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Physician leadership: influence on practice-based learning and improvement.

In response to the technology and information explosion, practice-based learning and improvement is emerging within the medical field to deliver systematic practice-linked improvements. However, its emergence has been inhibited by the slow acceptance of evidence-based medicine among physicians, who are reluctant to embrace proven high-performance leadership principles long established in other high-risk fields. This reluctance may be attributable to traditional medical training, which encourages controlling leadership styles that magnify the resistance common to all change efforts. To overcome this resistance, physicians must develop the same leadership skills that have proven to be critical to success in other service and high-performance industries. Skills such as self-awareness, shared authority, conflict resolution, and nonpunitive critique can emerge in practice only if they are taught. A dramatic shift away from control and blame has become a requirement for achieving success in other industries based on complex group process. This approach is so mainstream that the burden of proof that cooperative leadership is not a requirement for medical improvement falls to those institutions perpetuating the outmoded paradigm of the past. Cooperative leadership skills that have proven central to implementing change in the information era are suggested as a core cultural support for practice-based learning and improvement. Complex adaptive systems theory, long used as a way to understand evolutionary biology, and more recently computer science and economics, predicts that behavior emerging among some groups of providers will be selected for duplication by the competitive environment. A curriculum framework needed to teach leadership skills to expand the influence of practice-based learning and improvement is offered as a guide to accelerate change.

Delivery of Health Care↗

Towards a curriculum for the consultant biostatistician: identification of central disciplines.

The variation in the background of biostatistical consultants is huge. This varying background in formal education complicates communication. It may obscure clients' expectations as well as any discussion on qualifications and registration. To tackle these disadvantages as well as to facilitate the training of a new colleague, we need to find common ground. The aim of this paper is to identify the central disciplines which constitute the foundation of biostatistical consultancy. Any task-aimed curriculum should be based on these disciplines. Curriculum design theory was used to guarantee a logical and rational process. The result is the identification of a sextet of disciplines: applied statistics; methodology; epidemiology; communication; computational science, and personal effectiveness.

Biometry↗

Medical informatics conference papers: a content analysis of research in a new discipline.

One of the hallmarks of a mature discipline is a varied and robust body of literature describing the research activities of the discipline. Medical informatics has rapidly become an accepted scientific discipline, having emerged from two long established disciplines (medical and computer science). This study looks at one form of scientific communication as a descriptive indicator of the maturity of medical informatics as a discipline. Conference proceedings were selected because they represent one of the first means of communication within a discipline in a semiformal format. Findings confirm that conference papers report research, development, and application projects across a wide range of topics; identify a possible trend toward increased funding; and show widespread use of empirical and quantitative research and analytical techniques. Deficiencies in the conference papers are also discussed.

Congresses as Topic↗

To Matrix, Network, or Hierarchy: That Is the Question.

The authors present a structural analysis of three spatial diagrams-matrices, networks, and hierarchies-that specifies 10 properties on which these diagrammatic representations are hypothesized to differ: global structure, building block, number of sets, item/link constraints, item distinguishability, link type, absence of a relation, linking relations, path, and traversal. Each property has a "value" for each diagram, and these property values constitute the applicability conditions for the representations. Twenty-three college students (computer science majors and math educators) selected the type of diagram they thought would be most efficient for organizing the information in each of 18 short scenarios and verbally justified the reasons for their selections. The verbal protocols were coded with respect to the structural analysis. Both the representation selection and verbal justification data provided strong support for the structural analysis. Additionally, a factor analysis of students' justifications indicated that the organization of their knowledge is consistent with the structural analysis. Students' use of the structural properties to select appropriate representations and to justify those selections indicates that the structural analysis has psychological force.

Cognition↗

A computer program for application in epidemiological analysis.

