Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Cod Liver Oil”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 487 records · Page 27Linked to original sources

Infant feeding in the 20th century: formula and beikost.

The early years of the 20th century were notable for improvements in general sanitation, dairying practices and milk handling. Most infants were breast-fed, often with some formula feeding as well. Availability of the home icebox permitted safe storage of milk and infant formula, and by the 1920s, feeding of orange juice and cod liver oil greatly decreased the incidence of scurvy and rickets. Use of evaporated milk for formula preparation decreased bacterial contamination and curd tension of infant formulas. From 1930 through the 1960s, breast-feeding declined and cow's milk and beikost were introduced into the diet at earlier and earlier ages. Although commercially prepared formulas, including iron-fortified formulas replaced home-prepared formulas, few infants were breast-fed or formula fed after 4-6 mo of age. Iron deficiency was prevalent. From 1970 through 1999, a resurgence of breast-feeding was associated with a prolongation of formula feeding and an increase in usage of iron-fortified formulas. By the end of the century, formula feeding of older infants had largely replaced feeding of fresh cow's milk and the prevalence of iron deficiency had greatly decreased.

Bottle Feeding↗

Dietary recommendations for vitamin D: a critical need for functional end points to establish an estimated average requirement.

From its inaugural value in 1941, the Recommended Dietary Allowance (RDA) for adults for vitamin D has remained close to 400 IU (10 microg) level. This original recommended intake was based on the observation that the amount of vitamin D activity in a teaspoon of cod liver oil was sufficient to prevent rickets in infants. Since that time until 1997, determination of vitamin D requirements and status was more conjecture than science. In 1997, when the recommended intake level of vitamin D was set as an adequate intake value rather than an RDA, much has been learned about metabolism of vitamin D. The circulating metabolite 25-hydroxyvitamin D is the major static indicator of vitamin D status. Using its response to diet in the absence of sun exposure, a dose-response study suggests a mean requirement of at least 500 IU (12.5 microg) from which an RDA could be set. Other factors may need adjustment, such as sun exposure and body fat. However, functional indicators of status are needed. The role of vitamin D in calcium metabolism (i.e., calciotropic functions) is better understood; bone turnover and parathyroid hormone are potential indicators. Vitamin D has noncalciotropic functions arising from extrarenal synthesis of the active metabolite 1,25 dihydroxyvitamin D involving cell proliferation and immunity, from which function indicators of status may be derived. Despite gaps in our knowledge, there are data from which new dietary reference intake values for vitamin D may be set.

Canada↗

Conditioning as an adjunct in the pharmacotherapy of lupus erythematosus.

Several studies have provided evidence suggesting that "placebo effects" represent conditioning phenomena and that learning processes influence the response to placebo medication. This case report describes an adolescent with severe lupus erythematosus who received cyclophosphamide (CY) paired with taste (cod liver oil) and smell (rose perfume) as conditioned stimuli. The regimen was based on conditioning experiments with animals who had lupuslike autoimmune disease. After the initial pairings, the taste alone was offered between CY treatments. Over 12 months, the patient received six rather than 12 CY treatments, half the cumulative dose that might have been administered. The patient improved clinically, and 5 years later continues to do well.

Adolescent↗

Determining the lumbar vertebral segments on magnetic resonance imaging.

STUDY DESIGN: A study to test the ability of an additional cervicothoracic localizer scan to decrease interobserver discrepancy in the identification of vertebral segments in magnetic resonance imaging of the lumbar spine. OBJECTIVES: To investigate whether lumbar vertebral segments can be identified correctly from lumbosacral magnetic resonance localizer scans, the degree of interobserver discrepancy, and the value of an additional cervicothoracic localizer scan. SUMMARY OF BACKGROUND DATA: In magnetic resonance imaging of the lumbar spine, it may be difficult to identify transitional lumbosacral vertebral segments. METHODS: The sagittal and coronal lumbosacral localizer scans of 141 consecutive patients referred for magnetic resonance imaging of the lumbosacral spine were reviewed independently by two radiologists with the aim of locating the L5 vertebra. An additional sagittal cervicothoracic localizer scan also was performed in each case. The final study group consisted of 129 patients. The L5 vertebra was identified by counting caudally from C2 using the sagittal cervicothoracic and lumbosacral localizer scans. In the 54 most recently studied patients, cod liver oil capsule surface markers were placed near the thoracolumbar junction to quantify any marker shift between the two sagittal localizer scans. RESULTS: The lumbar segments could be identified consistently by counting caudally using cervicothoracic and lumbosacral localizer scans. Using sagittal lumbosacral localizer scans alone, the lumbar vertebral segments could be identified correctly in only 80.2% of patients. Coronal lumbosacral localizer scans produced similar results (82.2%). The accuracy fell to 77.9% when using a combination of both sagittal and coronal lumbosacral localizer scans. There was a 11.6% interobserver discordance in assessment of these levels. Lumbosacral transitional vertebrae were identified in 17 patients (13.2%), including 8 sacralized L5 and 9 lumbarized S1 vertebrae. Apparent surface-marker shift between cervicothoracic and lumbosacral localizer scans was insignificant, averaging only 1.9 mm (range, 0.0-5.6 mm). CONCLUSIONS: The addition of a cervicothoracic localizer scan in magnetic resonance imaging of the lumbosacral spine is highly recommended.

