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An analysis of population growth rates within typological categories of small southern cities.

"The research reported here presents a typology of small cities, as well as an analysis of the causes of population growth within city types. For this research eighty-eight incorporated cities and towns in the South Atlantic and East South Central census divisions [of the United States] were chosen for investigation, all having 1960 populations between 10,000 and 50,000." Path models are constructed for each city class using the decennial rate of population growth between 1960 and 1970 as the endogenous variable and net migration and employment changes as intermediate variables.

Americas↗

An econometric model for forecasting regional population growth.

"An econometric model for forecasting net migration and natural increase is proposed and then estimated using time-series data for Texas. The model is simulated five years out-of-sample and found to be quite accurate in forecasting future population growth. It outperforms simpler prediction methods, thus indicating that explicit modeling of net migration and natural increase is superior to modeling only total population."

Americas↗

Overview of the arthritis Cost Consequence Evaluation System (ACCES): a pharmacoeconomic model for celecoxib.

Pharmacoeconomic analyses have become useful and essential tools for health care decision makers who increasingly require such analyses prior to placing a drug on a national, regional or hospital formulary. Previous health economic models of non-steroidal anti-inflammatory drugs (NSAIDs) have been restricted to evaluating a narrow range of agents within specific health care delivery systems using medical information derived from homogeneous clinical trial data. This paper summarizes the Arthritis Cost Consequence Evaluation System (ACCES)--a pharmacoeconomic model that has been developed to predict and evaluate the costs and consequences associated with the use of celecoxib in patients with arthritis, compared with other NSAIDs and NSAIDs plus gastroprotective agents. The advantage of this model is that it can be customized to reflect local practice patterns, resource utilization and costs, as well as provide context-specific health economic information to a variety of providers and/or decision makers.

Aged↗

Carbon dynamics and land-use choices: building a regional-scale multidisciplinary model.

Policy enabling tropical forests to approach their potential contribution to global-climate-change mitigation requires forecasts of land use and carbon storage on a large scale over long periods. In this paper, we present an integrated modeling methodology that addresses these needs. We model the dynamics of the human land-use system and of C pools contained in each ecosystem, as well as their interactions. The model is national scale, and is currently applied in a preliminary way to Costa Rica using data spanning a period of over 50 years. It combines an ecological process model, parameterized using field and other data, with an economic model, estimated using historical data to ensure a close link to actual behavior. These two models are linked so that ecological conditions affect land-use choices and vice versa. The integrated model predicts land use and its consequences for C storage for policy scenarios. These predictions can be used to create baselines, reward sequestration, and estimate the value in both environmental and economic terms of including C sequestration in tropical forests as part of the efforts to mitigate global climate change. The model can also be used to assess the benefits from costly activities to increase accuracy and thus reduce errors and their societal costs.

Carbon↗

Climatic conditions and migration: an econometric inquiry.

"This paper has examined the impact of climate on migration. It has compared the results that are obtained when various indicators of climatic conditions, both those which have been used in the literature and those which have not, are included in a regression used to explain migration behavior. The results suggest that individuals do indeed consider climatic conditions in different areas when deciding where to live; people generally prefer areas which have moderate climates to areas which have either extremely hot or extremely cold climates. The results also indicate that the climate variables which yield the best results are generally those which have not been used in the literature." The study is based on U.S. data concerning in-migration to 36 SMSAs between 1960 and 1970.

Americas↗

Net migration estimation in an extended, multiregional gravity model.

A multi-regional framework is developed in order to analyze net migration over time to all 10 Canadian provinces within an integrated system of equations. "An extended gravity model is the basis for the equation specification and the use of constrained econometric estimation techniques allows for the provincial interdependence of the migration decision while at the same time ensuring that an important system-wide requirement is respected." The model is estimated using official Canadian data for the 1960s and 1970s. "The results suggest the predominance of the push factor for interprovincial migration for most provinces, although net migration to the Atlantic provinces is also shown to be subject to pull forces from the rest of the country." The effects of wage rate variables, unemployment, and political disturbances in Quebec on inter-provincial migration are noted.

Americas↗

Demographic disaggregation in the construction of regional econometric models: a statistical evaluation.

"A cohort-component method is used to construct historical annual age/sex disaggregations of total population. In econometric models of six substate areas [in the United States], regressions are estimated with and without the disaggregated data for five model variables expected to be dependent on the size of particular population subgroups. Statistical tests are performed to determine significant differences in residual variance of estimation with and without the disaggregated data. Although age/sex population projections may be a desired model output per se, the results indicate that the population subgroup data generally do not improve estimation of other model variables." (summary in FRE, ITA, JPN, )

Age Distribution↗

Incorporating information about cost-effectiveness into evidence-based decision-making: the evidence-based practice center (EPC) model.

