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PubMedDate not supplied

Homeostasis: a framework for integrating the life sciences.

Nurse education curricula continue to emphasize the holistic nature of health and ill-health. As a concept, holism recognizes that the interactions between a person and his/her environment are significant factors in shaping the individual, and important determinants of wellbeing. Psychosocial interactions as a basis for health now figure prominently in nursing curricula. In contrast, the applied biological sciences have increasingly become marginalized, yet knowledge of the biological construct of the individual, and an understanding of how it is influenced by psychosocial interactions, are also necessary if holistic care is the aim. Nursing models attempt to reinforce holistic principles, but the integrative nature of health and illness needs to be established before their application. This article proposes that the concept of homeostasis, and its relationship to systems theory, provides a workable framework for teaching the basis of health, and so forms a foundation for the application of nursing theory and nursing models.

Biological Science Disciplines↗
PubMed1991

Clinical chemistry: a professional field for physicians and natural scientists in Europe.

1. Clinical chemistry is definitely an interdisciplinary subject between natural science and medicine. The major part of clinical chemistry is natural science and therefore theoretical science. To a lesser extent, however, clinical chemistry is practical science or "action science" which is aimed at a certain action. 2. The question "Is clinical chemistry a professional field for physicians, for scientists or for both?" can be answered with the statement: It follows from its historical development and its characteristic theory and practice, and is de facto true throughout the world, that clinical chemistry is a professional field for physicians and natural scientists. 3. The broad scope of the technical field and the challenges to be expected in future within the framework of the European Community will require the recruiting aspiring clinical chemists both from medicine and from the natural sciences. 4. Qualified postgraduate training is more important than the nature of the initial study course. 5. Apart from providing special knowledge and particular abilities, postgraduate training must make the younger generation familiar with the ways of thought of the physician and of the natural scientist. 6. Successful work as a clinical chemist requires "extra-functional" qualifications, such as the ability to conduct dialogue and teamwork with the clinician. 7. The national differences which exist in the definition of the professional pattern "clinical chemist" are a hindrance to the future development of the discipline in the European Community. The starting point for recognition of the profession must be an agreed definition among the professionals of the countries of the European Community of the professional field of the clinical chemist.

Chemistry, Clinical↗
PubMed2005

Enhancing methodological clarity: principle-based concept analysis.

AIMS: The aim of this paper is to operationalize the principle-based method of concept analysis. BACKGROUND: While nursing has embraced the use of concept analysis as a valid and significant entree into an area of research, methodological development has created strategies of inquiry that vary in purpose and in the nature of their findings. DISCUSSION: We propose that, as the primary utility of concept analysis is to determine the existing state of the science so that further work may be strategically and appropriately planned, the method described as principle-based concept analysis is superior in providing evidence to support subsequent inquiry into the concept of interest. Three problematic issues are discussed in an effort to clarify and procedurally explicate the strategies employed in this approach: selecting disciplinary literatures for inclusion in the analysis; conceptually-driven sampling issues; and within- and across-discipline analytic techniques. CONCLUSION: In this form of concept analysis, each principle contributes to an understanding of the strengths and limitations of the present state of the concept in the scientific literature. We believe that this perspective will enable nursing to begin to harness the power of concept analysis for advancing science rather than simply imagining what a concept could be or constructing what we believe it should be.

Concept Formation↗
PubMed1981

Human genetics teaching in U.S. medical schools.

Information about instruction in genetics was obtained fron 103 of the 107 U.S. four-year medical schools. Seventy-two percent of the schools provide a compulsory course in genetics, but there was great variation in duration, content, departmental responsibility for giving the course, and in the disciplines of those doing the teaching. The variability in the number of hours devoted to teaching genetics was reflected in the competence of the students in giving correct answers to questions on genetics posed by the National Board of Medical Examiners. Electives and continuing education courses on genetics are given by two-thirds and one-half of the schools, respectively; but the subject receives very little attention in departments of preventive, community, or family medicine or in schools of allied health sciences. These findings suggest that genetics has not yet found a natural and comfortable context in the curricula of U.S. medical schools.

Education, Medical↗
PubMed1994

Should nurses be studying bioscience? A discussion paper.

