Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “LINGUISTICS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 487 records · Page 27Linked to original sources
PubMed2003

Age constraints on first versus second language acquisition: evidence for linguistic plasticity and epigenesis.

Does age constrain the outcome of all language acquisition equally regardless of whether the language is a first or second one? To test this hypothesis, the English grammatical abilities of deaf and hearing adults who either did or did not have linguistic experience (spoken or signed) during early childhood were investigated with two tasks, timed grammatical judgement and untimed sentence to picture matching. Findings showed that adults who acquired a language in early life performed at near-native levels on a second language regardless of whether they were hearing or deaf or whether the early language was spoken or signed. By contrast, deaf adults who experienced little or no accessible language in early life performed poorly. These results indicate that the onset of language acquisition in early human development dramatically alters the capacity to learn language throughout life, independent of the sensory-motor form of the early experience.

Adolescent↗
PubMed2001

African diversity from the HLA point of view: influence of genetic drift, geography, linguistics, and natural selection.

This study investigates the influence of different evolutionary factors on the patterns of human leukocyte antigen (HLA) genetic diversity within sub-Saharan Africa, and between Africa, Europe, and East Asia. This is done by comparing the significance of several statistics computed on equivalent population data sets tested for two HLA class II loci, DRB1 and DPB1, which strongly differ from each other by the shape of their allelic distributions. Similar results are found for the two loci concerning highly significant correlations between geographic and genetic distances at the world scale, high levels of genetic diversity within sub-Saharan Africa and East Asia, and low within Europe, and low genetic differentiations among the three broad continental areas, with no special divergence of Africa. On the other hand, DPB1 behaves as a neutral polymorphism, although a significant excess of heterozygotes is often observed for DRB1. Whereas the pattern observed for DPB1 is explained by geographic differentiations and genetic drift in isolated populations, balancing selection is likely to have prevented genetic differentiations among populations at the DRB1 locus. However, this selective effect did not disrupt the high correlation found between DRB1 and geography at the world scale, nor between DRB1 and linguistic differentiations at the African level.

Africa South of the Sahara↗
PubMed1997

Isomorphism between cell and human languages: molecular biological, bioinformatic and linguistic implications.

The concept of cell language has been defined in molecular terms. The molecule-based cell language is shown to be isomorphic with the sound- and visual signal-based human language with respect to ten out of the 13 design features of human language characterized by Hockett. Biocybernetics, a general molecular theory of living systems developed over the past two and a half decades, is found to provide a physical theory underlying the phenomenon of cell language. The concept of cell language integrates bioenergetics and bioinformatics on the one hand and reductionistic and holistic experimental data on the other to account for living processes on the molecular level. The isomorphism between cell and human languages suggests that the DNA of higher eucaryotes contains two classes of genes--structural genes corresponding to the lexicon and 'spatiotemporal genes' corresponding to the grammar of cell language. The former is located in coding regions of DNA and the latter is predicted to reside primarily in noncoding regions. The grammar of cell language is identified with the mapping of the nucleotide sequences of DNA onto its 4-dimensional folding patterns that control the spatiotemporal evolution of gene expression. Such a mapping has been referred to as the second genetic code, in contrast to the first genetic code which maps nucleotide triplets onto amino acids. The cell language theory introduces into biology the linguistic principle of 'rule-governed creativity,' leading to the formulation of the concept of 'rule-governed creative molecules' or 'creations.' This concept sheds new light on molecular biology, bioinformatics, protein folding, and developmental biology. In addition, the cell language theory suggests that human language is ultimately founded on cell language.

Cell Biology↗
PubMed2003

Linguistic relevance of duration within the native language determines the accuracy of speech-sound duration processing.

As indexed by electrophysiological measures, in native speakers of a language with linguistically significant opposition between short and long phonemes, the pre-attentive detection accuracy of duration changes in speech sounds was tuned in comparison with that in non-speech sounds. This was not observed in advanced second-language users of the same language, suggesting that second-language acquisition does not lead to speech-specific tuning of the duration processing as does native language acquisition in early childhood.

Adolescent↗
PubMed2006

Early speech- and language-impaired children: linguistic, literacy, and social outcomes.

