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Evidence of poxvirus in dusky dolphin (Lagenorhynchus obscurus) and Burmeister's porpoise (Phocoena spinipinnis) from coastal Peru.

In 1990, 74 dusky dolphins (Lagenorhynchus obscurus) and 10 Burmeister's porpoises (Phocoena spinipinnis) were examined for the presence of hyperpigmented marks and pinhole lesions on the skin (tattoo lesions) at the fishing terminal of Pucusana, central Peru. Prevalences of tattoo lesions were 8.1% and 30% in the dolphins and porpoises, respectively. Intracytoplasmic poxviruses were demonstrated by transmission electron microscopy in ultrathin sections of three of eight samples of infected epidermis from both species. The reason for the negative results in others is unclear but may be related to stages of infection with low virus density or even incorrect classification of some lesions as genuine viral tattoos. An irregular arrangement of tubules on the outer viral membrane, similar to those in orthopoxviruses, was visible in negative contrast preparations for P. spinipinnis. This is the first record of poxvirus in porpoises (Phocoenidae) and also the first report for dusky dolphins, and generally for cetaceans of the southern hemisphere.

Animals↗

A survey for selected viral, chlamydial, and parasitic diseases in wild dusky-headed parakeets (Aratinga weddellii) and tui parakeets (Brotogeris sanctithomae) in Peru.

Thirty-eight free-ranging dusky-headed parakeets (Aratinga weddellii) and 13 tui parakeets (Brotogeris sanctithomae) were caught and released in Parque Nacional del Manu in southeastern Peru from 19 July to 5 August 1993. Blood and fecal samples were collected and sera were evaluated for titers to Pacheco's disease herpesvirus, psittacine polyomavirus, paramyxovirus-1, and Chlamydia psittaci. Fecal samples were examined for evidence of ascarid or coccidial infection by fecal flotation, and blood smears were examined for hemoparasites. Five (50%) of 10 A. weddellii serum samples tested by complement fixation (CF) for psittacine polyomavirus antibodies were positive, and three (19%) of 16 A. weddellii samples tested by virus neutralization (VN) for psittacine polyomavirus antibodies were positive, yielding a total of 8 (38%) of the 21 A. weddellii samples positive for psittacine polyomavirus. Based on CF for herpesvirus, four (11%) of 38 A. weddellii samples had antibodies against herpesvirus. All B. sanctithomae were negative for psittacine polyomavirus and psittacine herpesvirus. Thirty-five of the A. weddellii tested were negative for Chlamydia psittaci by CF, latex agglutination, and elementary body agglutination, and all B. sanctithomae were negative for Chlamydia psittaci by the CF test. Nine A. weddellii and eight B. sanctithomae evaluated for paramyxovirus-1 titers by the hemagglutination inhibition test were negative. All fecal samples were negative for ascarids or coccidia by fecal flotation, and all blood smears were negative for hemoparasites by direct microscopic examination. This is the first known description of psittacine polyomavirus and psittacine herpesvirus in free-ranging parrots. Serologic evidence of Pacheco's disease herpesvirus in wild A. weddellii is interesting in light of the fact that Aratinga spp. are considered to be possible carriers of this virus in captivity.

Animals↗

Rapid and inexpensive approaches to managing abnormal vaginal discharge or lower abdominal pain: an evaluation in women attending gynaecology and family planning clinics in Peru.

