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Is substance abuse in schizophrenia related to impulsivity, sensation seeking, or anhedonia?

OBJECTIVE: The authors compared impulsivity, sensation seeking, and anhedonia in a group of schizophrenic patients with and without lifetime substance abuse or dependence. METHOD: Patients (N=100) with schizophrenia or schizoaffective disorder (per DSM-III-R criteria) were assessed with the Composite International Diagnostic Interview's section on psychoactive substance use disorder, the Positive and Negative Syndrome Scale, the Barratt Impulsivity Scale, the Zuckerman Seeking Sensation Scale, and the Chapman Physical Anhedonia Scale. RESULTS: The mean scores for impulsivity and sensation seeking were higher in the group with substance abuse (N=41) than in the group without substance abuse (N=59). No significant difference between groups was found regarding physical anhedonia. CONCLUSIONS: As in the general population, high levels of impulsivity and sensation seeking are associated with substance abuse in patients with schizophrenia.

Adult↗

Risk-taking behaviour and criminal offending: an investigation of sensation seeking and the Eysenck personality questionnaire.

This study investigated relationships between hostility, Zuckerman's sensation seeking, and Eysenck and Eysenck's personality scales within a prison population, to explore whether they could be conceptualized in terms of two socialized and unsocialized sensation seeking factors. Participants included 79 incarcerated adult male offenders (age range = 18-62). Findings support the distinction between socialized and unsocialized sensation seeking and suggest that these factors represent more overarching personality factors. Psychoticism was a clear marker of the more broad impulsive, unsocialized sensation seeking factor, rather than representing a supertrait in its own right. This factor was also represented by lie, disinhibition, and boredom susceptibility scales. Findings relating to hostility also supported such a reformulation, as unsocialized scales did cluster together to predict the unsocialized hostility factor, whereas unsocialized scales did not. The results demonstrate the need for a theoretical reformulation of the two given theories of personality.

Adolescent↗

Sensation-seeking, life events and depression. The Cardiff Depression Study.

BACKGROUND: The relationship between adversity and genetic risk factors in depression could be mediated by familial 'hazard prone' traits, as reflected in high levels of sensation-seeking. AIMS: To examine whether high sensation-seeking scores are associated with more adverse life events resulting in depression. METHOD: In a sib-pair design, 108 probands with depression and their siblings and 105 healthy control subjects and their siblings were compared for psychopathology, life events and scores on the Sensation-Seeking Questionnaire (SSQ). RESULTS: The SSQ scores were correlated negatively with depression, were familial and were correlated positively with less severe events, but not the severe events typically associated with depressive onsets. CONCLUSIONS: The SSQ measures a familial personality trait and depression is associated with lower scores. Although high sensation-seeking is associated with a higher rate of life events, these carry little threat.

Adolescent↗

Field-dependence, sensation-seeking, and preference of paintings.

College students (122 males and 88 females) completed the Group Embedded Figures Test measure of field-dependence, and Sensation-Seeking Scale, and performed preference ratings on 40 slides of paintings. Factor analysis revealed six hypothesized and one unhypothesized preference dimensions that underlay preference ratings of paintings. It was hypothesized that the cognitive structuring ability associated with field-dependence would result in certain relationships between field-dependence and preference for paintings. Further, it was hypothesized that preference for novel, complex, and dynamic experiences, associated with sensation-seeking, would result in certain relationships between sensation-seeking and preference for paintings. For the full sample, three of five hypothesized relationships between field-dependence and preference for paintings were obtained, while three of four hypothesized relationships were found between sensation-seeking and preference for paintings.

Journal Article↗

Sexual sensation seeking: scale development and predicting AIDS-risk behavior among homosexually active men.

Sensation seeking, the propensity to prefer exciting, optimal, and novel stimulation or arousal, is a potential mediating factor in sexual risk for human immunodeficiency virus infection (HIV), the cause of acquired immunodeficiency syndrome (AIDS). However, the most widely used measure of sensation seeking, the Sensation Seeking Scale (Zuckerman, Kolin, Price, & Zoob, 1964), contains numerous culturally outdated items and items that do not pertain to sexual behavior. In this study, 106 homosexually active men completed newly developed measures of sensation seeking related to sexual and nonsexual experiences, as well as a measure of sexual compulsivity. Results show that the new scales were internally consistent and time-stable. Additional analyses demonstrated convergent, divergent, and discriminant validity for these scales, showing them to be of use as mediating variables in models of high-risk sexual behavior. Implications for HIV prevention and behavior change are discussed.

