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PubMed1993

Vitamin C status in elderly women: a comparison between women living in a nursing home and women living independently.

The vitamin C status in blood fractions in 135 elderly women aged 65 years and older was studied within the framework of the Dutch Nutrition Surveillance System. Mean (+/- standard deviation) vitamin C intake (mg/day) was lower among women living in a nursing home (54 +/- 27 mg/day) than among women living in service flats (97 +/- 55 mg/day) and women living independently (132 +/- 44 mg/day). (Service flats are apartments in which the rent includes housekeeping and, when ordered, meal service.) Marginal vitamin C values (< 23 mumol/L) in blood fractions and even levels as low as those found in clinical scurvy (< 11 mumol/L) were frequently observed. In the nursing home, 35% of the women had plasma vitamin C values below 11 mumol/L, and 23% had values between 11 and 23 mumol/L. Blood levels were not significantly affected by age, smoking status, or use of particular drugs but were strongly (r = .47 or, after logarithmic transformation, r = .64) associated with daily intake of vitamin C. Low intake of vitamin C resulted from an overall low food consumption and selective restriction of food products rich in vitamin C. Vitamin C losses caused by food preparation practices and distribution in the nursing home's catering system reduced actual vitamin C intake levels but these losses were not substantially greater than those that are assumed to occur as a result of preparation practices by women living independently.

Activities of Daily Living↗
PubMed1982

Anosmia and play fighting behavior in prepubescent male and female rats.

Prepubescent male and female rats were paired after intranasal treatment with isotonic zinc sulfate or saline solutions to determine the influence of peripheral anosmia upon play fighting behavior. In Experiment 1, male isolate residents pinned intruders significantly more often than intruders pinned residents but anosmia treatment had no influence on pinning behavior. In Experiment 2, males and females differed significantly in all major categories of play fighting but anosmia treatment had no influence on play fighting of either males or females. In Experiment 3, male groups matched for play fighting behavior prior to intranasal zinc or saline treatment were paired with like-treated males. All males in all pairings engaged in play behavior but anosmic males played less than controls. Evidently, intranasal zinc treatment depresses play behavior only when both members of a pair are anosmic. Play behavior is more markedly affected by resident-intruder status and by gender than by peripheral anosmia.

Aggression↗
PubMed1989

Lifestyle and mortality among Norwegian men.

Information on six different habits (cigarette smoking, physical activity, frequency of alcohol and of fruit/vegetable consumption, and daily bread and potato consumption) was obtained by two postal surveys (1964 and 1967) among Norwegian men. The answers were related to mortality among 10,187 respondents ages 35-74 years at the start of the follow-up period (1967-1978). Analyses, stratified by age, place of residence, marital status, and socioeconomic group, showed an association between the six variables and observed/expected deaths, as well as odds ratio estimates. A health practice score, obtained by adding the number of favorable habits, showed a strong inverse relationship with total mortality as well as deaths from cancer, cardiovascular diseases, and other causes. Odds ratio estimates for men with only favorable habits vs those with at most one such habit, were 0.31 for total mortality, 0.44 for cancer, and 0.36 for cardiovascular mortality. Separate analyses among current smokers and nonsmokers showed a particularly strong association between the five other habits and mortality from cardiovascular disease.

Adult↗
PubMed1991

The pediatrician's concept of the normal adolescent.

Complete medical assessment of an adolescent requires understanding of the normal psychological state, including self-image. To determine the pediatrician's knowledge about the self-image of normal adolescents, 33 house staff and 36 attending pediatricians in a major teaching center completed the Offer Physician-Adolescent Questionnaire (OPAQ), a scale that measures adult perceptions of adolescent self-image. Forty-one male and 28 female pediatricians completed the 50-item questionnaire as they believed a "mentally healthy, well-adjusted adolescent" would. Pediatricians' responses did not differ by sex, age, or status as resident or attending. Percentage endorsements for each item were converted to standard scores for 11 scales. The scale scores were then compared with previously established norms for healthy adolescents and adolescents with cystic fibrosis. Pediatricians accurately predicted the normal adolescent responses for only two scales: vocational and educational goals and superior adjustment. Pediatricians responded more positively than the adolescents to items on the idealism scale. For the remaining eight scales, the pediatricians responded more negatively than did normal adolescents and teens with cystic fibrosis. The pediatricians' view of normal adolescent self-image seems to be more pessimistic than what adolescents report.

Adolescent↗
PubMed1991

Duration and correlates of post-partum abstinence in four sites in Zaire.

