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Ante partum bed rest and unexplained infantile crying.

AIM: The aim of this study was to assess whether bed rest during pregnancy is a risk factor for infantile colics. METHODS: In a previous paper a questionnaire was administered to 86 women (43 of whom had stayed in bed during pregnancy for a mean of 3.4+/-1.2 months, and 43 were controls) about the clinical history and the present state of their 11-15 year old babies. In the present paper we traced these women and assessed the presence/absence of unexplained infant crying (UIC, infantile colic), diagnosed by a physician in the first year of life of these children. Forty mothers answered the inquiry, and we compared their answers with 40 control mothers. RESULTS: Babies born after maternal bed rest during pregnancy had a higher incidence of UIC than the control group (26/40 vs 11/40; P=0.0015). No significant correlation was found between UIC and allergies or between UIC and maternal or artificial breast feeding. CONCLUSIONS: Our retrospective study shows a possible association between bed rest and UIC: further studies, including other important variables (stress, drugs, smoking) are needed.

Bed Rest↗

The secret.

Explore the source record for details and available documents.

Circadian Rhythm↗

Structure and irregularity in the spontaneous behavior of young infants.

Persistent, irregular fluctuations in spontaneous motor activity are common in the young of many vertebrate species, but whether the irregularity is intrinsic to the dynamics of motor activation or the result of random perturbations is not known. Analysis of the second-by-second variation in the general body movement of awake human infants 1 and 3 months after birth revealed low dimensional structure in the characteristically irregular motor activity and exponential rates of divergence of initially similar states of motor activation. Results support the conclusion that irregularity is an intrinsic property of the dynamics of motor activation involving relatively few effective degrees of freedom and raise questions about the advantages or disadvantages of irregularity built into early behavioral organization.

Activity Cycles↗

Comparison of motor self-regulatory and stress behaviors of preterm infants across body positions.

Occupational therapists working with infants in neonatal intensive care units (NICUs) make positioning recommendations to optimize self-regulation, with little published data supporting this practice. In this retrospective descriptive study, 15 hospitalized preterm infants (M(gestational age) = 32 weeks) were videotaped during non-caregiving periods in order to record the frequency of specific behaviors in relation to six infant positions (prone nested, prone un-nested, side-lying nested, side-lying un-nested, supine nested, and supine un-nested). Behaviors coded were those that suggest infant stress or motor efforts at self-regulation, as defined for the original study. Mixed effects regressions and post-hoc Tukey Honestly Significant Difference tests were used to analyze the data, after the calculation of a ratio of the number of behaviors in each position. Higher ratio values reflect a greater occurrence of behaviors. The number of motor self-regulatory and stress behaviors were related to infant position, with the highest ratios of behaviors observed in side-lying un-nested and the lowest in prone nested. Behavior ratios did not differ between prone un-nested and prone nested, nor between supine un-nested and supine nested. More self-regulatory and stress behaviors were related to longer periods of fussing and crying. Longer periods of light sleep were related to fewer stress behaviors. Infants performed the fewest stress behaviors in prone nested, prone un-nested, or side-lying nested. These positions may benefit infants in the NICU by reducing the need for motor-based self-regulatory behaviors and potentially conserving energy for growth.

Child Development↗

Maternal smoking during pregnancy and behavioural characteristics in 2 - 4-month-old infants.

The study aimed to assess potential relationship between maternal smoking during pregnancy and behavioural characteristics in 2 - 4-month-old infants. It covered period from 1999 to 2000 and comprised 250 randomly selected, apparently healthy singleton born infants from community setting (129 boys, 121 girls). The mothers were asked to complete the questionnaires addressing infant, maternal, demographic major characteristics with particular emphasis on maternal smoking during pregnancy. To objectively assess behavioural peculiarities of the infants, the mothers were requested to complete the Early Infancy Temperament Questionnaire. Of 250 mothers, 64. women (25.6 %) smoked during pregnancy. The infants of smoking mothers were more often born low birth weight and were also lighter at study; more frequently they were born at earlier gestational age, had lower Apgar score at 5 th minute, were less frequently breast fed at birth and at the time of study. Mothers who smoked during pregnancy were younger, had lower educational level, and less frequently were married. The infants born to smoking mothers had more frequent fussy periods occurring at about the same time of the day, protesting behaviour at face washing and washing in bath, indifferent attitude to the mother when held by new person, extreme reactions (either indifference or much feeling) during diapering and bowel movement, less attention to the parents during parent-infant play activity, and more sensitivity to the wet diaper. They were also characterised by more intensive reactions (displayed more amount of energy regardless of positive or negative behaviour) compared with the babies from the non-smoking group. This association remained after adjustment has been made for major potential confounders, and had a significant "dose-response" effect. Maternal smoking during pregnancy may serve as a risk factor for infant's behavioural deviations.

