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PubMed1997

Polymerization of acrylic bone cement using differential scanning calorimetry.

The polymerization of acrylic bone cement using differential scanning calorimetry (DSC) was investigated. The polymerization reaction of the acrylic bone cement was found to be an approximately first order reaction. Two kinds of reaction rate constants for the polymerization reaction were observed. Both rate constants were calculated before and after the peak time. The effects of the addition of tricalcium phosphate (TCP) on the polymerization reaction of standard Surgical Simplex-P Radiopaque Bone Cement have been investigated by DSC. The TCP content had a strong retardation effect on the rate constants. The thermal stability of the acrylic bone cement was also studied by thermogravimetric analysis.

Acrylates↗

PubMed2000

Posterior capsular opacification in phacotrabeculectomy : a long-term comparative study of silicone versus acrylic intraocular lens.

PURPOSE: To investigate the long-term outcomes of silicone versus acrylic intraocular lens (IOL) implantation in phacotrabeculectomy (PT) with special emphasis on posterior capsular opacification. DESIGN: Long-term follow-up on prior 1-year prospective, randomized study. PARTICIPANTS: A total of 200 eyes of 200 consecutive primary open-angle glaucoma patients who had undergone primary PT with capsular bag implantation of either a silicone IOL (102 eyes) or an acrylic IOL (98 eyes) according to the initial short-term prospective, randomized study protocol. INTERVENTION: The study eyes underwent primary trabeculectomy, phacoemulsification, and posterior chamber IOL implantation. Adjunctive mitomycin C was used selectively, primarily in patients with one or more risk factors for filtration failure. MAIN OUTCOME MEASURES: Incidence of posterior capsular opacification (PCO), best-corrected visual acuity (BCVA), intraocular pressure (IOP), number of pressure-lowering medications, and filtration success rates, defined as maintenance of target IOP while on one (criteria 1) or zero (criteria 2) pressure-lowering medications without further surgical intervention. RESULTS: At 3-year follow-up, the PCO rate and BCVA did not differ significantly between the two groups (P: > 0.05 for both). In addition, there were no significant differences in IOP, number of medications, and filtration success rate between the two groups (P: > 0.05 for each). CONCLUSIONS: There were no significant long-term differences between the silicone and acrylic IOL groups in PCO, BCVA, IOP, number of medications, and success of filtration surgery after PT. Both groups attained significant improvement in BCVA and IOP control after surgery.

Acrylic Resins↗

PubMed1997

Decentration and tilt of polymethyl methacrylate, silicone, and acrylic soft intraocular lenses.

PURPOSE: The purpose of the study is to investigate the periodic changes regarding the decentration and tilt of the intraocular lens (IOL) and to compare any differences in the decentration and tilt among polymethyl methacrylate (PMMA), silicone, and acrylic soft IOLs. METHODS: A total of 225 cataractous eyes undergoing IOL implant surgery were randomized into 3 groups based on the type of IOL: group A, one-piece PMMA IOL; group B, three-piece silicone IOL; and group C, three-piece acrylic soft IOL. Both the length of the decentration and the degree of the tilt of the IOL were quantitated using the Anterior Eye Segment Analysis System (EAS-1000). All eyes underwent EAS-1000 examinations at 1 week as well as 1, 3, 6, 9, and 12 months after surgery. RESULTS: All IOLs were confirmed to be implanted accurately in the capsular bag after continuous curvilinear capsulorhexis was accomplished. No statistically significant differences were observed regarding the IOL decentration or tilt between the various postoperative periods in any of the three IOL groups. Furthermore, the differences regarding both the IOL decentration and the tilt between the three IOLs were not determined to be statistically significant throughout the observation period. CONCLUSIONS: As long as the IOL was placed properly in the capsular bag after the continuous capsulorhexis, neither the decentration nor the tilt of the IOL showed a significant progression up to 12 months after surgery. Furthermore, both the extent of the decentration and tilt almost were the same among the PMMA, silicone, and acrylic soft IOLs.

