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At least 487 records · Page 27Linked to original sources
PubMed1992

A study on Lu-null families in South Wales.

Red cells of 75614 blood donors in South Wales were screened with anti-Lu(b) revealing 54 Lu(b-) donors of which 15 were also Lu(a-) giving a frequency of 0.0002 for the Lu(a-b-) phenotype in South Wales. The families of 11 Lu-null propositi were investigated to determine which of the three known genetic backgrounds, dominant, recessive or X-linked recessive, was responsible for their Lu-null phenotype. In 10 of the 11 families the Lu-null phenotype was caused by the dominant suppressor gene In(Lu). The first reported family demonstrating independence of In(Lu) and LU, through the Au groups, is described together with the third family demonstrating suppression of P1 by In(Lu). The families showed that In(Lu) is not closely linked to HLA. The genetic background for the 11th propositus was not determined; homozygosity of the silent allele LU is a possible but unproved explanation.

Female↗
PubMed1992

Survey of colposcopy service provided by genito-urinary medicine in England and Wales.

OBJECTIVE: To investigate the expansion of colposcopy services within genito-urinary medicine (GUM) in England and Wales since 1985. DESIGN: Data collected by postal and verbal communication from 189 genito-urinary medicine clinics in England and Wales in January 1990. SUBJECTS: Consultant and junior genito-urinary physicians practising colposcopy. MAIN OUTCOME MEASURES: Number of clinics providing colposcopy service; indication for colposcopy, treatment facilities available, waiting lists and training opportunities, compared with that in 1985. RESULTS: Of the 189 genito-urinary medicine clinics contacted, 60 provided a colposcopy service and 55 of these returned completed questionnaires. There has been a 67% increase in the number of colposcopies in use and over 50% of clinics have the facilities to treat cervical pathology. Waiting lists were minimal for both examination and treatment. Both men and women are examined with the colposcope for a variety of indications. At present, 52% of career grade GUM physicians practise colposcopy compared to 24% in 1985 and 94% of senior registrars compared with 42% in 1985 were in training or trained in colposcopy.

Colposcopy↗
PubMed2002

Clinical, provider and sociodemographic predictors of late initiation of antenatal care in England and Wales.

OBJECTIVE: To identify factors that are predictive of late initiation of antenatal care in England and Wales. DESIGN: A multivariate binomial regression model was constructed to examine the association between clinical, provider and sociodemographic characteristics and late initiation of antenatal care. SETTING: Nine maternity units in Northern England and North Wales. POPULATION: A total of 20,771 women with a singleton pregnancy who delivered a liveborn or stillborn baby between 1 August 1994 and 31 July 1995. All analyses were based on the 17,765 (85.5%) women for whom information on gestational age at initial presentation for antenatal care and other variables incorporated into the regression model was retrievable from the case records. RESULTS: Primiparous women of high obstetric risk were 13.4% more likely to initiate antenatal care after 10 weeks of gestation than a low risk reference group (adjusted OR 1.134, 95% CI 1.011, 1.272; P = 0.0312), and 34.3% more likely to initiate antenatal care after 18 weeks of gestation (adjusted OR 1.343, 95% CI 1.046, 1.724; P = 0.0208). This association between high obstetric risk status and late initiation of antenatal care was not replicated among multiparous women. When the effects of other independent variables on gestational age at booking were examined, the following characteristics were associated with failure to initiate antenatal care by 10 weeks of gestation (P < or = 0.05): maternal age at booking, smoking status, ethnicity, type of hospital at booking, the planned pattern of antenatal care and the planned place of delivery. Adopting a criterion of 18 weeks of gestation exacerbated the association between clinical and sociodemographic characteristics and late initiation of antenatal care, but appeared to dilute the association between provider characteristics and late initiation of antenatal care. CONCLUSIONS: There is a pressing need for further research to identify the specific concerns of late bookers, to identify areas where new interventions might encourage the uptake of services and to gauge the likely impact of increased dissemination of information about the availability of antenatal care services.