The aim of this study was to follow-up prospectively a cohort of preschool children originally recruited from successive referrals to speech and language therapy community clinics and to investigate their linguistic, literacy, and social outcomes at 7 to 10 years of age. Three hundred and fifty children aged 84 to 113 months (mean age 99.9mo [SD 5.4mo]) were singletons from monolingual backgrounds where there was concern about their speech and language development. Children who had severe learning difficulties, autism, oromotor deficits, dysfluency, or dysphonia were excluded. Altogether 196 (56%), 134 males and 62 females, were seen at follow-up. A control group of children who had never been referred for speech and language therapy, 57% of whom were males, was also recruited (n=94; mean age 104.4mo [SD 6.8mo]). All children were assessed on standardized measures of speech, language, and literacy. Teachers and parents completed questionnaires on educational and social outcomes. In total, 139 children in the cohort were within the normal range on standardized language assessments. About 30% of the original cohort of children continue to struggle with language, literacy, and social difficulties. The study demonstrates the long-term nature of language impairment and reinforces the need for awareness among professionals in child development and education of the ongoing needs of this population of children.

Age Factors↗
PubMed2002

Surname analysis of the Corsican population reveals an agreement with geographical and linguistic structure.

The surname is a cultural trait that is extremely useful for historical and linguistic studies and can effectively be used as a genetic marker. In many human populations the surname is inherited in the paternal lineage, and can therefore be considered a marker for the Y chromosome. In this study, surnames were recorded from the white pages of telephone directories in current use in Corsica in 1993. All surnames present in thirteen villages scattered over the whole island and covering the main historical regions were transcribed. Surname variability was found to be higher in coastal villages, and lower in more isolated communities. The isonymy detected among the thirteen villages allowed the calculation of kinship values, visualized in a tree showing two main clusters, one referring to the northern villages and one encompassing the villages of the south. The pattern reflects the administrative division of the island, with the exception of Vico, which belongs to the southern administrative region but is geographically close to the northern villages, and Ghisoni, which belongs to the northern district but is more similar to the village of Bastelica in the southern district. The data presented here show a structure in the surname distribution that is in substantial agreement with the geographical patterns. The kinship values are consistent with a moderated gene flow among villages producing a surname structure according to the geographic features of the territory.

Family↗
PubMed2001

Missing the forest for the trees? Deficient memory for linguistic gist in obsessive-compulsive disorder.

BACKGROUND: Patients with obsessive-compulsive disorder (OCD) exhibit recall deficits on word learning tasks, mediated by their failure to detect semantic connections among the words. METHODS: In the present experiment, using methods devised by Bransford & Franks (1971), we tested whether this encoding problem impairs their extraction of gist from complex linguistic material. RESULTS: Consistent with our hypothesis, OCD patients extracted less gist from related sentences than did healthy participants. The groups did not differ in recognition memory for individual sentences or in criterion for affirming previously encountered sentences as 'old', as evinced by signal detection indices of memory sensitivity (d') and response bias (beta), or in recognition memory confidence. CONCLUSIONS: These data provide further evidence that OCD patients exhibit less reliance on organizational strategies than do healthy control participants. These data are consistent with neuropsychological research suggestive of prefrontal executive problems in OCD.

Adult↗
PubMed1991

A cross-linguistic perspective on the development of temporal systems.

The purpose of this research was to evaluate the development of temporal location within a cross-linguistic experimental design. The research focused on the transition from a temporal system based on absolute temporal relation involving speech time and event time to a more complex system involving relative temporal relationships and reference time. A comprehension test was constructed with problems which were diagnostic of two salient distinctions within each of three temporal systems. The procedure was based on a two-choice sentence-picture matching task. The children who participated were from Poland, the USA and Finland, and there were 12 children at each of the following age levels: 2;6, 3;6, 4;6, 5;6, and 6;6. The Polish and American children solved problems requiring absolute temporal location at 2;6, and the older children eventually solved most of the problems requiring relative location. The Finnish children followed a different pattern taking longer to comprehend both types of problems. A second experiment confirmed the Finnish pattern of development. The results of the comprehension test were compared to observations of conversational and narrative discourse which were the product of two elicitation procedures. The research demonstrates the way in which conceptual development places a universal constraint on the developmental process and how the specific properties of individual languages also have an effect.

Child↗
PubMed1997

The effect of perceptual similarity and linguistic input on children's acquisition of object labels.

This study investigated whether and when children establish various semantic relations between old and new words. Fifty two-year-olds were taught labels for objects previously referred to by an overextended term. We found that children were more likely to learn a new label when (a) it referred to a new object that was perceptually dissimilar, rather than similar, to a known one, and (b) when linguistic information indicated it had an inclusion, rather than a mutually exclusive, relation to a known label. Children were more likely to interpret a new label as mutually exclusive to a known one when their referents were perceptually dissimilar. These findings are discussed in light of theories of lexical development, particularly with regard to conceptualizations of constraints on the acquisition of word meaning.

