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PubMed2005

Upper palaeolithic and late stone age human diet.

Undoubtedly modern mankind is an omnivorous species. Nevertheless, types of diet changed at the time of anthropogenesis. The Upper Palaeolithic period is the crucial time because of the appearance of anatomically modern humans in Europe. The main goal in this period investigation is to find the Neanderthal man-Upper Palaeolithic man diet distinction. A sharp early Holocene rise in humidity and temperature and melting of the permafrost resulted in the complete destruction of traditional migration routes, campsite losses, and the flora and fauna of inland territories changing. All these factors affected nutrition patterns, too. The comparison of the different Mesolithic and Neolithic groups' diet patterns allow us to discuss problems of the influence of cultural and ecological factors. The bone tissue chemical concentrations (Ca, Zn, Sr, Cu) from Upper Palaeolithic, Mesolithic and Neolithic burials are considered to reconstruct individual and group patterns of nutrition. The results of the atomic absorption method were used.

Bone and Bones↗
PubMed1985

Termination of strict diet therapy in phenylketonuria. A study on EEG sleep patterns and computer spectral analysis.

For several years and under various aspects we have studied diet termination in twenty-two early and late treated patients with phenylketonuria. Time of diet termination was the completed eighth year. For evaluation of possible functional CNS deficits, we applied psychometric tests, methods for testing psychomotor behavior and, in addition, neurophysiological parameters and registrations of sleep EEG. EEG morphology was studied visually and the rhythms of the different phases of sleep were quantified by computerized spectral analysis. EEG was studied during diet therapy when phenylalanine levels in blood were low and after a relatively short period of four months with elevated phenylalanine blood levels. At least two years after diet termination with correspondingly elevated phenylalanine blood levels the EEG was studied once more. Compared to the respective findings before diet termination in these patients there were no significant changes of the sleep EEG seen, neither on visual nor on spectral analysis. We have seen in this study minor EEG changes in early treated children and overtly pathological EEG changes in late treated PKU patients with cerebral damage, both before and after diet termination. Ultrastructural CNS defects may be the cause of these anomalies which do not respond to the actual biochemical situation at the age of eight to ten years. The morphology of such defects may include altered synaptic maturation and may occur already in an early phase before the diet therapy is implemented.

Central Nervous System↗
PubMed1992

Changing from a mixed diet to a Scandinavian vegetarian diet: effects on nutrient intake, food choice, meal pattern and cooking methods.

Twenty healthy, non-smoking, normal-weight omnivores volunteered for a nutrition counselling programme and changed from a mixed to a Scandinavian lactovegetarian diet. Dietary surveys were performed before and 3, 6 and 12 months after the dietary shift. The major trends when changing from a mixed diet to a lactovegetarian diet included an increase in the consumption of fruits, berries, vegetables, herbal tea and dairy products, and a decrease in the intake of biscuits and buns, sweets, alcoholic beverages, coffee and tea. There was a total absence of fish, eggs and meat products at 3 and 6 months after the dietary shift. At 12 months after the dietary shift two subjects ate small amounts of these animal products. The energy intake decreased throughout the study. The nutrient intake showed the greatest change between the period before and 3 months after the dietary shift. Between 3, 6 and 12 months after the dietary shift there were only minor changes. The observed change in meal pattern is associated with the change in consumption of various food items, the change in nutrient intake and the change in food preparation methods. Further studies should try to clarify the relationship between meal pattern and food intake, nutrient intake and food preparation methods, because counselling on meal pattern most certainly is more rapid and more easily understood than counselling on food and nutrient intake.

Adult↗
PubMed1986

Seasonal variation in food intake, pattern of physical activity and change in body weight in a group of young adult Dutch women consuming self-selected diets.

The effect of season on the energy balance was examined in 114 young adult Dutch women consuming self-selected diets. Energy intakes and patterns of physical activity were assessed monthly 14 times with the 24-h recall method. After this period of 14 months, in the second year the same estimates were made with intervals of 2-3 months to check if the seasonal variations observed were not accidental. The study did not demonstrate seasonal variations in the mean energy intake of the group under study. However, the intake of fat appeared to be higher in the winter and spring than in the summer and autumn, whereas for the intake of mono- and di-saccharides the reverse seemed to be true. The intake of dietary fibre was higher in the autumn than in the summer, with intermediate values for winter and spring. Small seasonal fluctuations were observed in body weight and time spent on various physical activities. On the one hand, these fluctuations are too small to indicate physiological significance, on the other hand they are wide enough to be taken into account in the design of many longitudinal studies on the relation between diet and disease.