Data on 2223 women with a child less than 25 months of age from four sites of two regions in Zaire were analyzed. The univariate correlates of current abstinence were determined on this population. A sub-sample of 778 women was then drawn for the development of multivariable model of predictors of the duration of abstinence. The median duration of abstinence in the two urban and two rural sites ranged from 4.5 to 8.8 months. The final multivariable model showed that low socio-economic status, rural residence, more living children, prolonged duration of breastfeeding and non-Zairian nationality were all important predictors of prolonged duration of abstinence. The relationship of duration of abstinence to that of amenorrhea is also important. While approx. 18% of the women included in this analysis continued to abstain for at least one month beyond the resumption of menses, the vast majority who did resume relations represent a target population for utilization of an alternate means of pregnancy prevention.

Adult↗
PubMed2004

Individual-based spatially-explicit model of an herbivore and its resource: the effect of habitat reduction and fragmentation.

We present an individual-based, spatially-explicit model of the dynamics of a small mammal and its resource. The life histories of each individual animal are modeled separately. The individuals can have the status of residents or wanderers and belong to behaviorally differing groups of juveniles or adults and males or females. Their territory defending and monogamous behavior is taken into consideration. The resource, green vegetation, grows depending on seasonal climatic characteristics and is diminished due to the herbivore's grazing. Other specifics such as a varying personal energetic level due to feeding and starvation of the individuals, mating preferences, avoidance of competitors, dispersal of juveniles, as a result of site overgrazing, etc., are included in the model. We determined model parameters from real data for the species Microtus ochrogaster (prairie vole). The simulations are done for a case of an enclosed habitat without predators or other species competitors. The goal of the study is to find the relation between size of habitat and population persistence. The experiments with the model show the populations go extinct due to severe overgrazing, but that the length of population persistence depends on the area of the habitat as well as on the presence of fragmentation. Additionally, the total population size of the vole population obtained during the simulations exhibits yearly fluctuations as well as multi-yearly peaks of fluctuations. This dynamics is similar to the one observed in prairie vole field studies.

Animal Feed↗
PubMedDate not supplied

Pneumonia in the nursing home.

Pneumonia syndromes may be caused by infection or the aspiration of food, acid, or particulate material. Antibiotic-resistant organisms or recurrent aspiration should be considered if the response to treatment is poor. Clinicians should consider discontinuing antibiotics if the resident's status rapidly returns to baseline after a noninfectious macro-aspiration event. The natural history of this process, however, is not well characterized. Diagnostic procedures including sputum gram stain, culture, and urinary antigen testing should be pursued to diagnose pathogens not covered by empiric therapy or to focus therapy with narrow spectrum agents. Sources of aspiration, including pharyngeal dysphagia, periodontal disease, and gastric regurgitation, should be identified and treated in hopes of preventing recurrence.

Age Distribution↗
PubMed2005

Monitoring for Pb and Cd pollution using feral pigeons in rural, urban, and industrial environments of Korea.

This study was aimed at evaluating the lead (Pb) and cadmium (Cd) contamination status using resident pigeons from rural (island), central urban (Seoul), and four industrial complex areas in Korea with varying traffic density as well as atmospheric metal pollution records. We also discussed the results with respect to metal exposure trends in urban area after introduction of lead-free gasoline in Korea. Mean concentrations of Pb and Cd in bone and kidney of pigeons from Seoul were comparable to those from industrial complex areas and were about 15-20 times those at the reference site. This suggests that exposure to metals in the urban environment is as high as in the industrial areas. Lead and Cd concentrations in lungs of pigeons from Seoul were significantly higher by more than three times in 2000 than in 1991 (p < 0.01), whereas the residues in liver, kidney, and bone remained at a similar level, despite the introduction of unleaded gasoline in 1993. The Pb and Cd concentrations in tissues of pigeons did not decrease as atmospheric metal levels decreased. Ingestion may be more important than inhalation in exposing pigeons to Pb and Cd in this study.

Animals↗
PubMed2004

Eating, drinking and being depressed: the social, cultural and psychological context of alcohol consumption and nutrition in a Brazilian community.

Much has been written about the socioeconomic distribution of nutritional status, both in more economically developed, and in developing nations. In general, persons of lower socioeconomic status suffer adverse consequences of poor nutritional status, although these consequences can vary depending on the level of development, i.e. in more developed countries the problem tends to be one of over-nutrition and obesity, while in developing countries the problem tends to be one of under-nutrition and nutritional deficiencies. In this paper, we explore the socioeconomic distribution of dietary intake in a Brazilian city, in an area that in some ways is neither prototypically developed or underdeveloped. The analysis presented here was stimulated by the surprising observation of no socioeconomic differences in total caloric intake in the context of extreme differences in income distribution. Further examination showed that socioeconomic differences in total caloric intake appeared after controlling for alcohol intake. A complete analysis of the data suggests that lower income leads to lower cultural consonance, which in turn leads to higher depression, higher alcohol intake, and higher total caloric intake. In this model, alcohol ingestion can be seen as both a psychological and nutritional adaptive strategy to economic, social and cultural marginality in a highly stratified society.