Adolescent↗
PubMed2004

Dramatic reduction in triplet and higher order births in England and Wales.

The proportion of multiple births has increased markedly since 1980 in England and Wales. A major contribution to this trend is thought to be the widespread introduction of assisted reproductive technologies. Despite a continuing (but slower) upward trend in twin maternities, analysis of recent data shows that the rate of triplet and higher order births in England and Wales has declined by one-quarter since 1998. This probably reflects both voluntary and statutory regulation of treatment regimes. This downward trend will help alleviate the high burden of perinatal morbidity and mortality associated with multiple births.

Adult↗
PubMed1989

Trends in invasive cancer of the cervix uteri in New South Wales, 1973-1982.

Data from the New South Wales (NSW) Central Cancer Registry comprising all new cases of, and deaths from, invasive cancer of the cervix uteri registered in persons aged 15 years and over for the 10-year period 1973 to 1982 were examined using log-linear regression to determine whether incidence and mortality had been changing in NSW. Allowing for the estimated fraction of women who had undergone hysterectomy, this cancer had decreased significantly in incidence (-1.3% per year) as well as mortality (-3.6%). There were no significant trends in relation to age at diagnosis, stage at diagnosis or histological type. Overall, younger age at diagnosis was associated with an earlier stage at presentation and there was no evidence for a trend towards more severe disease in young women during the 10-year period. No evidence was found for an increasing incidence of adenocarcinoma. By 1982 the age-standardized incidence rate was 10.4 per 100,000 (12.5 per 100,000 after adjustment for the hysterectomy fraction). Cancer of the cervix uteri was more common in Inner and Western Sydney and less common in the Northern Metropolitan region of Sydney and rural New South Wales.

Adenocarcinoma↗
PubMed1994

Patterns of oral and pharyngeal cancer incidence in New South Wales, Australia.

Incidence and mortality rates for oral and pharyngeal cancers have been reported to be increasing in Europe and the United States, with particularly large increases in mortality in central and eastern Europe. Such increases have been noted to be birth cohort-based, primarily affecting young and middle-aged men. In this report oral and pharyngeal cancer incidence data from New South Wales, Australia has been analysed for the period 1972-90. Although an increase in the incidence of oral and pharyngeal cancer occurred during the mid-1970s and early 1980s, it did not continue. This pattern is consistent with Australian trends in per capita consumption of tobacco, alcohol, fruit and vegetables. Individual regions within metropolitan Sydney showed substantial geographical variation with age-specific rates of oral and pharyngeal cancers (combined) in middle-aged men being at least three times higher in the city of Sydney than in New South Wales as a whole. Given the preventable nature of the disease, such high rates need not occur.

Adult↗
PubMed2004

Cross-sectional study of risk factors for the clinical expression of ovine Johne's disease on New South Wales farms.

OBJECTIVE: To explore the environmental and management risk factors that promote the clinical expression of ovine Johne's disease on farms in New South Wales. DESIGN: Cross-sectional study. PROCEDURE: A questionnaire about the farm, flock and their management was mailed to all farmers known to keep infected sheep in the area zoned residual for ovine Johne's disease in New South Wales. The resultant data were analysed by multivariate statistical methods, specifically examining the factors associated with farmers reporting some mortality due to ovine Johne's disease; the reported annual incidence of ovine Johne's disease-associated mortality; the youngest age at which sheep die from ovine Johne's disease; whether scouring was a feature of the disease; and the season of peak mortality from ovine Johne's disease. RESULTS: Fine wool Merino sheep were more likely to die from ovine Johne's disease than other sheep types. Mortality was higher on farms with light sandy soils and those with a high proportion of improved pastures containing subterranean clover. Winter shearing was also associated with clinical expression. The time that the infection had been present on a farm was not strongly associated with mortality. Higher stocking density, high rainfall and access to open water, factors that are believed to aid transmission, were not found to be influential. CONCLUSION: Clinical expression appears to be principally associated with light infertile soils and their associated pastures and pasture improvement practices which may lead to micronutrient deficiencies or imbalances. Genetic effects are also important and are likely to be exacerbated by physiological stressors, such as winter shearing.