The importance of computer science as a working tool for the health sector is an unquestionable fact in any modern society. EPIDEMO, developed by the authors, can be defined as a set of programs whose main characteristic is its ability to process a given series of data in a totally integrated way, with an epidemiological and statistical approach. EPIDEMO is a program with a good relational database, which allows preliminary statistical analyses of data that can easily be expanded with more specific statistical options, and is compatible with other programs available on the market. It is a useful, accurate and versatile tool that meets the needs of health professionals in the field of epidemiological research.

Databases, Factual↗

Nuclear medicine training in china.

There are diverse approaches to the teaching of nuclear medicine in China: (1) Nuclear medicine is taught as part of the clinical curriculum in most medical schools. (2) Three medical schools undertake undergraduate training in nuclear medicine. (3) Four medical schools train nuclear medicine specialists to graduate level. (4) Eight medical schools have been authorized to provide a postgraduate programme in nuclear medicine leading to an M.S. degree. Among them, four are also permitted to offer Ph.D. degrees. (5) No less than 20 medical schools offer a course in "Isotope techniques and their biomedical applications" for graduate students in various fields of medicine. (6) Many departments of nuclear medicine in medical schools offer short-term training courses or continuing education workshops on specific topics in nuclear medicine. (7) Some schools of pharmacy offer radiopharmacy courses. (8) Members of staff undergo in-service training in computer science, foreign languages, radiology, etc. (9) Graduate students and more senior scientists or physicians are sent abroad to pursue advanced training. (10) Foreign students have been admitted to our nuclear medicine centres for further training. (11) Exhibitions, summer camps and radio broadcasts have been used to inform the community of the usefulness of nuclear medicine.

China↗

Chimeras of human lysozyme and alpha-lactalbumin: an interesting tool for studying partially folded states during protein folding.

Protein folding is an extremely active field of research where biology, chemistry, computer science and physics meet. Although the study of protein-folding intermediates in general and equilibrium intermediates in particular has grown considerably in recent years, many questions regarding the conformational state and the structural features of the various partially folded intermediate states remain unanswered. Performing kinetic measurements on proteins that have had their structures modified by site-directed mutagenesis, the so-called protein-engineering method, is an obvious way to gain fine structural information. In the present review, this method has been applied to a variety of proteins belonging to the lysozyme/alpha-lactalbumin family. Besides recombinants obtained by point mutations of individual critical residues, chimeric proteins in which whole structural elements (10-25 residues) from alpha-lactalbumin were inserted into a human lysozyme matrix are examined. The conformational properties of the equilibrium intermediate states are discussed together with the structural characterization of the partially unfolded states encountered in the kinetic folding pathway.

Amino Acid Sequence↗

Mathematical tools in analytical mass spectrometry.

Over the last few decades, mass spectrometry has become a powerful tool for exploring various aspects of molecular processes occurring in biological systems. Such exploration is leading to a greater understanding of various complex life processes; unraveling these processes poses the greatest challenge to contemporary bioscience. With due respect to sample preparation, data analysis is rapidly becoming a major obstacle to the conversion of experimental knowledge into valid conclusions. It is interesting to note that many problems related to mass spectrometry can be solved using techniques from computer science, graph theory and discrete mathematics. The aim of this manuscript is to recollect several essays that demonstrate the power and the need to apply such skills to mass spectrometry data interpretation. Special attention is paid to situations where traditional chemical analysis reaches its limits but mathematical reasoning can still allow us to reach valid conclusions.

Journal Article↗

How to teach evidence-based surgery.

