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At least 487 records · Page 27Linked to original sources
PubMed1995

Evidence for a global scanpath strategy in viewing abstract compared with realistic images.

Scanpaths, the repetitive sequences of saccadic eye movements, occurred when subjects viewed slide projections of both realistic and abstract art. Variance analysis demonstrated that global/local eye movement indices were lower for local scanning by professional art viewers who relied on more global viewing, particularly in abstract images. Non-professional, unsophisticated subjects carried their local scanpath patterns from realistic images on to abstract images. The blink rate of professional subjects viewing abstract images was also significantly lower, indicating increased visual effort. Non-professional viewers showed no difference in blink rates.

Adult↗
PubMed1991

Adaptive regression and ego identity.

An inventory of adaptively regressive experiences (Taft Ego Permissiveness Inventory) and the Identity Status Interview were administered to 71 college students (35 female, 36 male). As hypothesized, Moratorium status individuals (actively engaged in identity formation) showed a greater disposition to adaptive regression than did individuals in other statuses. This supports the view that adaptive regression may serve an important function in the identity formation process. Contrary to hypothesis, Achievement status individuals did not show greater disposition to adaptive regression than those in Foresclosure status. Females showed substantially greater disposition to adaptive regression than did males.

Adolescent↗
PubMed1993

Psychotic symptoms in depression and borderline personality disorder.

The authors investigated the prevalence of psychotic symptoms in depression and borderline personality disorder employing the Diagnostic Interview for Borderlines. Clear-cut delusions and hallucinations were rare among the borderlines. However, derealization and depersonalization symptoms were common and were found to be prevalent as among depressives. The prevalence of these symptoms among patients with both borderline personality disorder and depression was similar to that among patients with only borderline personality disorder or depression. The relationship between depression and borderline personality disorder and the significance of psychotic symptoms in these disorders is discussed.

Adolescent↗
PubMed1995

Induction of depersonalization by the serotonin agonist meta-chlorophenylpiperazine.

Sixty-seven subjects, including normal volunteers and patients with obsessive-compulsive disorder, social phobia, and borderline personality disorder, received ratings of depersonalization after double-blind, placebo-controlled challenges with the partial serotonin agonist meta-chlorophenylpiperazine (m-CPP). Challenge with m-CPP induced depersonalization significantly more than did placebo. Subjects who became depersonalized did not differ in age, sex, or diagnosis from those who did not experience depersonalization. There was a significant correlation between the induction of depersonalization and increase in panic, but not nervousness, anxiety, sadness, depression, or drowsiness. This report suggests that serotonergic dysregulation may in part underlie depersonalization.

Adult↗
PubMed1996

The creation of protection and hope in patients with malignant brain tumours.

The malignant brain tumour disease condenses much of the anguish of cancer diseases. The brain is a vital and delicate organ, and the prognosis is generally unfavourable. The patient is exposed and has to rely on cognitive manoeuvres to manage the mental stress. The purpose of this study was to generate new insights into how the patient constructs a new sense of reality when confronted with the malignant brain tumour diagnosis. Within grounded theory methodology, 30 patients with malignant gliomas were interviewed twice, in direct connection with diagnosis, surgery and radiotherapy. In addition, their partners were interviewed, and quantitative instruments (SMMSE, RDCQ) were used as additional references for assessing the patients cognitively and emotionally. Eleven patients were excluded from the final analysis because of cognitive impairment of personality change. Most of the patients were aware of the fact that the brain tumour exposed them to grave danger, but they were also able to use various cognitive manoeuvres to create protection and hope. This process originated from different sources: the body; helpful relations; cognitive schemata; and the handling of information. The importance of the body to raise hope is emphasized. In the discussion we consider this process as an expression of how the patient brings together reality and hope, thus creating her/his own illusion. These findings are also related to adjacent psychoanalytic theory, proposing a theoretical reference with clinical implications when discussing "What to tell cancer patients."

Adaptation, Psychological↗
PubMed1992

The Iowa therapeutic community model of chemical dependency treatment.

A model of inpatient chemical dependency treatment used in several facilities in Iowa is described. Through combining 12 Step, Therapeutic Community and Reality Therapy concepts, the issues of denial, control, and self centeredness are addressed in developmental phases. Individualizing the program through multidisciplinary input is explained in terms of identifying hindrances in perceiving reality and assisting the patients reduce resistance in a downhill process of increasing wholeness and growth.