Animal Husbandry↗
PubMed1992

Mortality from respiratory system cancer in New South Wales and Sydney.

Differential and spatial analyses of respiratory system cancer were undertaken for New South Wales and Sydney for the period 1980-1986. The source of data was death certificate information on the unit list mortality file tapes provided by the Australian Bureau of Statistics. Characteristics of persons dying included age, sex, birthplace, occupational status and cause of death (ICD9 classification). The aim was to identify populations at risk from respiratory system cancer, and where they were located. Deaths were disaggregated for the abovementioned categories by cross-tabulation at the state level and for geographical areas having populations with higher levels of respiratory cancer mortality. Never-married males of lower occupational status had higher rates of respiratory cancer, mainly lung cancer. Divorced men also had higher mortality as did widowers who were in lower occupational status work, while married men in managerial work also had significantly high mortality. The marital status variation was mostly not found with females, although significantly high female mortality was found in several low socioeconomic status areas of Sydney. Mortality of both sexes was significantly higher in metropolitan Sydney than in the rest of New South Wales and associations between older age mortality and some industrial areas were found in Sydney.

Adolescent↗
PubMed1992

An outbreak of measles in the Hunter area of New South Wales.

An outbreak of measles occurred in 1990 in the Port Stephens Shire of New South Wales. The incidence of confirmed cases of measles and associated histories of immunisation are detailed by age for the period 24 June 1990 to 31 December 1990. Data were obtained from health and education professionals and from interviews with parents. Among the 158 cases were 116 school pupils, 82 of whom attended two large primary schools which had attack rates of 9.4 per cent and 4.1 per cent. The cases also included 29 persons who had been appropriately immunised. Inadequate immunisation coverage was seen as the principal cause of the outbreak in the Port Stephens Shire. Observance of institutional protocol was regarded as a principal impediment to disease counter-measures in a neighbouring measles-affected area. Regulated immunisation of young children and cooperative interaction among service providers could ultimately lead to the control of this serious disease in New South Wales.

Adolescent↗
PubMed1994

Assessing utilisation of health technologies: coronary artery bypass graft surgery in New South Wales.

The New South Wales health system aims to provide the most effective and efficient health care in a context of scarce resources and increasing availability of expensive technologies. The aging of the population and the management of chronic disease place further demands on the health system. Examination of the pattern of provision of services over time and between groups can serve to illustrate trends in clinical management practices which may affect other elements of the health system. In this paper we report an evaluation of the patterns of coronary artery bypass graft surgery (CABG) in New South Wales, within subgroups of the population and over time. The results demonstrate increased utilisation of this procedure in the population over recent years, particularly among the older age groups. We found differences in procedure rates between geographic areas which suggest that there are differences in the management of ischaemic heart disease between population subgroups. These patterns are examined in the context of the available literature on the health outcomes of CABG relative to other management options for ischaemic heart disease.

Adult↗
PubMed1994

Evaluation of the New South Wales Cancer Council Pap Test Reminder Service.

This study aimed to assess the effect of reminder letters on Pap test rates for women enrolled on the New South Wales Cancer Council Pap Test Reminder Service and to identify predictors of response to the letter. Ten weeks after they had received their reminder letter a questionnaire was sent to 3086 women. It was completed by 1525 (49 per cent) women, of whom 1393 (91 per cent) said they had received their reminder letter. Of these 1393, 48 per cent (95 per cent confidence interval 46 per cent to 51 per cent) reported having a Pap test within 10 weeks of the reminder letter arriving. The proportion of women having a Pap test in response to the reminder letter did not differ by age, region of residence or language spoken at home. Women were less likely to have had a Pap test if they did not know how they were enrolled, were of low socioeconomic status or had some tertiary education. Women on the reminder service have 15-month rescreening rates at least 9 per cent higher than other women in New South Wales; for women aged 50 to 69 in nonmetropolitan areas the increase is estimated at 19 per cent. Reminder services may be a cost-effective way to increase Pap test rescreening rates. Reminder services need accurate records and to follow up changes in address and date of next test.

