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At least 469 records · Page 26Linked to original sources
PubMed1975

[The technique of quantitative determination of streptokinase in the patient's plasma (author's transl)].

A method of a quantitative determination of plasma streptokinase concentrations in patients undergoing streptokinase infusion is described. The principle of this method is based on the clot lysis time recorded by the thromboelastograph. The test clot constituents were bovine fibrin, bovine plasminogen, human euglobulin, EDTA, human plasma (of unknown streptokinase quantity) and thrombin. As rather high concentrations (fixed excess) of plasminogen (euglobulin) and fibrinogen were present in the test coagulum, no interference with changing plasminogen and fibrinogen levels of the patient's plasma was observed. Furthermore, due to high EDTA concentrations, no interaction with platelet functions and coagulation factors took place. The standard deviation in measuring 2 u streptokinase in 1 ml human plasma was determined as s = +/- 0.19 u/ml, of 5 u streptokinase at s = +/- 0.47 u/ml and of 20 u streptokinase at s = +/- 2.5 u in 1 ml of human plasma. Plasma samples of patients undergoing fibrinolytic treatment were investigated with regard to their streptokinase content. Streptokinase concentration values varied between 0.7 u and 15 u/ml plasma. The average half life of streptokinase in the organism was 18 min. The decay of streptokinase in plasma at different temperatures and over various periods of time was also determined. A considerable loss of streptokinase in the plasma during storage at room temperature could be observed. Therefore, the determination procedures should be carried out without delay.

Animals↗
PubMed1977

[Morphological and functional studies in a case of primary (idiopathic) thrombocythaemia in childhood (author's transl)].

Primary (idiopathic) thrombocythaemia is a rare disease in childhood. Haemorrhagic diathesis and splenomegaly are principal findings besides thrombocytosis. The cases of a nine year old girl with thrombocyte levels between 2.8 and 4.5 X 10(6) microliter is described. The examination in light and electron microscopy revealed various morphological abnormalities in thrombocytes and megakaryocytes. Platelet function was disturbed in various degrees. The impact of functional abnormalities on the haemorrhagic diathesis is discussed. The findings in this child were compared to those of the better characterized picture of primary and secondary thrombozytosis in adulthood. Possible pathogenic relations to myeloproliferative diseases are also discussed.

Blood Platelets↗
PubMed1975

[The effect of acetylsalicylic-lysine on platelet function (author's transl)].

Fifteen minutes after the intravenous administration of two different doses of acetylsalicylic lysine, a pronounced inhibition of collagen-induced platelet aggregation was observed in healthy volunteers. A proportionate dose response to the differing doses could not be demonstrated. Platelet function investigated by the glass bead filter method according to Hellem decreased however significantly and dose-dependently after the injections. The clot formation in the thromboelastogram was not disturbed after the administration of the drug in spite of decreased platelet function.

Adult↗