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[Changes in the leukocyte capacity for rosette formation as affected by actinolysate in actinomycosis patients and healthy donors].

The action of actinolysate on the capacity of lymphocytes and neutrophils for rosette-formation has been studied in patients with actinomycosis of the maxillofacial area and with chronic nonspecific inflammatory processes, as well as in healthy donors. Actinolysate has been found to have different influence on cell activity. In actinomycosis patients with the low capacity of cells for spontaneous E-rosette-formation with sheep red blood cells (SRBC) actinolysate suppresses their activity still greater, while in cases of the high capacity of cells for spontaneous epsilon-rosette-formation with SRBC this capacity is increased. In chronic nonspecific inflammatory processes in the maxillofacial area and in healthy donors the reverse tendency is observed.

Actinomyces↗

Actinomycosis of the liver.

We present our first case of actinomycosis in Trinidad and we believe this is also the first reported case of hepatic actinomycosis in the West Indies.

Actinomycosis↗

[Genital actinomycosis and the intrauterine device. Apropos of 3 cases].

Three cases of actinomycosis are reported. In two of these three patients, both of whom had worn an intra-uterine device for several years, the actinomycosis probably followed secondary to previous appendicitis. In the third case, however, it was primary and directly linked to the presence of the I.U.D. From these observations and from studying the literature, this type of infection should be suspected in any women wearing an I.U.D. who has a tubo-ovarian abscess.

Abscess↗

[Isolated actinomycosis of the spinal cord].

A brief review of the literature on the actinomycosis of the central nervous system and particularly on that of the spinal cord is given. The authors observation concerns a 7-year-old boy with a clinical diagnosis of congenital defect of sacrum, suppuration of dermoid with fistula in the sacral region, epiduritis, cauditis. At the necropsy the actinomycosis of the lower thoracic and lumbar parts of the spinal cord with the involvement of bone and soft tissue in the sacral region and formation of scarring fistula was found.

Actinomycosis↗

Abdominal actinomycosis--a late complication of gastrectomy.

A patient with abdominal actinomycosis, two years after gastrectomy, is reported. First suspicion of this diagnosis was aroused by fistula formation in the abdominal wall. The correct diagnosis was only established by Gram-staining. Treatment with high doses of penicillin resulted in rapid and complete recovery. This is one of the most misdiagnosed diseases because of its variety of clinical presentation. This case is reported to emphasize the rare occurrence and the difficulty in making an early diagnosis. The diagnosis of abdominal actinomycosis should be considered in any patient in whom persistent or unusual cutaneous fistulas develop after surgical procedures on the gastrointestinal tract.

Abdomen↗

[Tumor-like organ manifestations of actinomycosis].

This report describes a 36-year-old male suffering from a disease which began with subcutaneous nodules and tumors that opened to form fistulae for past 5 years. These lesions, localized in various areas, were combined with tumorlike symptoms of brain, lungs and liver. The histologic examination of one subcutaneous nodule led to the diagnosis of actinomycosis. The differential diagnosis of various forms of actinomycosis are discussed.

Actinomycosis↗

[Renal actinomycosis].

A case of actinomycosis of the kidney in a man of 69 is described. The autopsy revealed a pyo-destructive process in the right kidney and paranephria with melting of the surrounding tissues and formation of fistulas. Histologically, a destructive variant of the development of actinomycotic granulomas with degenerating druses of the ray fungus and mycelial inclusions was revealed. This case may be classified as the primary form of actinomycosis.

Actinomycosis↗

Pelvic actinomycosis associated with use of intrauterine device: a new challenge for the surgeon.

Pelvic actinomycosis associated with the use of an intrauterine device (IUD) is a recently recognized combination. The usual manifestation of the disease are those of mild pelvic inflammatory disease (PID) in a woman who uses an IUD. The disease is easily recognized on Papanicolaou-stained cervicovaginal smears. Early treatment involves removal of the IUD and administration of penicillin. Rarely, the disease may be serious and may require drainage of intra-abdominal abscesses, hysterectomy with salpingo-oophorectomy, or both. The second known death from pelvic actinomycosis associated with use of an IUD is reported.

Actinomycosis↗

[Actinomycosis of the stomach after gastric resection (author's transl)].

A case report is given of a patient, who developed actinomycosis at the anastomosis after Billroth II type of resection of the stomach. Physical examination revealed an upper abdominal mass in this patient; a clear diagnosis could not be established before surgery was done, the most likely diagnosis was considered to be a pancreatic pseudocyst. During surgery a carcinoma of the stomach was suspected. Microscopic examination finally yielded the diagnosis of tumor-like actinomycosis in the area of the anastomosis. Diagnosis, differential diagnosis and therapy are discussed.

Actinomycosis↗

Abdominal actinomycosis.

Four cases of abdominal actinomycosis managed during a two year period at Ndola Central Hospital are reported with a review of relevant literature. Difficulties associated in diagnosing this form of the disease are stressed. It is suggested that a limited form of surgery in combination with parenteral penicillin therapy is usually effective in the management of abdominal actinomycosis.

Abdomen↗

Actinomycosis. A cause of pulmonary and mediastinal mass lesions in children.

