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[Economic evaluation and rationing: is age an adequate criteria?].

Old age is one of the criteria used for priority setting in a context of limited resources and of health care rationing. Rationing on age is supported by the various types of economic analysis. However, economic evaluations have methodological limitations and sometime lead to conclusions that compromise the efficiency objective. In addition, an utilitarist approach is criticized for neglecting the equity objective of the health care system. Age is an imperfect reflect of health status and prognosis at an individual level, which remain difficult to translate into an easily defined criterion for rationing purposes.

Aged↗

A defense of visible health care rationing.

Health care rationing, when defined as resource allocation that makes use of a power relationship, is inescapable in every health care system. Central to this paper is the question: Is visible (publicized and centralized) health care rationing a requirement of justice or an affront to public morality? Inasmuch as health care is a public good, it is argued that health care resources should be visibly rationed in order to satisfy prevailing notions of procedural justice.

Community Participation↗

Health care rationing in the United States: are we there yet?

Given the skyrocketing costs of health care in the United States, some experts propose official health care rationing as a solution to the crisis. Others maintain the position that health care is already being rationed because of cost, and always has been. This paper presents evidence supporting both viewpoints and, by exploring two definitions of "rationing," shows that they are not mutually exclusive. Practical applications to optometry as a health profession are mentioned.

Health Care Costs↗

Rational-emotive therapy: an excellent counseling theory for NPs.

Rational-emotive therapy (RET) is a comprehensive, multimodal, active-directive and relatively brief form of psychotherapy that is particularly suited for use by nurse practitioners. RET theory assumes that people have innate tendencies to think rationally and irrationally; therefore, people have the ability to fulfill and actualize themselves and to easily upset and defeat themselves. The basic tenets of RET help people distinguish between their own rational and irrational beliefs, and their consequent appropriate and inappropriate emotions and behaviors. Many cognitive, emotive and behavioral methods are used to help clients minimize their symptoms of anxiety, depression, self-hatred and rage. Nurse practitioners using RET can help their clients make profound philosophic changes that prevent future emotional problems and encourage maximum health and self-actualization.

Counseling↗

Rationing of health care in medicine.

A conference on 'Rationing of health care in medicine' was organised by the Royal College of Physicians and the Institute of Health Services Management on 11 November 1992. In his opening remarks the President, Professor Leslie Turnberg, declared it an opportune time to be hosting a conference on such a topical subject. Rationing of health services exists; the challenge is to find how to do it rationally.

Health Care Rationing↗

Rationing the public's health and the optometric agenda.

BACKGROUND: Universal access to health care at an affordable price is a major issue on the current agenda of the nation's legislative, corporate and health care decision makers. METHODS: The current literature and prevailing ideologies on health service rationing and health care reform were reviewed and evaluated in the context of optometric practice. RESULTS AND CONCLUSION: The socio-political nature of the decision making process may lead to recommendations for reforms and market interventions that contravene the agenda of health care providers. To maintain quality of care and contain costs, and as a basis for allocation, judgments must be made about the value of specific services. Some services may be rationed according to the ratio of benefit to cost and their perceived net value to society. If rationing prevails, optometric services will be included in the process of prioritization and allocation.

Economic Competition↗

Rationing health care. Impact on critical care.

Critical care practitioners are faced with ethical dilemmas every day. The increasing costs of health care coupled with the scarcity of resources, including critical care nurses, have created yet another ethical dilemma--rationing of health care. Rationing of critical care is occurring today and current conditions indicate that these decisions will become an increasing issue in the delivery of critical care services. This article identifies some of the ethical issues associated with the rationing of critical care and examines the foundations of ethical thought upon which such decisions can be based. Understanding the overall cost containment movement as well as the potential problems associated with medical gatekeeping will allow critical care practitioners to better deal with the ethical dilemmas of today as well as help them anticipate those that will arise in the near future.

Cost Control↗

Rationing surgery: rules or constraints?

