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At least 469 records · Page 26Linked to original sources
PubMed1989

Painting group portraits: studying life outcomes for aggressive and withdrawn children.

Aggression and social withdrawal have long been of interest to personality psychologists. The present article presents a longitudinal study of the development of children selected from a community sample who were high on aggression and withdrawal. The selection of outcome variables is discussed, and outcomes during adolescence are described. For both males and females, high aggressiveness was predictive of low intelligence, poor school achievement, and psychiatric problems. For females, high aggressiveness was also predictive of general health problems. High social withdrawal was predictive of poor school achievement. Females who were high on withdrawal also had an elevated rate of abortions. Individuals who were high on both aggression and withdrawal had relatively poor social competence, had general problems with behavior, had low intelligence, and were performing poorly in school.

Adaptation, Psychological↗
PubMed2006

Mitochondrial DNA portrait of Latvians: towards the understanding of the genetic structure of Baltic-speaking populations.

Mitochondrial DNA (mtDNA) variation was investigated in a sample of 299 Latvians, a Baltic-speaking population from Eastern Europe. Sequencing of the first hypervariable segment (HVS-I) in combination with analysis of informative coding region markers revealed that the vast majority of observed mtDNAs belong to haplogroups (hgs) common to most European populations. Analysis of the spatial distribution of mtDNA haplotypes found in Latvians, as well as in Baltic-speaking populations in general, revealed that they share haplotypes with all neighbouring populations irrespective of their linguistic affiliation. Hence, the results of our mtDNA analysis show that the previously described sharp difference between the Y-chromosomal hg N3 distribution in the paternally inherited gene pool of Baltic-speaking populations and of other European Indo-European speakers does not have a corresponding maternal counterpart.

Baltic States↗
PubMedDate not supplied

Portrait of a newborn.

To discover whether the American woman has a preconceived idea of her newborn's appearance, ten primigravidas were asked to draw their newborns-to-be and were interviewed about their expectations. Responses were analyzed for recurring themes and compared with a stereotypical baby described by Lorenz. The informants' general descriptions of their newborns-to-be were specific to the particular family. The newborns were closer in appearance to an older baby than to a newborn. The informants' newborns had two of the Lorenz's six stereotypical attributes.

Female↗
PubMed1998

The serine, threonine, and/or tyrosine-specific protein kinases and protein phosphatases of prokaryotic organisms: a family portrait.

Inspection of the genomes for the bacteria Bacillus subtilis 168, Borrelia burgdorferi B31, Escherichia coli K-12, Haemophilus influenzae KW20, Helicobacter pylori 26695, Mycoplasma genitalium G-37, and Synechocystis sp PCC 6803 and for the archaeons Archaeoglobus fulgidus VC-16 DSM4304, Methanobacterium thermoautotrophicum delta H, and Methanococcus jannaschii DSM2661 revealed that each contains at least one ORF whose predicted product displays sequence features characteristic of eukaryote-like protein-serine/threonine/tyrosine kinases and protein-serine/threonine/tyrosine phosphatases. Orthologs for all four major protein phosphatase families (PPP, PPM, conventional PTP, and low molecular weight PTP) were present in the bacteria surveyed, but not all strains contained all types. The three archaeons surveyed lacked recognizable homologs of the PPM family of eukaryotic protein-serine/threonine phosphatases; and only two prokaryotes were found to contain ORFs for potential phosphatases from all four major families. Intriguingly, our searches revealed a potential ancestral link between the catalytic subunits of microbial arsenate reductases and the protein-tyrosine phosphatases; they share similar ligands (arsenate versus phosphate) and features of their catalytic mechanism (formation of arseno-versus phospho-cysteinyl intermediates). It appears that all prokaryotic organisms, at one time, contained the genetic information necessary to construct protein phosphorylation-dephosphorylation networks that target serine, threonine, and/or tyrosine residues on proteins. However, the potential for functional redundancy among the four protein phosphatase families has led many prokaryotic organisms to discard one, two, or three of the four.

Amino Acid Sequence↗
PubMed1985

A qualitative dynamic analysis of reiterant speech production: phase portraits, kinematics, and dynamic modeling.

The departure point of the present paper is our effort to characterize and understand the spatiotemporal structure of articulatory patterns in speech. To do so, we removed segmental variation as much as possible while retaining the spoken act's stress and prosodic structure. Subjects produced two sentences from the "rainbow passage" using reiterant speech in which normal syllables were replaced by /ba/ or /ma/. This task was performed at two self-selected rates, conversational and fast. Infrared LEDs were placed on the jaw and lips and monitored using a modified SELSPOT optical tracking system. As expected, when pauses marking major syntactic boundaries were removed, a high degree of rhythmicity within rate was observed, characterized by well-defined periodicities and small coefficients of variation. When articulatory gestures were examined geometrically on the phase plane, the trajectories revealed a scaling relation between a gesture's peak velocity and displacement. Further quantitative analysis of articulator movement as a function of stress and speaking rate was indicative of a language-modulated dynamical system with linear stiffness and equilibrium (or rest) position as key control parameters. Preliminary modeling was consonant with this dynamical perspective which, importantly, does not require that time per se be a controlled variable.

Female↗
PubMed2003

Portrait of a killer: the mitochondrial apoptosome emerges from the shadows.

Apoptosis (programmed cell death) is a physiological process used to eliminate superfluous, damaged, infected, or aged cells in multicellular organisms. During apoptosis the cellular architecture is dismantled from within in a highly controlled fashion. Members of the caspase family of cysteine proteases are responsible for the destructive phase of apoptosis. One major pathway to caspase activation involves the formation of a multisubunit protease activation complex called the apoptosome. The apoptosome is assembled in response to signals that provoke mitochondrial outer membrane permeabilization and the release of cytochrome c into the cytosol. Recent studies indicate that the apoptosome is a wheel-like structure consisting of seven molecules of Apaf-1 and a similar number of caspase-9 dimers. Knowledge of the structure of the apoptosome will likely lead to the design of therapeutic modulators of apoptosis.

Apoptosis↗
PubMed2001

A portrait of Alzheimer secretases--new features and familiar faces.

The amyloid beta-peptide (Abeta) is a principal component of the cerebral plaques found in the brains of patients with Alzeheimer's disease (AD). This insoluble 40- to 42-amino acid peptide is formed by the cleavage of the Abeta precursor protein (APP). The three proteases that cleave APP, alpha-, beta-, and gamma-secretases, have been implicated in the etiology of AD. beta-Secretase is a membrane-anchored protein with clear homology to soluble aspartyl proteases, and alpha-secretase displays characteristics of certain membrane-tethered metalloproteases. gamma-Secretase is apparently an oligomeric complex that includes the presenilins, which may be the catalytic component of this protease. Identification of the alpha-, beta-, and gamma-secretases provides potential targets for designing new drugs to treat AD.

ADAM Proteins↗
PubMed2002

Portraits of science. "The most versatile physicist of his generation".

P. M. S. Blackett (1897-1974) entered Cambridge University and the Cavendish Laboratory as a young veteran of the first world war. His innovative research with the Wilson cloud chamber resulted in photographic evidence of nuclear transformation and the existence of the positron. In the 1950s and 1960s, he helped to pioneer the use of paleomagnetic evidence in support of the theory of continental drift. A leader of operational research during the second world war, Blackett became an outspoken critic in the postwar period of American atomic policy and British development of nuclear weapons, taking on a public role for which he was sometimes criticized.

Journal Article↗