Two patients with intrathoracic actinomycosis were examined. One child was asymptomatic and had a slowly expanding lesion in the left upper lobe. The other child had a chronic illness with back pain, weight loss, amenorrhea, and a posterior mediastinal mass. Establishing the cause of these lesions and making the distinction between a neoplastic process and infection were particularly difficult in both cases. Intrathoracic actinomycosis should be considered in the differential diagnosis of pulmonary and mediastinal mass lesions.

Actinomycosis↗

[Genital actinomycosis, following insertion of intra-uterine device (IUD) -- possibilities for prevention (author's transl)].

Occurrence of actinomyces infection, following IUD insertion, was observed by the authors in two cases. A pathogenetic role has been positively ascribed to the IUD. In one case, actinomycosis was histologically confirmed on a surgically removed and accompanied by severe tuberculoid tissue reaction. In the second case, actinomyces colonies were recorded and identified from the IUD which had been removed for adnexitis. Good success was obtained by early medication. Prevention and early detection will be possible by vaginal smears prior to insertion of an IUD and with the latter in place, after some time, as well as by testing the IUD proper for actinomycosis, after its removal.

Actinomycosis↗

Intrauterine device-associated actinomycosis simulating pelvic malignancy.

We describe pelvic and rectal actinomycosis in a patient with an intrauterine contraceptive device. The presentation was that of an indolent, noninfectious process which mimicked a pelvic malignancy. As in many cases of pelvic actinomycosis, the diagnosis was not suspected preoperatively. Moreover, suppurative disease progressed despite removal of the intrauterine device. In patients who have intrauterine contraceptive devices or who have had them removed recently, abdominal pain, recurrent vaginal bleeding or adnexal masses should prompt a diligent search for potentially pathogenic actinomyces in the genital tract.

Actinomyces↗

Actinomycosis of the common bile duct presenting as chronic cholecystitis.

Actinomycosis of the common bile duct can masquerade as cholecystitis. This is the first report of a case. The bacteriologic and pathologic characteristics are described. This opportunistic saprophytic organism took advantage of 15 years of prednisone therapy for rheumatoid arthritis. The actinomycosis was successfully treated with tetracycline-deoxycycline for 6 weeks.

Actinomycosis↗

[Abdominal actinomycosis].

Actinomycosis is a non opportunistic chronic infection caused by a superior bacteria that forms grains in the pus or affected organs. Fifty four cases have been reported in the last 50 years in the chilean literature, 51% were abdominal actinomycoses, 25.5% pelvic and 18.5% pulmonary. Fourteen cases have been treated in the last 9 years at San Borja Arriaran. Of these 7 were abdominal (1 parietal and 6 visceral forms) and four involved the rectosigmoid; two were ileocecal and occurred after an appendicectomy. The presenting picture was of a giant abdominal mass in two cases (one with a colocutaneous fistula), rectal stricture in one case, tubo-ovarian abscess with colonic involvement in one case, parietal mass in one case and a fistula after an appendicectomy in two cases. Actinomyces Israelli was found in the histopathological study in three cases and in the bacteriological study in two. All visceral forms were treated with penicillin plus tetracycline or amoxicillin during 6 to 12 months with complete and permanent recovery. Two patients required a colonic resection due to a iatrogenic damage and an associated diverticular disease. Three patients required a colostomy to overcome the obstruction, all of them are asymptomatic and without colostomy 18 months to 8 years later. Due to its different presentation forms, actinomycosis has been called "the great pretender" and in several occasions the histological or bacteriological diagnosis is not achieved.

Abdomen↗

[Thoracic actinomycosis with lung, mediastinal and pericardial involvement. A case report].

A case of actinomycosis is reported in a 17-years-old woman with pleural and pericardial effusions and anterior mediastinal mass. Histopathological diagnosis of actinomycosis was performed by mediastinal mass biopsy. There was no evidence of immunodeficit or neoplasia. Probably a dental manipulation favoured the Actinomyces infection. Treatment with antibiotics resulted in a reduction of mediastinal mass and in a complete resolution of pleural and pericardial effusions.

Actinomycosis↗

[Actinomycosis of the minor pelvis associated with prolonged use of intrauterine contraceptive devices (IUD)].

Pelvic actinomycosis is a rare disorder caused by Gram-positive anaerobic bacteria Actinomyces Israeli, and it is commonly associated with the prolonged use of IUD. The authors present two cases of pelvic actinomycosis in patients who used IUD for prolonged periods of time (eight and fourteen years). The diagnostic procedure in both cases lasted long and the definite diagnosis was made only after the pathohistological examination of the material taken during the surgical treatment. Actinomyces Israeli should be considered as one of the causes of the diagnosed pelvic inflammation especially when it is associated with the prolonged use of IUD.

Actinomycosis↗

[A case of pulmonary actinomycosis; histological diagnosis obtained from transbronchial lung biopsy specimen].

We report the first case of pulmonary actinomycosis that was diagnosed by histological findings of transbronchial lung biopsy specimen. A 60-year-old man was admitted because of cough and bloody sputa. His chest roentgenogram and CT scan revealed a cavitary opacity in the apex of the left lung. Histological findings of the biopsy specimen showed multiple basophilic actinomyces granules accompanied by an acute inflammatory exudate, confirming the diagnosis of pulmonary actinomycosis. We prescribed antibiotic treatment and a good response was obtained.

Actinomycosis↗