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PubMedDate not supplied

Modifications with aging in the role played by vision and proprioception for movement control.

Young and older adults performed manual aiming movements to a visible target for either 40 or 200 trials. Under each level of practice, half of the subjects practiced the task under normal visual conditions (proprioception + vision [PV] condition), whereas the other half were not permitted to see their ongoing movement toward the target (proprioception-only [P] condition). Each acquisition trial was followed with knowledge of results (KR). After the last acquisition trial, all subjects were transferred to a common task in which only the target to be reached was visually available, with no KR. During acquisition, the younger subjects were found to be spatially more accurate than their older counterparts, and this was so regardless of the number of acquisition trials. Withdrawing KR during the transfer test did not modify the spatial accuracy of the subjects who had trained under the P condition. This indicates that the subjects had a reliable reference of the movement to be realized. Withdrawing vision of the moving hand and KR in the transfer test caused a significant increase in spatial error for both the older and the younger subjects. However, the increase in error was less pronounced for the older than for the younger subjects. In fact, the older subjects performed as well in the transfer test as the subjects who had trained in the P condition. This pattern of results suggests that in the transfer test, the older subjects could still guide their movements with the proprioceptive information that was available during both acquisition and transfer. However, such was not the case for the younger subjects. This suggests that, unlike the younger subjects, the older subjects could still rely on the proprioceptive cues available during acquisition in the PV condition. These results are taken to indicate that practicing with numerous sources of afferent information, as was the case in the PV condition, resulted in an integrated reference store for the younger subjects. In contrast, while practicing the task in the PV condition, the older subjects appeared to process independently from each other the different sources of sensory information available.

Adult↗
PubMed1961

Activation of the feeding reflex in Hydra littoralis. I. Role played by reduced glutathione and quantitative assay of the feeding reflex.

A simple and accurate quantitative assay of the glutathione-activated feeding reflex in Hydra is described. The results show: (a) There are a limited number of receptor-effector systems, probably localized in the area immediately around the mouth and on the tentacles. (b) Concentrations of glutathione greater than 5 x 10(-6)M activate all these systems; 10(-5)M glutathione elicits a half-maximum response. (c) Glutathione must be constantly present at the receptor site in order for a response to occur. (d) The response stops in the presence of excess glutathione because of some change within the Hydra, and not as a result of any alteration to the glutathione. The present state of knowledge concerning the mechanism by which glutathione combines with and activates the glutathione receptor to elicit the feeding reflex is summarized.

Animals↗
PubMed2002

Type II alveolar cells play roles in macrophage-mediated host innate resistance to pulmonary mycobacterial infections by producing proinflammatory cytokines.

Roles of type II pneumocytes in macrophage (Mphi)-mediated host resistance to pulmonary Mycobacterium tuberculosis (MTB) and M. avium complex (MAC) infections were studied. Electron microscopy of the lung sections of mice given intratracheal infection indicated that the organisms invaded both Mphis and type II pneumocytes. When Mono-Mac-6 Mphis(MM6-Mphis) and A-549 type II pneumocytes (A-549 cells) were cocultivated, bacterial growth in MM6-Mphis was reduced by A-549 cell-derived soluble factors, indicating the roles of type II pneumocytes in Mphi-mediated host resistance to mycobacteria. MTB- or MAC-infected A-549 cells showed increased mitochondrial RNA expression of cytokines and surfactant proteins (SPs), in the order tumor necrosis factor-alpha (TNF-alpha) > or = granulocyte-Mphi colony-stimulating factor (GM-CSF) > Mphi chemoattractant protein > or = interleukin-8 > SP-D. Anti-TNF-alpha and anti-GM-CSF antibodies attenuated A-549 cell-dependent inhibition of intramacrophage mycobacteria, indicating their crucial roles in A-549 cell-mediated potentiation of Mphi antimycobacterial activity.

Animals↗
PubMed2006

Deficient transendothelial migration of leukocytes in Q fever: the role played by interleukin-10.

