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At least 487 records · Page 27Linked to original sources

Field trial of billings ovulation method of natural family planning.

There are couples with unmet family planning needs and couples who do not use any modern method, yet they desire to space or avoid pregnancies. Many of them look for safe and effective options like the natural family planning methods. The Billings Ovulation Method based on single index cervical mucus parameter is one such option. The present multicentre trial conducted in India has shown an encouraging use-effectiveness of the method, indicating method failure as low as 1.5 +/- 0.3 and use-failure 15.9 +/- 0.8 per 100 users at 21 months. The method continuation rates have also been as high as 88.3/100 users at 6 months and 52.0/100 users at 21 months.

Adult↗

Some observations on the development of a 'scoring system' in an expert system for prediction of ovulation.

As part of the construction of an expert system for the diagnosis of infertility we have developed a scoring system for the identification of conditions which can interfere with ovulation. The scores were obtained from a group of clinicians, and the arithmetic means of these scores were used in the actual system. Correlation between the scores obtained from individual clinicians was very poor (r = 0.345 +/- 0.134). Correlation improved when groups of clinicians were compared. Thus scores derived from a group of clinicians will reflect more reliably the 'general medical opinion'. Scores derived from the opinion of clinicians should be regarded with caution until probabilities or weighting factors derived from real clinical data become available.

Expert Systems↗

Single endometrial aspiration for determination of ovulation.

The possibility of utilizing a single endometrial aspiration for the determination of ovulation was explored and compared with endometrial histology, serial vaginal cytology and plasma progesterone. A total of 180 women with normal, regular cycles and no pelvic pathologic conditions were studied. A correlation of 90.5% was observed between aspiration smears and histology. Vaginal cytology and histology agreed in 71.7% of the cases, while plasma progresterone and endometrial histology correlated in 95% of the women. Endometrial aspiration appeared to be an accurate, quick, inexpensive, convenient and a one-time method, which could be repeated in successive cycles without any patient discomfort.

Endometrium↗

Serum prolactin profiles of normal human conceptual cycles.

Commencing on day 10 of the menstrual cycle through onset of subsequent menses, or confirmation of pregnancy, daily sera collected from 15 women planning pregnancy were analyzed by radioimmunoassays (RIA) for prolactin (hPRL), estradiol-17 beta and luteinizing hormone (hLH). Two of the observed subjects became pregnant in the single cycles studied. The profiles of these hormones during the early gestation following spontaneous ovulation were established. No distinct midcycle peaks of hPRL were observed in either subject. Enormous spikes were observed in daily prolactin values, with wide variations between subjects.

Adolescent↗

Therapeutic insemination with fresh semen.

[Beginning of abstract missing from journal] were studied. Every female patient presented normal ovulation, tubal patency and morphologic and functional integrity of her genital tract. Their husbands presented normal spermogram in 45 cases (23.4%), oligospermy in 145 (75.5%) and azoospermy in 2 (0.96%). The number of the inseminations ranged from 1 to 10 series, in each of which a daily trial was attempted, three times every other day in the ovulatory period. The insemination technique included vaginal, intracervical and intra-uterine deposition of homologous fresh semen. The results expressed in terms of pregnancy achieved rates of 28.12% with 24.07% abortions.

Abortion, Spontaneous↗

The effects of Cyclofenil on the Cervical Mucus Score (Insler).

Daily simultaneous cervical mucus evaluation and ultrasonography of the Graafian follicular growth and ovulation were studied (in the mid-cycle) in 8 infertile British women during 30 Cyclofenil-stimulated cycles, and compared with 18 non-stimulated normal ovulatory cycles in 12 subjects (controls). In the 16 Cyclofenil-induced ovulatory cycles, there was an early (5 days prior to the day of ultrasonic ovulation) Full Cervical Mucus Score (Insler) in 69% of the cycles, and the Full Cervical Mucus Score lasted for 7 days or more in 63% of the cycles. In 38%, there was persistence of the Full Cervical Mucus Score on the third day after ultrasonic ovulation. In the 14 Cyclofenil-treated anovulatory cycles, a Full Cervical Mucus Score was recorded on one or more occasions in the mid-cycle in 29% of the cycles. The classical teaching of prediction of the probable timing of ovulation by Cervical Mucus Scoring is not applicable to Cyclofenil-stimulated cycles.