The objectives of teaching evidence-based surgery (EBS) are to inform and convince that EBS is a method of interrogation, reasoning, appraisal, and application of information to guide physicians in their decisions to best treat their patients. Asking the right, answerable questions, translating them into effective searches for the best evidence, critically appraising evidence for its validity and importance, and then integrating EBS with their patients' values and preferences are daily chores for all surgeons. Teaching and learning EBS should be patient-centered, learner-centered, and active and interactive. The teacher should be a model for students to become an expert clinician who is able to match and take advantage of the clinical setting and circumstances to ask and to answer appropriate questions. The process is multistaged. Teaching EBS in small groups is ideal. However, it is time-consuming for the faculty and must be clearly and formally structured. As well, evidence-based medicine (EBM) courses must cater to local institutional needs, must receive broad support from the instructors and the providers of information (librarians and computer science faculty), use proven methodologies, and avoid scheduling conflicts. In agreement with others, we believe that the ideal moment to introduce the concepts of EBM into the curriculum of the medical student is early, during the first years of medical school. Afterward, it should be continued every year. When this is not the case, as in many countries, it becomes the province of the surgeon in teaching hospitals, whether they are at the university, are university-affiliated, or not, to fulfill this role.

Decision Making↗

Urologic oncology in the twenty-first century.

The perspective of urologic oncology in the twenty-first century is presented regarding detection, treatment, and prevention of cancer. There is increasing importance of a cancer information network. Biotechnology and medical engineering based on advances in computer science will be the two key technologies related to such advancement. Ethical, legal, social, and economic issues provoked by the technologic advances will increase in gravity at the same time. Balancing humans in terms of scientific technologic developments and state of mind will be a serious issue.

Humans↗

Measurement and prediction of energy expenditure in males during household and garden tasks.

Participation in at least 30 min of moderate intensity activity on most days is assumed to confer health benefits. This study accordingly determined whether the more vigorous household and garden tasks (sweeping, window cleaning, vacuuming and lawn mowing) are performed by middle-aged men at a moderate intensity of 3-6 metabolic equivalents (METs) in the laboratory and at home. Measured energy expenditure during self-perceived moderate-paced walking was used as a marker of exercise intensity. Energy expenditure was also predicted via indirect methods. Thirty-six males [ X (SD): 40.0 (3.3) years; 179.5 (6.9) cm; 83.4 (14.0) kg] were measured for resting metabolic rate (RMR) and oxygen consumption ( VO(2)) during the five activities using the Douglas bag method. Heart rate, respiratory frequency, CSA (Computer Science Applications) movement counts, Borg scale ratings of perceived exertion and Quetelet's index were also recorded as potential predictors of exercise intensity. Except for vacuuming in the laboratory, which was not significantly different from 3.0 METs ( P=0.98), the MET means in the laboratory and home were all significantly greater than 3.0 ( P</=0.006). The sweeping and vacuuming MET means were significantly higher ( P<0.001) at home than in the laboratory, whereas the converse applied for window cleaning and lawn mowing. Measured RMR was significantly lower ( P<0.001) than the 1-MET constant. Estimating METs by fitting random intercept regression models to the data resulted in standard deviations for the "leave-one-out" prediction errors (predicted-measured) of 0.4 and 0.5 METs for the laboratory and home equations, respectively. While the means indicate that all the activities were performed at a moderate intensity, there was great inter-individual variability in energy expenditure. The laboratory and home-based equations predicted with correct classification rates of 89% and 88%, respectively, whether energy expenditure was <3.0 or >/=3.0 METs.

Activities of Daily Living↗

Healthcare informatics research: from data to evidence-based management.

Healthcare informatics research is a scientific endeavor that applies information science, computer technology, and statistical modeling techniques to develop decision support systems for improving both health service organizations' performance and patient care outcomes. The analytical strategies include (1) the formulation of a data warehouse for exploration, (2) data mining, (3) the application of confirmatory statistical analysis, (4) simulation via an interface with computer and information system technologies, and (5) translational research. Healthcare informatics research will help to direct evidence-based strategic management.

Decision Support Systems, Clinical↗

Artificial reproduction technologies (RTs) - all the way to the artificial womb?

