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At least 469 records · Page 26Linked to original sources
PubMed1997

Extension of receiver operating characteristic analysis to data concerning multiple signal detection tasks.

RATIONALE AND OBJECTIVES: When receiver operating characteristic (ROC) studies involve multiple detection tasks in the same patient, the correlations among the within-patient interpretations and the shortage of patients raise several analytic challenges. The authors propose methods for both parametric and nonparametric analysis of this type of data. METHODS: First, they computed one accuracy statistic for each task. Then one jackknife "pseudovalue" was calculated for each task and each patient. Then, they formed a summary index from the accuracy statistics and calculated the standard error of this summary index on the basis of the observed correlations among the jackknife pseudovalues. The method was extended to comparisons of two diagnostic systems and illustrated by using data from a clinical study. RESULTS AND CONCLUSION: This approach can be used with rating or quantitative data and with any index of accuracy, whether calculated parametrically or nonparametrically.

Angiography↗
PubMedDate not supplied

Supramolecular formation of antibodies with viologen dimers: utilization for amplification of methyl viologen detection signals in surface plasmon resonance sensor.

Monoclonal antibodies for 1-(carboxypentyl)-1'-methyl-4,4'-bipyridinium dichloride have been prepared. The complex formation of one of the antibodies, 10D5, with viologen dimer has been studied by a biosensor technique based on surface plasmon resonance. The dissociation constants of the complex between antibody 10D5 and methyl viologen or viologen dimer are found to be (2.0 +/- 0.2) x 10 (-7) and (1.5 +/- 0.5) x 10 (-7) M, respectively. Enhancement of response signal intensities in SPR is observed by the addition of the antibody solution to the viologen dimer-antibody complex indicating the formation of linear supramolecules between the antibody and viologen dimer. Amplification of methyl viologen sensing processes is realized by the inhibition of the complex formation between antibodies and viologen dimer-antibody complexes by methyl viologen and signal enhancement due to the supramolecular formation of the antibody and viologen dimer. The sensitivity in this system is found to be 2 orders larger than that obtained in the simple addition of methyl viologen to the antibody immobilized to the surface of the sensor chip.

Antibodies, Monoclonal↗