Adult↗
PubMed2004

Cell adhesion molecule T-cadherin regulates vascular cell adhesion, phenotype and motility.

T-cadherin (T-cad), an unusual glycosylphosphatidylinositol (GPI)-anchored member of the cadherin family of cell adhesion molecules, is widely expressed in the cardiovascular system. The expression profile of T-cad within diseased (atherosclerotic and restenotic) vessels indicates some relationship between expression of T-cad and the phenotypic status of resident cells. Using cultures of human aortic smooth muscle cells (SMC) and human umbilical vein endothelial cells (HUVEC) we investigate the hypothesis that T-cad may function in modulating adhesive properties of vascular cells. Coating of culture plates with recombinant T-cad protein or with antibody against the first amino-terminal domain of T-cad (anti-EC1) significantly decreased adhesion and spreading of SMC and HUVEC. HUVECs adherent on T-cad or anti-EC1 substratum exhibited an elongated morphology and associated redistribution of the cytoskeleton and focal adhesions to a distinctly peripheral location. These changes are characteristic of the less-adhesive, motile or pro-migratory, pro-angiogenic phenotype. Boyden chamber migration assay demonstrated that the deadhesion induced by T-cad facilitates cell migration towards a serum gradient. Overexpression of T-cad in vascular cells using adenoviral vectors does not influence cell adhesion or motility per se, but increases the detachment and migratory responses induced by T-cad substratum. The data suggest that T-cad acts as an anti-adhesive signal for vascular cells, thus modulating vascular cell phenotype and migration properties.

Antibodies↗
PubMed1975

Breast cancer in patients with Hashimoto's thyroiditis.

The case records of four groups of women over thirty on the books of a thyroid clinic were used to explore a possible association between breast cancer and Hashimoto's thyroiditis. The index group consisted of 1810 women (10 160 person-years of observation) with Hashimoto's thyroiditis, and the three control groups, matched by sex, age, marital status, and residency, were selected from patients with myxoedema (essential hypothyroidism), benign nodular goitre, or hyperthyroidism. The incidence of breast cancer for the index group, though not for control groups, was significantly higher than that expected from data for the general population, suggesting that patients with Hashimoto's thyroiditis are one high-risk population for breast cancer.

Adenocarcinoma↗
PubMed2002

Striving towards efficiency in the Greek hospitals by reviewing case mix classifications.

In order to verify the efficiency level of Greek public hospitals, this paper evaluates the most recent indicators. Relevant data were collected from the two following databases: (a) hospitals' utilisation data generally and per clinical speciality [Ministry of Health, Athens, (Data based) 1995]; (b) Patients' and hospitals' characteristics per diagnosis [National Statistical Office, Athens, (Data based) 1993]. As explanatory variables, the study examines supply and demand factors following case mix classifications. Firstly, average length of stay (ALOS) and secondly, cost per case were regressed as dependent variables. The study highlights the extent of variability across hospitals for different groups of patients with the same condition. The results specify the most important factors that affect ALOS and cost pertaining to efficiency. Per speciality analysis shows occupancy, size-type of the hospital, beds and doctors per speciality, access and use of outpatient services, and surgical operations, etc. as the most significant factors. Per disease-diagnosis analysis shows age of over 65 years, gender, residence, marital status, surgical operation and insurance as the most important factors. General cost analysis in all National Health Systems (NHS) hospitals shows that economies of scale appear in: (a) district and/or specialised hospitals of 250-400 beds; (b) regional and/or teaching hospitals of over but near to 400 beds. Consequently, the author determines the 'Greek' Diagnostic Related Groups (DRGs), based on the cost per clinical speciality in the nine basic specialities and on the cost per diagnosis of the top 15 diagnoses. Further to the scientific results, such studies will enhance much necessary discussions on the organisation of service delivery and financing, by following case mix classification.

Adolescent↗
PubMed1998

Estonian medical birth registry 1992-1994: association of risk factors with perinatal mortality.