BACKGROUND: As U.S. health care expenditures climb, the need to set limits on surgery is becoming more generally accepted. If limits are necessary, how should they be established and by whom? This article considers two fundamental approaches, rules and constraints. RESULTS: With rules, payers or policymakers ration care by prioritizing and then restricting specific procedures. Although they have the advantage of explicitness, rules based on treatment prioritization are limited by patient heterogeneity and the lack of outcomes data necessary to rank many procedures. Rules are unambiguous and free the surgeon from the obligation to set limits, but they do not accommodate clinical judgment or patient preferences. With constraints, limits are set on surgical resources (e.g., the number and distribution of surgeons), but individual surgeons determine which procedures are provided to which patients. Although constraints are more feasible than rules, it is difficult to establish an "adequate" supply of surgical resources and to ensure that limits set by the individual surgeon are based on treatment efficacy. While preserving clinical autonomy, constraints require the surgeon to assume the responsibility of rationing care. CONCLUSIONS: Surgeons should consider carefully the approach to rationing that best serves their professional interests, their patients, and society.

Ethical Theory↗

Neuropsychologic predictors of competency in Alzheimer's disease using a rational reasons legal standard.

OBJECTIVE: To identify neuropsychologic predictors of competency performance and status in Alzheimer's disease (AD) using a specific legal standard (LS). This study is a follow-up to the competency assessment research reported in this issue of the archives. DESIGN: Univariate and multivariate analyses of independent neuropsychologic test measures with a dependent measure of competency to consent to treatment. SETTING: University medical center. SUBJECTS: Fifteen normal older control subjects and 29 patients with probable AD. MAIN OUTCOME MEASURES: Subjects were administered a battery of neuropsychologic measures theoretically linked to competency function, as well as two clinical vignettes testing their capacity to consent to medical treatment under five different LSs. The present study focused on one specific LS: the capacity to provide "rational reasons" for a treatment choice (LS4). Neuropsychologic test scores were correlated with scores on LS4 for the normal control group and the AD group. The resulting univariate predictors were then analyzed using stepwise regression and discriminant function to identify the key multivariate predictors of competency performance and status under LS4. RESULTS: Measures of word fluency predicted the LS4 scores of controls (R2 = .33) and the AD group (R2 = .36). A word fluency measure also emerged as the best single predictor of competency status for the full subject sample (n = 44), correctly classifying 82% of cases. Dementia severity (Mini-Mental State Examination score) did not emerge as a multivariate predictor of competency performance or status. Interestingly, measures of verbal reasoning and memory were not strongly associated with LS4. CONCLUSIONS: Word fluency measures predicted the normative performance and intact competency status of older control subjects and the declining performance and compromised competency status of patients with AD on a "rational reasons" standard of competency to consent to treatment. Cognitive capacities related to frontal lobe function appear to underlie the capacity to formulate rational reasons for a treatment choice. Neuropsychologic studies of competency function have important theoretical and clinical value.

Aged↗

Reliability and validity of the Rational Behavior Inventory with a clinical population.

Administered to mental health outpatients (N = 75) who were receiving Psychotherapy the Rational Behavior Inventory as well as several other scales of psychological adjustment prior to their first therapy session. Their therapists also completed several of these scales on their clients. This procedure was repeated for a subsample upon termination of treatment. Correlations were computed among measures, and t-tests were conducted between pre- and posttreatment scores. Significant correlations were found between all measures in the expected directions, and significant pre- to post-scale differences were identified consistent with the expected effects of treatment. These results are interpreted as initial evidence for the Rational Behavior Inventory's reliability and validity with a clinical group. Future research is suggested to examine the Rational Behavior Inventory's relationship to other measures of cognitive dysfunction.

Adaptation, Psychological↗

Conformationally constrained CCK8 analogues obtained from a rationally designed peptide library as ligands for cholecystokinin type B receptor.