In this paper, I argue that the development of an artificial womb is already well on its way. By putting together pieces of information arising from new scientific advances in different areas, (neo-natal care, gynecology, embryology, the human genome project and computer science), I delineate a distinctive picture, which clearly suggests that the artificial womb may become a reality sooner than we may think. Currently, there is a huge gap between the first stages of gestation (using in vitro fertilization) and the 22nd week (inside the womb). At the present time this gap seems an insurmountable barrier for fully developing a fetus outside a natural womb - a notion better known as ectogenesis. The history of science however, suggests that impenetrable barriers are such only temporarily. It is just a matter of time (and due research) until someone - intentionally or by chance - accesses the right answer and finds a way to overcome existing obstacles. Despite misgivings that the case of the artificial womb presents too many barriers, it would be naive to suppose things would happen any differently. I observe in this paper, that it is time to acknowledge the consequences of new developments in different areas of scientific research which are leading to the advent of an artificial womb; and I modestly suggest that we might initiate a discussion on this topic now, while we have still enough time to decide what we may want and why.

Cell Differentiation↗

Interactive modelling and simulation of biochemical networks.

The analysis of biochemical processes can be supported using methods of modelling and simulation. New methods of computer science are discussed in this field of research. This paper presents a new method which allows the modelling and analysis of complex metabolic networks. Moreover, our simulation shell is based on this formalization and represents the first tool for the interactive simulation of metabolic processes.

Biochemical Phenomena↗

Ca2+ imaging in single living cells: theoretical and practical issues.

The measurement of intracellular calcium ion concentrations [( Ca2+]i) in single living cells using quantitative fluorescence microscopy draws from a diverse set of disciplines, including cellular biology, optical physics, statistics and computer science. Over the last few years, we have devised and built a number of systems for measuring [Ca2+]i with Fura-2, and have applied them in the exploration of a wide range of biological processes controlled by Ca2+. In this report we discuss these systems and their advantages and limitations. We also describe the theoretical and practical problems associated with using Fura-2 to measure [Ca2+]i, and the solutions that we, and others, have developed to overcome them. The approaches described should provide useful guidance for others interested in imaging [Ca2+] distribution in living cells. The factors that limit current methods are discussed, and areas for future development are highlighted.

Animals↗

Electrodiagnostic evaluation of the visual system: the role of the clinician.

Visual electrodiagnosis is a new discipline with a long history. The foundations include the disciplines of psychophysics, neurophysiology, electronics, computer science, statistics and medicine. However, with such a complex heritage, visual electrodiagnosis has taken a considerable time to evolve to its present form. Today visual electrodiagnostic assessment is relevant, not only for conditions primarily affecting the visual system, but also in more generalised pathological states in which eye changes may be a manifestation. Pressures for more refined and accurate diagnoses stem both from a continuing improvement in knowledge of disease processes by the medical profession and greater expectations on the part of patients seeking advice. Specialised investigative services such as electrodiagnosis, if these are appropriately funded and maintained, provide data to clinicians which is repeatable and objective, without resorting to invasive technology.

Adult↗

The Coronary Drug Project. Role of the National Institutes of Health.

A clinical trials staff within an Institute is essential for adequate participation in and monitoring of any large cooperative clinical trial supported by that Institute. At minimum such a staff should consist of a medical scientist with professional interests and experience in clinical trials methodology; a biometrician with direct experience and interest in the design, large-scale data collection, data analysis, and quality control needs of such trials; a contract specialist; and additional consultants in the technical areas related to the clinical disease or intervention study, such as pharmacology, laboratory operations, computer science, or other areas. The continuity of professional development and experience of such a staff is essential to expand the capabilities for participation and advancement of this rapidly developing science of the design, organization, and conduct of cooperative clinical trials.

Biometry↗

Insight into protein nuclear magnetic resonance research.

Nuclear magnetic resonance (NMR) is one of the most powerful techniques to investigate the geometry of molecules in solution. It has been widely applied, in recent years, to the study of protein conformation. However, full reconstruction of the 3-D structure of such macro-molecules, still constitutes a real challenge for the spectroscopist. Skills as diverse as biology, spectroscopy, signal processing, or computer sciences, are required. This paper presents various aspects of the research in that domain, and our contribution to it.

Algal Proteins↗