Child Language↗
PubMed2003

Patient expectations of benefit from phase I clinical trials: linguistic considerations in diagnosing a therapeutic misconception.

The ethical treatment of cancer patients participating in clinical trials requires that patients are well-informed about the potential benefits and risks associated with participation. When patients enrolled in phase I clinical trials report that their chance of benefit is very high, this is often taken as evidence of a failure of the informed consent process. We argue, however, that some simple themes from the philosophy of language may make such a conclusion less certain. First, the patient may receive conflicting statements from multiple speakers about the expected outcome of the trial. Patients may be reporting the message they like best. Second, there is a potential problem of multivocality. Expressions of uncertainty of the frequency type (e.g., "On average, 5 out of every 100 patients will benefit") can be confused with expressions of uncertainty of the belief type (e.g., "The chance that I will benefit is about 80%"). Patients may be informed using frequency-type statements and respond using belief-type statements. Third, each speech episode involving the investigator and the patient regarding outcomes may subserve multiple speech acts, some of which may be indirect. For example, a patient reporting a high expected benefit may be reporting a belief about the future, reassuring family members, and/or attempting to improve his or her outcome by a public assertion of optimism. These sources of linguistic confusion should be considered in judging whether the patient's reported expectation is grounds for a bioethical concern that there has been a failure in the informed consent process.

Clinical Trials, Phase I as Topic↗
PubMed2000

Eye movements and lexical access in spoken-language comprehension: evaluating a linking hypothesis between fixations and linguistic processing.

A growing number of researchers in the sentence processing community are using eye movements to address issues in spoken language comprehension. Experiments using this paradigm have shown that visually presented referential information, including properties of referents relevant to specific actions, influences even the earliest moments of syntactic processing. Methodological concerns about task-specific strategies and the linking hypothesis between eye movements and linguistic processing are identified and discussed. These concerns are addressed in a review of recent studies of spoken word recognition which introduce and evaluate a detailed linking hypothesis between eye movements and lexical access. The results provide evidence about the time course of lexical activation that resolves some important theoretical issues in spoken-word recognition. They also demonstrate that fixations are sensitive to properties of the normal language-processing system that cannot be attributed to task-specific strategies.

Cognition↗
PubMed1999

Processing linguistic and perceptual dimensions of speech: interactions in speeded classification.

Performance on selective-attention and divided-attention tasks shows strong and consistent interactions when participants rapidly classify auditory stimuli whose linguistic and perceptual dimensions (the words low vs. high, low and high pitch, low and high position in space) share common labels. Compared with baseline performance, response times were greater when one or two irrelevant dimensions varied (Garner interference) and when combinations of attributes were incongruent rather than congruent (congruence effects). Performance depended only on the congruence relationships between the relevant dimension and each of the irrelevant dimensions and not on the congruence relationships between the irrelevant dimensions themselves. In selective attention, an additive multidimensional model accounts well for the patterns of both Garner interference and congruence effects.

Attention↗
PubMed2005

Can language do the driving? The effect of linguistic input on infants' categorization of support spatial relations.

Two experiments explored the effect of linguistic input on 18-month-olds' ability to form an abstract categorical representation of support. Infants were habituated to 4 support events (i.e., one object placed on another) and were tested with a novel support and a novel containment event. Infants formed an abstract category of support (i.e., looked significantly longer at the novel than familiar relation) when hearing the word "on" during habituation but not when viewing the events in silence (Experiment 1) or when hearing general phrases or a novel word (Experiment 2). Results indicate that a familiar word can facilitate infants' formation of an abstract spatial category, leading them to form a category that they do not form in the absence of the word.

Female↗
PubMed2006

A linguistic model for the rational design of antimicrobial peptides.

Antimicrobial peptides (AmPs) are small proteins that are used by the innate immune system to combat bacterial infection in multicellular eukaryotes. There is mounting evidence that these peptides are less susceptible to bacterial resistance than traditional antibiotics and could form the basis for a new class of therapeutic agents. Here we report the rational design of new AmPs that show limited homology to naturally occurring proteins but have strong bacteriostatic activity against several species of bacteria, including Staphylococcus aureus and Bacillus anthracis. These peptides were designed using a linguistic model of natural AmPs: we treated the amino-acid sequences of natural AmPs as a formal language and built a set of regular grammars to describe this language. We used this set of grammars to create new, unnatural AmP sequences. Our peptides conform to the formal syntax of natural antimicrobial peptides but populate a previously unexplored region of protein sequence space.

Amino Acid Sequence↗
PubMed2000

Inferring the impact of linguistic boundaries on population differentiation: application to the Afro-Asiatic-Indo-European case.