Adult↗

Breastfeeding and return to ovulation in Bangkok.

Twenty-seven breastfeeding mothers and nine non-breastfeeding postpartum comparison mothers in Bangkok, Thailand were followed longitudinally until ovulation resumed. A simple set of guidelines is described involving three obvious milestones for the breastfeeding mother to safely use the natural contraceptive benefit of breastfeeding. Those milestones are the first menses, the initiation of supplementation and the child's monthly birthday. In the absence of menses and supplementation, 93% of breastfeeding mothers remained anovular for 3 months postpartum and 88-89% for up to 6 months. Further, the work of other investigators suggests that the proportion ovulatory provides an overestimate of those at risk of pregnancy. The guidelines suggest a way to estimate the period of lactational infertility and may be most useful on a programmatic level.

Adult↗

Clinical efficacy of LH-color: a new home ovulation test.

In this study we evaluate the efficacy of a new home ovulation test to identify LH surge (LH-Color, Organon). Fifty-five spontaneously ovulating women were followed during their cycles with twice daily urinary LH testing as well as daily ultrasound and BBT charts. In 39 (70.91%) of the 55 patients, ovulation occurred within 24 h after the decoloration of the LH-Color. Follicular collapse as visualized by ultrasonography, took place in all patients within 36 h after the decoloration of the LH-Color. Thus a good correlation was found between urinary LH surge and ultrasound. We conclude that the rapid LH test was able to predict impending ovulation.

Adult↗

Ovulation prediction: changes in the concentrations of urinary estrone-3-glucuronide, estradiol-17 beta-glucuronide and estriol-16 alpha-glucuronide during conceptional cycles.

The concentrations of estrone-3-glucuronide (E1-3-G), estradiol-17 beta-glucuronide (E2-17 beta-G), estriol-16 alpha-glucuronide (E3-16 alpha-G) and LH/hCG have been measured in daily samples of early morning urine from six women who conceived during the period study. The specimens were collected from the second day of menstruation until the values for hCG were greater than 200 U/l. The aim of the study was to assess which of the metabolites should be measured preferentially to predict ovulation by 72 h and hence identify the probable start of the fertile period. The peak of LH was used as a reference point for ovulation and defined as Day 0. A defined rise (50% increase over the mean of three preceding values) in the concentration of each steroid metabolite occurred on the following days (mean and range): E1-3-G Day LH-4.7 (-3 to -6), E2-17 beta-G Day LH-3.7 (-3 to -6) and E3-16 alpha-G Day LH-4.5 (-3 to -6). The concentration (nmol/l; mean and range) of each metabolite on the day of the rise was: E1-3-G (106; 78-137), E2-17 beta-G (19; 5 to 27) and E3-16 alpha-G (28; 18-40). It is concluded that the measurement of each estrogen glucuronide provides similar information and quantitatively E1-3-G is the most important.

Adult↗

Recent advances in chemiluminescence-based immunoassays for steroid hormones.

Several formats of solid-phase separation techniques for the measurement of steroids and urinary steroid conjugates using chemiluminescence as an end point are described. These formats include: (1) immunoadsorption of second antibodies directed against the first antibody on solid support; (2) specific immunoadsorbents consisting of primary antibodies covalently coupled to polymer beads; (3) second antibody coupled to a polymer containing magnetic particles. In these assays a steroid-chemiluminescent marker conjugate serves as the labelled ligand, and highly specific homologous monoclonal antibodies are used to provide optimal specificity and rigorous standardization. These techniques enabled the direct measurement of steroid glucuronides in diluted urine and of steroids in plasma.

Animals↗

Estimating basal body temperature with single-use thermometers.