The growth of bioscience knowledge over the last two decades has increased the potential benefits of scientifically based patient care by contributing to the theory of clinical care. However, there is little evidence that knowledge, derived from the human biosciences is being fully incorporated into nursing theory and practice. Nursing has developed its own unique professional body of knowledge, heavily influenced by behavioural science. If nursing theory leans towards behavioural science, but practice is devoted to problems of biological disturbance, nursing may be facing a widening theory-practice gap, greater than other professions. The theory-practice gap in nursing may be widened by the exclusion of bioscience from nursing theory. Nurses' relative disinterest in the natural sciences can be attributed both to sociological reasons and to problems stemming from the symbol-object dichotomy that recur in the teaching of natural sciences. Reflection on practice and examination of education method are suggested as strategies for re-introducing bioscience into nursing theory and practice. A challenge facing nurse educators is the integration of biological science into the nurses' conceptual ecologies. For, if nursing fails to make bioscience its own, much of the clinical welfare of patients will become a medical monopoly.

Behavioral Sciences↗
PubMed2004

Synergy between medical informatics and bioinformatics: facilitating genomic medicine for future health care.

In this paper, we review the results of BIOINFOMED, a study funded by the European Commission (EC) with the purpose to analyse the different issues and challenges in the area where Medical Informatics and Bioinformatics meet. Traditionally, Medical Informatics has been focused on the intersection between computer science and clinical medicine, whereas Bioinformatics have been predominantly centered on the intersection between computer science and biological research. Although researchers from both areas have occasionally collaborated, their training, objectives and interests have been quite different. The results of the Human Genome and related projects have attracted the interest of many professionals, and introduced new challenges that will transform biomedical research and health care. A characteristic of the 'post genomic' era will be to correlate essential genotypic information with expressed phenotypic information. In this context, Biomedical Informatics (BMI) has emerged to describe the technology that brings both disciplines (BI and MI) together to support genomic medicine. In recognition of the dynamic nature of BMI, institutions such as the EC have launched several initiatives in support of a research agenda, including the BIOINFOMED study.

Biotechnology↗
PubMed1992

Does the philosophy of medicine exist?

There has been a great deal of discussion, in this journal and others, about obstacles hindering the evolution of the philosophy of medicine. Such discussions presuppose that there is widespread agreement about what it is that constitutes the philosophy of medicine. Despite the fact that there is, and has been for decades, a great deal of literature, teaching and professional activity carried out explicitly in the name of the "philosophy of medicine", this is not enough to establish that consensus exists as to the definition of the field. And even if consensus can be obtained as to what constitutes the philosophy of medicine, this does not mean that it exists as a field. In order to constitute a field, an inquiry must be well-integrated with other cognate inquiries and disciplines, have an established canon of key books, textbooks, anthologies and articles, and a set of distinctive and defining problems. The philosophy of medicine as it currently exists fails to satisfy these criteria and, thus, fails to exist as a field of inquiry. The non-existence of the philosophy of medicine is unfortunate. Medicine and philosophy would both benefit from the development of the philosophy of medicine as a field. The philosophy of medicine is an essential foundation for bioethics, it should provide insights into some of the key problems of the philosophy of science such as the nature of explanation and theoretical evolution, and, ought help to shape the goals as well as the methods used in both experimentation and research in medicine and the health sciences.

Bioethics↗
PubMedDate not supplied

Developing scientific and policy methods that support precautionary action in the face of uncertainty--the Institute of Medicine Committee on Agent Orange.

To be precautionary, decisions must be made to prevent the impacts of potentially harmful activities even though the nature and magnitude of harm have not been proven scientifically. The Institute of Medicine's Committee on the Health Effects in Vietnam Veterans of Exposures to Herbicides provides a novel example of science and policy structures that support precautionary action in the face of uncertainty. What makes this example unique is the clear set of precautionary decision rules that lowered the standard for evidence, which formed the basis for policy. These rules, established by Congress, strongly influenced the way scientific information was weighed and the subsequent compensation decisions. They encouraged committee members to think outside the confines of their disciplines and develop new tools and methods to fit their unique mandate. The result was a methodology, supported by strong institutional structures, that allowed scientists to discuss the evidence as a whole, reach decisions as a group, and clarify uncertainties.

2,4,5-Trichlorophenoxyacetic Acid↗
PubMed1982

Some implications of a science of adaptive responses.

The concept of occupational therapy as a "science of adaptive responses," as proposed by King in her 1978 Eleanor Clarke Slagle Lecture, is explored and expanded on in this article. The authors postulate an adaptation continuum consisting of homeostatic reactions, adaptive responses, adaptive skills, and adaptive patterns--a continuum that places the adaptive response in a sequential and interdependent relationship to other human responses that serve an adaptive function. Assuming that authentic occupational therapy practice is "eliciting adaptive responses" (1), the authors use the continuum to delineate the domain of occupational therapy as compared to the primary concerns of other health disciplines and to indicate the nature of collaboration between them in areas that overlap. Finally, they draw attention to some of the issues and questions that emerge from the analysis.

