T2-weighted, dynamic, and postcontrast T1-weighted images with histopathological correlation.

BACKGROUND: To identify the reasons for misdiagnosis of the degree of stromal invasion by uterine cervical cancer with various magnetic resonance sequences. METHODS: T2-weighted, dynamic, and postcontrast T1-weighted images were obtained in the sagittal plane in 20 patients with uterine cervical cancer. After evaluating these sequences for the degree of stromal invasion, histologic specimens were directly correlated with these images. RESULTS: The degree of stromal invasion was correctly diagnosed in 15 of the 20 cases on T2-weighted images, in 12 on dynamic images, and in eight on postcontrast T1-weighted images. All misdiagnoses were due to overestimation. Histologically, peritumoral stroma showed inflammation or edema in two patients, whereas no histological abnormality was found in the other patients. A hyperintense rim, i.e. , a peritumoral enhanced ring-shaped structure, was observed on the enhanced images of five patients. The hyperintense rim corresponded to the periphery of the tumor in three patients and to the cervical stroma in two patients. CONCLUSION: T2-weighted images permitted the most accurate evaluation of stromal invasion by uterine tumors. Overdiagnosis may be due to an abnormal intensity of the cervical stroma, which was observed more frequently on dynamic and postcontrast T1-weighted images than on T2-weighted images.

Adult↗
PubMedDate not supplied

Diffusion-weighted MR imaging with single-shot echo-planar imaging in the upper abdomen: preliminary clinical experience in 61 patients.

BACKGROUND: To determine the potential ability of diffusion-weighted magnetic resonance (MR) imaging with single-shot echo-planar imaging (DW imaging) in the upper abdomen by apparent diffusion coefficient (ADC) and signal:intensity ratio (SIR) measurements. METHODS: DW imaging was performed in 61 clinical patients. ADCs in the liver, pancreas, spleen, kidney, and different pathological conditions were calculated. Spleen-to-liver SIR and segmental intensity difference of the liver (SID) were also calculated. RESULTS: The mean ADCs (mm(2)/s) were 2.28 x 10(-3) +/- 0.07 in the liver, 1.44 x 10(-3) +/- 0.05 in the spleen, 1.94 x 10(-3) +/- 0.19 in the pancreas, and 5.76 x 10(-3) +/- 0.06 in the kidney. The mean ADC of cirrhotic liver was 1.96 x 10(-3) +/- 0.62, which was lower than that of normal liver. Other pathologic conditions also showed ADCs different from those of normal tissues. All DW images showed significantly higher spleen-to-liver SIRs and SIDs than did T2-weighted images (p < 0.05). CONCLUSION: The mean ADCs obtained with DW imaging were different in each upper abdominal organ and with each pathologic condition. DW images showed better soft tissue contrast than did T2-weighted images with regard to SIR and CNR in depicting and characterizing upper abdominal disorders.

Adult↗