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At least 469 records · Page 26Linked to original sources
PubMed2005

Selective IgA immune unresponsiveness to Proteus mirabilis fumarate reductase A-chain in rheumatoid arthritis.

OBJECTIVE: To determine if selective immune unresponsiveness to microbial antigens is associated with predisposition to rheumatoid arthritis (RA). METHODS: Proteins from Proteus mirabilis lysate were isolated by SDS-PAGE and examined by Western blotting for antibody responses in sera from patients with RA compared to healthy subjects and patients with psoriatic arthritis (PsA). RESULTS: Although RA patients had marked IgA immune responses to many P. mirabilis proteins compared to healthy subjects, selective unresponsiveness was found in RA to a 66 kDa protein identified as fumarate reductase A-chain (FRD-A) by mass spectroscopy. This was confirmed in Western blots with recombinant FRD-A from P. mirabilis. IgA unresponsiveness to FRD-A was found in 21/59 (35.6%) RA patients compared to 7/63 (11.1%) healthy individuals (p < 0.01) and 6/52 (11.5%) patients with PsA (p < 0.01). IgA unresponsiveness to FRD-A was present in 20/46 (43.5%) RA patients with IgA rheumatoid factors (RF) compared to 1/13 (7.7%) without RF (p < 0.025). CONCLUSION: Our results identify a selective hole in the IgA immune repertoire for P. mirabilis FRD-A in a subset of IgA RF-positive patients with RA.

Adult↗
PubMedDate not supplied

Serological classification and epitope specificity of Proteus penneri S29 lipopolysaccharide.

INTRODUCTION: Gram-negative bacteria of genus Proteus are common human intestinal and urinary tract pathogens. In the genus Proteus there are four clinically important named species: P. mirabilis, P. vulgaris, P. penneri, and P. hauseri, and three unnamed Proteus genomospecies: 4, 5, and 6. The clinical significance of P. penneri, described in 1982 as a new species, is poorly documented. The aim of this work is serological characterization and classification of a ceftriaxone-susceptible P. penneri S29 strain isolated from a 34-year-old patient with postneurosurgical meningitis. In this characterization we will also include a ceftriaxonresistant strain, P. penneri R15, isolated from the same patient after 12 days' treatment with ceftriaxon and other antibiotics. MATERIAL/METHODS: Rabbit polyclonal O-antisera were obtained against these two strains and purified and lipopolysaccharides (LPS) were extracted from the bacterial mass of the P. penneri S29 and R15 strains. In the serological investigations the following tests were used: enzyme immunosorbent assay (EIA), passive immunohemolysis (PIH), inhibition of these tests, absorption of rabbit O-antisera with the respective LPS, and repeated PIH, SDS/PAGE, and Western blot techniques. RESULTS: The serological studies of the LPS extracted from both P. penneri strains showed the identity of both preparations of O-polysaccharides from LPS. In P. penneri S29 O-antiserum, four different types of antibodies were described and characterized. CONCLUSIONS: Both investigated P. penneri S29 and R15 strains were classified to the Proteus O31ab serogroup.

Adult↗
PubMed1991

[Neonatal proteus mirabilis adrenal gland abscess].

The authors describe a case of unilateral adrenal abscess in a neonate, which was diagnosed at 13 days of age by abdominal ultrasonography. The newborn presented with persistent high white blood cells after Proteus mirabilis omphalitis. Magnetic resonance imaging and needle aspiration confirmed the diagnosis. This is the second case of Proteus mirabilis neonatal adrenal abscess reported in the literature. Percutaneous drainage allowed complete recovery.

Abscess↗
PubMedDate not supplied

[A new method of sterilization of donor eyes].

Microbiologic examinations of 200 pairs of donor eyes have revealed Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Proteus infection of 124 pairs of eyes (62 percent). Sensitivities of the isolated microorganisms to various antibacterial drugs was examined. Gentamicin and chlorhexidine proved to be the most effective in respect of the microorganisms isolated from cadaveric eyes. These results enabled the authors suggest a new method for donor eyes sterilization, consisting in placing the donor eyes in aqueous solution of chlorhexidine (0.05 percent) and gentamicin (0.0125 percent) for 10 min immediately before surgery. This method was tried with 300 pairs of cadaveric eyes. Its high efficacy was confirmed by the absence of postoperative complications induced by infection transmission via the transplant. Early infectious complications were recorded in 8 patients of the reference group, where the transplants were sterilized routinely; in 4 cases it was a P. aeruginosa infection.

Anti-Bacterial Agents↗
PubMed1990

[Xanthogranulomatous pyelonephritis in infancy and childhood. Report of two cases].

We are reporting 2 cases of xanthogranulomatous pyelonephritis in boys of 7 and 2 year-old. The inflammatory lesion had extended to perirenal tissues and appeared as a lumbar abscess in case 1. The kidneys affected were diffusely compromised by the lesion. Both cases showed Proteus mirabilis after microbiologic cultures. Definitive diagnosis was done by pathology examination. Nephrectomy was curative.

Abscess↗