OBJECTIVES: To assess low abdominal pain, yellow vaginal discharge, other symptoms and signs, and demographic and behavioural variables as predictors for cervical or vaginal infection. METHODS: A cross sectional study of women attending gynaecology and family planning clinics in Lima, Peru was undertaken. 630 consecutive eligible female patients with chief or elicited complaints of yellow vaginal discharge, low abdominal pain, or both were interviewed and examined, together with a comparable reference group without these complaints. Vaginal specimens were tested for trichomoniasis and bacterial vaginosis. Endocervical specimens were tested for Neisseria gonorrhoeae and Chlamydia trachomatis using the ligase chain reaction. RESULTS: Infections found included chlamydial infection in 69 women (10.9%), gonorrhoea in 10 (1.6%), and either infection in 77 (12.2%); trichomoniasis in 46 (7.3%), bacterial vaginosis in 189 (30%), and either infection in 209 (33.2%). Cervical infection with C trachomatis and/or N gonorrhoeae was independently associated with history of a new sex partner within the last 3 months, more than one sex partner within the last year, use of condoms never or in less than 50% of sex acts, history of sex partner with STD within the last year; with symptoms of persistent low abdominal pain and of yellow vaginal discharge; and with signs of profuse and yellow vaginal discharge, cervical ectopy, easily induced endocervical bleeding, or brown cervical secretion. Using these findings, an algorithm was created that had a positive predictive value (PPV) of 36% for cervical infection among women reporting chief or elicited complaint of this abnormal vaginal discharge and a PPV of 25% among those without a complaint. A chief complaint of yellow vaginal discharge had a PPV of 50% for trichomoniasis or bacterial vaginosis. Among women without a chief complaint of yellow vaginal discharge, clinical findings of yellow vaginal discharge had a PPV of 55%. CONCLUSIONS: Where economic and technical constraints preclude testing, clinical findings and risk assessment are helpful in detecting vaginal and cervical infections. Several demographic, behavioural, clinical, and laboratory variables were predictive of infection in this population.

Abdominal Pain↗

Utilization of maternal health-care services in Peru: the role of women's education.

This article explores the hypothesis that formal education of women influences the use of maternal health-care services in Peru, net of the mother's childhood place of residence, household socioeconomic status and access to health-care services. The findings are consistent with the hypothesis; both cross-sectional and fixed-effects logit models yield quantitatively important and statistically reliable estimates of the positive effect of maternal schooling on the use of prenatal care and delivery assistance. In addition, large differentials were found in the utilization of maternal health-care services by place of residence, suggesting that much greater efforts on the part of the government are required if modern maternal health-care services are to reach women in rural areas.

Adult↗

[Characterization of a novel wild-type t(wMPI) haplotype of the house mouse (Mus domesticus L.) from Peru].

Data on molecular genetic analysis of the novel wild-type twMP1 haplotype found in a population of Mus domesticus from Peru are presented. Complementation attribution of the novel haplotype as well as fertility of heterozygotes and transmission ratio distortion (TRD) of the t-carrying chromosome in the progeny of the heterozygous males were studied. Molecular analysis was carried out by means of blot hybridization with the four t-specific probes (Tu48, Tu66, Tu119, and Tu122). Comparison of the results obtained with the data on the structure and properties of the t complexes permitted conclusion on the complete lethality of the haplotype described.

Animals↗

Measles epidemiology and outbreak response immunization in a rural community in Peru.

Only limited data are available on the impact of measles outbreak response immunization (ORI) in developing countries. We conducted a community survey in Espindola, a rural border community in northern Peru, following a measles outbreak and subsequent ORI to study the epidemiology and impact of the outbreak and to evaluate the costs and benefits of measles ORI. During the outbreak, 150 of the 553 Espindola residents developed clinical cases of measles. Adults accounted for 44.0% of cases, and were frequently identified as primary cases. The attack rate among all susceptible people was 45.5% and was highest (61.2%) for the 16-20 year age group. Among adults, significant risk factors for developing measles included being aged 16-20 years (relative risk [RR] = 3.06, 95% CI = 2.08, 4.49) and being male (RR = 1.73, 95% CI = 1.11, 2.71). Among serologically confirmed cases, 60.7% developed diarrhoea and 32.1% pneumonia. The overall case-fatality rate was 3.3%, but reached 19.1% in the 0-23-month age group. Failure to reach children through either routine immunization or national campaigns made this community vulnerable to the severe and extensive impact of measles virus importation. The ORI campaign targeted non-measles case children aged 6 months to 15 years, regardless of their previous immunization status, and was effective in terminating this measles outbreak and in preventing morbidity, loss of livelihood and death despite the involvement of large numbers of adults in measles transmission. The last measles case occurred within 3 weeks of completing ORI. The ORI campaign, which would have cost approximately US$ 3000 in 1998, saved as many as 1155 person-days of work among 77 adults, prevented an estimated 87 cases of diarrhoea and 46 cases of pneumonia, and averted 5 deaths.

Adolescent↗

Polaroid imaging at an archaeological site in Peru.

This article describes the use of Polaroid photography as an adjunct to conventional radiography at a remote archaeological site in northern Peru. The Polaroid system provided several important benefits, including the ability to produce images in 90 seconds without a darkroom or wet processing. This enabled researchers to examine specimens ad hoc, test exposures in the field and determine the most appropriate position to demonstrate internal structures.