Humans↗

The role of the PHEX gene (PEX) in families with X-linked hypophosphataemic rickets.

For over a hundred years, the bane of rickets (a disease of bone), has been prominent in those countries that have participated in, and seeded, the industrial revolution. Industrialisation had major effects of the demography of populations, and many people moved to dark, heavily industrialised cities to find work. It soon became apparent that rickets could be cured by supplementing the diet with cod liver oil and exposure to sunlight. This in turn led to the discovery that photoactivation of 7-dehydrocholesterol was required to produce vitamin D, an indispensable regulator of bone mineral metabolism. Although inadequate exposure to light and poor dietary intake are the main causes of rickets and osteomalacia, recent research has confirmed the role of familial, and tumour forms of the disease. This review will describe the recent advances in our knowledge of the molecular defects in X-linked hypophosphataemic rickets (HYP), and oncogenic hypophosphataemic osteomalacia (OHO). Although HYP and OHO have different primary defects, both diseases have similarities that suggest a linked or overlapping pathophysiology. Also, without doubt, the recent cloning of the gene defective in HYP (the PHEX gene), has given researchers a new reagent to explore the molecular regulation of bone and its links to kidney endocrine function. The fact that the PHEX gene codes for a Zn metallopeptidase raises new and intriguing questions, and adds new momentum to the research on diseases of bone mineral metabolism.

Animals↗

Ischaemic heart disease, serum lipids and platelets in Norwegian populations with traditionally low or high fish consumption.

In an inland and a coastal community, mortality from coronary heart disease (CHD) was registered over a 10-year period. Healthy males representing these two communities were investigated. A dietary registration showed a high saturated fat intake and a daily consumption of fish of 132.4 and 55.1 g and 0.9 and 0.2 g of eicosapentaenoic acid (EPA), in the two groups respectively. The contents of n-3 fatty acids in platelet phospholipids and primary bleeding times were similar, but collagen-induced platelet aggregation was higher in the coastal area. Higher serum triglyceride levels, higher content of saturated fatty acids and lower content of linoleic acid in platelet phospholipids were observed in males from the coastal area. CHD mortality was higher in the coastal area for both sexes. Daily dietary supplement of cod liver oil prolonged the bleeding time, reduced n-6 and increased n-3 fatty acids of platelet phospholipids. This studies indicate that a high content of lean fish and diet rich in saturated fat is not sufficient to prevent CHD.

Animals↗

Dynamics of n-3 and n-6 fatty acids in phospholipids of heart muscle.

The purpose of this paper is to describe the dynamics of n-3 and n-6 polyunsaturated fatty acids in major phospholipids of heart muscle. The profile of n-3 and n-6 fatty acids was examined in rats in relation to various risk factors of coronary heart disease such as stress (catecholamines), ageing and dietary fat. The level of n-3 and n-6 fatty acids in cardiac phospholipids was also examined in relation to coronary heart disease and sudden cardiac death in man. Severe stress caused great changes in the fatty acid profile of phospholipids. Corresponding changes were observed during adaptation to neonatal stress. Rats fed diets containing cod liver oil, butter or corn oil showed different fatty acid composition of individual phospholipids in sarcolemma. Repeated epinephrine administration induced similar changes in the three dietary groups despite large differences in initial levels of individual n-3 and n-6 fatty acids. Fatal ventricular fibrillation in rats and sudden cardiac death in man were accompanied by a high ratio of 20:4 n-6/22:6 n-3. The balance between n-6 and n-3 fatty acids in cellular phospholipids seem to play an important role in sudden cardiac death.