Acquired Immunodeficiency Syndrome↗

Pre-treatment measures of impulsivity, aggression and sensation seeking are associated with treatment outcome for African-American cocaine-dependent patients.

We investigated whether measures of impulsivity, aggression and sensation seeking differed between cocaine-dependent subjects and controls, and whether these measures were related to treatment-outcome for cocaine patients. Pre-treatment assessments of impulsivity (Barratt Impulsivity Scale [BIS]), aggression (Buss-Durkee Hostility Inventory [BDHI]) and sensation seeking (Zuckerman Sensation Seeking Scale [SSS]) were obtained for 141 African-American cocaine-dependent patients entering a 12-week, intensive outpatient treatment program and 60 controls. The outcome measures were number of negative urine drug screens, days in treatment, dropout rates and number of treatment sessions. Cocaine patients reported significantly higher scores on the SSS, the BIS and the BDHI than controls. Furthermore, the SSS scores showed a significantly negative correlation with days in treatment and negative urines, and a significant positive correlation with the dropout rate. The BIS and the BDHI scores were significantly associated with days in treatment and dropout rates respectively. A combination of the three variables contributed significantly toward predicting retention and abstinence. Higher levels of pretreatment impulsivity and aggression and sensation seeking seem to associated with poor treatment outcome for cocaine dependent patients receiving intensive outpatient treatment. Combining these behavioral measures with other clinical predictors may help in early identification of 'poor responders' who may benefit from additional or alternative treatment approaches.

Adult↗

Sparing of sensation to pin prick predicts recovery of a motor segment after injury to the spinal cord.

We have reviewed 59 patients with injury to the spinal cord to assess the predictive value of the sparing of sensation to pin prick in determining motor recovery in segments which initially had MRC grade-0 power. There were 35 tetraplegics (18 complete, 17 incomplete) and 24 paraplegics (19 complete, 5 incomplete), and the mean follow-up was 29.6 months. A total of 114 motor segments initially had grade-0 power but sparing of sensation to pin prick in the corresponding dermatome. Of these, 97 (85%) had return of functional power (> or = grade 3) at follow-up. There were 479 motor segments with grade-0 power but no sparing of sensation to pin prick and of these only six (1.3%) had return of functional power. Both of the above associations were statistically significant (chi-squared test, p < 0.0001). After injury to the spinal cord, the preservation of sensation to pin prick in a motor segment with grade-0 power indicated an 85% chance of motor recovery to at least grade 3.

Chi-Square Distribution↗

Effects of ondansetron on respiratory pattern and sensation of experimentally induced dyspnea.

CONTEXT: Dyspnea remains a therapeutic challenge, especially in chronic respiratory conditions. Recent studies have shown that the induction of unpleasant dyspnea sensations activates areas in the insular cortex. OBJECTIVE: This study was designed to investigate the potential effects of ondansetron, a potent anti-serotonin agent, on induced dyspnea sensation. TYPE OF STUDY: A randomized double blind study. SETTING: Pulmonary Function Laboratory of Hospital das Clínicas de Ribeirão Preto. PARTICIPANTS: Ten healthy male volunteers (mean age +/- standard error = 23.1 +/- 0.41 years) without respiratory diseases and showing normal spirometric tests. INTERVENTIONS: Uncomfortable breathing was induced in the volunteers on two different days, via the use of inspiratory resistors (loads of 0, 7, 14 and 21 cm H2O/l/sec) and breathholding, two hours after taking 8 mg of ondansetron (Ond) or placebo (Plac). MAIN MEASUREMENTS: Respiratory discomfort during breathing under loading was evaluated on a 100-mm visual analog scale. The maximum length of time of voluntary apnea was measured in seconds. RESULTS: The mean maximum voluntary apnea time did not differ between the ondansetron and placebo days (Plac = 96 +/- 6.6 sec vs. Ond = 100 +/- 7.9 sec). Ondansetron did not influence the dyspnea sensation induced by different inspiratory loads (0 cm H2O/l/sec: Ond = 1.4 mm +/- 0.44 vs. Plac = 2.1 +/- 0.85 mm; 7 cm H2O/l/sec: Ond = 16.6 +/- 2.74 mm vs. Plac = 13.7 +/- 2.06 mm; 14 cm H2O/l/sec; Ond = 30.5 +/- 4.50 mm vs. Plac = 27.1 +/- 3.44 mm; 21 cm H2O/l/sec: Ond = 50.3 +/- 6.72 mm vs. Plac = 49.4 +/- 6.72 mm). Ondansetron led to significant decreases in tidal volume under basal conditions and when breathing under the highest inspiratory loading (0 cm H2O/l/sec: Ond = 0.83 +/- 0.26 l vs. Plac = 1.0 +/- 0.28 l; 21 cm H2O/l/sec: Ond = 0.86 +/- 0.23 l vs. Plac = 1.1 +/- 0.22 l) CONCLUSION: The present results suggest that 5-HT3 receptors do not play an important role in the mediation of dyspnea sensations.

