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PubMedDate not supplied

Development of a computer system in search of antifertility drug from indigenous plants.

Recent advancement in computer technology has increased the application of database in identification and verification systems used in research of indigenous drugs. To overcome some of the drawbacks of existing knowledge (systems) we have developed a computer version of a key for interfacing with pre-existing knowledgebase. Appearance of different types of biological databases on the World Wide Web (WWW) and hypertext links between them has made a large amount of information easily accessible to biologists. Storage of explicitly specified biological relationship between different entities as discrete entries can allow additional identification capabilities. These systems are designed to detect the identity of a natural product when it is unknown or to verify the product identity when an antifertility products is provided. We have built a database about the cytoskeleton that explores the natural product approach as antifertility drug and the gap in existing knowledge. The stored information is displayed along with other retrieved information. The system is capable to search for entities with specified properties. It is extensible so that new types of relationships may be incorporated.

Contraceptive Agents↗
PubMed1995

[Active computer systems for medical education: approach and implementation].

The methodological bases and ways of building and using the new type of the educational computer-aided systems for physicians, the Diagnostic trainer, are discussed in the paper. The user's work on the Diagnostic Trainer proceeds in the form of a game during which the system stimulates clinical cases while the user analyzes them. The Diagnostic Trainer uses its knowledge base for simulations and requires no clinical cases to be prepared beforehand. The Diagnostic Trainer never forces the user to do, but always fixes his/her attention on the available essential points and possible contradictions between the specific clinical case and the user's strategy to make a decision.

Computer-Assisted Instruction↗
PubMed1991

[A computer system for planning radiation therapy--the ROPLAN].

A computerized system of optimum plans of radiotherapy (computer SM 1420) was developed for the first time in the USSR. The ROPLAN system was adapted to a dosimetric design of irradiation sessions for all radiotherapy units, manufactured in the USSR, and provides for modes of initialization, design, storage and collection of data for all radiotherapeutic methods.

Humans↗
PubMed2000

[The workload of computer system engineers and mental health].

The nature of labor in Japan is changing from work which is physically demanding to work in which mental activity requiring intellectual and psychological ability results in production. The author studied and analyzed the type of workload experienced by system engineers in informatics. The results of a health study of 2,396 system design engineers in informatics at our company were analyzed (only data on 2,169 males were analyzed). Workload related to the 'quality', or type of work done ('Workload of quality') was felt by 63.5%, with 36.0% feeling workload related to the amount of work ('Workload of quantity'). A very large number of workers felt workload related to the quality, or type of work rather than to the amount of work. The relationship between emotional health indices and workload showed insomnia in 25.5% of workers who felt a 'Workload of quality', and in 11.1% of those who did not feel such a workload. Similarly, depressive mood was seen in 40.3% of workers who felt a 'Workload of quality', and in 18.7% of workers who did not. Insomnia was seen in 42.8% of workers with a feeling of a 'Workload of quality', and in 26.3% of those without. The relationship between workload, related to the quality and quantity of work was also strong for other mental health indices. Workload related to the quality of work was particularly strong. Workload related to the quality or type or work comes from a myriad of factors including the variety of work required from workers in informatics, the still developing nature of the production process, and the rapid pace of technical progress with each type of work carrying a different set of factors. The ability and personality of each individual worker also plays an important role. The results of the survey showed the importance of carrying out occupational healthcare activities in health management from the standpoint of work related health hazards or "quality of work"; in other words, from the standpoint of work type, system operation and the individuality of the worker.

Adult↗
PubMed2006

Design and performance characteristics of a digital flat-panel computed tomography system.

Computed tomography (CT) applications continue to expand, and they require faster data acquisition speeds and improved spatial resolution. Achieving isotropic resolution, by means of cubic voxels, in combination with longitudinal coverage beyond 20 mm would represent a substantial advance in clinical CT because few commercially available scanners are capable of this at present. To achieve this goal, a prototype CT system incorporating a movable array of 20 cm X 20 cm, 200-microm-pitch amorphous silicon flat-panel x-ray detectors and a conventional CT x-ray source was constructed at the General Electric Global Research Center and performance tested at The University of Texas M. D. Anderson Cancer Center. The device was designed for preclinical imaging applications and has a scan field of 13 to 33 cm, with a magnification of 1.5. Image quality performance measurements, such as spatial and contrast resolutions, were obtained using both industry standard and custom phantoms. Spatial resolution, quantified by the system's modulation transfer function, indicated improvement by a factor of 2.5 to 5 in isotropic spatial resolution over current commercially available systems, with 10% modulation transfer function modulations at frequencies from 19 to 31 lp/cm. Low-contrast detectability results were obtained from industry-standard phantoms and were comprised of embedded contrast regions of 0.3%, 0.5%, and 1.0% over areas of several mm2. Performance was sufficient to easily distinguish 1.0% contrast regions down to 2 mm in diameter relative to the background. On the basis of scans of specialized hydroxyapatite phantoms, the system response is extremely linear (R2=0.990) in bone-equivalent density regimens. Standard CT dose index CTDI100 and CTDIw measurements were also conducted to assess dose delivery using a 16-cm-CTDI phantom and a 120 kV 120 mAs scan technique. The CTDIw ranged from 30 mGy (one-panel mode) to 113 mGy (two-panel mode) for this system. Lastly, several in vivo canine and murine samples were examined, and preliminary results from these scans are presented. On the basis of our results, it is clear that flat-panel-based CT scanners are useful for high-contrast high-resolution clinical applications, providing up to a 20-fold increase in volumetric resolution over most commercially available scanners.

Contrast Media↗
PubMed1989

[Identification of Mycobacteria and measurement of whole cell fatty acids using a gas chromatography computer system].

The technique of combination gas chromatography with computer used in measuring fatty acids of 28 species standard Mycobacteria was introduced in this study. The data of components of fatty acids in this genus and GC graphs with satisfaction were gained. Several peaks with good reproducibility were distinguished automatically, based on which, M. tuberculosis, M. bovis and other comment atypical Mycobacteria may be separated respectively. It was showed that this method have the characteristics of accurate, sensitive and rapid by means of the identification of clinical strains, also have certain practical value in clinical laboratory.

Chromatography, Gas↗