Adult↗

Spontaneous motor activity in fetal and infant rats is organized into discrete multilimb bouts.

Spontaneous motor activity (SMA) is a ubiquitous feature of fetal and infant behavior. Although SMA appears random, successive limb movements often occur in bouts. Bout organization was evident at all ages in fetal (embryonic day [E] 17-21) and infant (postnatal day [P] 1-9) rats, with nearly all bouts comprising 1-4 movements of different limbs. A computational model of SMA, including spontaneous activity of spinal motor neurons, intrasegmental and intersegmental interactions, recurrent inhibition, and descending influences, produced bouts with the same structure as that observed in perinatal rats. Consistent with the model, bouts were not eliminated on E20 after cervical spinal transection, suggesting that the brain is not necessary to produce bout organization. These investigations provide a foundation for understanding the contributions of SMA to neuromuscular and motor development.

Animals↗

Maternal and professional assessment of breastfeeding.

This study explored the relationships among maternal and professional breastfeeding assessments and maternal reports of satisfaction with breastfeeding. Participants were 35 first-time breastfeeding mothers. The LATCH Breastfeeding Documentation Tool was used for data collection. This tool was used in its original version for professional assessment and in a modified version for maternal reporting. Results show high percentages (85.7 to 100) of agreement among lactation consultants using the LATCH tool which supports the reliability of the tool. Correlation coefficients between professional scores and maternal scores ranged from 0.18 for "A" (Audible swallowing) to 0.67 for "L" (Latch). It appears that, unlike lactation consultants, new mothers evaluate breastfeeding based upon their somatic experience rather than observation of infant behavior.

Adult↗

IV. Issues in grouping items from the Neonatal Behavioral Assessment Scale.

The various analyses of the NBAS that we have described do not permit any simple understanding of the significance of the scales. We have shown that other variables associated with the scale may have more significance than the scales themselves. Predominant state appears to be one of these variables. When the NBAS scores are correlated with behavior only 4 months later, only tiny relationships are evident, and, what is more, many of these relationships do not make obvious sense. In recent times there has been growing evidence that infant behavior shows little consistency or continuity over time (McCall, Eichorn, & Hogarty 1977). These data from the Brazelton NBAS seem to conform that notion. The message we want to end with is that we have still not reached the point where we can adequately understand the behavior of the human newborn. Simple relations between antecedent and consequent behaviors assessed by simple statistical procedures will not solve our problem. Bridging the gap between our global theorizing about newborn behavior and concrete deomonstrations of those theories will require a complex interplay of common sense and statistical sophistication.

Age Factors↗

Extraction of motion strength and motor activity signals from video recordings of neonatal seizures.

This paper presents two methods developed to extract quantitative information from video recordings of neonatal seizures in the form of temporal motion strength and motor activity signals. Motion strength signals are extracted by measuring the area of the body parts that move during the seizure and the relative speed of motion using a combination of spatiotemporal subband decomposition of video, nonlinear filtering, and segmentation. Motor activity signals are extracted by tracking selected anatomical sites during the seizure using a modified version of a feature-tracking procedure developed for video, known as the Kanade-Lucas-Tomasi (KLT) algorithm. The experiments indicate that the temporal signals produced by the proposed methods provide the basis for differentiating myoclonic from focal clonic seizures and distinguishing these types of neonatal seizures from normal infant behaviors.

Algorithms↗

Toy-oriented changes during early arm movements: hand kinematics.

UNLABELLED: In a recent cross-sectional study, we found that young infants changed their spontaneous arm movements in the presence of a toy, termed 'toy-oriented changes', in systematic ways beginning many weeks before their first consistent reaches [Bhat, A. N., Heathcock, J. H., & Galloway, J. C. (2005). Toy-oriented changes in hand and joint kinematics during the emergence of purposeful reaching. Infant Behavior and Development, 28(4), 445-465]. The purpose of the present study was to test specific hypotheses regarding toy-oriented changes in a longitudinal design. METHODS: Thirteen infants were observed every other week from 8 weeks of age up to the onset of reaching. At each session, hand and joint motions were observed with and without a toy present using a high-speed motion capture system. This paper focuses on the toy-oriented changes in hand variables. RESULTS: As predicted, infants displayed a meaningful pattern of toy-oriented changes, which systematically changed as infants approached the first week of reaching. During the Early phase (8-10 weeks before reaching), infants scaled down their movement length and speed in the presence of a toy. During the Mid phase (4-6 weeks before reaching), infants scaled up movement number and speed, increased movement smoothness, and decreased their hand-toy distance in the presence of a toy. During the Late phase (within 2 weeks of reaching), infants continued to change their hand's position to get closer to the toy and began contacting it. Interestingly, movement number and smoothness displayed similar developmental patterns, where movement length and speed displayed similar patterns. CONCLUSION: Toy-oriented adaptation of arm movements emerges in the first months of life and forms a complex, yet tractable continuum with purposeful reaching. These results provide a foundation to test more specific hypotheses of hand and joint coordination in both typically developing infants and those infants born at risk for coordination impairments.