Age Determination by Skeleton↗

[Becker's myotonia in Peru].

INTRODUCTION: The word myotonia was used for the first time by Strümpell in 1891. Diseases associated with this symptom are called myotonias. They are classified on the basis of their clinical features in: congenita myotonia, paramyotonia congenita, myotonic dystrophy and Schwartz-Jampel syndrome. Becker's myotonia is a generalized congenita nondystrophic myotonia transmitted as an autosomal recessive trait and caused by allelic mutation of the gene encoding the chloride channel CLC-1 of the skeletal muscle fiber surface membrane, localized on chromosome 7q35. At the present time, nondystrophic myotonias are referred as channelopathies. CLINICAL CASE: We describe a case of generalized myotonia in a Peruvian young male, descending of Europeans, without familial history. CONCLUSIONS: We discuss his clinical symptoms, laboratory and electrophysiologic findings, differential diagnosis, and response to the treatment with carbamazepine. We report the first case of Becker's myotonia in Peru.

Adolescent↗

[Nurses' work in Peru: origin and social conditions].

The study aimed at reviewing the history of the genesis and social formation of nurses work in Peru in order to understand it according to women's social situation in the context of a masculine society organized under capitalism. Thus, nursing formation was influenced by the Nightingale School and the exercise of the Peruvian nurses was characterized by the reproduction of social functions that are historically feminine, with a knowledge and practice subordinated to medical knowledge, that is mainly directed by a masculine ideology.

Female↗

[Clinical and genetic studies of a family from Peru affected by spinocerebellar ataxia type 7].

INTRODUCTION: Recently the clinical and genetic investigation of cerebellar diseases has experienced an extraordinary advance due to localization of the disorders in different chromosomal loci. This type of investigation has been done in Peru in the last decade, studying a Peruvian family from the Huarochiri province. PATIENTS AND METHODS: A Peruvian family of 65 individuals in five generations, affected by several neurological disturbances associated with ataxia, were studied by clinical, neurological, ophthalmological, neuroradiological and genetic methods. The genetic study was done in the neurogenetics laboratory of the University of Utah (Salt Lake City, United States). RESULTS: The patients showed equilibrium disturbances, gait difficulties, ophthalmoplegia, corticospinal signs, cognitive deficiencies, visual weakness, maculopathy, retinal degeneration, optic nerve atrophy and atrophy of the cerebellum, brain stem and cerebral hemispheres. The DNA in 30 individuals showed, in the neurologically affected, repeated expansion of CAG triplets in the short arm of chromosome 3p. CONCLUSIONS: The findings in this family suggests that they suffer from spinocerebellar ataxia type 7. This could be the first description of the disease in Latin-America.

Adult↗

Hepatitis C in Peru: risk factors for infection, potential iatrogenic transmission, and genotype distribution.

A large seroepidemiologic and genotyping study of hepatitis C virus (HCV) was conducted in Lima, Peru, during the periods of 1986 to 1993 (cohort A) and 1994 (cohort B). Anti-HCV seroprevalence rates were 15.6% (216 of 1,389) and 11.7% (168 of 1,438), respectively. Low rates were seen among volunteer blood donors (1.1% and 0.8%). Anti-HCV rates were much higher among patients undergoing hemodialysis (43.7% and 59.3%), hemophiliacs (60.0% and 83.3%), in those more than 39 years old (18.2% and 26.0%), in females (25.0% and 27.4%), and in less-educated persons (16.9%). Age- and gender-adjusted risk factors in cohort B included blood transfusion history (adjusted odds ratio [AOR] = 29.8), prior organ transplantation (AOR = 9.1) or a history of hepatitis (AOR = 4.9), previous hospitalization (AOR = 3.7), a history of intravenous drug use (AOR = 3.5), prior major surgery (AOR = 2.6), a history of acupuncture (AOR = 2.1), previous dental procedures (AOR = 1.2), and prior medical injections (AOR = 1.04). The most prevalent HCV genotype was type 1 (86%), followed by type 3 (10%) and type 2 (2%). Transmission through unsafe injection-related and medical/dental procedures appears to play an important role in HCV infection among Peruvians.

Adolescent↗

The expedition to Peru and Chile (1777-1788): inventory of scientific production.