Adult↗
PubMed1993

Three syndrome concept of schizophrenia. A factor analytic study.

One hundred and fifty-five DSM-IIIR schizophrenic patients were assessed for positive and negative symptoms using Andreasen's Scale for Assessment of Positive Symptoms (SAPS) and the Scale for Assessment of Negative Symptoms (SANS). Interrelationships of individual positive and negative symptoms were examined using a factor analysis. Results of the factor analysis are consistent with Liddle's proposition that there are three syndromes underlying symptomatology in schizophrenia: disorganization; psychomotor poverty and reality distortion.

Adolescent↗
PubMed1995

The development and reliability of the Mental Health Research Institute Unusual Perceptions Schedule (MUPS): an instrument to record auditory hallucinatory experience.

The Mental Health Research Institute Unusual Perceptions Schedule (MUPS) is a comprehensive instrument developed to record subjects' experiences of auditory hallucinations as completely as possible. The Schedule comprises a semi-structured interview and documents the physical characteristics of auditory hallucinations such as their onset and course, number, volume, tone, location, as well as other phenomena associated with them such as delusions. In addition, other aspects of hallucinations, such as coping strategies, contributing factors and subjects' personal views and reactions are also explored. In a sample of 100 subjects drawn primarily from the in-patient wards at Royal Park Hospital the MUPS was found to be an acceptable instrument to subjects in the field. Interrater reliability assessed in a subsample of 30 subjects was found to be high at the level of the individual items. Whether used in whole or part, the MUPS provides a reliable and acceptable method of assessing patients' experience of auditory hallucinations.

Adaptation, Psychological↗
PubMed2004

A positive emotional bias in confabulatory false beliefs about place.

Some neurological patients with medial frontal lesions exhibit striking confabulations. Most accounts of the cause of confabulations are cognitive, though the literature has produced anecdotal suggestions that confabulations may not be emotionally neutral, having a ('wish-fulfilment') bias that shapes the patient's perception of reality in a more affectively positive direction. The present study reviewed every case (N = 16) of false beliefs about place reported in the neuroscientific literature from 1980 to 2000, with blind raters evaluating the 'pleasantness' of the patient's actual and confabulated locations. In each case the confabulated location was evaluated as more pleasant. This striking finding supports the claim that there may be a systematic affective bias in the false beliefs held by neurological patients with confabulation.

Adult↗
PubMed2004

On the other hand am I rational? Hemispheric activation and the framing effect.

In recent decades the investigation of framing effects has become the foremost studied phenomenon of rational/irrational decision making. Two experiments were conducted to determine whether the functional specializations of the left and the right hemispheres would produce different responses to a traditional framing task. In Experiment 1, a behavioral task of finger tapping was used to induce asymmetrical activation of the respective hemispheres. In Experiment 2, a monaural listening procedure was used. In both experiments, the predicted results were found. Framing effects were found when the right hemisphere was selectively activated whereas they were not observed when the left hemisphere was selectively activated. The results are interpreted in light of a dual-processing approach of decision-making.

Adult↗
PubMed2006

A reversal of the normal pattern of parahippocampal response to neutral and fearful faces is associated with reality distortion in schizophrenia.

BACKGROUND: Individuals with schizophrenia demonstrate impaired recognition of facial expressions and may misattribute emotional salience to otherwise nonsalient stimuli. The neural mechanisms underlying this deficit and the relationship with different symptoms remain poorly understood. METHODS: We used event-related functional magnetic resonance imaging to measure neural responses to neutral, mildly fearful, and prototypically fearful facial expressions. The sample included 15 medicated individuals with chronic schizophrenia (SZ) and 11 healthy control individuals (CON), matched for gender (all male), age, and years of education. RESULTS: A repeated measures 3 x 2 analysis of variance (ANOVA) revealed a significant interaction between expression intensity and group in right parahippocampal gyrus (p < .01). Individuals with chronic schizophrenia demonstrated a decrease, whereas CON showed an increase, in right parahippocampal gyrus response to increasingly fearful expressions. Between-group comparison revealed greater activation in SZ than CON in right parahippocampal gyrus to neutral faces. The reality distortion dimension, but not neuroleptic medication dose, was positively associated with the right parahippocampal gyral and right amygdalar response to neutral faces in SZ. CONCLUSIONS: An abnormally increased parahippocampal response to neutral faces was positively associated with reality distortion in SZ. This may underlie the previously reported finding of a misattribution of emotional salience to nonsalient social stimuli in schizophrenia.