Adaptation, Psychological↗
PubMed2000

Breakthroughs in scientific research: the discipline of nursing, 1960-1999.

The period of 1960 to 1999 was an era of evolution and rapid growth of scientific research in the discipline of nursing during which specific knowledge realms, or subfields of the discipline, emerged and scientific breakthroughs occurred. This review presents the milestones or scientific breakthroughs of the era in the context of the prevailing thinking within and beyond the discipline of nursing. The nature of each scientific breakthrough in nursing is characterized as to the transdisciplinary change in thinking brought about by the work. The pathfinders for each scientific breakthrough are identified as well as their pathfinding modes. Opportunities for future scientific breakthroughs in nursing are presented.

Adult↗
PubMed2005

The impact of landsat satellite monitoring on conservation biology.

Landsat 7's recent malfunctioning will result in significant gaps in long-term satellite monitoring of Earth, affecting not only the research of the Earth science community but also conservation users of these data. To determine whether or how important Landsat monitoring is for conservation and natural resource management, we reviewed the Landsat program's history with special emphasis on the development of user groups. We also conducted a bibliographic search to determine the extent to which conservation research has been based on Landsat data. Conservation biologists were not an early user group of Landsat data because a) biologists lacked technical capacity--computers and software--to analyze these data; b) Landsat's 1980s commercialization rendered images too costly for biologists' budgets; and c) the broad-scale disciplines of conservation biology and landscape ecology did not develop until the mid-to-late 1980s. All these conditions had changed by the 1990s and Landsat imagery became an important tool for conservation biology. Satellite monitoring and Landsat continuity are mandated by the Land Remote Sensing Act of 1992. This legislation leaves open commercial options. However, past experiments with commercial operations were neither viable nor economical, and severely reduced the quality of monitoring, archiving and data access for academia and the public. Future satellite monitoring programs are essential for conservation and natural resource management, must provide continuity with Landsat, and should be government operated.

Biology↗
PubMed2001

Whole-cell biocomputing.

The ability to manipulate systems on the molecular scale naturally leads to speculation about the rational design of molecular-scale machines. Cells might be the ultimate molecular-scale machines and our ability to engineer them is relatively advanced when compared with our ability to control the synthesis and direct the assembly of man-made materials. Indeed, engineered whole cells deployed in biosensors can be considered one of the practical successes of molecular-scale devices. However, these devices explore only a small portion of cellular functionality. Individual cells or self-organized groups of cells perform extremely complex functions that include sensing, communication, navigation, cooperation and even fabrication of synthetic nanoscopic materials. In natural systems, these capabilities are controlled by complex genetic regulatory circuits, which are only partially understood and not readily accessible for use in engineered systems. Here, we focus on efforts to mimic the functionality of man-made information-processing systems within whole cells.

Computational Biology↗
PubMedDate not supplied

Children's work: the less-considered childhood occupation.

Children's work has largely been overlooked by researchers of many disciplines due to sociohistorical trends that fostered the notion that childhood should be a time free of work. Likewise, it has received little attention in occupational therapy most likely due to the influence of these historical developments on occupational therapy rhetoric and values. This paper begins by describing the influence of child labor laws and reformation on children's participation in work. Next, using a comprehensive review of the literature gathered from social sciences, a critical examination of the historical and current research on children's work is provided. This synthesis is framed in concepts of occupational science analyzing the evidence that describes the nature, form, function, and meaning of children's work. For occupational therapists working with children with disabilities, this research provides beginning guidelines for occupation-based work interventions and typical expectations for nondisabled children that may be applied using clinical reasoning to populations with disabilities.

Child↗
PubMed2002

Mental tools for thinking about DNA technologies in new ways.

OBJECTIVE: To investigate the nature of creative thinking in biomedical science with specific applications to molecular pathologies and DNA technologies. DATA SOURCES: Accounts of breakthroughs and inventions contained in autobiographies, biographies, interviews, and archival sources. STUDY SELECTION: Discoveries that have altered, or may yet alter, basic textbook accounts of biomedical sciences for which appropriate data sources exist. DATA EXTRACTION: Approximately 1000 data sources were analyzed, both within appropriate sciences and in other creative fields, such as the arts. DATA SYNTHESIS: The current analysis is based on a framework described in our previous book, Sparks of Genius, which outlines a general approach to understanding creative thinking. CONCLUSIONS: Creative thinking in all disciplines depends on a common mental "toolkit" that consists of 13 fundamental tools: observing, imaging, abstracting, pattern recognition, pattern forming, analogizing, body thinking, empathizing, dimensional thinking, modeling, playing, transforming, and synthesizing. Scientists recognize and solve problems by observing data that break the patterns established by theories; exploring a system by creating an abstract model with which they can play; and transforming data into feelings, sounds, and other forms that create surprising analogies to already-understood principles. The result of such personal thinking is knowledge combined with sensation and emotion--feeling and understanding synthesized into complete awareness. We illustrate some of these modes of thinking with reference to recent breakthroughs in DNA-related areas and suggest ways in which the use of "tools for thinking" can increase the probability of making further discoveries in the biomedical sciences.