Age Factors↗

Insulin-like growth factor II and binding proteins 1 and 3 from second trimester human amniotic fluid are associated with infant birth weight.

The developing fetus begins to swallow amniotic fluid (AF) early in gestation, a process that results in ingestion of numerous growth factors. Our objectives were 2-fold: 1) to assess the concentration and distribution of insulin-like growth factor II (IGF II) and its binding proteins (BP) 1 and 3 in 2nd trimester amniotic fluid using ELISA, and 2) to establish whether concentrations of AF IGF II and its binding proteins IGF BP1 and 3, measured early in pregnancy, were associated with and predictive of infant birth weight. Birth weights were categorized using recently developed birth-weight-for-gestational-age percentiles for fetal growth in which infants < 10% were classified as SGA (small-for-gestational-age) and those > 90% as LGA (large-for-gestational-age). AF samples were collected after routine genetic testing (15.1 +/- 0.04 wk, range 12-20 wk) from 543 mother-infant pairs in Montreal, QC, Canada. Maternal and fetal characteristics were obtained from questionnaires and medical chart review. Multivariate regression analysis that controlled for maternal height, prepregnancy weight, smoking behavior, infant gender, gestational age, parity, as well as amniocentesis week showed that higher AF IGF BP1 was associated with lower birth weight (partial r2 = 0.0062). Regression analyses revealed that AF IGF BP3 was positively associated with birth weight within LGA and macrosomia subpopulations (partial r2 = 0.0283 and 0.0404, respectively). These results show that 2nd trimester AF IGF BP1, BP3, and IGF II may emerge as early indicators of fetal growth.

Amniotic Fluid↗

Visual fields of infants assessed with a new perimetric technique.

The visual field of normal infants was assessed using a perimeter with LED stimuli and a forced-choice observation procedure. Central fixation was elicited by four central, pulsing LEDs and maintained with the aid of auditory stimuli. Field extent was derived from the four-alternative, forced-choice judgments of an adult who observed the infant's eye movements to peripherally illuminated LEDs. The binocular visual field of infants, ages 6-7 months, was similar to that of adults tested with the same apparatus. Area of the infants' binocular field was 93% that of the adults'. However, the infants' monocular fields were smaller than those of adults, averaging 74% of the adults' monocular field area. This may have been due to the distracting effect on infant behavior of the adhesive patch used for monocular testing. The visual fields of a young patient with hydrocephalus illustrate the potential clinical utility of this new perimetric technique for infants at risk of field defects.

Adult↗

Level of prenatal cocaine exposure and infant-caregiver attachment behavior.

The objective of this longitudinal prospective cohort study was to determine whether level of prenatal cocaine exposure, or the interaction between level of prenatal cocaine exposure and contextual risk variables, was associated with a higher rate of infant-caregiver insecure attachment and disorganized attachment, or with alterations in infant crying or avoidant behavior, after controlling for prenatal exposure to alcohol, tobacco, and marijuana, the quality of the proximal caregiving environment, and other covariates. Subjects were 154 full-term 12-month-old infants (64 unexposed, 61 with lighter cocaine exposure, 29 with heavier cocaine exposure) and their primary caregivers from low-income, urban backgrounds. Exposure status was determined in the maternity ward by biologic assay (infant meconium and/or maternal or infant urine) and maternal self-report. At the 12-month follow-up visit, infants were videotaped with their primary caregiver in Ainsworth's Strange Situation. Reliable coders masked to exposure status scored videotapes for attachment variables, amount of crying, and level of avoidance. Contrary to popular perceptions, level of prenatal cocaine exposure was not significantly related to secure/insecure attachment status, disorganized attachment status, or rated level of felt security. Foster care status also was not associated with attachment status. However, heavier prenatal cocaine exposure, in interaction with maternal contextual variables (public assistance or multiparity) was associated with alterations in infant socio-affective behavior, including a higher level of behavioral disorganization, more avoidance of the caregiver, and less crying.

Alcoholism↗

An intersubjective developmental perspective on interactions between deaf and hearing mothers and their deaf infants.

Most research into interactions between mothers and their infants with hearing impairments focuses on mothers' and infants' behaviors separately, speculating about the interplay among these behaviors and their effects on child development. In the present article, an intersubjective developmental theory focusing on the development of the "interworld" between deaf and hearing mothers and their deaf infants is used to integrate and interpret the seemingly incoherent research on early mother-deaf child interaction. Inspired by Stern's work (e.g., Stern, 1985), the intersubjective developmental theory distinguishes four stages in the development of intersubjectivity: emerging (birth-2 months), physical (2-8 months), existential (8-13 months), and symbolic (13 months and older), each characterized by a different type of mother-infant interaction. The integration of research findings on early mother-deaf child interaction into these four developmental stages offers new perspectives that can advance research and resolve certain early-intervention issues.