Acrylic Resins↗

PubMed2003

Preparation and in vitro characterization of poly(acrylic acid)-cysteine microparticles.

The purpose of the present study was to prepare and characterize a novel mucoadhesive microparticulate drug delivery system. Microparticles were prepared by the solvent evaporation emulsion technique using a poly(acrylic acid)-cysteine conjugate of an average molecular mass of 450 kDa with an amount of 308 micromol thiol groups per gram polymer. The cross-linking of thiol groups via the formation of disulfide bonds during this preparation process was pH-controlled. The resulting microparticles were characterized with regard to the degree of cross-linking and the amount of remaining free thiol groups, shape, size distribution and stability. Furthermore, the drug release behaviour using bromelain as model drug and the mucoadhesive properties were evaluated.Results demonstrated that the higher the pH of the aqueous phase was during the preparation process, the higher was the degree of cross-linking within the particles. However, even at pH 9, 8.9+/-2.2% of free thiol groups remained on the microparticles. Particles were of spherical and partially porous structure and had a main size in the range of 20-60 microm with a center at 35 microm. Because of the formation of disulfide bonds within the particles, they did not disintegrate under physiological conditions within 48 h. In addition, a controlled drug release of bromelain was achieved. Due to the immobilization of thiol groups on poly(acrylic acid), the mucoadhesive properties of the corresponding microparticles were improved threefold. These features should render poly(acrylic acid)-cysteine conjugate microparticles useful as drug delivery system providing a prolonged residence time on mucosal epithelia.

Acrylic Resins↗

PubMed1998

Synthesis of bioadhesive poly(acrylic acid) nano- and microparticles using an inverse emulsion polymerization method for the entrapment of hydrophilic drug candidates.

Bioadhesive latices of water-swollen poly(acrylic acid) nano-and microparticles were synthesized using an inverse (W/O) emulsion polymerization method. They are stabilized by a co-emulsifier system consisting of SpanTM 80 and TweenTM 80 dispersed in aliphatic hydrocarbons. The initial polymerization medium contains emulsion droplets and inverse micelles which solubilize a part of the monomer solution. The polymerization is initiated by free radicals, and particle dispersions with a narrow size distribution are obtained. The particle size is dependent on the type of radical initiator used. With water-soluble initiators, for example ammonium persulfate, microparticles were obtained in the size range of 1 to 10 micrometer indicating that these microparticles originate from the emulsion droplets since the droplet sizes of the W/O emulsion show similar distribution. When lipophilic radical initiators, such as azobis-isobutyronitrile, are used, almost exclusively nanoparticles are generated with diameters in the range of 80 to 150 nm, due to the limited solubility of oligomeric poly(acrylic acid) chains in the lipophilic continuous phase. These poly(acrylic acid) micro- and nanoparticles yielded excellent bioadhesive properties in an in-vitro assay and may, therefore, be suitable for the encapsulation of peptides and other hydrophilic drugs.

Acrylic Resins↗

PubMed1999

Drug and excipient diffusion and solubility in acrylate adhesives measured by infrared-attenuated total reflectance (IR-ATR) spectroscopy.

Infrared-attenuated total reflectance (IR-ATR) was used to measure drug and excipient diffusion in acrylate pressure-sensitive adhesives. The first part describes diffusion of drug and excipient from one adhesive layer to another. The IR-ATR spectrometer is used to continuously monitor the rate at which drug and excipient diffuse into the 'receptor' adhesive layer. In this way, the ability of the drug and/or excipient to leave an adhesive can be determined without any influence of receptor fluids or skin membranes. Data is reported here for terpineol and testosterone diffusion in isooctyl acrylate (IOA) and IOA-acrylic acid (AA) adhesives. It is shown that the diffusion rate is much higher in IOA adhesive than in IOA-AA adhesive. The second part describes the use of IR-ATR to measure the solubility of liquids in adhesives. In this method, a liquid excipient is placed in direct contact with an adhesive layer containing no excipient. The IR-ATR spectrometer is used to continuously monitor the rate at which excipient diffuses into the 'receptor' adhesive layer. At equilibrium, the IR spectrum can be compared to both the pure adhesive spectrum and the pure excipient spectrum to determine the solubility of the excipient in the adhesive. Data are reported here for terpineol in an IOA adhesive and for several liquids in an IOA-vinyl acetate adhesive.