Adult↗

Television campaigns and adolescent marijuana use: tests of sensation seeking targeting.

OBJECTIVES: This study evaluated the effectiveness of targeted televised public service announcement campaigns in reducing marijuana use among high-sensation-seeking adolescents. METHODS: The study used a controlled interrupted time-series design in 2 matched communities. Two televised antimarijuana campaigns were conducted in 1 county and 1 campaign in the comparison community. Personal interviews were conducted with 100 randomly selected teenagers monthly in each county for 32 months. RESULTS: All 3 campaigns reversed upward developmental trends in 30-day marijuana use among high-sensation seekers (P < .002). As expected, low-sensation seekers had low use levels, and no campaign effects were evident. CONCLUSIONS: Televised campaigns with high reach and frequency that use public service announcements designed for and targeted at high-sensation-seeking adolescents can significantly reduce substance use in this high-risk population.

Adolescent↗

Seasonal variations of physiological characteristics and thermal sensation under identical thermal conditions.

Seasonal variations of human thermal characteristics were inspected in thermal comfort and when constantly indoors. Metabolic rate, tympanic temperature, skin temperature, body fat, body weight and thermal sensation were measured under identical thermal conditions in a chamber over the course of one year. Experiments were carried out for each subject in both summer and winter. Six subjects were measured 35 times in summer and 45 times in winter. one subject was measured weekly for 14 months. Measurements for analyses were taken 40-60 min after entrance into the chamber. Results revealed the following. 1) For all subjects, the metabolic rate, tympanic temperature and body fat were lower in summer than in winter; thigh skin temperatures were higher in summer than in winter. The averaged individual ratio of seasonal difference was 11.9% for metabolic rate, 14.9% for body fat, 1.8% for thigh temperature and 0.53% for tympanic temperature. Seasonal differences of about 10% in metabolic rate were maintained in this study. 2) Seasonal variations of the variables were examined for phase relationships against the outdoor temperature. 2-1) Metabolic rate, thermal sensation, body weight and body fat changed in reverse phase, whereas skin temperature was in-phase. 2-2) Skin temperature lagged by about one month in both summer and winter. Body fat also lagged by about one month in summer, but corresponded to the phase in winter. Metabolic rates were also in-phase in winter but led about three months in summer. Thermal sensations lagged by about three months in winter but were in-phase in summer. Body weight was in-phase in summer and winter. 2-3) Summer disorders were observed particularly in seasonal variations of metabolic rates, tympanic temperature, skin temperatures, and thermal sensation, thereby suggesting that the effect of temperature exposure was altered by air-conditioner use.

Adipose Tissue↗

The conscious perception of the sensation of fatigue.

In this review, fatigue is described as a conscious sensation rather than a physiological occurrence. We suggest that the sensation of fatigue is the conscious awareness of changes in subconscious homeostatic control systems, and is derived from a temporal difference between subconscious representations of these homeostatic control systems in neural networks that are induced by changes in the level of activity. These mismatches are perceived by consciousness-producing structures in the brain as the sensation of fatigue. In this model, fatigue is a complex emotion affected by factors such as motivation and drive, other emotions such as anger and fear, and memory of prior activity. It is not clear whether the origin of the conscious sensation of fatigue is associated with particular localised brain structures, or is the result of electrophysiological synchronisation of entire brain activity.

Awareness↗

Concept of visual sensation.