Adult↗
PubMed1999

Two patterns of lipid deposition in the cholesterol-fed rabbit.

A central feature of arterial lipid deposition is its nonuniform and variable distribution. In immature human and rabbit aortas, spontaneous lesions occur most frequently downstream of branch points, but they tend to occur upstream of the same branches at later ages. In cholesterol-fed rabbits, the juvenile pattern has been seen regardless of age. These distributions may be determined by transport properties of the arterial wall, because uptake of plasma macromolecules is elevated downstream of aortic branches in immature rabbits and upstream in mature ones, except during cholesterol feeding, when the juvenile pattern is seen in adult vessels. The effect of cholesterol could reflect its inhibitory influence on the nitric oxide (NO) pathway because the adult transport pattern is NO dependent. Using protocols expected to preserve NO function and the mature pattern of transport during hypercholesterolemia, we made 2 attempts to induce upstream disease in rabbits. In trial I, plasma concentrations of cholesterol were kept within the normal human range for 15 weeks by using dietary levels of 0.05% to 0.2%. Although disease patterns reverse with age in human vessels exposed to these concentrations, lesions in both immature and mature rabbits occurred downstream of intercostal branch ostia. Trial II used older rabbits, a different base diet containing more vitamin E (96 mg/kg rather than 57 mg/kg), and higher levels of cholesterol (1%, administered for 8 weeks). For some animals, extra vitamin E (2000 mg/kg) was added to the diet. The mature pattern of lipid deposition was apparent around intercostal branches in the first group and was accentuated by the additional vitamin E, a change that was associated with a significant increase in the plasma concentration of NO metabolites. Spontaneous lesions, assessed on the base diet, were too rare to have influenced these distributions. This is the first report of upstream disease in the cholesterol-fed rabbit. The results support but do not prove the view that NO and transport are important in atherogenesis.

Animals↗
PubMed2005

Long-term maintenance of exercise and healthy eating behaviors in overweight adults.

BACKGROUND: Most people experience weight regain following the termination of a weight management program. The failure to maintain changes in diet and exercise patterns is a major factor. This study presents 24-month outcomes of a healthy-lifestyle weight management program designed to promote long-term changes in diet and exercise behaviors. METHODS: Overweight and obese adults (n = 144; BMI = 32.5 +/- 3.8) completed a 6-month clinic-based weight management program and were followed for an additional 18 months. Assessments completed at baseline, 6, 12, and 24 months included weight, body composition, dietary recalls, self-reported physical activity, and mediator variables based on Transtheoretical Model of Health Behavior Change. RESULTS: At 24 months, subjects maintained decreases in weight, % body fat, caloric intake, % kcal saturated fat, and increases in weekly exercise minutes (P < 0.05). Individuals who maintained regular exercise at 24 months had higher confidence scores and higher use of experiential and behavioral processes. Individuals who maintained a healthy diet at 24 months had lower temptation scores and higher use of experiential and behavioral processes. CONCLUSIONS: A healthy-lifestyle weight management program is successful at promoting long-term changes in exercise and dietary behaviors. Individuals who actively engage in the maintenance process are more likely to succeed.

Adult↗
PubMed1991

Distribution of calcium in central nervous system tissues and bones of rats maintained on calcium-deficient diets.

Current changing epidemiological pattern in the Western Pacific area suggests a contribution of the environmental factors to the pathogenetic process of amyotrophic lateral sclerosis (ALS). The condition of unbalanced mineral levels found in the soil and drinking water samples from the ALS foci showing low content of calcium (Ca) and magnesium (Mg) plus high content of aluminum (Al) was experimentally mimicked in this study using rats. In the groups fed low Ca, low Ca-Mg, and low Ca-Mg plus high Al diets, serum Ca levels were lower than that in the group fed the standard diet. Ca content of CNS tissues showed higher values in the unbalanced diet groups, especially in the spinal cord of low Ca-Mg plus high Al diet group, than those in the standard diet group, determined by inductively-coupled plasma emission spectrometry (ICP). Ca content in heart, liver, kidney, and abdominal aorta in groups fed low Ca-Mg, and low Ca-Mg plus high Al diets was higher than that in low Ca, and standard group. Ca content in muscle in the three unbalanced diet groups was significantly higher than in the standard diet group. Ca and Mg contents in lumbar spine and cortical bone showed lower values in the unbalanced diet groups than those values in the standard diet group. These findings suggest that under the condition of derangement of bone mineralization induced by unbalanced mineral diets fed to the experimental rats, Ca and Mg may be mobilized from bone, keeping their content in soft tissues, including CNS tissue, for utilization of vital activities, thereby resulting in a deposition of Ca while maintaining an almost normal value of magnesium in the CNS tissues.