Aging↗

Copper-zinc superoxide dismutase (CuZnSOD) in antioxidant deficient pigs.

Six piglets, aged 4 weeks (weaning) at the beginning of the experiment, were fed a diet lacking antioxidants (vitamin E and selenium) and enriched with oxidated cod liver oil (the peroxide value of which was 112.54 meqv/kg). Four of the experimental pigs were killed for necropsy at the age of 2 months and the remaining two pigs at the age of 3 months. Two piglets from the same litter served as controls. Myodegeneration of the skeletal muscles was induced in the experimental group. Macroscopically, the condition of nutritional myodegeneration ('white muscle disease') was characterized by a pale, yellowish colour and translucence of the skeletal muscles. The livers were pale and mottled. Light microscopy revealed degenerative alterations in the heart and skeletal muscle and infiltrations by lipidic substances. The ultrastructure of some lipidic droplets was analogous to those of ceroid and lipofuscin. Peroxisomes were frequent in degenerating hepatocytes. In order to elucidate the lysosomal involvement in the residual formation, light and electron microscopical immunocytochemistry using copper-zinc superoxide dismutase (CuZnSOD) was applied. Degradation of mitochondria in the skeletal muscles appeared to be due to the direct coalescence of mitochondria with primary lysosomes. Probably zinc was recruited into the antioxidant protection upon conclusion of the increased erythrocyte superoxide dismutase (E-SOD) activity.

Animals↗

The pioneer woman's view of migraine: Elizabeth Garrett Anderson's thesis "Sur la migraine".

This is a presentation of a doctoral thesis of 1870. The author was English but the thesis and the examinations were in French. Elizabeth Garrett Anderson, usually referred to as E.G.A., was the first woman in Britain to obtain the title of M.D., but not the first in Europe. Nadeshda Prokofevna Suslova, a Russian, received her M.D. in 1867 in Zurich, the most liberal university at that time, soon to be flooded by female students from Russia. E.G.A. had been applying to the few possible European universities but she settled for Paris after the Empress Eugenie had decided that she should be accepted there. This meant that she could succeed without having to be a Paris resident, just by writing a thesis and passing a series of examinations presided over by Paul Broca. This was important as she was already conducting private and dispensary practice, and could not find a locum (she insisted on a woman). E.G.A. had suffered many setbacks, for being a woman, as such being unacceptable in dissection rooms and operating theatres, and generally in a professional career where women were unheard of. She was finally permitted to receive her medical diploma from the Worshipful Society of Apothecaries of London. She wrote about her thesis: "I have chosen Headache as its subject. I had to find a subject which could be well studied without post-mortem observations, of which I can have but very few in either private or dispensary practice; and I wished also to take a large subject, one that demanded some insight into the harmony that exists between the main physiological functions." Marcia Wilkinson (M.W.), who worked in the Elizabeth Garrett Anderson Hospital in London for 35 years, heard there of E.G.A.'s thesis on migraine and sent for it from Paris. In 1966 she translated it into English from the original French, being interested both in the subject and in the person of this resolute and lucid woman. When H. Isler found the French thesis in the British Library he intended to translate it but, after discussion, we decided on a joint effort (95% of the translation is by M.W.; very few details were changed, and some footnotes added for better understanding). We think that E.G.A.'s text is a classic, showing profound understanding, sound practical advice, and also, in its theoretical part, the limits of neurophysiological knowledge in Paris when Brown-Sequard was "charge des cours" there. We may add that in her various examinations she had to answer questions, in French, on the use of footprints by the police, the general nature of fishes, toxic fishes, electric fishes, cod liver oil, and the secretion of tears. She earned much applause from the public, which consisted of male French students, and the overt appreciation of Paul Broca, head examiner, and Dr Wurtz, the Dean of the Faculte de Médecine. The impact of her thesis in the 19th century was modest. It appears to be rather marginal in the German literature of the early 20th century, but it has imprinted the management of migraine at the City of London Migraine Clinic in the last thirty years. The importance of nutrition, regular meals, regular habits, the need to supplement analgesics with antiemetics, and the treatment of the attack with rest, and great quantities of hot tea, were certainly related to E.G.A.'s doctrine. The internationally prevailing recommendation to give antiemetics, and then only analgesics, as well as the combination of both in one tablet, may thus be traced back to E.G.A. via the teachings of M.W. and Nat Blau.

