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At least 469 records · Page 26Linked to original sources
PubMed2003

Environmental and demographic risk factors for respiratory syncytial virus lower respiratory tract disease.

OBJECTIVE: To critically review the literature examining risk factors for development of severe respiratory syncytial virus lower respiratory tract infection (RSV LRI). STUDY DESIGN: A literature review was performed with the use of a MedLine search strategy. Clinical evidence of putative risk factors was rated by means of the US Preventive Services Task Force recommendations, and the quality of the data was critically assessed. Nonmedical risk factors examined included race/ethnicity, age of acquisition of RSV, sex, birth during the first half of the RSV season, breast-feeding, malnutrition, maternal education, socioeconomic status, crowding/siblings, day care, and tobacco smoke exposure. RESULTS: There was sufficient evidence available to conclude that (1) male sex, (2) age <6 months, (3) birth during the first half of the RSV season, (4) crowding/siblings, and (5) day care exposure are significant risk factors for severe RSV LRI. There was insufficient evidence to evaluate the effect of race/ethnicity on severe RSV LRI. The evidence for tobacco smoke exposure is mixed. Low maternal education (as a proxy for lower socioeconomic status), lack of breast-feeding, and malnutrition did not appear to increase the risk of severe RSV LRI or RSV hospitalization. CONCLUSIONS: Male sex, young age, birth in the first half of the RSV season, day care attendance, and crowding/siblings are independent risk factors for the development of severe RSV LRI.

Breast Feeding↗
PubMedDate not supplied

[Role of polymorphic variants of cytochrome P450 genes (CYP1A1, CYP2E1) and microsomal epoxide hydrolase (mEPHX) in pathogenesis of cystic fibrosis and chronic respiratory tract diseases].

Frequencies of CYP1A1, CYP2E1, and mEPHX polymorphic variants were analyzed in cystic fibrosis, chronic obstructive lung disease, bronchiectatic disease, chronic nonobstructive bronchitis, and recurring bronchitis. Mutations in CYP1A1 and mEPHX were shown to modify the severity of respiratory disorders in cystic fibrosis, the combination of CYP1A1 genotype Val/Val with the "very slow" mEPHX phenotype being most unfavorable (odds ratio OR = 12.30). Heterozygosity at both CYP1A1 and CYP2E1 was associated with chronic obstructive lung disease and recurring bronchitis (OR = 4.08 and 11.72, respectively). The "very slow" phenotype of mEPHX was predisposing to chronic respiratory disorders regardless of the CYP1A1 or CYP2E1 alleles (OR = 4.06). Basing on the above correlations, a combination of the "very slow" mEPHX phenotype with elevated cytochrome P450 (CYP1A1 and CYP2E1) activities was assumed to expedite severe respiratory disorders.

Chronic Disease↗
PubMed1998

Effects of tilmicosin on acute undifferentiated respiratory tract disease in newly arrived feedlot cattle.

OBJECTIVES: To evaluate effects of tilmicosin when used in fever-based and metaphylactic treatment programs to attenuate acute undifferentiated bovine respiratory disease (BRD) in cattle that recently arrived at feedlots, and to evaluate the effects of tilmicosin for the treatment of BRD. DESIGN: Randomized-block controlled study. ANIMALS: 1,639 calves from livestock auctions. PROCEDURES: Cattle were assigned to 3 groups. Cattle in the nonmedicated (control) group were not given antibiotics during processing. Cattle in the fever-based treatment group were given tilmicosin (10 mg/kg [4.5 mg/lb] of body weight, s.c.) during processing when their rectal temperature was > or = 40 C (104 F). All cattle in the metaphylactic treatment group were given tilmicosin (10 mg/kg, s.c.) during processing. Calves with BRD were treated with tilmicosin (10 mg/kg, s.c.). RESULTS: Morbidity rates in the metaphylactic (30.4%) and fever-based (44.7%) treatment groups were less than that for the nonmedicated group (54.8%). Mortality rate for the metaphylactic group during the first 28 days (1.1%) and during the entire study (1.7%) was less than that for the nonmedicated group (3.3 and 4.6%, respectively). Differences were not observed in therapeutic response rates among calves with BRD that were treated. CLINICAL IMPLICATIONS: Fever-based and metaphylactic treatment programs that used tilmicosin decreased the prevalence of BRD and improved growth of calves. Metaphylactic treatment decreased the number of fatalities caused by BRD in high-risk calves. Fever-based treatment was less effective than metaphylactic treatment for decreasing the prevalence of BRD in newly arrived cattle.

Acute Disease↗
PubMed2002

[Lung function and respiratory tract disease among stonewool factory workers].

INTRODUCTION: We examined the respiratory health of a Danish workforce exposed to man-made vitreous fibres (MMVF) during production. MATERIAL AND METHODS: Workers with more than five years' occupational exposure to MMVF (n = 377) were compared to a group without MMVF exposure (n = 381). Respiratory health was assessed by questionnaire, dynamic spirometry, and measurement of transfer factor. The overall response rate was 63%. A sample of non-responders was assessed by questionnaire and spirometry. RESULTS: On most spirometric indices, the two groups had comparable values. However, a larger proportion (14.5%) of the exposed subjects had an obstructive flow pattern than the controls (5.3%). Subgroup analyses showed that the elevated risk of airway obstruction associated with exposure was confined to heavy smokers. Transfer factor and prevalences of symptoms and self-reported disease were similar in the two groups. DISCUSSION: There is no indication of excess risk of lung fibrosis. However, a number of exposed workers have some degree of airflow obstruction, which cannot be explained by known confounders. An additive or synergistic action between smoking and fibre exposure on airflow obstruction can be speculated.

Adult↗