Animals↗
PubMed1993

The effect of a low essential fatty acid diet on hibernation in marmots.

We investigated the effect of an essential fatty acid (EFA)-deficient diet on hibernation patterns in yellow-bellied marmots (Marmota flaviventris). Fatty acid (FA) analysis of white adipose tissue (WAT) from animals maintained for 2 mo on the EFA-deficient diet suggested that little or no EFAs were present in the gonadal or omental fat depots. Hibernation about lengths of the EFA-deficient animals were significantly shorter (P < 0.01) than control animals. Stated another way, these animals aroused twice as frequently compared with control animals and used more energy to survive winter. Analysis of WAT composition and blood samples revealed that animals were highly lipolytic during winter. Furthermore, the release of FAs was not random: linoleate (cis-9,cis-12-octadecadienoic acid; 18:2, a diene EFA) was significantly (P < 0.05) under-represented in venous outflow from the gonadal WAT pad based on the percentage of this species in WAT. The concentration of saturated FAs was higher than that predicted from the WAT-FA composition. We conclude that linoleate is preferentially retained within WAT and that concentrations of this EFA may influence hibernation behavior. Thus EFAs may have a thermoregulatory role in hibernation in addition to their role as essential precursors for physiologically important lipids after hibernation is over.

Adipose Tissue↗
PubMed1995

Membrane and cytosolic protein phosphorylation patterns in the early stages of DEN-induced hepatocarcinogenesis in rats fed a high or low protein diet.

The membrane and cytosolic protein phosphorylation patterns in the early stages of diethylnitrosamine-induced rat liver carcinogenesis, promoted by 2-acetylaminofluorene in the diet plus partial hepatectomy (DEN-AAF-PH), were analyzed by two-dimensional gel electrophoresis in animals fed a low protein (5% casein) diet, or the original high protein (24% casein) diet, in order to modulate the development of GST-P-positive preneoplastic lesions. Compared with untreated controls, membrane and cytosolic protein phosphorylation patterns changed only slightly in low protein-fed rats 7 days post-hepatectomy, with no appearance of enzyme-altered hyperplastic foci in the liver sections. By contrast, high protein-fed animals demonstrated GST-P-positive preneoplastic lesions 7 days post-hepatectomy and several acidic and more basic high M(r) phosphorylated membrane (between 97 and 116 kDa) as well as cytosolic (between 97 and 200 kDa) proteins could be detected. In the presence of enzyme-altered hepatocytes in the liver sections, low protein-fed rats demonstrated at 60 days post-hepatectomy cytosolic protein phosphorylation patterns remarkably similar to those shown by 24% casein-fed animals at 7 days post-hepatectomy, suggesting close correlation between protein phosphorylation patterns and development of preneoplastic lesions during the early stages of DEN-AAF-PH liver carcinogenesis. This may arise by a constitutive activation of one or more signal transduction pathways, possibly involving protein kinase C, during liver tumour promotion.

Animals↗
PubMed1988

Circadian feeding and drinking patterns of genetically obese mice fed solid chow diet.

Feeding and drinking were recorded in male ob/ob mice and lean mice fed pelleted Purina Lab Chow No. 5001 with water to drink. The circadian patterns of eating and drinking of obese mice differed from those of lean mice, in both the proportional temporal distributions of feeding and of drinking behavior across the 24-hour day and in the absolute amounts consumed hourly. The pattern of increased food consumption by the obese mice was different than that underlying increased water consumption. When meal parameters were analyzed in terms of 'complete meals' of both feeding and drinking (the end of a meal defined as at least 12 consecutive minutes with no ingestion), obese and lean mice had the same number of meals and their periodicity was similar, but meal size was much greater in the obese mice. In the dark, both obese and lean mice showed strong postprandial correlations of meal size with time from the start of a meal to start of the next meal.

Animals↗
PubMed1988

The effect of L-carnitine on the apolipoprotein pattern of rats fed a cholesterol-rich diet.