Acrylates↗

PubMedDate not supplied

n-Butyl acrylate: prenatal inhalation toxicity in the rat.

n-Butyl acrylate was examined for its prenatal toxicity in Sprague-Dawley rats. Inseminated rats were exposed to concentrations of 0, 25, 135 and 250 ppm for a duration of 6 hours per day from the 6th to 15th day post coitum. Subsequently the animals were held to the 20th day post coitum. During the inhalation period concentrations of 135 and 250 ppm n-butyl acrylate led to maternal toxicity (delayed body weight gain depending on the concentration, clinical signs of irritation). At the end of the exposure period the signs subsided. The same concentrations induced embryolethality (increased number of dead implantations depending on the concentration). 25 ppm of n-butyl acrylate did not lead to maternal toxicity or embryolethality. Under the conditions chosen, a teratogenic effect of the test substance was not detected at any concentration.

Abnormalities, Drug-Induced↗

PubMedDate not supplied

n-Butyl acrylate: cytogenetic investigations in the bone marrow of Chinese hamsters and rats after 4-day inhalation.

Chinese hamsters and rats were exposed to an average concentration of 817 ppm and 820 ppm n-butyl acrylate (acrylic acid n-butyl ester), respectively for 4 days. In both animal species, the exposure led to distinct signs of toxicity; four of ten male Chinese hamsters died during the exposure period. The chromosome analysis carried out in the bone marrow of the animals after the 4-day inhalation did not indicate any chromosome-damaging effect of n-butyl acrylate. Under the experimental conditions chosen the percentage of metaphases damaged was always in the same range as that of the controls for both Chinese hamsters and rats.

Acrylates↗

PubMed2003

Skin irritation, basal epithelial cell proliferation, and carcinogenicity evaluations of a representative specialty acrylate and methacrylate.

Specialty acrylates and methacrylates (SAM) comprise a large family of industrial monomers. In the late 1980s, the United States EPA and the industry SAM Panel collaborated to evaluate the potential effects, particularly carcinogenesis, of this family of chemicals. As part of this arrangement, the SAM Panel, with EPA input and approval, conducted four studies with a representative acrylate, triethyleneglycol diacrylate (TREGDA), and methacrylate, triethyleneglycol dimethacrylate (TREGDMA). All studies used unoccluded skin application to male mice as follows: Study 1, evaluation of skin irritation compared to cell proliferation in the basal epithelium (BE) following 7 or 14 days of treatment; Study 2, 14-day dose range-finding study; Study 3, 90-day subchronic toxicity study; and Study 4, chronic bioassays employing the EPAs draft guidelines for dermal chronic bioassays. BE cell proliferation was determined in subchronic and carcinogenicity studies (Studies 1, 3, and 4). Organ weight changes (Studies 3 and 4) and increased mortality (Study 4) were observed for the highest dose of TREGDMA. However, there was no related histopathology. Both chemicals induced cell proliferation (7 days through 78 weeks) that correlated with acute and chronic inflammation of the skin. No skin tumors were observed in this study. TREGDA resulted in skin lesions at doses approximately 20-fold lower than TREGDMA. Most of the skin lesions showed similar patterns of microscopic cutaneous alteration suggestive of nonspecific irritation for both chemicals. However, the high concentration TREGDA group in the 78-week study also had evidence of epidermal cell necrosis. In contrast to earlier studies with acrylates, dose selection was based on careful examination of skin irritation and cell proliferation to avoid excessive skin damage. Under these conditions, TREGDA and TREGDMA were not carcinogenic.

