[Pulmonary emphysema and obstructive respiratory tract disease: etiology--diagnosis--prevention].
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The optimum conditions for carrying out the enzyme immunoassay (EIA) with a view to determine M. pneumoniae antigen and antibodies to them in the sera of patients with different respiratory diseases were established. The use of the specially modified EIA technique made it possible to reveal that patients with tuberculosis and chronic pneumonia showed similar occurrence of M. pneumoniae (35.7% and 35.0% of cases, respectively), while in patients with pulmonary sarcoidosis M. pneumoniae occurred in 27.2% of cases. At the same time the occurrence of antibodies in patients with chronic pneumonia and sarcoidosis was more than three times greater than in tuberculosis patients.
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A cross-sectional study, a follow-up study, and an intervention trial were carried out to investigate the association between mild vitamin A deficiency and the occurrence of diarrhea and respiratory diseases. Cross-sectional analysis was performed among 1,772 children, aged 1-8 years, in the Sakon Nakhon province of northeastern Thailand. Children with a history of diarrhea or respiratory disease had lower levels of serum retinol and retinol-binding protein. Adjusted for age, sex, nutritional status, and level of urbanization, logistic regression using data for 877 children showed a negative association between serum retinol and both diarrhea and respiratory diseases. A follow-up three months later (n = 146 children) showed that children with deficient serum retinol (less than 0.35 mumol/liter) had a fourfold greater risk of respiratory disease (p less than 0.01). No relation was found for diarrhea. An intervention trial (n = 166 children aged 1-5 years) showed that, during 2 months of follow-up after administration of oral vitamin A (200,000 IU), the control group (aged 3-5 years) had a higher incidence of respiratory disease (2.9 times) as well as diarrhea (3.1 times). Between 2 and 4 months, a significantly (p less than 0.025) higher incidence of respiratory diseases (2.5 times) could be observed in children aged 1-2 years. This study supports earlier reports on a greater risk of respiratory diseases and of diarrhea in mild vitamin A deficiency. Supplementation reduced the incidence of both diarrhea and respiratory disease for a period of at least 2 months.
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In 200 3-7-year-old children in two localities of Bratislava-city with different concentrations of NO2, SO2, dustiness with different bioclimatic factors and a different epidemiological position the authors investigated their effect on the frequency, incidence and types of relapsing respiratory diseases during different months in 1991. The different concentrations of the above substances in the atmosphere of the two localities did not affect the number of respiratory diseases nor their annual or monthly incidence. In the place with the increased NO2 concentration a significantly higher number of serious forms of respiratory diseases was found in the investigated group. In the locality with a more favourable oecological and epidemiological situation the adverse effect of monthly NO2 concentrations was manifested when it was potentiated by the SO2 concentration and combined with dustiness and dust fall-out. The authors found a significant correlation between the incidence of relapsing respiratory diseases and the atmospheric temperature and its relative humidity in the course of different months of the year.
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The authors investigate in a group of 211 children aged 2-6 years, incl. in particular a group of 33 2-year-old ones, in 1990 and checked in 1991 at two sites in Bratislava--a town with a varying concentration of NOX, SO2, dustiness and dust fallout--their influence on the incidence, type and course of relapsing respiratory disease. In both sites the concentrations of the mentioned noxious substances were beneath levels admitted by hygienists. In the place with higher concentrations, in particular of NOX, a significantly higher number of serious forms of relapsing respiratory diseases was recorded and an adverse course of the diseases in 2-6 year-old children and in particular in the 2-year-old ones.
In 40 patients with bronchopulmonary diseases, in prevalence of chronic type, the therapeutic value of a new antiphlogistic-balsamic compound was evaluated. The favourable results obtained, particularly as far as the rapidity of regression of signs and symptoms is concerned, showed that this drug may have a significant role in a combined scheme of treatment.
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