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The Utah anesthesia workstation.

A prototype anesthesia workstation has been developed to demonstrate the feasibility of a computer-assisted anesthesia workplace. The workstation provides a central display of information and aids the user in controlling and monitoring the anesthesia delivery system. The anesthesiologist interacts with the workstation through a Macintosh computer, which is easy for the clinician to understand and to use. Seventeen sensors and monitors transmit information from the anesthesia delivery system to the computer. The computer monitors this information using a set of rules, evaluated once each breath, to detect changes in the delivery system. If an event is detected, the computer alerts the anesthesiologist with a diagram, a text message, and an audible warning. A laboratory test of the monitoring system was performed to see if it properly identified 26 different critical events during simulated low flow and closed circuit anesthesia. Five hundred and eight-three of 660 simulated critical events (88%) were identified with the unique and correct message. On 35 occasions, multiple messages were displayed, including the correct one. Critical events were misidentified or not detected 42 times. Eight false positive alarms occurred during the 20 h of testing; all occurred as a result of baseline drift in a single transducer. These results demonstrate that a sophisticated monitoring system can reliably diagnose specific anesthesia machine failures.

Anesthesiology↗

Determining the probability of radioactive materials on properties in Monticello, Utah.

The former uranium mill site at Monticello, UT, is a surplus facility subject to cleanup under the Surplus Facilities Management Program. Surrounding properties contaminated with mill site material are also subject to cleanup and are referred to as Monticello Vicinity Properties. The objective of this study was to determine the probability that a vicinity property not addressed under the Monticello Vicinity Properties project could contain Monticello mill-related residual radioactive material in excess of Department of Energy guidelines. The study was conducted in a short time frame to protect public health. Statistical methods were used to select 48 random properties for radiological screening surveys. Results of this study may be used to predict the potential number of unassessed properties (results suggest approximately 20%) that contain radioactive contamination that exceeds Department of Energy guidelines and will require remedial action.

Environmental Exposure↗

Farming occupations and mortality from non-Hodgkin's lymphoma in Utah. A case-control study.

The association between farming occupations and the incidence of non-Hodgkin's lymphoma (NHL) was examined in a case-control study using a cancer registry to identify cases and controls and death certificates to determine the occupation and industry of employment of cancer patients. Case subjects were white males with a diagnosis of NHL who died between 1967 and 1982; control subjects were white males who died of colon cancer during the same period. Control and case subjects were frequency-matched for age and year of diagnosis; county of residence was not a matching variable. Death certificates with codable occupational information were located for 90% of the 249 case and 293 control subjects. A stratified analysis using test-based confidence intervals revealed an increased risk of NHL among farmers. The overall odds ratio, controlling for age and for year of diagnosis, was 1.3 (90% confidence limits 0.9-2.3). For diagnoses during 1952 through 1965, the odds ratio was 6.6, and for diagnoses during 1966 through 1971, the odds ratio was 3.1. The increased odds ratio was most pronounced among those aged 45 to 64 years at the time of diagnosis and those living in rural counties.

Adult↗

Utah's IBIS-PH: an innovative user interface solution for Web-based data query systems.

The ability to make good Web-based data query system (WDQS) project management decisions requires an understanding of the trade-offs inherent among various technology options. This article presents the current options available for the user interface and data display and compares the advantages and disadvantages of each for use in a WDQS. Relevant options are also discussed for back-end technologies such as Web and application servers and data storage mechanisms. We explain our decisions in developing the Indicator-based Information System for Public Health (IBIS-PH) query system to increase the probability of success and minimize risk. Finally, we compare the resulting IBIS-PH application characteristics with our original design requirements: broad public access; rich, interactive, and easy-to-use interface; portability; accessibility; maintainability of software and interface; supportability; low cost; and security.

Data Display↗

Genetic diversity and divergence among freshwater mussel (Anodonta) populations in the Bonneville Basin of Utah.

Populations of the freshwater mussel genus Anodonta appear to be in a state of rapid decline in western North America, following a trend that unfortunately seems to be prevalent among these animals (Mollusca: Unionoida). Here we describe the patterns of molecular divergence and diversity among Anodonta populations in the Bonneville Basin, a large sub-basin of the Great Basin in western North America. Using amplified fragment length polymorphism (AFLP) analysis, we found a striking lack of nuclear diversity within some of these populations, along with a high degree of structuring among populations (FST = 0.61), suggesting post-Pleistocene isolation, due either to a long-term loss of hydrologic connectivity among populations or to more recent fish introductions. We also found evidence of recent hybridization in one of these populations, possibly mediated by fish-stocking practices. Using mitochondrial sequence data, we compared the Bonneville Basin populations to Anodonta in several other drainages in western North America. We found a general lack of resolution in these phylogenetic reconstructions, although there was a tendency for the Bonneville Basin Anodonta (tentatively A. californiensis) to cluster with A. oregonensis from the adjacent Lahontan Basin in Nevada. We recommend further investigation of anthropogenic factors that may be contributing to the decline of western Anodonta and a broad-scale analysis and synthesis of genetic and morphological variation among Anodonta in western North America.

Animals↗