Academic Dissertations as Topic↗

Review of equine feeding and stable management practices in the UK concentrating on the last decade of the 20th century.

Equine feeding and stable management practices for horses kept in the UK vary greatly and it is probable that almost any permutation of regimen could be found somewhere. Unfortunately, there is uncertainty about the number of horses in the UK and very limited data are available on the ways horses are being fed and managed. This paper reviews some of the information that is available and provides an outline of some of the factors influencing the practices used. To a certain extent, the way UK horses are fed and managed primarily reflects the purpose for which they are kept (e.g. racing Thoroughbred vs. native breeding pony) as well as their location (urban vs. rural); the time of year; their breed/age as well as the owner's financial situation. In very general terms, the various ways that horses can be kept and managed fall between 2 extremes: the professional riders/owners/trainers who tend to keep horses and ponies either in large barns/stable yards managed by themselves or a head stable person and the more amateur competitor/leisure riders who tend to keep their horses at a livery yard or at their own or a friend's home. Many of these animals are kept under either part or full do-it-yourself (DIY) conditions. Common feeding practices range from feeding traditional home cereal-based mixes to feeding coarse mixes/pelleted compound manufactured feeds. Very few people, however, feed just a simple single grain or compound feed plus roughage diet. Many add other separate feeding stuffs and supplements including soaked sugar beet or straight molasses, primarily as palatability enhancers. Other common additions include cod liver oil, various types of vegetable oil, carrots, one or more vitamin/mineral mixes, herbal mixes and certain agents with ergogenic/performance-enhancing claims. Especially for horses used for competition purposes, provision of supplementary salt is common either by means of a salt block or lick or as an addition to the feed. The soaking of hay, for a variable time period, is another common practice. Although the type and amount of feed fed fundamentally varies according to the work load of the horse there tends to be marked seasonal variations in feeding practices due to the weather and the availability of pasture.

Animal Feed↗

Inhibition by retinoic acid of multiplication of virulent tubercle bacilli in cultured human macrophages.

The immunologically active vitamin retinoic acid (RA) was tested for the ability to increase the resistance of cultured human macrophages (MP) to experimental infection with virulent Mycobacterium tuberculosis Erdman (tubercle bacilli [TB]). It was added to MP in various concentrations and addition regimens. Protection against TB was measured by counting live TB (CFU) in lysates of samples of MP taken at 0, 4, and 7 days after MP infection. RA was protective when added after infection at the pharmacologic concentration of 10(-5) M and when added before infection at the physiologic concentration of 10(-7) M. The protection lengthened intracellular generation times for TB, occasionally caused bacteriostasis, and regularly kept CFU counts at 7 days (end of the period of infection) 1 to 2 log10 CFU below control values. Significant protection was seen in a series of 16 experiments with MP from seven different donors, but the degree of protection varied considerably. The protection depended partly on and was inversely proportional to concentrations of a serum substitute or autologous serum used as a supplement in the RPMI 1640 MP culture medium. It was strongest at concentrations of serum below 1%. RA at concentrations used in the MP cultures did not inhibit TB in the absence of MP. These results suggest that RA (vitamin A), like vitamin D, may have some immunoprotective role against human tuberculosis, as historically intimated by the regular use of vitamin A- and D-rich cod liver oil for the treatment of tuberculosis before the introduction of modern chemotherapy.

Cells, Cultured↗

Use of complementary therapies and non-prescribed medication in patients with Parkinson's disease.

Patients with Parkinson's disease resort to complementary therapy and non-prescribed medication in the hope of improving their quality of life. In the US 40% of patients with Parkinson's disease reported the use of at least one form of complementary therapy for Parkinson's disease. Data for the UK are limited. A structured questionnaire was administered to consecutive patients attending a Parkinson's disease clinic. Patients were excluded if they were cognitively impaired, if they were living in an institution, or if they declined to take part. The participants were asked about current and previous use of complementary therapy in general and Parkinson's disease in particular and were presented with an extensive list of complementary therapies and non-prescribed medications. The response rate was 90% and 80 patients met the inclusion criteria. Fifty four per cent (n=44) reported the use of at least one form of complementary therapy or non-prescribed medication either for Parkinson's disease or for some other indication, of whom 31 (38.7% of the total sample) used it solely for the treatment of Parkinson's disease. The most commonly used complementary therapies for Parkinson's disease were massage (n=9) and aromatherapy (n=8). Non-prescribed medication was mainly used for indications other than Parkinson's disease and the commonest drugs used were simple analgesics (n=7), cod liver oil (n=5), and multivitamins (n=4). The use of complementary therapy for Parkinson's disease correlated significantly (Pearson's r=0.44, p=0.01) with a younger age at diagnosis of Parkinson's disease. Comorbidity correlated significantly with complementary therapy use for indications other than Parkinson's disease (Pearson's r=0.29, p= 0.01). The use of complementary therapy for Parkinson's disease in this UK based clinic closely mimics that in the US. Non-pharmacological complementary therapy is mainly used for Parkinson's disease, while non-prescribed medication is more commonly used for other indications.