RATIONALE: There is a pressing need for guidance on how to incorporate economic information into evidence-based decision-making. Such guidance should take account of the quality and relevance of economic evaluations. OBJECTIVE: To summarize lessons learned in integrating information from decision analyses and cost-effectiveness analyses. KEY ISSUES: Several methods used by the Evidence-Based Practice Centers (EPCs) to conduct systematic reviews are applicable to assessing economic studies. We discuss methods to identify key questions for the review of economic studies. Reviews should assess how an economic model incorporates clinical logic and handles uncertainty about effectiveness. As is the case for metaanalysis of interventions, qualitative or quantitative synthesis of economic studies should explore heterogeneity to identify key uncertainties underlying divergent results as well as unsuspected sources of bias. CONCLUSIONS: Applying EPC methods to synthesis of economic information can increase their relevance to clinicians and policymakers and inform decisions that require tradeoffs between effectiveness and harms of interventions.

Cost-Benefit Analysis↗

Environmental degradation and remediation: is economics part of the problem?

It is argued that standard environmental economic and 'ecological economics', have the same fundamentals of valuation in terms of money, based on a demand curve derived from utility maximization. But this approach leads to three different measures of value. An invariant measure of value exists only if the consumer has 'homothetic preferences'. In order to obtain a numerical estimate of value, specific functional forms are necessary, but typically these estimates do not converge. This is due to the fact that the underlying economic model is not structurally stable. According to neoclassical economics, any environmental remediation can be justified only in terms of increases in consumer satisfaction, balancing marginal gains against marginal costs. It is not surprising that the optimal policy obtained from this approach suggests only small reductions in greenhouse gases. We show that a unidimensional metric of consumer's utility measured in dollar terms can only trivialize the problem of global climate change.

Carbon Dioxide↗

An economic analysis of two models of hospital care for AIDS patients: implications for hospital discharge planning.

The development of cost effective models of hospital care and discharge planning for people with HIV is a vital policy issue. However, almost no data exist evaluating cost and quality differences in alternate hospital models of care. This empirical study retrospectively evaluates social work discharge planning for patients with HIV disease in two hospital care models: a cluster AIDS unit and general inpatient site beds. The independent effect of each hospital model of care on length of stay is assessed in a multivariate analysis, controlling for level of care needs and other social and clinical factors. Results reveal that the cluster AIDS unit, where a specialized AIDS social work staff works in collaboration with the interdisciplinary AIDS team, is associated with a significant reduction in hospital length of stay for persons with HIV disease and complex discharge planning needs. These results support the hypothesis that discharge planning services, performed by specialized social workers, are a cost effective investment for hospitals treating patients with complex chronic conditions, such as AIDS. Further research should be developed to systematically evaluate the cost effectiveness of hospital-based social workers, using prospective experimental designs, in order to establish the net impact of social work discharge planning services on patient and family outcomes and institutional and social costs.

Acquired Immunodeficiency Syndrome↗

A model for estimating the impact of changes in children's vaccines.

OBJECTIVES: To assist in strategic planning for the improvement of vaccines and vaccine programs, an economic model was developed and tested that estimates the potential impact of vaccine innovations on health outcomes and costs associated with vaccination and illness. METHODS: A multistep, iterative process of data extraction/integration was used to develop the model and the scenarios. Parameter replication, sensitivity analysis, and expert review were used to validate the model. RESULTS: The greatest impact on the improvement of health is expected to result from the production of less reactogenic vaccines that require fewer inoculations for immunity. The greatest economic impact is predicted from improvements that decrease the number of inoculations required. CONCLUSIONS: Scenario analysis may be useful for integrating health outcomes and economic data into decision making. For childhood infections, this analysis indicates that large cost savings can be achieved in the future if we can improve vaccine efficacy so that the number of required inoculations is reduced. Such an improvement represents a large potential "payback" for the United States and might benefit other countries.

Child, Preschool↗

The "supply hypothesis" and medical practice variation in primary care: testing economic and clinical models of inter-practitioner variation.