A library of 14 cyclic peptide analogues derived from the octapeptide C-terminal sequence of the human cholecystokinin hormone (CCK(26-33), or CCK8) was designed, synthesized, and characterized. The 14 peptide analogues were rationally designed to specifically interact with the CCK type B receptor (CCK(B)-R) on the basis of the structure of the bimolecular complex between CCK8 and the third extracellular loop of CCK(B)-R, namely CCK(B)-R(352-379). The rational design of new ligands for CCK(B)-R has relied on stabilization by cyclic constraints of the structural motifs that bring the key residues of the ligand (especially Trp 30, Met 31, and Phe 33) in the proper spatial orientation for optimal interaction with the receptor. The binding affinity of the new ligands for CCK(B)-R was assessed by displacement experiments of (111)In-radiolabeled CCK8 in cells that overexpress the CCK(B) receptor. The new ligands generally showed binding affinities lower than that of parent CCK8, with the best compounds having IC50 values around 10 microM. Structure-activity relationship data show that preservation of the Trp 30-Met 31 motif is essential and that the Phe 33 side chain must be present. NMR conformational studies of the compound with maximal binding affinity (cyclo-B11, IC50=11 microM) in DPC micelles shows that this compound presents a turn-like conformation centered at the Trp 30-Met 31 segment, as planned by rational design. Such a conformation is stabilized by its interaction with the micelle rather than by the cyclic constraint.

Cholecystokinin↗

[The effect of solids from pig manure as food components in rations for fat bulls, heifers and calves on the crude nutrient and amino acid content of the longissimus dorsi muscle].

In continuation of our studies on the use of pig manure in ruminant feeding, the present paper is concerned with the investigation of the effects of solids from semi-liquid pig manure as ration components on the crude nutrient and amino-acid contents of the longissimus dorsi muscles of bulls, heifers and calves from experimental and control groups each including 6 animals. There was no difference in the crude protein, pure protein and crude ash contents between the control and the experimental groups. On the contrary, the data on dry matter and crude fat in the longissimus dorsi muscle were significantly lower in the experimental animals than in the control animals. This difference is explained by the fact that the energy content of the experimental ration (containing solids from semi-liquid pig manure) is lower than that of the standard ration. The results obtained from the analysis for 17 amino acids show that the change in amino-acid content of the muscle protein is not determined by the use of solids from semi-liquid pig manure.

Amino Acids↗

Testing the utility of rationally engineered recombinant collagen-like proteins for applications in tissue engineering.

Collagens are attractive proteins as materials for tissue engineering. Over the last decade, significant progress has been made in developing technologies for large-scale production of native-like human recombinant collagens. Yet, the rational design of customized collagen-like proteins for smart biomaterials to enhance the quality of engineered tissues has not been explored. We mapped the D4 domain of human collagen II as most critical for supporting migration of chondrocytes and used this information to genetically engineer a collagen-like protein consisting of tandem repeats of the D4 domain (mD4 collagen). This novel collagen has been utilized to fabricate a scaffold for support of chondrocytes. We determined superior qualities of cartilaginous constructs created by chondrocytes cultured in scaffolds containing the mD4 collagen in comparison to those formed by chondrocytes cultured in bare scaffolds or those coated with wild-type collagen II. Our results are a first attempt to rationally engineer collagen-like proteins with characteristics tailored for specific needs of cartilage engineering and provide a basis for rational engineering of similar proteins for a variety of biomedical applications.

Cartilage↗

Semantic Domains of Rational Numbers and the Acquisition of Fraction Equivalence.

This study examined how the semantic meanings of rational numbers embodied in graphical representations pose a constraint on children's construction of the concept of fraction equivalence. A test consisting of graphical representations representing the part-whole and measuring semantic meaning was given to 205 fifth-graders and 208 sixth-graders from China. Results showed that the fifth-graders' overall performance on equivalent fraction items was poor across the semantic domains of rational numbers. The sixth-graders showed significantly improved performance on the equivalent fraction items representing the part-whole relation but not on those representing the measure aspect of rational number. The results provide evidence that semantic meanings of fractional numbers in different relevant contexts also constitute a source of difficulty in children's constructing the concept of fraction equivalence, in addition to the multiplicative nature of the concept. Copyright 2001 Academic Press.

Journal Article↗

Complex niches favour rational species.