When patients use both a standard glass mercury ovulation thermometer and a single-use thermometer to compile separate charts of their daily early morning resting oral temperature, the single-use thermometers are shown to record accurate temperatures. They could be useful in subfertility clinics for women who have difficulty in reading conventional glass thermometers.

Body Temperature↗

Prediction and self-prediction of ovulation in clomiphene citrate-treated patients.

We studied 15 infertile patients for a total of 25 cycles in order to compare the predictive value of the following parameters in timing ovulation: basal body temperature (BBT), cervical mucus, serum E2 and LH, follicular growth as shown by ultrasonography, and urinary LH. The patients themselves tested urinary LH at home using Clearplan kits. BBT had low value as a predictive test for the time of ovulation, whereas ultrasonography had a predictive value of 9%, serum E2 50%, cervical mucus 59%, serum LH 63.6% and Clearplan kits 63.6%. The best predictive reliability in timing ovulation was obtained by considering both serum LH and E2 measurements. The Clearplan kits were as reliable as serum LH measurements and have greater practical advantages.

Adult↗

Comparison of endocrine changes and ultrasound as means of identifying ovulation in the bitch.

Twenty bitches were monitored through pro-oestrus and oestrus using both circulating plasma hormone levels and ultrasonic examination of the ovaries. Using luteinising hormone (LH) as being the generally accepted optimum indicator of the day of ovulation, comparisons were made of the accuracy of progesterone and ultrasound to identify ovulation. Progesterone agreed with LH in 12 of 20 bitches and was within one day in seven of the other eight. Ultrasound was less accurate in that only four of the 16 estimates agreed, with a further six being within one day. However, if only the bitches which were examined by ultrasound with the latest equipment were included, while only three of 11 coincided, six of the remaining eight were within one day of the LH estimated ovulation. It is concluded that, at present, of the rapid assessments, the measurement of plasma progesterone is a better estimator of ovulation than ultrasound.

Animals↗

Using an ovarian monitor as an adjunct to natural family planning.

The need to identify a reliable ovulation predictor has received attention by the scientific community in recent years. For couples practicing natural family planning, a more precise identification of the fertile phase would be a welcome adjunct to their method. A home ovarian monitor invented by Professor J. B. Brown of Melbourne, Australia, enables couples to measure the principal urinary metabolite of ovarian estrogen and progesterone. The charted results reveal the hormonal pattern of the menstrual cycle and thus identify the beginning, peak, and end of the fertile period. A study involving 21 couples was conducted with the purpose of assessing overall acceptability, including ease of use, motivation, and client satisfaction. At the completion of the study, 12 couples indicated a high degree of motivation and satisfaction with the monitor. None reported difficulty with the test procedure. Increased confidence in natural family planning was cited as the most positive evaluation and the time required to perform the test, as the most negative.

Adult↗

Reproductive hormones associated with the ovarian cyst response to GnRH.

Eighteen cows with ovarian cysts were administered 100 mug of GnRH and bled prior to treatment, at half hour intervals for 4 hours posttreatment and on days 1, 5 and 9 posttreatment. Blood plasma was analyzed for estradiol-17beta, progesterone and LH by radioimmunoassay. Response to treatment was recorded as positive if ovulation was detected within 30 days posttreatment. Fourteen cows (78%) initiated ovarian cycles by 30 days posttreatment. Mean pretreatment concentrations of estradiol-17beta, progesterone and LH and the GnRH induced LH release were not different for positive or no response cows. However, all seven cows that had pretreatment progesterone concentrations greater than 1.0 ng/ml had a positive response to treatment. Eight of the remaining eleven cows had a progesterone response (mean progesterone concentrations on days 5 and 9 posttreatment) greater than 1.0 ng/ml; seven had a positive response to treatment. In summary, most cows with ovarian cysts administered GnRH will initiate ovarian cycles within 30 days if: 1) pretreatment progesterone concentrations are greater than 1.0 ng/ml or 2) if progesterone response is greater than 1.0 ng/ml.

Journal Article↗