Aged↗

How common is self-treatment in non gonococcal urethritis?

OBJECTIVE: To assess the prevalence of self-treatment in men with new episode non gonococcal urethritis (NGU). METHOD: Three hundred consecutive men with new episode NGU attending an open access genitourinary medicine clinic were interviewed using a semi-structured questionnaire. Details of treatment used before attending the clinic were obtained. RESULTS: Thirty (10%) men had used treatment, for an average of 7 days, prior to the clinic attendance. Agents used included antibiotics (11), savion or iodine (4), vitamin tablets (4), cisapride (2), local anaesthetic gel (2), antiseptic cream (2), cod liver oil (1), ferrous sulphate (1), naproxen (1), clotrimazole cream (1) and a poultice (1). Over 70% of the men reporting antibiotic use had self-medicated and in one case a fixed drug eruption had ensued. CONCLUSION: A significant number of men with NGU self-treat. In addition to the adverse effects of such treatment and the potential effect on culture tests, clinic attendance may be postponed, the use of appropriate therapy delayed, and sexual contacts will remain at risk. Early attendance for treatment and contact tracing is essential and should be actively promoted.

Adult↗

Dietary omega 3 fatty acids and endothelium-dependent relaxations in porcine coronary arteries.

Dietary supplementation with cod-liver oil significantly augments endothelium-dependent relaxations in porcine coronary arteries. The present study was designed to examine the effect of dietary administration of omega 3 polyunsaturated fatty acids (mainly eicosapentaenoic acid, the major component of fish oil) on endothelium-dependent relaxations in porcine coronary arteries. Male Yorkshire pigs were maintained 4 wk on a regular diet with or without supplementation with purified eicosapentaenoic acid (3.5 g/day) and docosahexaenoic acid (1.5 g/day). Endothelium-dependent relaxations were examined in vitro. In rings from the treated group, endothelium-dependent relaxations were augmented in response to bradykinin, serotonin, and ADP, but not to the calcium ionophore A23187. These augmentations were not altered by indomethacin but were significantly inhibited by methylene blue, an inhibitor of guanylate cyclase. In the treated group, endothelium-dependent relaxations to aggregating platelets also were significantly augmented; platelet-induced contractions of quiescent rings were inhibited more by the presence of the endothelium than in arteries from the control group. Bioassay experiments demonstrated that the release of endothelium-derived relaxing factor(s) by bradykinin and relaxations of the vascular smooth muscle to the factor(s) were greater in arteries from the treated group. These observations indicate that dietary omega 3 polyunsaturated fatty acids augment receptor-operated endothelium-dependent relaxations, partly due to the augmented release of endothelium-derived relaxing factor(s) and partly due to the augmented relaxation of the vascular smooth muscle to the factor(s).

Animals↗

Efficacy of topical application of eosin compared with zinc oxide paste and corticosteroid cream for diaper dermatitis.

BACKGROUND: Corticosteroids, zinc paste and eosin 2% are well-known topical agents for the treatment of moderate to severe diaper dermatitis. Among these treatments, the aqueous solution of eosin 2% is extensively used in several European countries, but not in the USA or Israel. OBJECTIVE: To assess the therapeutic efficacy of eosin 2% solution compared to the other treatment modalities for diaper dermatitis. METHODS: Fifty-four infants with diaper dermatitis, recruited from hospital wards and community clinics, were randomly assigned to three treatment groups: zinc oxide paste (containing allantoin 0.5%, cod liver oil 17% and zinc oxide 47epercnt;); clobetasone butyrate 0.05%, and aqueous solution of eosin 2%. The severity of the disorder was graded on a 6-point scale by observation and quantitative measurement of the lesions. The groups were compared for rates and time to heal. Due to the red color of eosin, a double-blind controlled study was impossible. RESULTS: Following 5 days of treatment, the rate of complete healing in the group treated with eosin (61%) was significantly higher (p = 0.0479) than that in the zinc oxide paste and corticosteroid groups (22 and 33%, respectively). Furthermore, in cases of partial healing, the degree of improvement was higher in the eosin group than the other two (p = 0.0205). The fastest improvement was observed in the group treated with corticosteroid cream. CONCLUSION: Considering the potential hazards of topical corticosteroids and the greater overall efficacy of eosin 2% solution, we suggest that eosin is the preferred treatment for diaper dermatitis.