Acrylates↗

PubMed1996

Acrylic bone-cement. Influence of mixer design and unmixed powder.

The effects of hand mixing with two different mechanical mixing systems (fixed versus rotating central axis) on unmixed powder content, macroporosity, density, and bending strength of acrylic bone-cement are compared. The effects of voids and unmixed powder on cement bending strength are also evaluated. In acrylic cement, both unmixed powder monomer and voids 1 mm and larger can be easily visualized and analyzed on radiographs of 3-mm-thick samples. Image analysis allowed demonstration of a significant increase in unmixed powder content (P < .0001), in cement prepared using a vacuum mixing system with a fixed central axis compared with both the rotating axis system and hand mixing. The rotating-axis system produced cement of higher density compared with hand mixing only (P = .004). There was a significant correlation between the number of voids measured per square centimeter and cement bending strength (P < .0001), as well as an independent and significant correlation between unmixed powder content and cement bending strength (P < .0001). Mechanical mixing using a fixed central axis produced significantly weaker cement compared with both hand mixing (P < .015) and the rotating-central-axis system (P < .0001). A 15% drop in strength between the two mechanical mixing systems was observed. It is therefore concluded that the use of different rotating systems in mechanical mixers can influence void and unmixed powder content and, consequently, the mechanical properties of acrylic cement, and that unmixed powder is an independent factor affecting the bending strength of the cement.

Acrylates↗

PubMed2000

Positive and negative dysphotopsia in patients with acrylic intraocular lenses.

PURPOSE: To report the incidence, management, and prevention of patient reports of glare and streaks around a point source of light or a dark shadow in the temporal field of vision after acrylic intraocular lens (IOL) implantation. SETTING: A private practice. METHODS: Cases in which patients complained vigorously of dysphotopsia were catalogued prospectively during the implantation experience in 6668 consecutive eyes having surgery between January 1995 and June 1999. The techniques of topical-intracameral anesthesia, temporal clear corneal incisions, and phacoemulsification were used in all cases. Alternate IOL styles were selected for use from July 1999 to April 2000. RESULTS: Fourteen cases (0.2%) were identified. The complaints resolved in 1, were diminished in 1, and were tolerated without change in 7. Five eyes of 4 patients required IOL exchange with capsular bag placement of a poly(methyl methacrylate) (PMMA) or silicone lens for resolution of symptoms. Selecting alternate IOL styles reduced the incidence of dysphotopsia. CONCLUSIONS: Glare and streaks from a point source of light represent positive photic expressions of dysphotopsia, and temporal dark shadows represent similar negative photic expressions. Both appear to be associated with shiny square-edge optics made of high-refractive-index acrylic polymer. Intraocular lenses of PMMA and silicone with rounded edges, along with square-edge acrylic IOLs with nonreflective edges, appear less likely to cause clinically significant pseudophakic dysphotopsia.

Acrylates↗

PubMed2001

Inflammation after phacoemulsification in diabetic retinopathy. Foldable acrylic versus heparin-surface-modified poly(methyl methacrylate) intraocular lenses.

PURPOSE: To evaluate inflammation after cataract surgery in patients with nonproliferative diabetic retinopathy (NPDR) and compare results with 2 intraocular lenses (IOLs): a foldable hydrophobic acrylic and a heparin-surface-modified (HSM) poly(methyl methacrylate) (PMMA). SETTING: Department of Ophthalmology, University of Vienna, Vienna, Austria. METHODS: Patients with NPDR were randomized for implantation of an HSM PMMA IOL (811C, Pharmacia) through a 6.0 mm sclerocorneal incision (30 patients) or a foldable hydrophobic acrylic IOL (AcrySof, Alcon) through a 4.0 mm sclerocorneal incision (32 patients). Both IOLs had 6.0 mm optics. All patients were treated according to a standardized protocol. The degree of flare in the anterior chamber was measured with the Kowa 1000 laser flare-cell meter 1 day preoperatively and 1 day, 1 week, and 1 and 3 months postoperatively. RESULTS: In both IOL groups, flare was highest on the first postoperative day and decreased to preoperative levels by 3 months after surgery. There was no statistically significant difference in relative flare values between the 2 groups. CONCLUSION: There was no difference in postoperative inflammation in eyes with a foldable hydrophobic acrylic IOL implanted through a small incision and those with a rigid HSM PMMA IOL. Postoperative inflammation results indicate that the lenses are equally suitable for the use in patients with diabetic retinopathy.