OBJECTIVE: To investigate the association of different maternal sociodemographic characteristics and infant sex with perinatal mortality among primiparas and multiparas. STUDY DESIGN: Analysis of routine data from the Estonian Medical Birth Registry covering the whole of Estonia. A total of 47 358 infants (including stillborns) with a birth weight 1000 g or more from 1992 through 1994 were studied. Perinatal mortality rate, crude odds ratio (OR) and adjusted OR (calculated by a logistic regression model) were used to evaluate the association. OR values were adjusted for maternal age at delivery, maternal ethnicity, educational level, residence, marital status, smoking status, history of previous abortion and infant sex. RESULTS: The perinatal mortality rate was 12.2 per 1000 total births among primiparous and 14.3 among multiparous women. The highest adjusted ORs of perinatal deaths were found in older (35 years and over) primiparas (1.78; 95% confidence interval (CI 0.88-3.57)) and multiparas (1.81; 95% CI 1.29-2.55), in unmarried (single) primiparas (1.59; 95% CI 1.14-2.20) and multiparas (1.98; 95% CI 1.29-3.05), in smoking primiparas (1.69; 95% CI 1.09-2.63) and multiparas (1.51; 95% CI 1.02-2.25), and in multiparas with unknown smoking status (1.98; 95% CI 1.18-3.33). CONCLUSION: The study provides further evidence that perinatal mortality is positively associated with increased maternal age, unmarried (single) status and smoking.

Adult↗
PubMed2003

Burn mortality: recent trends and sociocultural determinants in rural India.

In 1998, India was the only country in the world where fire (burns) was classified among the 15 leading causes of death. High mortality in young married women from burns has already become an alarming and contentious medical problem in rural India. The incidences of burn mortality by age, sex, residence, marital status; manner and reasons have been reported only infrequently from the rural parts of India. From a total of 4042 medicolegal deaths reported at an Apex medical centre of a rural health district, over a period of 5 years 1997-2001, 942 deaths (23.3%) were due to burns; with mortality rate of 15.1 per year per 100,000 population. Of all burn death cases, 80.8% were females, 82.4% married ones, 71.9% belonged to the young age group of 21-40 years and 75.0% came from the rural parts of the district. Out of all burn deaths, 50.7% were accidental, 47.8% suicidal and 1.5% were homicidal in manner. In all female suicides, burns was the commonest method adopted by over 60% females. Torture by in-laws (32.1%) was the commonest reason for committing suicide by burns in married women. The present study has tried to identify the high-risk group and reasons for high burn mortality in this rural area. Religious and sociocultural reasons prevalent in the area are discussed, which play the determinant role in such a high mortality rate in burns in rural India. Further studies in India into psychodynamics of sociocultural, religious and family life are advised.

Adolescent↗
PubMed1997

Ethnic differences in the prevalence of asthma in middle class children.

BACKGROUND: Studies have shown a higher prevalence of asthma among boys compared with girls and in blacks compared with whites, but it has been difficult to separate socioeconomic from racial effects because the blacks in the studied populations were more likely to have low socioeconomic status. OBJECTIVE: To compare the prevalence of asthma in a socioeconomically homogeneous, middle class, multiethnic population of schoolchildren. METHODS: Based on a telephone survey of all families of third-graders in Southfield, Michigan, we ascertained the prevalence of physician-diagnosed asthma and probable undiagnosed asthma. One reason Southfield was chosen for study was because the city comprises an integrated middle class population with only 4% blacks and 7% whites having incomes below federal poverty limits. RESULTS: The lifetime prevalence of asthma was 9.5% (12% for blacks and 6% for whites) and higher in boys (14%) than girls (5%), a pattern that was reflected in period prevalence estimates. The lifetime prevalence of probable undiagnosed asthma was greater in blacks (16.6%) than whites (10.8%), with little sex difference. Adjusting for sex and maternal education, the prevalence of physician-diagnosed asthma and probable asthma were associated independently with black ethnicity. CONCLUSIONS: Our study is unique in the similarity of the black and white families' socioeconomic status and residence in the same middle class community. Since access to medical care and macro-environmental conditions were similar across this study population, our results are consistent with the hypothesis that differences in biologic factors between blacks and whites and boys and girls play a role in asthma risk.

Adolescent↗
PubMed1989

Determinants of breast-feeding and post-partum amenorrhoea in Orissa.

A life table analysis is made of the duration of breast-feeding and post-partum amenorrhoea in Orissa, India, taking one variable at a time using data from a baseline survey of fertility and mortality (BSFM) conducted on the lines of the World Fertility Survey. Then a multivariate (proportional hazard) analysis showed that socioeconomic factors including residence, caste status and education influence the breast-feeding and post-partum amenorrhoea periods. There was no effect of maternal age on the length of breast-feeding, but mean length of post-partum amenorrhoea varied with age. The durations of breast-feeding and post-partum amenorrhoea are strongly related.

Amenorrhea↗