Medical practice variation (MPV) is marked, apparently ubiquitous across the health sector, well documented, and continues to be a focus of professional and policy interest. MPV have stimulated two paths of investigation, one economic in emphasis and the other more-clinical in orientation; while health economists have stressed the potential role of income incentives in medical decision-making, health services research has tended to emphasise clinical ambiguity as a factor in practitioner decisions. Both sets of explanations converge in an implicit "supply hypothesis" that posits contextual practitioner and practice attributes as influential in clinical decisions. Data on inter-practitioner variation are taken from a large and representative regional survey of general practitioners in New Zealand, a country in which unsubsidised fee-for-service is the predominant mode of remuneration in primary care. The paper assesses the impact on three important areas of clinical decision-making prescribing, test ordering, request for follow-up -- of three key conceptual dimensions -- income incentives, physician agency, and clinical ambiguity (operationalised as local doctor density, practitioner encounter initiation, and diagnostic uncertainty respectively). Predictions are made about inter-practitioner variations in the rate of clinical activity in the three areas. The results of the analysis using multi-level statistical techniques are: 1. the extent of competition -- local doctor density -- seems to have no effect on the pattern of clinical decision-making; 2. doctor-initiated visits are, if anything, associated with lower rates of intervention; 3. diagnostic uncertainty is associated with higher rates of investigations and follow-up, both of which have clinical plausibility; 4. there is no significant interaction effect between density and uncertainty. It is concluded that, for the clinical activities studied and for the practitioner attributes as operationalised in this investigation, a clinical, rather than an economic, model of practitioner decision-making provides a more plausible interpretation of inter-practitioner variation in rates of clinical activity in general practice. The "supply hypothesis" requires further analytical refinement and empirical assessment before it can be applied as a generic explanatory framework for MPV.

Family Practice↗

Cost modeling for alternate routes of administration of opioids for cancer pain.

The economic considerations relative to neuraxial infusion can be looked at with different types of economic models, including cost-minimization, cost-effectiveness, and cost-benefit analyses. A theoretical predictive model was developed about 2 years ago using a computer spreadsheet and based on four levels of supportive data. The model shows that the breakeven point at which it becomes less expensive to administer opioids with an intrathecal/implanted pump, rather than an epidural/external pump, is between 3 and 6 months after the start of pain management. In addition, the break even point between systemic treatment and spinal delivery with an implanted system is between 1 1/2 and 2 1/2 years from start of pain treatment.

Analgesics, Opioid↗

Drug pricing for a novel treatment for wet macular degeneration: using incremental cost-effectiveness ratios to ensure societal value.

OBJECTIVE: Health economic models can assist policy-makers in determining the value of novel treatments from the viewpoint of society. In this context, value is defined as the benefit of treatment, given its cost. A new treatment for wet age-related macular degeneration (AMD), juxtascleral administration of anecortave acetate, 15 mg for depot suspension (Retaane), is now in a late-phase clinical trial. In a theoretical analysis, we sought to determine the cost at which this treatment might offer economic value to society, using incremental cost-effectiveness ratios (ICERs). METHODS: A series of 1-year cost-utility models was created for the investigational treatment and standard treatment (photodynamic therapy [PDT] with verteporfin [Visudyne]). Value to society was defined in terms of theoretical associated ICERs (in US dollars): $100,000 per quality-adjusted life-year (QALY), $50,000/QALY, $20,000/QALY and $0/QALY, the point of economic indifference. Models were created from the societal perspective and included a patient-derived utility assessment involving regression equations to estimate time trade-off preferences, event probabilities derived from a randomized clinical trial comparing the safety and efficacy of anecortave administration and PDT with verteporfin, decision analysis and relevant costing information. RESULTS: An ICER of $100,000/QALY would be associated with an anecortave cost of $3022/vial, an ICER of $50,000/QALY with an anecortave cost of $2986/vial and an ICER of $20,000/QALY with an anecortave cost of $2964/vial. The point of economic indifference between anecortave administration and standard therapy would occur with an anecortave cost of $2950/vial. INTERPRETATION: In theory, an anecortave cost of $2986/vial is associated with an ICER of $50,000/QALY, the threshold used by many health technology assessment and reimbursement agencies.

Clinical Trials, Phase III as Topic↗

[Nursing and the environmental question: proposal of a theoretical model for the professional practice].

Considering the side effects of environmental changes over the population's health, a theoretical model is proposed in this study in order to incorporate ecologic matters into the nursing practices. The reference for this work is the eco-socialist-marxist theory. The model is based on the analysis of the capitalist economic process, its production technologies and consumption. It is known that this economic model generates ecoinequalities and anthropogenic impacts that rebound on the health-disease profile of the population. The nursing action, permeated by ecological awareness, can prevent and also combat ecoinequalities and destructive human actions on the environment.

Environment↗