We present here a quantitative way to assess the impact of language-family boundaries on population differentiation and to evaluate the homogeneity of the genetic processes along these boundaries. Our estimator (delta a) of the impact of the boundary is based on an isolation by distance (IBD) model and measures the added genetic distance between populations located on different sides of the boundary. We compare this statistic with another estimator of group differentiation (F(CT)) computed under an analysis of variance framework that does not assume any particular spatial structure of the populations. Monte Carlo simulations are used to study the behaviour of these statistics under a two-dimensional stepping-stone model. Simulations show that F(CT) can suggest the existence of a frontier when populations only differ because of IBD. This spurious behaviour is much less frequent for the delta a statistic. However, the large variance associated with the delta a statistic, and the fact that it should only be computed in the presence of IBD, may limit the use of this statistic. Overall, the origin and the effect of the boundary is best understood by comparing different statistics and by testing for the presence of IBD on each side of the boundary as well as across the boundary. We illustrate our approach by examining the boundary between Afro-Asiatic and Indo-European populations. These populations are globally genetically differentiated, but the effect of the linguistic boundary on gene flow seems geographically very heterogeneous. This boundary appears to be the result of a secondary contact between two differentiation centres rather than an enhancer of population differentiation.

Africa↗
PubMed2002

Listener comprehension of severely dysarthric speech: effects of linguistic cues and stimulus cohesion.

This study is the second in a two-part series examining the effects of linguistic variables on listener processing of dysarthric speech. The first study (see K. C. Hustad & D. R. Beukelman, 2001) examined the effects of experimentally imposed topic cues, alphabet cues, and combined cues along with a control condition in which no cues were provided on intelligibility of unrelated and related sentences produced by 4 women with severe dysorthria secondary to cerebral palsy. The present study examined the effects of these same variables on listener comprehension of severely dysarthric speech produced by the same speakers. In addition, the relationship between intelligibility and comprehension was examined for each cue and stimulus cohesion condition. Consistent with intelligibility results, the present study found that combined cues resulted in higher comprehension scores than any other cue condition and that no cues resulted in lower comprehension scores than any other cue condition for both related and unrelated sentences. In addition, comprehension scores were higher for alphabet cues than for topic cues in the related-sentences condition. Findings dissimilar from intelligibility results were as follows: (a) comprehension scores associated with alphabet and topic cues did not differ for unrelated sentences, and (b) comprehension scores were higher for related than for unrelated sentences in each cue condition. Finally, significant positive relationships between intelligibility and comprehension data were found only for topic cues in the unrelated-sentences condition and for alphabet cues in the related-sentences condition.

Adult↗
PubMed2003

Processing and linguistic markers in young children with specific language impairment (SLI).

Thirty-two 5-year-old children with specific language impairment (SLI) and 32 chronological age (CA) controls completed 4 tasks that were considered potential positive markers for SLI. Children's performance on 2 linguistic tasks (past tense and noun plurals task) and 2 processing tasks (nonword repetition and digit recall) were examined. This approach allowed the examination of more than 1 type of marker simultaneously, facilitating both comparisons between markers and also the evaluation of combinations of markers in relation to identifying SLI. Children with SLI performed significantly worse than CA controls in all 4 marker tasks. Specificity/sensitivity analysis of the 4 marker tasks revealed nonword repetition and the past tense task to have the best overall accuracy at the 25th and 16th percentile. Finally, stepwise discriminant analysis revealed nonword repetition and past tense marking to be the best markers for identifying young children with SLI.

Child, Preschool↗
PubMed2004

The search for common ground: Part I. Lexical performance by linguistically diverse learners.

This study examines lexical performance by 3 groups of linguistically diverse school-age learners: English-only speakers with primary language impairment (LI), typical English-only speakers (EO), and typical bilingual Spanish-English speakers (BI). The accuracy and response time (RT) of 100 8- to 13-year-old children in word recognition and picture-naming tasks were analyzed. Within each task, stimulus difficulty was manipulated to include very easy stimuli (words that were high frequency/had an early age of acquisition in English) and more difficult stimuli (words of low frequency/late age of acquisition [AOA]). There was no difference among groups in real-word recognition accuracy or RT; all 3 groups showed lower accuracy with low-frequency words. In picture naming, all 3 groups showed a longer RT for words with a late AOA, although AOA had a disproportionate negative impact on BI performance. The EO group was faster and more accurate than both LI and BI groups in conditions with later acquired stimuli. Results are discussed in terms of quantitative differences separating EO children from the other 2 groups and qualitative similarities linking monolingual children with and without LI.

Child↗