1. L-Carnitine was administered to hypercholesterolemic rats for eight days, after which the blood was collected by intracardiac puncture and lipoproteins were collected by preparative ultracentrifuge. 2. The chemical composition of lipoproteins of normal rats and hypercholesterolemic rats before and after L-carnitine treatment was determined. 3. The total serum B and E apoproteins were assayed by rocket electrophoresis, while apoproteins in VLDL, IDL, LDL and HDL were determined by densitometric scanning of SDS and TMU polyacrylamide disc gel electrophoresis. 4. The results obtained showed that the L-carnitine treatment tends to restore to normal values both the chemical composition of lipoproteins and the apoproteins pattern of rats fed on a diet enriched with cholesterol.

Animals↗
PubMed2006

Adipose gene expression response of lean and obese mice to short-term dietary restriction.

Overweight and obesity lead to higher morbidity risks, which are alleviated even by mild weight loss. To gain insight in the molecular effects of weight loss in adipose tissue, we analyzed the effects of short-term dietary restriction (DR) on mice fed a low-fat diet (lean mice) or a high-fat diet (obese mice). Female C57Bl6/J mice on both diets were on DR until an average body weight loss of 20%, which was achieved in 8 to 12 days depending on body weight at the start of DR. Plasma free fatty acids and blood glucose levels decreased significantly on DR. In the (restricted) low-fat diet groups, gene expression analysis using adipose-enriched cDNA microarrays revealed only two transcripts to be significant differentially expressed by DR: up-regulation of malic enzyme (Mod1) and down-regulation of major urinary protein 1 (Mup1). Real-time polymerase chain reaction analysis confirmed these findings and showed, for the high-fat diet groups, an identical expression pattern for Mup1, whereas Mod1 showed an opposed gene expression pattern for the high-fat diet groups. In conclusion, initial weight loss induces transcriptional changes only in a very small number of adipose genes, which also depends on the (restricted) diet used.

Adipose Tissue↗
PubMedDate not supplied

Milk casein-based diet containing TGF-beta controls the inflammatory reaction in the HLA-B27 transgenic rat model.

BACKGROUND: A casein-based formula containing TGF-beta has been successfully used in adolescents during acute episodes of Crohn's disease. The role played by this molecule requires confirmation. We have examined the capacity of a TGF-beta containing diet to control the intestinal inflammation in HLA-B27 transgenic rats, and compared its effects with a similar diet devoid of TGF-beta. METHODS: Three groups of rats were studied. HLA-B27/hbeta2M transgenic rats were fed with a casein-based rat-adapted diet containing TGF-beta or a control casein-based diet without TGF-beta. Fischer control animals were fed the latter. Body weight, dietary intake, tissue weights, fecal samples, leukocyte counts, and acute phase response were analyzed. Intestinal inflammation was assessed by histology, myeloperoxidase, and mRNA expression of cytokines. MUC2 protein expression was assessed by immunohistochemistry. Breakdown of muscle protein was examined. RESULTS: The test diet improved diarrhea increasing the fecal dry matter and the colonic inflammation as shown by a lower inflammatory score (2.43 +/- 1.13 vs 4.42 +/- 0.53, p < .05), lower mucosal thickness (431.25 +/- 72.29 vs 508.57 +/- 81.32 microm, p = .08) and decreased IFNgamma mRNA expression. MUC2 protein expression was increased in HLA rats fed the TGF-beta diet compared with HLA rats fed the control diet, but restitution to normal pattern was not observed. The test diet also decreased leukocytosis and the acute phase response and improved the muscle catabolic response. CONCLUSION: The TGF-beta containing diet has a beneficial effect in an animal model of intestinal inflammation. Our observations support a potential role for dietary TGF-beta in the restoration of immune homeostasis.

Acute-Phase Reaction↗
PubMed1985

The effect of diet on the metabolism of long acting theophylline.

Recently some concern has been expressed of the effect of diet on the metabolism of theophylline. This brief trial in normal healthy adults observed the effect of fasting, high fat, low fat, and liquid fat/low carbohydrate diet on the metabolism of a sustained-release theophylline preparation (Theo-Dur). On analysis of the mean theophylline level values, there were no significant differences in the theophylline levels between the diets. However, in certain individuals there were differences in the theophylline absorption rates between diets. No consistent pattern was seen.

Adult↗
PubMed2004

Impact of a preventive medicine and nutrition curriculum for medical students.

