Extracellular Accumulation of a New Amino Acid, O-2-Hydroxypropylhomoserine, from 1,2-Propanediol by Flavobacterium rigense.
[This corrects the article on p. 1046 in vol. 35.].
Journal Article↗
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[The suitability of propylene glycol (1,2-propanediol) as an active antimicrobial adjuvant in ointments].
Propylene glycol was tested for its antimicrobial activity as well as its possible irritant effect in ointments. With regard to the antimicrobial effect, vehicles containing more than 5% propylene glycol proved to be superior to those containing glycerol. 269 volunteers with or without eczema who had been treated with 10% propylene glycol under occlusion and by means of the Duhring chamber method, showed very few irritations; there was almost none observed in patients tested with an ointment containing glycerol instead. We did not find any allergic sensitization against propylene glycol.
Adjuvants, Pharmaceutic↗
The comparative potency of phenobarbital and five 1,3-propanediol dicarbamates for hepatic cytochrome P450 induction in rats.
Using a reproducible screening procedure for rat liver cytochrome P450 isoenzyme induction/inhibition, five dicarbamate drugs (meprobamate, mebutamate, carisoprodol, tybamate, and W-554) were compared with sodium phenobarbital and found to be from 25 to 100 times less potent hepatic cytochrome P450 inducers than phenobarbital.
Animals↗
[Various aspects of 1,2-propanediol and 1,3-butanediol metabolism following parenteral administration combined with glucose and sorbitol (experimental study)].
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Alkaline Phosphatase↗
The stereochemistry of the conversion of D and L 1,2-propanediols to propionaldehyde.
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Alcohol Oxidoreductases↗
[Effects of 2 methyl-2- (1 methyl propyl) 1-3 propanediol dicarbamate and (alpha bromo-alpha-ethyl butyryl) urea on glycemia of rabbits].
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Animals↗
Observations of the effects of 3-chloro-1,2-propanediol on the female reproductive tract and pituitary gonadotrophs of the gerbil (Meriones hurrianae).
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Animals↗
[Kinetics of the transformation of 1,2-propanediol to propionic aldehyde, catalyzed by glycerol dehydratase from Aerobacter aerogenes].
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Aldehydes↗
The dose-dependent glycogen-depleting effect of 1,2-propanediol on the myocardium of the eight and one-half day chick embryo.
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Animals↗
[Effect of 3-chloro-1,2-propanediol on the tests and seminal vesicles in rats. Histochemical study].
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Animals↗
The effect of SK&F 525-A, 2-diethylaminoethyl-2,2-diphenylvalerate hydrochloride, on the in vivo metabolism of beta-(0-toloxy)-1,2-propanediol.
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Animals↗
Antifertility activity of alpha-chlorohydrin (3-chloro-1, 2 propanediol, U-5897) on the female rats.
alpha-chlorohydrin administration brings about regression in the corpus luteum and shedding of the uterine endometrium, indicating its luteolytic activity, alpha-chlorohydrin inhibited vaginal keratinization and interrupted the sex cycle. A dioestrous leucocytic pattern of the vaginal smear is retained during medication. Decreased synthesis of RNA, protein, sialic acid and glycogen concentration in the uterus and vagina suggest possible antioestrogenic action of the compound. The antifertility action of the drug may be due to its antioestrogenic property.
Adrenal Glands↗
Nature and site of action of 3-chloro-1,2-propanediol--an oral antifertility agent for the male.
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Animals↗
[Glucose and ketone body levels in the blood of cows during late pregnancy and at the initiation of lactation, as well as their modification through 1,2 propanediol (propylene glycol)].
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Acetoacetates↗
Studies on protein multimers. II. A study of the mechanism of urease dissociation in 1,2-propanediol: comparative studies with ethylene glycol and glycerol.
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Binding Sites↗
[Pharmacology of a metabolite of the chloramphenicol, D threo-1-nitrophenyl-2-dichloracetamide-1,3 propanediol].
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Acetylcholine↗
[Influence of a new synthetic derivative with central depressive activity, 2,2-bis-chloromethyl-1,3-propanediol on some biological and clinical parameters].
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Adult↗
The role of potassium in experimental quinidine intoxication, and its treatment with 2-amino-2-hydroxymethyl-1, 3-propanediol (THAM).
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Animals↗