Acrylic Resins↗

PubMed2001

Refractive stabilization after temporal phacoemulsification with foldable acrylic intraocular lens implantation.

PURPOSE: To determine the rate of stabilization of refractive error after temporal small incision phacoemulsification with insertion of an acrylic foldable intraocular lens (IOL) (AcrySof MA30). SETTING: A university hospital anterior segment referral practice. METHODS: The records of 100 consecutive patients with good visual potential having phacoemulsification with acrylic IOL implantation who had good visual acuity on the first postoperative day were reviewed. Refractive data at 1 day, 1 week, and 1 and 4 months were compared. RESULTS: The mean spherical equivalent refraction was +0.31 diopter (D), -0.33 D, -0.51 D, and -0.35 D at 1 day, 1 week, 1 month, and 4 months, respectively. Cylinder by refraction was 1.17 D, 1.09 D, 0.96 D, and 0.99 D, respectively. From 1 week on, the cylinder power and axis did not differ significantly from that at 4 months. At 1 week, the spherical equivalent was within +/-0.50 D of the 4-month refraction in 66.1% of eyes and the cylinder was within +/-0.50 D in 72.9%. At 1 month, the corresponding values were 87.1% and 85.7%. CONCLUSION: The refractive error stabilized rapidly after temporal phacoemulsification with acrylic IOL implantation.

Acrylic Resins↗

PubMed2002

Effect of the speed of sound in Sensar acrylic lenses on pseudophakic axial length measurements.

PURPOSE: To evaluate adjusting for the change in sound velocity through an intraocular lens (IOL) to determine axial length measurements in pseudophakic eyes. SETTING: Allergan, Inc., Irvine, California, USA. METHODS: The effect of sound velocity through the Sensar (Allergan) acrylic IOL was evaluated using a previously published methodology. RESULTS: The analysis yielded the correction factors for pseudophakic axial length measurements for Sensar acrylic and SLM-2 silicone (Allergan) IOLs. CONCLUSION: The sound speed for the Sensar acrylic IOL differs significantly from that of PMMA and various silicone materials. Corrections for material sound speed must be made to obtain correct pseudophakic axial lengths.

Acrylic Resins↗

PubMed2002

Uveal and capsular biocompatibility of 2 foldable acrylic intraocular lenses in patients with uveitis or pseudoexfoliation syndrome: comparison to a control group.