Adolescent↗
PubMed1994

Differential and spatial aspects of suicide mortality in New South Wales and Sydney, 1980 to 1991.

Occupational and marital status dimensions of suicide mortality in New South Wales were examined for the periods 1980 to 1985 and 1986 to 1989-90 respectively, and marital status and birthplace group mortality profiles were examined in relation to grouped occupations, with a view to identifying the relative influence of these differentiating factors on suicide mortality. Spatial analysis was undertaken for different ages, in major regions of New South Wales and statistical local areas in Sydney for the period 1985 to 1991, and associations with socioeconomic characteristics of geographic areas were investigated. Despite residential revitalisation in inner city areas, higher mortality in several inner city localities has persisted over time while levels have risen in some outer areas. Never-married and divorced men in manual work were most at risk of committing suicide and never-married and divorced women had elevated suicide levels. Male suicide levels were elevated among farmers and related workers, and youth and adult male suicide levels were elevated in inland regions of the state. Possible explanations for the variations are discussed.

Adult↗
PubMed1989

Infection control in general dental practice. Results of a postal survey of 600 registered dental practitioners in New South Wales.

A postal survey of 600 dental practitioners in New South Wales was conducted in 1986 to establish a data base on current infection control protocols as they apply to everyday dental practice. Three hundred and sixty-three replies (60 per cent) were returned, representing approximately 16 per cent of Australian Dental Association members in New South Wales (1987).

Communicable Disease Control↗
PubMed1997

Musculoskeletal symptoms in New South Wales dentists.

This study describes the prevalence and distribution of symptoms of musculoskeletal disorders occurring in New South Wales dentists and investigates the relationship between these symptoms and work practices. Four hundred and forty two members of the Australian Dental Association (New South Wales Branch), were randomly selected and sent questionnaires. Eighty per cent (n = 355) responded. No significant differences in reported symptoms were found when considering age, experience, handedness, operating position or period of working without a break. Eighty-two per cent of the respondents reported experiencing one or more musculoskeletal symptoms during the previous month. Sixty-four per cent of the sample reported suffering pain (the majority reported back pain) and 58 per cent headaches. Most severe symptoms reported were pain (39%) and headaches (25%). Those in the youngest age category of less than 35 years (26%), were significantly more likely to have headaches (chi 2 4df p < 0.05). Female dentists were more likely to rate the severity of their most severe symptom higher (chi 2 1df p < 0.05), and to report more frequent pain (chi 2 2df p < 0.05) and headaches (chi 2 2df p < 0.05). Those practising four-handed dentistry were significantly more likely to be in the 35-44 age range (chi 2 4df p < 0.01), to work for longer periods before taking a 10-minute break (chi 2 5df p < 0.05) and to report frequent pain (chi 2 2df p < 0.05). The results support the findings of previous studies conducted overseas but additional information about musculoskeletal symptoms in this occupational group has been identified.

Adult↗
PubMed2005

Temperature-driven Campylobacter seasonality in England and Wales.

Campylobacter incidence in England and Wales between 1990 and 1999 was examined in conjunction with weather conditions. Over the 10-year interval, the average annual rate was determined to be 78.4 +/- 15.0 cases per 100,000, with an upward trend. Rates were higher in males than in females, regardless of age, and highest in children less than 5 years old. Major regional differences were detected, with the highest rates in Wales and the southwest and the lowest in the southeast. The disease displayed a seasonal pattern, and increased campylobacter rates were found to be correlated with temperature. The most marked seasonal effect was observed for children under the age of 5. The seasonal pattern of campylobacter infections indicated a linkage with environmental factors rather than food sources. Therefore, public health interventions should not be restricted to food-borne approaches, and the epidemiology of the seasonal peak in human campylobacter infections may best be understood through studies in young children.

