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At least 487 records · Page 27Linked to original sources
PubMed1986

Diagnosis of metastatic malignant melanoma by fine needle aspiration biopsy: a clinical and pathologic correlation of 298 cases.

Fine needle aspiration biopsies (FNABs) from 298 lesions in patients with suspected metastatic melanoma were studied. The results were correlated either with histopathologic diagnoses on resected lesions or with prolonged clinical follow-up. Of 165 malignant aspirates, 160 were confirmed either by surgical resection (65 cases) or by an appropriate clinical course (95 cases). Of the 107 benign lesions with adequate follow-up, 73 were confirmed as benign. There were 25 false negatives: 19 were inadequate samples, and 6 were presumed failures of needle localization. No interpretative errors were identified. Although 3 cases of FNAB-diagnosed malignant melanoma could not be confirmed by surgical biopsy, the cytologic findings were typical of malignant melanoma. Clinical follow-up, however, suggested that the cytologic diagnosis was in error. One case of a second unrelated malignancy (an adenocarcinoma of the lung) was correctly diagnosed with the use of FNAB. Because of its high degree of accuracy, FNAB has proved useful in the differential diagnosis of subcutaneous nodules, enlarged lymph nodes, and lung nodules.

Biopsy, Needle↗
PubMedDate not supplied

[Reconstruction of the retracted eye socket].

The various methods of treatment of the contracted eyesocket are discussed according to the severity of the disease and are illustrated by examples of treated patients. A method to keep the newly grafted cavity expanded by means of a conformer, stabilised by external fixation to the frontal bone, is described.

Adult↗
PubMed1986

Use of surface coils in magnetic resonance imaging of orbit and knee.

Surface coils are specially designed radio-frequency receiver coils used for magnetic resonance imaging (MRI) of special anatomical regions, for instance, orbit and knee joint, with a higher spatial resolution than that obtained with conventional MRI techniques. They are designed to fit the anatomical part to be imaged, thus enabling a coil to be placed in close proximity to relevant structures. Surface coils can take these different shapes because they are only used for detecting the MR signal and thus do not need to meet particular design specifications for optimal radio-frequency homogeneity. We report our clinical experience with nearly 100 patients in the first year in the special surface-coil approach of orbit and knee joint.

Cranial Nerve Neoplasms↗
PubMedDate not supplied

[Orbital and ocular tumors in the Republic of Mali].

Analysing 82 cases of oculo-orbital tumours in Malian patients, the authors find the classical features characterizing ocular carcinoma in Africa, i.e. early arising, development, late request for treatment. They stress on the age of the patients at the occasion of the first request for treatment in case of retinoblastoma, and notice the special frequency of squamous cell carcinoma with conjunctival or limbic localization.

Adolescent↗
PubMed1986

Molecular detection and differentiation of deletions in band 13q14 in human retinoblastoma.

Five cloned DNA segments within or adjacent to human chromosome band 13q14 were mapped by a combination of in situ hybridization and DNA dosage blotting. The DNA was isolated from human retinoblastoma patients with deletions varying in size and precise location. One of these deletions occurred in mosaic form, requiring T-cell cloning to obtain cells uniformly containing the deletion and useful for blotting. Regions of overlap between the intervals on chromosome #13 deduced for each probe from the two different mapping methods permitted a more precise location for each, from which a physical ordering of these five probes could be obtained. This ordered set of probes constitutes the start of a grid spanning band 13q14 of potential use in the diagnosis and understanding of human retinoblastoma.

Chromosome Deletion↗
PubMed1985

[Round table: Infratentorial hemangioblastoma].

Posterior fossa is the main location of hemangioblastomas of the CNS. Etiological, gross anatomical, clinical and thérapeutic study performed by F. Resche et al. is based on analysis of 20 large series and 624 separated cases of the literature and on results of a cooperative study of the S.F.N.C. (Société française de Neurochirurgie) which collected 262 cases. It is the largest series gathered up to the present. Among the S.F.N.C. series there were 151 males and 111 females. The age ranged from 2-71 with two peaks in 31-35 and 46-50 in the male population. The mean age at the time of diagnosis is 38 but lower in the female group than in the male one. The mean age is significantly lower in familial cases. Cerebellum is the main location of infratentorial hemangioblastomas. Brain stem hemangioblastomas occurred in less of ten per cent of cases (3,77% in the S.F.N.C. series). Solitary tumors are located in the cerebellar hemipheres in about 80 per cent of cases, where they are of macrocystic type (type 2) in a proportion of two third; vermian tumors are equally of cystic and solid (type 3 and 4) types. Whatever their gross anatomic type and location, infratentorial hemangioblastomas usually have a superficial margin at the leptomeningeal layer. Associated axial and extra-axial lesions are analysed. Angiomatosis retinae are in 30-40% of cases the first manifestations of disease, occurring before infratentorial tumor. Pathogenic features are studied. Lethal potential of renal carcinomas and pancreatic nesidio-blastomas of Lindau's disease is pointed out. Histo and cyto pathologic aspects of infratentorial hemangioblastomas are analysed by J. Hassoun. Morphological (photonic and ultra-structural) characteristics are seen and an attempt on histogenetic interpretation is given. From a clinical point of view it is important to note that hemangioblastomas, although they are vascular tumors, are exceptionally revealed by an intrathecal bleeding. The most common initial symptoms are manifestations of increased intracranial pressure without or only with light signs of cerebello-vestibular disturbances. (F. Resche et al.) Potential occurrence of polycythemia in cerebellar hemangioblastoma is a well-known fact. J.P. Caron et al. report a case of a cerebellar hemangioblastoma with polycythemia where plasmatic, C.S.F. and saline extract tumor erythropoietin levels have been measured. Elevate erythropoietin levels were found in the C.S.F. and the tumor suggesting true ectopic hormonal production which is responsible for the polycythemia encountered in this patient.(ABSTRACT TRUNCATED AT 400 WORDS)

Cerebellar Cortex↗
PubMed1979

Prospects for the immunodiagnosis of ocular tumours.

Amongst other properties, malignant neoplasms are characterized by having antigenic determinants not normally found in mature healthy tissue. Consequently an immune response is usual on the part of the host and in recent years interest has centred on the twin possibilities of putting this property to diagnostic and therapeutic use. In our own laboratory we have concentrated on the diagnostic potential of immunological techniques in the investigation of pigmented tumours of the uvea. We have found that not only malignant melanomata, but also many naevi, can provoke an immunological reaction and we have shown that this is directed largely against contractile elements in the cytoplasm. Such reactions, which are not strictly tumour-specific, may be a source of diagnostic confusion and need to be excluded if immunology is to be of value in distinguishing malignant lesions of the uveal melanocytes from innocuous naevi.

Antibodies↗