Biotechnology↗
PubMed2002

A lived experience of dualism between the natural and human science paradigms in nursing.

AIM: To describe the use of narrative as both phenomenon and method to illuminate college nurse educators' nursing knowledge development through their day-to-day stories on the institutional landscape, which shape and are shaped by health-care and nursing education changes. BACKGROUND: The Ontario health-care reform in Canada and a shift in nursing curriculum have brought to light a different dimension of a theory-practice issue. The traditional predominant natural science approach in nursing is now no longer considered responsive to the unique characteristics of patients' health-care needs. Emerging from current nursing education is an emphasis on a human science paradigm. However, as many college nurse educators moved back and forth between their classrooms to clinical settings, they experienced tremendous tensions in living between the new caring paradigm and the old culture of biomedical science ideology. Compounding this challenge is a lack of understanding by the policymakers and administrators of the importance of nurses' contribution vis-à-vis an ailing health-care system. This growing complexity demands that nursing, as a practice discipline, should articulate its unique body of knowledge for advancing contributions in health care. METHODS: My stories of experience and those of my participants were analysed narratively to determine the knowledge and understanding developed from living the complex and interwoven changes in nursing education and practice. FINDINGS: Through living, telling, retelling and reliving our stories, my participants and I recognized a false dualism between the seemingly polarized biomedical and human science paradigms. CONCLUSION: The meaning of certainty-uncertainty inherent in nursing teaching and practice demands that nurse educators rethink how stories of experience play out in their understanding of teaching future graduates the interrelationships between these two approaches.

Attitude of Health Personnel↗
PubMed2004

Out of fertile muck: the evolving narrative of nursing.

The ongoing debate over the appropriateness of embracing multiple research traditions in nursing is discussed, and the impacts of that debate on the development of nursing knowledge and the nature and structure of the discipline are explored. It is asserted that this previously healthy debate has become stalled between extreme positions of unbounded pluralism and critical exclusivism. The author suggests that one possible solution may lie in connecting the elements of human living, human healing, and human wholeness in an evolving narrative that crosses paradigmatic and theoretic boundaries, and reflects the unique meanings revealed in nursing practice and scholarship.

Humans↗
PubMedDate not supplied

Public health 101 for informaticians.

Abstract Public health is a complex discipline that has contributed substantially to improving the health of the population. Public health action involves a variety of interventions and methods, many of which are now taken for granted by the general public. The specific focus and nature of public health interventions continue to evolve, but the fundamental principles of public health remain stable. These principles include a focus on the health of the population rather than of individuals; an emphasis on disease prevention rather than treatment; a goal of intervention at all vulnerable points in the causal pathway of disease, injury, or disability; and operation in a governmental rather than a private context. Public health practice occurs at local, state, and federal levels and involves various professional disciplines. Public health principles and practice are illustrated by a case study example of neural tube defects and folic acid. The application of information science and technology in public health practice provides previously unfathomed opportunities to improve the health of the population. Clinical informaticians and others in the health care system are crucial partners in addressing the challenges and opportunities offered by public health informatics.

Birth Certificates↗
PubMed2005

The phosphorus transfer continuum: linking source to impact with an interdisciplinary and multi-scaled approach.

This critical review introduces a template that links phosphorus (P) sources and mobilisation processes to the delivery of P to receiving waters where deleterious impact is of concern. It therefore serves as a key introductory paper in this special issue. The entire process is described in terms of a 'P transfer continuum' to emphasise the interdisciplinary and inter-scale nature of the problem. Most knowledge to date is derived from mechanistic studies on the sources and mobilisation of P using controlled experiments that have formed the basis for mitigation strategies aimed at minimising transfer from agricultural fields. However, our ability to extrapolate this information to larger scales is limited by a poor knowledge base while new conceptual advances in the areas of complex systems and fractal dynamics indicate the limitations of past theoretical frameworks. This is compounded by the conceptual and physical separation of scientists working at different scales within the terrestrial and aquatic sciences. Multi-scaled approaches are urgently required to integrate different disciplines and provide a platform to develop mechanistic modelling frameworks, collect new data and identify critical research questions.

Fresh Water↗