PURPOSE: To evaluate the uveal and capsular biocompatibility of hydrophilic acrylic (Hydroview) and hydrophobic acrylic (AcrySof) intraocular lenses (IOLs) after phacoemulsification in eyes with pseudoexfoliation syndrome (PEX) or uveitis and compare the results with those in a control group. SETTING: Department of Ophthalmology, University of Vienna, Vienna, Austria. METHODS: This prospective nonrandomized comparative trial comprised 143 eyes recruited consecutively. Of these, 49 eyes had PEX, 43 had uveitis, and 51 served as controls. A standardized surgical protocol was used. Cell reaction, anterior (ACO) and posterior (PCO) capsule opacification, and flare were evaluated 1 year after cataract surgery. RESULTS: Regarding uveal biocompatibility, the number of foreign-body giant cells (FBGCs) increased in proportion to associated ocular pathologies in both IOL groups. The difference between the Hydroview control and Hydroview uveitis groups was statistically significant. The number of FBGCs was greater on AcrySof IOLs than on Hydroview IOLs in all 3 groups. The difference in FBGCs between the 2 IOL types was statistically significant in the control and PEX groups. Regarding capsular biocompatibility, lens epithelial cell (LEC) outgrowth was inversely correlated with intraocular inflammation. Outgrowth was statistically significantly higher with Hydroview IOLs, occurring in 85% in the control group, 45% in the PEX group, and 28% in the uveitis group (P <.0001). With AcrySof lenses, the percentages were 0%, 8%, and 4%, respectively. The PEX and uveitis groups were more likely to develop ACO than the control group (P <.012). There was no statistically significant difference in ACO between the 2 IOL types in the 3 patient groups. The PCO was statistically significantly greater in the uveitis group than in the control group (P <.026) and statistically significantly more dense on Hydroview than on AcrySof IOLs in all 3 patient groups (P <.002). Flare was statistically significantly higher in the uveitis group than in the PEX and control groups with both IOL types (P <.012). There was no statistically significant difference in flare between the 2 IOL types. CONCLUSIONS: Uveal and capsular biocompatibility depends on the intensity of ocular inflammation. The greater the inflammation, the less the biocompatibility of hydrophilic and hydrophobic acrylic materials. AcrySof stimulated more FBGCs. The Hydroview material had better uveal but poorer capsular biocompatibility than AcrySof. The sharp optic edge effect of the AcrySof IOL and the advantages of the Hydroview lens in normal eyes are less apparent in compromised eyes.

Acrylic Resins↗

PubMed2002

Clinical performance of Alcon SA30AL and SA60AT single-piece acrylic intraocular lenses.

PURPOSE: To report the clinical performance characteristics of single-piece acrylic Alcon SA30AL and SA60AT intraocular lenses (IOLs). SETTING: A private practice in Marshalltown, Iowa, USA. METHODS: In a review of 2630 consecutive cases operated on from January 2000 through July 2001, ease of IOL insertion and integrity of the haptic architecture were evaluated in a prospective fashion at implantation. Subgroups of cases were studied prospectively to evaluate 3 factors: same-day incision competence after implantation (postoperative intraoperative pressure [IOP], 107 cases); 2- to 5-week A-constant validation (200 cases); 1-day, 2-week, and 1- and 5-month descriptions of optic centration with respect to pupil and capsule anatomy (79 cases); and a 1-day versus 9-month photographic comparison of IOL centration (70 cases). A retrospective evaluation of the population's diagnostic codes tabulated complications including increased postoperative iritis, cystoid macular edema, neodymium:YAG (Nd:YAG) laser intervention for posterior capsule opacification, and pseudophakic dysphotopsia. A retrospective review of a subgroup of 140 consecutive cases was done to categorize postoperative optic clarity. RESULTS: Overall, the IOLs were easy to implant with no haptic or optic damage using a forceps or the Monarch injector. Subgroup studies confirmed good performance in the following parameters: There were no cases of incision incompetence evidenced by an abnormally low postoperative IOP. The lowest postoperative IOP was 6 mm Hg, with the overall mean IOP increasing to 29 mm Hg from the 17 mm Hg measured a mean of 102 minutes after surgery. The manufacturer's published A-constant was almost identical to that obtained in review (118.4 versus 118.38 for the SA30AL and 118.35 for the SA60AT). In verbal descriptions, IOL optic centration was assessed to be within 0.4 mm of perfect in 75 (95%) of 79 cases. Slitlamp photographs showed that 52 (98%) of 53 IOLs were in the same position 9 months after surgery as on the day of surgery. One IOL optic appeared to rotate 14 degrees. There were no cases of decentration greater than 1.0 mm in either optic centration subgroup. Given a normal postoperative topical steroid regimen, there were no cases of substantially increased or prolonged iritis. There were 17 cases (0.65%) of macular edema. An Nd:YAG laser posterior capsulotomy was performed in 0.64% (13/2044) in the SA30AL group over a mean of 9 months (range 2 to 23 months) and in 0.34% (2/586) in the SA60AL group over a mean of 5.5 months (range 5 to 6 months). Pseudophakic dysphotopsia was diagnosed in 26 eyes of 18 patients (1% of 2630 cases), with 1 patient requiring an IOL exchange. Optic glistenings were observed in 11 (11%) of 100 SA30AL cases at a mean follow-up of 8 months. No glistenings in 40 cases were seen in the SA60AT group at a mean follow-up of 3 months. CONCLUSIONS: The single-piece acrylic lenses performed well in all regards. Although not as intense as observed with the earlier 3-piece designs, pseudophakic dysphotopsia occurred in a few patients with the single-piece acrylic lens. Intraocular lens exchanges with single-piece IOLs may be accomplished with less difficulty early rather than late.