Adult↗
PubMed2006

Pattern of use and subjective effects of Salvia divinorum among recreational users.

BACKGROUND: Salvia divinorum is a member of the Lamiaceae family and contains the psychotropic diterpene and kappa-opioid receptor agonist salvinorin-A. Originally a shamanic inebriant used by the Mexican Mazatec Indians, the plant and its preparations are becoming increasingly popular among non-traditional users. METHODS: Demographic data and information on pattern of use and subjective effects were obtained by means of self-report questionnaires from a sample of 32 recreational users of salvia and other psychedelics. RESULTS: Involvement with salvia appeared to be a recent phenomenon. Smoking the extract was the preferred form of administration. Subjective effects were described as intense but short-lived, appearing in less than 1 min and lasting 15 min or less. They included psychedelic-like changes in visual perception, mood and somatic sensations, and importantly, a highly modified perception of external reality and the self, leading to a decreased ability to interact with oneself or with one's surroundings. CONCLUSIONS: Although some aspects of the subjective effects reported were similar to high doses of classical psychedelics with serotonin-2A receptor agonist activity, the intense derealization and impairment reported appear to be a characteristic of salvia. The observed simultaneous high scores on the LSD and PCAG subscales of the Addiction Research Center Inventory (ARCI) have been previously reported for other kappa-opioid agonists, and support kappa receptor activation as the probable pharmacologic mechanism underlying the modified state of awareness induced by salvia.

Adult↗
PubMed2006

High sensitivity to multisensory conflicts in agoraphobia exhibited by virtual reality.

The primary aim of this study was to evaluate the effect of auditory feedback in a VR system planned for clinical use and to address the different factors that should be taken into account in building a bimodal virtual environment (VE). We conducted an experiment in which we assessed spatial performances in agoraphobic patients and normal subjects comparing two kinds of VEs, visual alone (Vis) and auditory-visual (AVis), during separate sessions. Subjects were equipped with a head-mounted display coupled with an electromagnetic sensor system and immersed in a virtual town. Their task was to locate different landmarks and become familiar with the town. In the AVis condition subjects were equipped with the head-mounted display and headphones, which delivered a soundscape updated in real-time according to their movement in the virtual town. While general performances remained comparable across the conditions, the reported feeling of immersion was more compelling in the AVis environment. However, patients exhibited more cybersickness symptoms in this condition. The result of this study points to the multisensory integration deficit of agoraphobic patients and underline the need for further research on multimodal VR systems for clinical use.

Adult↗
PubMed2005

EEG correlates of multimodal ganzfeld induced hallucinatory imagery.

Multimodal ganzfeld (MMGF) frequently induces dreamlike, pseudo-hallucinatory imagery. The aim of the study was to explore EEG correlates of MMGF-induced imagery. In a screening phase, seven 'high-responders' were selected by frequency and quality of their reported hallucinatory experience in MMGF. Each of these subjects then participated in three MMGF sessions (45 min) with simultaneous 19 channel EEG recordings and indicated occurrences of imagery by pressing a button. Relative spectral power changes during percept formation (30 s preceding subjects' reports) with respect to intra-individual baselines (no-imagery EEG) were analysed. At the beginning of the 30-s 'image formation' period alpha was slightly reduced than in the 'no-imagery' periods. This was followed by increased power in the higher alpha frequency band (10-12 Hz) which then declined in a monotonic fashion. This decline in higher alpha power was accompanied by increased power in the beta frequency bands. Throughout the image formation period there was a steady decline in power of low frequency alpha (8-10 Hz). Correlations between descriptors of subjective experience and EEG power changes were evaluated in terms of their global average magnitude and variability in time. Results indicate that the acceleration of alpha activity is a nonspecific effect of MMGF. In contrast, the tri-phasic profile of faster alpha activity seems to be a specific correlate of the retrieval and transformation of memory content in ganzfeld imagery.