Chronic Q fever is characterized by deficient cell-mediated immune response, lack of granulomas, and dysregulation of the cytokine network. Altered transendothelial migration (TM) of peripheral-blood mononuclear cells might account for impaired immune response. TM of lymphocytes and monocytes was decreased in patients with Q fever endocarditis, compared with that in patients recovering from acute Q fever and in control subjects. This defect is related to interleukin (IL)-10, a cytokine involved in the chronic evolution of the disease; neutralizing anti-IL-10 antibodies corrected TM of mononuclear cells from patients with Q fever endocarditis. IL-10 may account for deficient protective immunity in patients with Q fever endocarditis by impairing TM.

Adult↗
PubMed2003

The critical role played by animal source foods in human (Homo) evolution.

Wild primates take most of the daily diet from plant sources, eating moderate to small amounts of animal source foods (ASF). Plant materials make up from 87% to >99% of the annual diet of great apes, the closest living relatives of modern humans (Homo sapiens sapiens). Reflecting their close genetic relationship, gut form and nutrient requirements of apes and humans (Hominoidea) are very similar, as is their pattern of digestive kinetics-one predicated on a relatively slow turnover of ingesta. In plant-eating mammals, in contrast to carnivorous mammals, greater body size is associated with lower dietary quality. Turning to ASF as a routine rather than occasional dietary component would have permitted the evolving human lineage to evade the nutritional constraints placed on body size increases in apes. Without routine access to ASF, it is highly unlikely that evolving humans could have achieved their unusually large and complex brain while simultaneously continuing their evolutionary trajectory as large, active and highly social primates. As human evolution progressed, young children in particular, with their rapidly expanding large brain and high metabolic and nutritional demands relative to adults would have benefited from volumetrically concentrated, high quality foods such as meat. Today, many humans, particularly those in high income nations, have a variety of high quality, non-ASF dietary alternatives, but such foods were not generally available to paleolithic human ancestors nor to many people today in low income nations.

Animals↗
PubMed1997

Effect of 1 Gy X-rays in G1 phase on activation of cell cycle checkpoints in human lymphocytes: role played by chromosomal aberrations.

The effect of X-irradiation (1 Gy) during G1 on the transition from G1 to S and on the length of G2 over cell cycles subsequent to irradiation was studied in human lymphocytes from six different donors. After irradiation a delay was observed in the onset of S phase, as was an extension of the G2 phase lasting throughout the three to four subsequent cell divisions. The extension of G2 and of the cell cycle as a whole is partly related to the presence of chromosome aberrations in the cell. This is demonstrated by: (i) the presence of a larger number of chromosome aberrations in M1 cells corresponding to sampling times longer after that of irradiation; (ii) the presence of a larger number of chromosome aberrations in cells with a longer G2. The most significant chromosome aberrations in this respect are isochromatid fragments. Lastly, we observed that irradiation during G1 activates another checkpoint governing the way mitosis proceeds. This takes the form of an extension of metaphase; in this case also, in some cells, activation of a possible checkpoint during preanaphase seems to be related to the presence of aberrations.

Adult↗
PubMed1994

Possible differences in the regenerative roles played by thioltransferase and thioredoxin for oxidatively damaged proteins.

A possible involvement of thioltransferase (also known as glutaredoxin) in the regenerative reaction of proteins inactivated by oxidative stress were examined in vitro using the enzyme purified from bovine liver. Thioltransferase at physiological concentrations, together with glutathione, glutathione reductase and NADPH, regenerated the oxidatively damaged proteins with a comparable potency to that of thioredoxin. Experiments performed with protein substrates with their critical cysteine residues oxidized differently, that is, phosphofruktokinase and glyceraldehyde 3-phosphate dehydrogenase with mixed disulfide bonds and glyceraldehyde 3-phosphate dehydrogenase with sulfenyl or sulfinyl groups, indicated that thioltransferase regenerated the proteins inactivated by mixed disulfide formation more efficiently than thioredoxin, whereas thioredoxin preferentially regenerated the proteins inactivated by monothiol oxidation to sulfenic or sulfinic acid. These findings suggested that thioltransferase exerted regenerative effects on oxidatively damaged proteins like its cognate protein, thioredoxin, but with different substrate specificity, and their relative contribution to the regeneration reaction is dependent on the form of the oxidized thiols of the damaged proteins.

Glutaredoxins↗