On the whole living things evolve from simpler to more complex forms, though not undirectionally. The evolution of more complex species makes the environment more complex and also makes the evolution of even more complex species possible and more selectable. With the evolution of sentients, species can be classified according to their degree of rationality. A more rational species is one whose behaviour (i.e. of its individual members) is controlled (relatively) more by the reward-penalty system than by the automatic, inflexible, programmed responses. In two reasonable simple models, it is shown that a more complex environment favours the evolution of more rational species. This result partly explains the dramatic speed of evolution based mainly on random mutation and natural selection, a speed doubted by creationists.

Animals↗

When rational men fall sick: an inquiry into some assumptions made by medical anthropologists.

Medical anthropologist spend most of their time eliciting and interpreting people's statements about sickness and health. For this task, they make certain assumptions about the importance of language and reason. In this paper I argue that their assumptions are tailored to fit an hypothetical Rational Man rather than real people. The concept of 'explanatory models of sickness' is used to illustrate this point. My critique begins by drawing attention to two non-cognitive determinants of people's statements: their degree of emotional arousal and their capacities for discoursing on medical subjects. These determinants are briefly discussed and then set aside, to make room for the paper's argument proper. This starts with the observation that medical anthropologists tend to overlook the fact that they have established a cognitive no man's land stretching between their informants' statements and the cognitive structures which are supposed to generate these statements. I survey this void, using a five-fold model of medical knowledge. People use one kind of knowledge to organize their medical experiences and perceptions. In Rational Man writing, this form of knowledge is considered equivalent to cognitive structures (e.g., causal models, classificatory schemes), but I argue that is also includes knowledge of prototypical sickness events and knowledge that is embedded in actions, social relations, and material equipment. The theoretical implications of the five-fold model are outlined. This is followed by an analysis of the reasoning processes in which people use medical knowledge to produce the statements whose meaning we wish to learn. I demonstrate the importance of being able to distinguish operational and monothetic forms of reasoning from pre-operational and polythetic ones. Rational Man writers are described as ignoring the latter pair. The concept of 'prototypes' is reintroduced to illustrate these points.

Adaptation, Psychological↗

The behavioural and welfare implications of housing demand under rationing. The United Kingdom experience.

"The present study investigates, on pooled budget data (1968/1985) from United Kingdom Family Expenditure Surveys, the consequences of relaxing the assumption of free choice in housing, while continuing to maintain the assumption of unrationed demand for other items. Since the demand equations are estimated jointly as a system, introducing rationed demand for one item will have consequences for the other demand equations. We investigate the nature and magnitude of such changes using the framework of a general demographic demand system that allows for non-linear/non-separable commodity demand behaviour and also permits the equivalence scales to vary between the rationed and unrationed items." The author finds that "unlike in previous studies, the rationed demand system fails to reject linear preferences."

Demography↗

Economic impact of a rational use of antibiotics in intensive care.

OBJECTIVE: To evaluate the economic impact of a rational policy in antibiotic treatment. DESIGN: Comparative study with a retrospective and a prospective part. SETTING: An 11-bed intensive care unit (ICU) in a general hospital. PATIENTS: All patients admitted to the unit in 1994, 1995 and 1996. INTERVENTIONS: In 1995, a program of cost control was started and a contract of agreed objectives signed with the director of the hospital. This contract included a commitment to refund the eventual savings in order to improve the quality of care. Prescribing protocols were established by consensus as guidelines for a rational policy in antibiotic therapy. MEASUREMENTS AND RESULTS: The cost of antibiotic therapy, the patients' characteristics and the incidence of nosocomial infection were compared prior to and during the program. The expenses for antibiotic drugs decreased by 19% in 1995 and by 22% in 1996. Most of the savings were refunded to the ICU and contributed to the employment of an additional nurse and the purchase of new material. In number of patients, type of disease, mean age, Simplified Acute Physiology Score, occupancy rate, length of stay, omega score, artificial ventilation, readmission within 7 days, mortality and incidence of nosocomial infection, no significant difference was found. CONCLUSIONS: We proved a positive economic impact of a rational policy in antibiotic therapy realized with a contract of agreed objectives. The savings made while applying our program of cost control were used to improve the quality of care.

Anti-Bacterial Agents↗