Adult↗
PubMed2006

Macroscopic streamer growths in acidic, metal-rich mine waters in north wales consist of novel and remarkably simple bacterial communities.

The microbial composition of acid streamers (macroscopic biofilms) in acidic, metal-rich waters in two locations (an abandoned copper mine and a chalybeate spa) in north Wales was studied using cultivation-based and biomolecular techniques. Known chemolithotrophic and heterotrophic acidophiles were readily isolated from disrupted streamers, but they accounted for only <1 to 7% of the total microorganisms present. Fluorescent in situ hybridization (FISH) revealed that 80 to 90% of the microbes in both types of streamers were beta-Proteobacteria. Terminal restriction fragment length polymorphism analysis of the streamers suggested that a single bacterial species was dominant in the copper mine streamers, while two distinct bacteria (one of which was identical to the bacterium found in the copper mine streamers) accounted for about 90% of the streamers in the spa water. 16S rRNA gene clone libraries showed that the beta-proteobacterium found in both locations was closely related to a clone detected previously in acid mine drainage in California and that its closest characterized relatives were neutrophilic ammonium oxidizers. Using a modified isolation technique, this bacterium was isolated from the copper mine streamers and shown to be a novel acidophilic autotrophic iron oxidizer. The beta-proteobacterium found only in the spa streamers was closely related to the neutrophilic iron oxidizer Gallionella ferruginea. FISH analysis using oligonucleotide probes that targeted the two beta-proteobacteria confirmed that the biodiversity of the streamers in both locations was very limited. The microbial compositions of the acid streamers found at the two north Wales sites are very different from the microbial compositions of the previously described acid streamers found at Iron Mountain, California, and the Rio Tinto, Spain.

Betaproteobacteria↗
PubMed2006

Active surveillance for tuberculosis in Wales: 1996-2003.

AIMS: To estimate the incidence of active tuberculosis (TB) and study the use of chemoprophylaxis for latent TB in children in Wales, and to identify potential areas for improving prevention and management. METHODS: Active surveillance for TB in children aged 0-15 years from July 1996 to December 2003, using the Welsh Paediatric Surveillance Scheme. RESULTS: A total of 232 children, 102 with active TB (2.3 per 100 000) and 130 with latent TB (2.9 per 100 000), were identified. Nearly half (45%) belonged to ethnic minorities (19% were of black African origin), a much higher proportion than the base population. Pulmonary disease was the most common presentation (47%), including six (9%) children who were sputum smear positive. There were 10 cases of disseminated TB, nearly all in white children under 10 years of age. Less than two thirds of eligible children (27/46, 59%) were known to have received BCG immunisation. The source of infection was an adult household contact in most cases, but was not known in 44 cases, particularly among teenagers. Four community outbreaks occurred during the surveillance period, including three in high schools. CONCLUSION: TB incidence in children in Wales remains low, but the epidemiology is changing with an increasing proportion of cases in black African children. The high proportion of patients with disseminated TB is of particular concern. TB in teenagers was often associated with school outbreaks. Many eligible children do not receive BCG immunisation, indicating further scope for prevention.

Adolescent↗
PubMed1991

Trends in prevalence and survival of very low birthweight infants, England and Wales: 1983-7.

Between 1983 and 1987 over 99% of all infants born in England and Wales had their birth weights recorded when the birth was registered. Trends in occurrence and one year survival of those who weighed under 1500 g at birth have been calculated in 100 g groups, separately for single and multiple births. By 1987 singleton live births in England and Wales who weighed between 700 and 799 g had a 43% chance of surviving to 1 year compared with a 32% chance five years earlier; those who weighed 800 to 899 g had a 55% chance compared with 46%. The absolute number of survivors weighing between 500 and 999 g at birth increased by nearly 50% between 1983 and 1987, and there was a 30% increase overall in survivors weighing less than 1500 g.

Age Factors↗