A direct-realist account of visual sensation is outlined. The explanatory notion of elements in visual sensation (atomic sensations) is reinterpreted, and the suggested interpretation is formally justified by constructing a Boolean algebra for visual sensations. The related notion of sensory levels (visual field vs visual world) is discussed.

Color Perception↗

Forearm vs whole-body sensations of self-motion: some results on the role of the sensorimotor context.

Making a subject's visual surroundings move can give rise to sensations of self-motion, which can either be restricted to the arm or involve the whole body. The aim of the present study was to investigate the role played by the sensorimotor context in eliciting one or the other of these two types of illusory movement. Whether the type of sensation experienced by the subjects depended on their adoption of an actively maintained or relaxed posture was examined. Analysis showed subjects' posture was certainly one of the factors involved: a rigidly held position favoured the occurrence of whole body sensations of movement, whereas a relaxed attitude favoured occurrence of arm-restricted sensations. This postural factor alone does not, however, account for the variations recorded in our experiment which seem to be related to the stimulus parameters as well as to individual factors.

Adult↗

Sensation seeking and self-reported criminality among student-athletes.

The present study was conducted to assess whether student-athletes self-report more criminal activities than other students and whether there is a relation between sensation seeking and criminal behavior. In comparison to the control sample of 38, 34 student-athletes scored significantly higher on Zuckerman's Sensation Seeking Scale, Form V, and on a modified version of Canter's Self-report Deviance Checklist. Sensation seeking was not related to self-reported criminality among the control group, but among student-athletes moderately high correlations were found. These findings might suggest another dimension of the theory of sensation seeking among athletes.

Adolescent↗

Effects of attention and expectation on tickle sensation.

The purpose of the present study was to examine the changes of the tickle sensation reflected in effects of the direction of attention to one's own body (Exp. 1) and the expectation of the experimenter's gestures (Exp. 2). In Exp. 1, for 15 subjects, when tickled on their own foot soles, the tickle sensation was not significantly changed by attending to the stimulus and to one's own sole. These results suggested the importance of instructions. In Exp. 2, 6 subjects were tickled and were required to report their experience while they looked at the experimenter's gestures and were tickled. Although the subjects' stimulations were unaffected by looking at the gestures, the tactual stimulus elicited a tickle sensation. From these results, quantitative and qualitative differences in subjects' tickle sensation may be identified.

Adult↗

Sensation seeking and subjective unpleasantness ratings of stimulus intensity.

Zuckerman's Sensation Seeking Scale measures tendency to seek novel, varied, complex, and intense sensations and experiences and the willingness to take risks for the sake of such experiences. In this study, the subjective experience of sensory intensity change was explored by asking six high and six low sensation seekers to expose themselves to a combined sound and vibration stimulus that increased in intensity until one of three different levels of subjective unpleasantness was reached. Analysis showed that high sensation seekers consistently exposed themselves to longer periods of stimulation and thus higher intensities.

Adult↗

Sex, perceptions of attractiveness, and sensation seeking and ratings of the likelihood of having sexually transmitted diseases.

Association of attractiveness, sex, and sensation seeking with perceptions of sexually transmitted diseases were examined. Subjects (64 women and 56 men) were given a picture and brief description of a target and asked to rate the accuracy of statements based on information provided. Pictures depicted a man or woman previously rated as attractive or unattractive by volunteers. The hobbies listed skydiving and rock climbing for high sensation seekers and reading and listening to music for low sensation seekers. Analysis indicated a significant three-way interaction with the attractive male targets described as high sensation-seeking and being perceived by men as most likely to have a sexually transmitted disease.

Adult↗

Sensation seeking and symptoms of disruptive disorder: association with nicotine, alcohol, and marijuana use in early and mid-adolescence.

This study examined the association of Sensation Seeking and symptoms of Disruptive Disorders and investigated the associations of each with the risk of nicotine, alcohol, and marijuana use in 11- to 14-yr.-old boys and girls from psychiatric and pediatric clinics (n = 206). Sensation Seeking and symptoms of Disruptive Disorder were significantly related, and both were associated with drug use. In particular, Sensation Seeking was strongly associated with drug use in early and mid-adolescents seen in a clinical setting. Measurement of Sensation Seeking and symptoms of Disruptive Disorder should help identify and characterize youth who are at increased risk for drug use during early and mid-adolescence-a time when onset of use may be a harbinger of long-term habit.

Alcoholism↗