The aim of this work is to provide an inventory of the scientific corpus produced by the Spanish members of the Expedition to Peru and Chile (1777-1788). This material is divided into six large sections. The first section covers the different versions of the diary of the journey taken by the Expedition. The second section covers the drafts and workbooks used by the Expedition members for the writing of "Flora Peruviana et Chilensis," the manuscripts and published editions of this work, the materials used in the preparation of both the "Prodromus" and the "Systema Vegetabilium," the contributions of the assistants on the Expedition and some monographs of taxonomic interest. The third section is dedicated to quinological studies and other pharmacological works undertaken by Hipólito Ruiz López and José Pavón Jiménez. The fourth section includes the writings concerning Ruiz's dispute with Antonio José Cavanilles. The fifth section contains texts which set forth the botanical thought of the members of the Expedition. The sixth and final section includes the Expedition members' writings on various subjects, from anthropology and ethnography to others of a purely historical nature.

Botany↗

[Testimonies of an autochthonous illness on the anthropomorphic pottery in ancient Peru].

The vases belonging to the Mochica civilization of the Precolombian period in Peru represent images that strongly recall pain and illness. In particular the anthropomorphic vessels show in a very realistic fashion severe facial lesions probably associated with different diseases such as cutaneous Leishmaniasis. The different types of leishmaniasis may, in fact, produce asymptomatic visceral, cutaneous, or muco-cutaneous infections, the latter causing remarkable facial deformities like those represented in the vascular production.

Ceramics↗

Breast-feeding and contraception in Peru.

This retrospective study examined duration of breast-feeding and concurrent contraceptive use among 5,648 Peruvian women. Data were gathered during 1986-1992 as part of the Demographic and Health Survey (DHS). The women gave birth to 7,951 infants, 95% of whom were breastfed; 44% of the mothers used contraception while breastfeeding. Consistent with the literature, mothers using oral contraception breastfed for significantly less time than those using other methods. Unexpectedly, mothers using periodic abstinence or withdrawal breastfed longer (15.5 and 15.3 months) than those using other methods or non-contraceptors. Among mothers changing contraceptive methods while breastfeeding the same child, those changing to abstinence and withdrawal breastfed longest (18 months). The relationship of duration of breast-feeding with contraceptive use remained after controlling for other predictors of duration of breast-feeding. Additional data are needed to explain this phenomenon in Peru and perhaps elsewhere.

Analysis of Variance↗

[Overview of the health situation in Peru].

This work presents a general view of the health situation in Peru in the last few decades by presenting a short historic development of health and pointing out the changes that have taken place as a consequence of the social, economic and political transformations and affected the population's health. The process of change in public and private health services, the influence of conceptions and sanitary policies of international organizations, the health system and the health situation are mentioned. Two problems of great impact are presented: the cholera epidemics and political violence.

Delivery of Health Care↗

Seminar on the use of demographic knowledge for population policy formulation in Latin America. Lima, Peru, 14-17 January 1986. An overview.

The author reports on a seminar on the application of demographic knowledge to population policy in Latin America. "In the absence of reliable empirical evidence, the actual objective of the seminar became an exploration, with Brazil, Mexico, Peru and Bolivia as case studies, of questions such as: what applications, what knowledge, what relationships, what emphases, what transmission mechanisms, what communication channels, what investment by public and private agencies are needed to respond to the demand--actual and potential--for demographic knowledge for policy purposes." The seminar brought together not only academics, but parliamentarians, members of international agencies, and other professionals concerned with population issues. The focus of the discussion was on ways and means of improving existing flows of information and of expanding knowledge available for policy purposes.

Americas↗

Migration and the life cycle of households in southern Peru.

"This paper examines the relationships between migration and the life cyle of households in contexts where the economic activities of peasant families are increasingly diversified and where off-farm labor has come to form a vital part of subsistence strategies. Research from the department of Puno, southern Peru is used to explore the issues this raises including: (a) differences between externally induced economic differentiation and the life cycle dynamics of peasant households; (b) the differing migratory patterns of rich and poor households; and (c) the effects of migration on household labor supply and productive organization. The paper concludes by suggesting that for poor families, who exercise less control over the timing of the migratory process, migration may cause disruptive effects in [production], a reorientation of the household division of labor, and changes in reproductive decision-making."

Americas↗