Acoustic Stimulation↗
PubMed2004

Engagement of the prefrontal cortex in representational momentum: an fMRI study.

Behavioral studies have identified a robust phenomenon that an observer's memory of the final position of a moving target is shifted a little further in its motion direction, which is usually called representational momentum (RM). However, the neural substrates underlying RM are poorly understood. The current study measured hemodynamic responses in association with RM using functional magnetic resonance imaging (fMRI). Two experiments using block and event-related designs, respectively, were conducted in which subjects compared the orientation of a probe rectangle with the remembered orientation of the final inducing figures in a set of rotating rectangles. Both experiments showed that, relative to the control task in which behavioral data did not show RM effects, RM task induced stronger activation in the prefrontal cortex. However, no activation was found in MT/MST complex in association with RM. The fMRI results suggest that RM may not simply reflect implicit motion perception and high level cognitive mechanisms underpinned by the prefrontal cortex may be involved in the RM effect.

Adult↗
PubMed2006

Discriminating imagined from perceived information engages brain areas implicated in schizophrenia.

Some of the symptoms of schizophrenia may reflect a difficulty discriminating between information that was perceived from the outside world and information that was imagined. This study used fMRI to examine the brain regions associated with this reality monitoring ability in healthy volunteers, who recollected whether information had previously been perceived or imagined, or whether information had been presented on the left or right of a monitor screen. Recent studies have suggested that schizophrenia may be associated particularly with dysfunction in medial anterior prefrontal cortex, thalamus, and cerebellum. In our data, activation in all three of these regions of interest was significantly greater during recollection of whether stimuli had been perceived or imagined versus recollection of stimulus position. In addition, reduced prefrontal activation was associated with the same misattribution error that has been observed in schizophrenia. These results indicate a possible link between the brain areas implicated in schizophrenia and the regions supporting the ability to discriminate between perceived and imagined information.

Adult↗
PubMed2004

Memory consolidation in sleep; dream or reality.

We discuss several lines of evidence refuting the hypothesis that procedural or declarative memories are processed/consolidated in sleep. One of the strongest arguments against a role for sleep in declarative memory involves the demonstration that the marked suppression or elimination of REM sleep in subjects on antidepressant drugs or with brainstem lesions produces no detrimental effects on cognition. Procedural memory, like declarative memory, undergoes a slow, time-dependent period of consolidation. A process has recently been described wherein performance on some procedural tasks improves with the mere passage of time and has been termed "enhancement." Some studies, but not others, have reported that the consolidation/enhancement of perceptual and motor skills is dependent on sleep. We suggest that consolidation or enhancement, initiated in waking with task acquisition, could in some instances extend to sleep, but sleep would serve no unique role in these processes. In sum, there is no compelling evidence to support a relationship between sleep and memory consolidation.

Animals↗
PubMed2005

Emotional content and reality-monitoring ability: fMRI evidence for the influences of encoding processes.

Memory for emotional items can be less prone to some types of memory distortion, such as reality-monitoring errors, than memory for neutral items. The present fMRI study examined whether this enhanced reality-monitoring accuracy reflects engagement of distinct processes recruited during encoding of emotional information. Participants only imagined named objects (word-only trials) or imagined named objects and then also viewed photos of them (word-picture trials). Half of the items were emotional (e.g., snake, casket). Later, participants heard object names and indicated whether the corresponding photo had been shown. Reality-monitoring errors occurred when participants attributed an item from a word-only trial to a word-picture trial. Such misattribution errors occurred less frequently for emotional than neutral items. Activity in emotion-processing regions (e.g., orbitofrontal cortex, amygdala) reduced the likelihood of later misattributions, likely due in part to interactions with regions that promote memory accuracy (e.g., the hippocampus). Distinct neural processes also increased the likelihood of reality-monitoring errors, depending on the emotional content of the items. Activity spanning the fusiform and parahippocampal gyri (likely reflecting mental imagery) increased the likelihood of reality-monitoring errors for neutral items, while activity in the anterior cingulate increased the likelihood of reality-monitoring errors for emotional items.

Adolescent↗