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At least 487 records · Page 27Linked to original sources
PubMed2003

Development of a canine model for recurrent respiratory papillomatosis.

A canine model for recurrent respiratory papillomatosis (RRP) was developed with canine oral papillomavirus (COPV) inoculated into the buccal mucosa and supraglottic larynx of 5 beagles. The animals received systemic immunosuppression with daily oral prednisone at doses of 0, 1, 2, 3, and 4 mg/kg. Buccal papillomata developed at 6 weeks in all animals and regressed by 10 weeks in the animals that received 0 and 1 mg/kg. The other animals had continuous growth of their buccal papillomata for 26 weeks. The animal that received 2 mg/kg developed papillomata on the lingual surface of the epiglottis that continued to grow through 26 weeks. Systemic oral prednisone successfully maintained COPV-induced oral and laryngeal papillomata in beagles. Thus, COPV-induced oral and laryngeal papillomata that are prednisone-maintained may have utility as a model for RRP.

Animals↗
PubMed1968

Cytodiagnosis.

Explore the source record for details and available documents.

Ascites↗
PubMedDate not supplied

Dermal graft for protection of the pharyngeal suture line in cancer surgery of the head and neck.

We studied the effect of free buried dermal grafts to primary pharyngeal closures among 24 nonirradiated patients undergoing radical head and neck surgery to determine if this technique would reduce the incidence of postoperative pharyngocutaneous fistula. For a control group we selected 23 patients who had undergone similar operations as the patients in the study group, but who did not have dermis used for pharyngeal protection. Our results indicate that dermal grafts do not alter the incidence of fistulization following cancer surgery of the head and neck.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

[Cobalt therapy in the treatment of carcinoma of the oropharynx].

A clinical retrospective evaluation of 177 cases of carcinoma of the oropharynx treated with Cobalt therapy from 1959 to 1965 has been made. The analysis of long term results has shown that Cobalt therapy alone does not satisfactorily control carcinomas of oropharynx. In fact, less than 30% of the patients is still alive after 3 years. Survival is directly affected by the local extent of disease since, while the 5-year survival of T1 and T2 cases is respectively 26.8% and 21.5%, only 6.5% of patients with T3 carcinomas is still alive after 5 years. Particularly disappointing is the survival rate in cases with mono- or bilateral involvement of neck nodes, since none of these cases are alive 2 years after the initial therapy. In 69.4% of the cases, treatment failure has to be attributed to minimal response or early recurrence of primary tumor, while lymph node relapses have been observed in more than 25% of the cases. To allow a detailed clinical evaluation of the results, the different regions of the oropharynx should be considered separately, since differences in clinical evolution of various carcinomas would call for a different therapeutic approach. The results of this study in oropharyngeal carcinomas, indicate that improvement of long term results may only be obtained through a multidisciplinary therapeutic approach.

Cobalt Radioisotopes↗
PubMed1989

Feline oral neoplasia: a ten-year survey.

A retrospective histological study was conducted on 371 neoplasms of the oral cavity in cats. Oral neoplasia accounted for 10% of feline neoplasms identified during the survey period. Eighty-nine percent of the oral neoplasms were malignant. Twenty different oral neoplasms were found. The most common were squamous cell carcinoma (61.2%), fibrosarcoma (12.9%), and fibromatous epulis of periodontal ligament origin (7.8%).

Animals↗
PubMed1986

A comparative review of the Hammersmith (1971-75) and Edinburgh (1977-82) neutron therapy trials of certain cancers of the oral cavity, oropharynx, larynx and hypopharynx. Medical Research Council Neutron Therapy Working Group.

Because of apparent inconsistencies in the two trials of neutron therapy carried out under its auspices, the MRC in 1982 requested a comparative review of the data in the Hammersmith and Edinburgh trials in so far as the clinical material allowed of such comparison. It was clear that the two trials were not only not contemporaneous (Hammersmith 1971-75; Edinburgh 1977-82) but that they differed in site and stage of disease as well as in the parameters of radiation dosage. Only a fraction of the patients were comparable and this review, which sets out the differences in design and conduct of the two trials, focuses on squamous-cell carcinoma in the four sites--oral cavity, oropharynx, larynx and hypopharynx--which were common in both. The first 120 patients entered into the Edinburgh trial have been compared with the 95 patients selected from 161 in the Hammersmith trial who would have been eligible at Edinburgh by reason of the site of disease and histology. Thus, Hammersmith patients with tumours of salivary glands, sinuses and neck nodes were, of necessity, excluded. Within such limitations the data on case distribution, tumour size and stage, the parameters of radiation dosage and the outcome in terms of tumour control, survival and treatment morbidity have been subjected to rigorous assessment and analysis. The important aspects in which the two investigations had differed included the stage of disease (more advanced at Hammersmith, with 63% of patients having fixed nodes, compared with 27% at Edinburgh); radiation dosage (the median neutron dose being 5% lower at Edinburgh than at Hammersmith while the median photon dose was l0% higher at Edinburgh); the "photon arm" of the Edinburgh trial being on site whereas that at Hammersmith had been at multiple centres; and the years in which the trials had been carried out. The two series are comparable in terms of treatment failure (local recurrence or late radiation death) following local tumour control. The results are also consistent in associating an increased incidence of late severe radiation morbidity and of intercurrent deaths with neutron therapy. In three other respects the results of the two series differ. At Edinburgh there was advantage to the photon-treated patients in terms of overall mortality, whereas at Hammersmith the advantage was to those treated with neutrons. The incidence of tumour regression for patients randomised to photons was much lower in the Hammersmith trial than for neutrons, whereas in Edinburgh the two modalities gave similar results.

Clinical Trials as Topic↗
PubMed1975

Kinetics of tumor growth and of cell proliferation in U.R.D.T. cancers: therapeutic implications.

After a brief survey of the factors of clinical tumor radioresistance the available data on the growth rate and on the kinetics of cell proliferation of U.R.D.T. tumors are reviewed. The growth fraction and the cell turnover rate appear to be similar in U.R.D.T. tumors and in other squamous cell carcinomas. These two parameters are correlated with clinical tumor radiosensitivity and chemosensitivity. The possible value of tailoring fractionation and drug administration to the biological characteristics of the tumor is discussed.

Animals↗
PubMed1977

The case for elective prophylactic neck dissection.

The possibility of improving the cure rate of cancer of the head and neck by radical neck dissection of the clinically negative neck (elective neck dissection) continues to pose a therapeutic dilemma. This paper seeks to review the available information, analyze relevant aspects of the issue and attempt to draw conclusions which will be helpful both to physicians and their patients. The discussion is confined to squamous carcinoma of the larynx, pharynx, and oral cavity.

Carcinoma, Squamous Cell↗
PubMed1980

Distant metastases in head and neck epidermoid carcinoma.

Autopsy findings and case histories of 64 cases of epidermoid carcinoma of the head and neck at the Denver Veterans Administration Hospital between 1967 and 1977 were reviewed. Forty percent of these cases had metastases below the clavicles at autopsy. Incidence of metastasis was related to size of the primary lesion. Correlation with nodal involvement was equivocal. Our data was combined with that of similar studies done by O'Brien in 1970 and Gowen in 1963 and resulted in a combined autopsy series of 247 cases. Overall, 47% had distant metastases at autopsy.

Carcinoma, Squamous Cell↗