Acrylic Resins↗

PubMed2003

Retinal image contrast and functional visual performance with aspheric, silicone, and acrylic intraocular lenses. Prospective evaluation.

PURPOSE: To compare the effects of an aspheric intraocular lens (IOL) (Tecnis Z-9000, Pharmacia Corp.) with those of conventional silicone (AA4207VF, Staar Surgical) and acrylic (AcrySof SA60AT, Alcon Surgical) lenses on retinal imaging and functional visual performance. SETTING: Eye Laser Center, Tucson, Arizona, USA. METHODS: In this prospective study, 221 eyes of 156 patients were randomly assigned to receive 1 of 3 IOLs. Visual acuity was measured preoperatively and 1 day, 1 and 3 weeks, and 1, 3, and 6 months postoperatively. Fundus photography and photopic and mesopic functional acuity contrast testing were performed preoperatively and 3 months postoperatively. RESULTS: The differences in the preoperative and postoperative spherical and astigmatic refractive errors and best corrected visual acuity among groups were not statistically significant. The postoperative uncorrected visual acuity was best in the aspheric group in the first month. Functional acuity contrast testing showed the aspheric IOL group had a 38% to 47% increase in photopic vision, 38% in photopic with glare, 43% to 100% in mesopic, and 9% to 100% in mesopic with glare. There was no increase in photopic vision in the acrylic group but increases of 38% in photopic with glare, 25% to 50% in mesopic, and 36% to 50% in mesopic with glare. The spherical silicone IOL group had no increase in contrast testing from preoperatively. Digital analysis of retinal imaging showed increased threshold luminance levels in the aspheric group (range 116 to 208 cd/m2) and a 4-fold increase in image contrast. CONCLUSIONS: All 3 IOLs led to improved visual acuity after cataract surgery. The aspheric IOL provided a significant improvement in retinal image contrast and visual performance measured by visual acuity and functional acuity contrast testing. This improvement was greatest in night vision and night vision with glare compared to the performance of conventional spherical silicone and acrylic IOLs.

Acrylates↗

PubMed1996

Visual function in pseudophakic eyes with poly(methyl methacrylate), silicone, and acrylic intraocular lenses.

PURPOSE: To evaluate the quality of visual function after cataract surgery and intraocular lens (IOL) implantation with three lens materials. SETTING: Klinik Dardenne, Bonn Bad Godesberg, Germany. METHODS: In a prospective, randomized study, 55 patients having uncomplicated phacoemulsification received IOLs made of three materials: 16 received acrylic IOLs, 20 received silicone IOLs, and 19 received poly(methyl methacrylate) (PMMA) IOLs. Pseudophakic patients with accompanying eye diseases were excluded. Visual acuity, glare sensitivity, contrast sensitivity, and mesopic acuity were evaluated 6 weeks postoperatively. RESULTS: Postoperatively, best corrected visual acuity was excellent in all three lens groups. Acuity under bright light conditions and contrast sensitivity were low in all groups; mesopic acuity was extremely low in 73% of patients. Glare and contrast sensitivity were significantly better with PMMA and acrylic IOLs. CONCLUSION: The visual quality achieved in pseudophakic eyes with three different lens materials was lower than expected. The results of individual visual function tests were better for PMMA and acrylic IOLs than for silicone IOLs.

Acrylates↗