BACKGROUND: United States public health goals call for increased physician counseling about diet and exercise, but many medical schools lack adequate curriculum on these topics. At Harvard Medical School, second-year students take a preventive medicine and nutrition (PMN) course. This study evaluated the impact of this innovative curriculum on students' confidence about addressing patients' diet and exercise patterns and on their own health habits. METHODS: Students enrolled in the 2003 PMN course (N =137) completed a confidential 43-item written survey before and after the course. Surveys were completed by 134 students (98%) and 118 students (86%), respectively. The survey assessed students' diet and exercise habits and students' confidence in their ability to address diet and exercise with patients and family members. RESULTS: Students' confidence in their ability to assess and counsel about diet and exercise significantly improved after the course (all p <0.001). The course was also associated with a decrease in students' self-reported consumption of saturated fat (p =0.002) and trans fatty acids (p <0.001). Following the course, 72% of students perceived an improvement in their diet but only 18% perceived an improvement in exercise habits. CONCLUSIONS: An innovative PMN course improved medical students' confidence in diet and exercise counseling and perceived dietary habits. Improving these mediators of physician counseling in medical students may translate into changes in their practice patterns.

Adult↗
PubMed1980

Glucose homeostasis in a carnivorous animal (cat) and in rats fed a high-protein diet.

Glucose homeostasis in a carnivorous (cat) and in an omnivorous (rat) animal fed a high-protein, low-carbohydrate (HP) diet followed a pattern similar to that previously found in carnivorous birds [Am. J. Physiol. 234 (Regulatory Integrative Comp. Physiol. 3): R115-R121, 1978]. Thus, compared to controls given carbohydrate-rich (HC) diets. HP-fed animals had, in the fed state, lower levels of blood sugar, lower concentrations of liver glycogen, and a tendency to reduced body glucose mass. During fasting, their liver glycogen was little mobilized and their glycemia remained remarkably constant. Accordingly, their body glucose mass remained unchanged. Gluconeogenic capacity, already high in the fed state, was not further activated by fasting. Phosphoenolpyruvate carboxykinase activity actually decreased in rat liver cytosol, remaining unchanged in cat liver cytosol and mitochondria. [3H]glucose turnover studies revealed that in HP-fed cats and rats glucose replacement rates in the fed state were as high as in HC-fed animals and that the resistance of their glycemia to fasting depended on the high gluconeogenic capacity and not on a more efficient reduction of glucose utilization.

Animals↗
PubMed2002

Position of the American Dietetic Association: total diet approach to communicating food and nutrition information.

It is the position of the American Dietetic Association that all foods can fit into a healthful eating style. The ADA strives to communicate healthful eating messages to the public that emphasize the total diet, or overall pattern of food eaten, rather than any one food or meal. If consumed in moderation with appropriate portion size and combined with regular physical activity, all foods can fit into a healthful diet. Public policies that support the total diet approach include Reference Dietary Intakes, Food Guide Pyramid, Dietary Guidelines for Americans, Nutrition Labeling and Healthy People 2010. The value of a food should be determined within the context of the total diet because classifying foods as "good" or "bad" may foster unhealthy eating behaviors. Eating practices are influenced by taste and food preferences, concerns about nutrition and weight control, physiology, lifestyle, environment, and food product safety. To increase the effectiveness of nutrition education in promoting sensible food choices, dietetics professionals plan communications and educational programs that utilize theories and models related to human behavior. Communication campaigns/programs should implement an active, behaviorally focused approach within the larger context of food choices. Nutrition confusion can be reduced by emphasizing moderation, appropriate portion size, balance and adequacy of the total diet over time, the importance of obtaining nutrients from foods, and physical activity.

Advertising↗
PubMed1983

Patterns of week-to-week table-salt use by men and women consuming constant diets.

Ad-libitum table-salt use by subjects on constant diets was analysed to determine patterns of individual consistency or variation. Data were obtained from two studies in which free-living subjects ate all meals in a metabolic unit. In one study, 24 men consumed a diet constant in all respects except caloric level and source of dietary fibre over an 80-day period. In the other study, 13 women consumed a diet which varied only in caloric level and riboflavin content over a 67-day period. The menu for each study consisted of a conventional breakfast, lunch, dinner and snacks. Table-salt use was recorded as week-to-week weights of individually assigned salt shakers. Large and significant interindividual differences were observed in the amounts of salt added to the same menu. In contrast, a high degree of intraindividual consistency in salt use was observed from week-to-week and, among the women, across menstrual cycle phases. When food portions were increased during the second half of the men's study, table-salt use increased but the amount used per 1000 kcal remained relatively constant. In both sexes, variance in salt use increased proportionately with the mean.

Adult↗