Administration, Cutaneous↗

Risk factors for nuclear lens opacification: the Reykjavik Eye Study.

PURPOSE: The purpose of this study is to examine risk factors for nuclear lens opacification in citizens of Reykjavik. METHODS: 1,045 persons, 583 females and 462 males aged 50 years and older, were randomly sampled and underwent a detailed eye examination and answered a questionnaire. In all Scheimpflug photography of the anterior eye segment was done including the lens as well as retroilluminated photography of the lens. These photographs were used for the diagnosis of lens opacification. The data was analyzed using a logistic regression model. RESULTS: An increased risk for all grades of nuclear opacifications was found with ageing (OR = 1.228, 95% CI = 1.192-1.264, p = 0.000), cigarette smoking for more than 20 pack/years (OR = 2.521, 95% CI = 1.521-4.125, p = 0.000) and pipe or cigar smoking (OR = 2.478, 95% CI = 1.200-5.116, p = 0.014). Outdoor exposure, cortical lens opacification grade II and III and computer usage were not found to be linked to higher risk of nuclear opacification. No correlation was found between nuclear opacification and the consumption of vitamins, herring, sardines and shrimps, cod-liver oil or plant oil, nor were iris color, hyperopia, systemic steroid use, cardiovascular disease, diabetes, glaucoma and pseudoexfoliation found to have a significant effect. CONCLUSIONS: Ageing is a major risk factor for nuclear lens opacification, and smoking is a major modifiable risk factor. Cortical and nuclear lens opacifications do not share the same modifiable risk factors.

Aged↗

Diet-induced residual formation in pigs.

Six piglets, aged 4 weeks (weaning) at the beginning of the experiment, were fed a diet lacking antioxidants (vitamin E and selenium) and enriched with oxidated cod liver oil (the peroxide value of which was 112.54 meqv/kg). Four of the experimental pigs were killed for necropsy at the age of 2 months and the remaining two pigs at the age of 3 months. Two piglets from the same litter served as controls. Myodegeneration of the skeletal muscles was induced in the experimental group. The livers were pale and mottled. Light microscopy revealed degenerative alterations in the heart and skeletal muscle and infiltrations by lipidic substances. The ultrastructure of some lipidic droplets was analogous to those of ceroid and lipofuscin. Peroxisomes were frequent in degenerating hepatocytes. In order to elucidate the lysosomal involvement in the residual formation, light and electron microscopical immunocytochemistry using copper-zinc superoxide dismutase (CuZnSOD), was applied. Probably zinc was recruited into the antioxidant protection concluding upon the increased erythrocyte superoxide dismutase (E-SOD) activity.

Aging↗

Rickets and deprivation: a Nigerian study.

Under-fives in 461 households were assessed clinically to determine the prevalence of rickets in sub-urban and rural communities in the Sahel savanna. Overt rickets was found in 11 (2.4%) of households and abnormalities suggestive of rickets in 69 (14.9%). There were significant variations (p < 0.05) in the prevalence of rickets in association with ethnic grouping (higher in southerners and non-Kanuri, non-Hausa-Fulani northerners), religion (more prevalent among Christians), and mother's occupation and educational status (higher with working class mothers and mothers with at least a primary education). A significantly higher prevalence was also associated with late introduction (at more than seven months of age) of cereals to the infant's diet, more than one under-five in a household and presence of under-fives aged 13-43 months. In contrast, no significant variations in prevalence were observed in association with duration of breast feeding, use of multivitamins or cod liver oil, history of convulsions in under-fives, sex, nutritional status, or history of diarrhoea within a recall period of six months. Thus, rickets is common in under-fives in rural and sub-urban communities in the Sahel savanna and may be related more to environmental and dietary factors than to culture and religion. Further studies are required to determine the relative roles of vitamin D or calcium deficiency to facilitate the planning and execution of a community-based intervention programme in the area.

Chi-Square Distribution↗