Increased levels of serum immunoglobulins G and M in women using intrauterine contraceptive devices.
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To gain a better understanding of the mechanism of action of intrauterine devices (IUDs), a search was made for ova in the genital tracts of 115 women using no contraception and of 56 women using IUDs, all of whom volunteered for study in conjunction with surgical sterilization. Ova were recovered from tubal flushings between 48 and 120 hours after the midcycle peak of luteinizing hormone in 39% of the IUD users compared with 56% of women in the control group (0.05 less than P less than 0.10). This suggests an action of the IUD before the ovum reaches the uterus. Eggs with a microscopic appearance consistent with fertilization were recovered from the fallopian tubes of half of the women using no contraception who had intercourse within the fertile period of the reproductive cycle and from whom ova were recovered. In contrast (P less than 0.01), no eggs with this appearance were recovered in IUD users who had intercourse within the fertile period. No ova were recovered from the body of the uterus of any of the IUD users. Fertilized ova are less likely to reach the uterine cavity containing an IUD. Thus, the principal mode of IUDs is by a method other than destruction of live embryos.
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Three frequently used IUD's were studied in model experiments by ultrasound. The position of the IUD in the uterine cavity can be best outlined by longitudinal and transverse ultrasound section of the uterus in the anteflected or retroflected position. Only rarely can the position of the IUD be properly visualized if the uterus is in middle position and the applicator placed transversly. There is the possibility of misinterpretation of the string as an IUD. The data correlate well with ultrasound results of women wearing an IUD.
The influence of ASA and paracetamol on menstural blood loss and on some hematologic parameters was investigated in 23 women without an IUD and 10 women with an IUD. Neither in women with normal nor in women with small defects in the hemostatic mechanism were statistically significant increases in menstrual blood losses observed during treatment with ASA or paracetamol when compared to placebo. There was no linear correlation between bleeding time and basal menstrual blood loss or between the blood losses induced by ASA and paracetamol and the bleeding time.
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A case of a 28-year-old gravida 3 para 2 woman with an ileal penetration by an intrauterine device (IUD) is reported. Four weeks following insertion of a Multiload-Cu 375, the woman underwent laparotomy due to persistent vague abdominal pain and translocation of the IUD. The device had perforated the fundal uterine wall and the two flexible side arms and the copper-bearing rod had completely eroded into the wall of the ileum with only the strings protruding outside the small bowel mesentery. Resection of an ileal segment with end-to-end anastomosis was performed. The woman made an uneventful recovery. It appears that a translocated Multiload-Cu 375 IUD body can penetrate and be entirely embedded within the bowel wall as early as 4 weeks following translocation. This report documents the shortest interval between insertion and proven bowel injury by an IUD.
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68 pregnancies were observed with an intrauterine device in place, and the threat no longer visible in the cervical canal. The various diagnostic and therapeutic possibilities are described. Ultra-sonography is capable of localizing the I.U.C.D. in 4/5 of the cases. In some cases a positive identification of the I.U.C.D. is only possible by radiographic methods. In order to reduce the maternal risk of infection and to increase the chances for an uncomplicated course of the pregnancy the intra-uterine device needs to be extracted even when the threat is no longer visible. The hysteroscopic localization and extraction was found to be the safest and most effective method of retrieval. Among 26 cases, removal was feasible in 25 cases, and 21 pregnancies remained undisturbed.
Actinomycosis involving the female genital tract is more common among IUD users than others. The diagnosis is difficult and often delayed. It has been suggested that the finding of Actinomyces-like organisms or A. israelii in cervical smears indicates a risk of developing actinomycosis. A. israelii has not been regarded as a part of the indigenous genital flora. A group of IUD users without symptoms of genital tract infections were compared with a control group without IUDs. No Actinomyces-like organisms were found on cytological examination of cervical smears. Immunofluorescent staining and cultures identified A. israelii in 4% of the IUD users and in 3% of the non-users. Serologic precipitin tests for actinomycosis were negative in all women. None developed actinomycosis on follow-up of positive cases. The study indicates that A. israelii is a commensal of the female genital tract. The identification of A. israelii alone does not indicate that the patient risks developing actinomycosis. Other methods such as a serology test should be useful in defining the clinical significance of the findings.
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The efficacy and side effects of 6 different IUDs used by 790 women during 22826 menstrual cycles is reported. The conclusion is that modern IUDs have a negligible effect on the health of users if properly followed by regular checkups.
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