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At least 487 records · Page 27Linked to original sources
PubMed2006

Nitric oxide and cardiovascular system.

Endothelium has many important functions including the control of blood-tissue permeability and vascular tonus, regulation of vascular surface properties for homeostasis and inflammation. Nitric oxide is the chief molecule in regulation of endothelial functions. Nitric oxide deficiency, which is also known as endothelial dysfunction, is the first step for the occurrence of many disease states in cardiovascular system including heart failure, hypertension, dyslipidemia, insulin resistance, diabetes mellitus, hyperhomocysteinemia and smoking. This review deals with the importance of nitric oxide for cardiovascular system. It also includes the latest improvements in the diagnosis and treatment of endothelial dysfunction.

Coronary Artery Disease↗
PubMed1999

[Cardiovascular system in subjects who have previously suffered from hemorrhagic fever with renal syndrome].

AIM: To study cardiovascular system in convalescence of hemorrhagic fever with renal syndrome (HFRS). MATERIALS AND METHODS: ECG was made in 112 patients who had HFRS 1-3, 4-12 and 12 months ago (groups 1, 2 and 3, respectively). Ultrasound assessed hemodynamics in 27 patients. RESULTS: In HFRS patients the electric axis right deviation was observed statistically more frequently (45%, 24%, 28.6%, 5% of cases of groups 1, 2, 3 and control). 20% of group 1 patients had overloading of right heart. Ultrasound detected dilation of the right ventricle and decrease of blood flow velocity in the pulmonary artery. CONCLUSION: Patients after HFRS may have changes in the lesser circulation which emerge as a rule in early convalescence.

Adolescent↗
PubMed1981

[Functional state of the cardiovascular system in patients operated on for a secondary atrial septal defect].

The functional state of the cardiovascular system in 64 adults with a secondary atrial septal defect and in 120 patients who were operated on for this disease was studied by means of the physical exercise test on a bicycle ergometer. In the late postoperative period, the physical working capacity of patients who underwent operation before the age of 20 years was 92% with respect to that of healthy individuals. The physical working capacity of patients in whom the atrial septal defect was closed after the age of 20 was only 76% as compared to the capacity of healthy individuals. The study showed surgical management of an atrial septal defect to be highly effective. The best functional results in the late postoperative period were produced in patients who were operated on before the age of 20.

Adult↗
PubMed1985

Localisation of neuropeptide Y in nerves of the rat cardiovascular system and the effect of 6-hydroxydopamine.

The distribution of neuropeptide Y (NPY) in the rat cardiovascular system has been examined by radioimmunoassay, chromatographic analysis of tissue extracts, and immunocytochemistry. High concentrations of NPY were identified throughout the heart and within the major blood vessels of the rat in particular in the renal and superior mesenteric arteries. NPY-immunoreactivity was localised to dense plexuses of nerves in the adventitia of the arteries. Treatment of rats with 6-hydroxydopamine resulted in a significant reduction of NPY concentrations in the major vessels. A depletion of extractable NPY was also seen in the heart of the treated animals. Only few degenerated NPY-containing nerve fibres (swollen and fragmented) were observed in the heart and in the adventitia of the blood vessels. It is concluded that NPY containing nerves of the heart and blood vessels are sensitive to treatment with 6-hydroxydopamine. The pharmacological properties of this peptide suggest that these NPY-containing nerve fibres may act as efferent vasoconstrictor nerves to the blood vessels.

Adrenergic Fibers↗
PubMed1982

Naloxone induces excitation of the cardiovascular system and a rise in myocardial oxygen consumption in fentanyl and meperidine-anesthetized dogs.

Naloxone, when administered for the purpose in reversing opiate-induced respiratory depression after morphine- or fentanyl-anesthesia may precipitate an increase in sympathetic tone with subsequent cardiovascular reactions. In order to investigate which variable of the cardiovascular system is affected most and to compare whether the effects after fentanyl anesthesia (0.05 mg/kg) differ markedly from those after sole equianesthetic meperidine-anesthesia (20 mg/kg), naloxone (5 microgram/kg) was given shortly (15 min.) after opiate injection. In the fentanyl group (n = 7) compared to the anesthetic level the antagonist induces an increase in heart-rate by 100%, in LV dP/dt max (inotropic state of the myocardium) by 90%, in mean peripheral blood pressure (afterload of the heart by 80%, in myocardial oxygen consumption by 50% and in left ventricular pressure by 42%. After 32 minutes all variables had returned to anesthesia values. In the meperidine-group (n = 7) naloxone induced an increase in heart-rate by 13%, in LV dP/dt max by 75%, in mean peripheral blood pressure by 65%, in myocardial oxygen consumption by 25% and in left ventricular pressure by 78%. After 25 minutes all increased variables had returned to prenaloxone values. The study indicates that the more potent the opiate agonist, the more naloxone is liable to induce a hyperexcitatory state of the cardiovascular system. This excitatory state is also reflected in an elevated myocardial oxygen consumption. Therefore caution is advised in administering naloxone to patients after sole opiate-anesthesia, who have an impaired myocardial oxygen supply. (Acta anaesth. belg., 1982, 33, 89-97).

Anesthesia, General↗
PubMed1990

[Effect of endothelin on the release of angiotensin II from rat cardiovascular system].

The existence of angiotensin II immunoreactive substance in rat cardiovascular system was demonstrated by RIA and immunohistochemistry techniques. In atrium, aorta and cultured rat aorta smooth muscle cells, angiotensin II content is 7.2 + 2.7 pg/mg protein, 152.4 + 59.2 pg/mg protein and 3.5 + 0.8 pg/2 x 10(5) cells respectively. Endothelin, a potent vasoconstricting polypeptide, can enhance the release of angiotensin II from cultured rat aorta and aortic smooth muscle cells significantly. The results suggest that endothelin may be involved in the regulation of local blood flow and vascular tone, and it may also implicate the pathogenesis of some cardiovascular diseases such as cardiohypertrophy and vascular hypertrophy.

Angiotensin II↗