Communication↗

[Effects of the D4 dopamine receptor gene variation on behavior problems at 6 years of age].

Association of the 7-repeat allele of the D4 dopamine receptor (DRD4) exon 3 polymorphism with attention deficit/hyperactivity disorder is well-established, and a link with mother-reported aggressiveness was also found in healthy pre-schoolers assessed by the quantitative scale of the Child Behavior Checklist. In the present study, we hypothesized that children carrying the 7-repeat allele would show more attention problems and externalizing (aggressive and delinquent) behavior at 6 years of age. Further, we hypothesized a potential mediating role of early temperament in the relationship of DRD4 gene with behavior problems. Mothers filled in the Achenbach Child Behavior Checklist for 88 six-year-old firstborn children (51 boys, 35 girls) followed from birth. Mother-reported temperament for the same children was assessed by the Rothbart Infant Behavior Questionnaire at 12 months. Genotypes of the DRD4 repeat polymorphism were determined using buccal cells. Significant main effects of gender and DRD4 genotype were observed on 6-year behavioral problems. Boys showed more attention problems and externalizing behavior, and children lacking the 7-repeat variant showed more externalizing and internalizing behavior. These effects remained significant after controlling for 1-year temperament. Our results did not confirm the negative effect of the 7-repeat allele on attention problems and externalizing behavior measured on quantitative scales. On the contrary, we found elevated problem scores in the absence of the 7-repeat allele. Further research including environmental risk factors is needed to clarify the role of the DRD4 gene in the development of externalizing behavior.

Aggression↗

[Infant crying diary: a useful aid in distinguishing between normal and excessive crying behavior].

Three infant girls aged 9, 10 and 8 weeks, who cried excessively according to their parents, were referred by the general practitioner to the paediatrician. Using a crying diary it was possible to ascertain that one infant fulfilled the criteria of infantile colic. The diary showed that a second infant was not crying excessively and her mother could be reassured that her baby's behaviour was normal. The third infant proved to be suffering from an organic disease (Alpha-I antitrypsin deficiency), which had not been obvious at clinical assessment. The crying diary provided clues that warranted further investigation. The parents of all 3 infants were reassured and the crying lessened over a period of several weeks. When parents complain that their child cries excessively, it is useful to chart the amount of crying time in a diary. Registration for one week is sufficient. If the child does not suffer from an organic disease, the mainstay of treatment is to explain normal crying behaviour and that it often helps if the infant is not offered too many stimuli. Parents can be reassured that spontaneous resolution will generally occur at the age of three months.

Adult↗

Studying temperament via construction of the Toddler Behavior Assessment Questionnaire.

The Toddler Behavior Assessment Questionnaire (TBAQ) was constructed by an iterative process of item generation intended to ensure content validity, by repeated item analyses focused on internal consistency and discriminant properties, and by scale revision. During the construction and initial validation processes reported in this article, data from 1,012 records were utilized. Internal consistency reliability estimates typically exceeded .80 for each scale. Evidence for convergent validity with other temperament questionnaires and for longitudinal stability was also obtained. Besides yielding a promising instrument, this assessment research has conceptual ramifications. For instance, components of negative affectivity (anger proneness and fearfulness) were independent, and item analyses suggested that shyness and other fears were independent as well. Consistent with most current views of temperament, the TBAQ temperament scales revealed some relationship and/or contextual specificity, as exemplified by the finding of only moderate parental agreement. The rank ordering on most temperament dimensions was impressively preserved from age 12 months, when the Infant Behavior Questionnaire (IBQ) was used, to age 18 months, when the TBAQ was used (especially when subtle differences between the IBQ and TBAQ were taken into account). Most of the analyses benefit from replication.

Child Behavior↗

Imprinted genes and mother-offspring interactions.

A subset of mammalian genes is subject to genomic imprinting. These imprinted genes show parent of origin specific monoallelic or parental allele-biased expression, such that for some genes, it is mainly the maternally inherited allele that is expressed, whereas for others, expression occurs mainly from the paternal copy. Evolutionary theory predicts that these genes will have a role in the mother-offspring interaction in mammals, and indeed many imprinted genes have a role in growth and placental function, and consequently influence prenatal development. In addition to the developing foetus, there is increasing evidence to suggest that imprinted genes influence the pre-weaning mother-offspring relationship, and consequently the development of the offspring into adulthood. In this review, we present an overview of the role imprinted genes play in the mother-offspring relationship using examples from the human and animal literature.

Animals↗