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Management of an above-knee amputee with complex medical problems using the CAT-CAM prosthesis.

The purpose of this case report is to 1) briefly describe the traditional above-knee (AK) quadrilateral socket, 2) describe the contoured adducted trochanteric-controlled alignment method (CAT-CAM) socket, 3) describe the management of a patient with a temporary CAT-CAM prosthesis, and 4) explain how the CAT-CAM prosthesis approach has resolved a medically complex clinical problem. The 49-year-old patient in this case study received a left AK amputation in 1984 and was provided with a quadrilateral socket. She abandoned this prosthesis after 2 years because of her dissatisfaction with the device (ie, poor fit, awkwardness, excessive energy expenditure) and because of her compromised cardiac condition. The patient was fitted with a CAT-CAM prosthesis in 1988 and reported increased comfort, ease of donning and doffing, and increased gait efficiency with the CAT-CAM prosthesis as compared with the quadrilateral socket. The patient required 19 days of prosthetic training and was discharged independent in ambulation and transfers using two straight canes. We consider the CAT-CAM prosthesis an improvement over the quadrilateral socket for increasing ambulation independence in the individual with AK amputation and other medical complications.

Amputation, Surgical↗

Revision ossicular reconstruction with the titanium Kurz prosthesis.

OBJECTIVE/HYPOTHESIS: One European multicenter study has reported favorable outcomes after ossicular reconstruction with the titanium Kurz prosthesis. At the time of this study, however, no study has analyzed its outcomes when used for reconstruction after prior failure with another implant (revision reconstruction). The study reports our experience with the titanium Kurz prosthesis for revision ossicular reconstruction. STUDY DESIGN: A retrospective review was made of all revision ossicular reconstructions at our institution from October 1998 to September 2001. METHODS: Seventeen cases were reviewed. Patients were divided into two groups: patients who underwent revision ossicular reconstruction with the Kurz prosthesis and patients who underwent revision ossicular reconstruction with another prosthesis (the "other" group). Audiograms were reviewed and air-bone gaps were calculated for each patient. RESULTS: The average postoperative air-bone gap after Kurz revision was 15.6 dB, a statistically significant improvement over the average postoperative air-bone gap from the "other" revision group (P =.022). CONCLUSION: The titanium Kurz prosthesis has been an effective implant at our institution for revision ossicular reconstruction. Future research should focus on a prospective, randomized trial comparing the Kurz prosthesis with other prostheses currently in use.

Adolescent↗

Retained rear-tip extenders in redo penile prosthesis surgery: a case for heightened suspicion and thorough physical examination.

INTRODUCTION: Penile Prosthesis infection is a dreaded complication that can occur after primary inflatable penile implants. Redo prosthesis operations and salvage procedures have become increasingly popular after these inflections. These operations, however, have higher rates of re-infection as compared to primary implants. AIM: We describe a patient who was referred for repeat redo penile prosthesis surgery in whom retained rear-tip extenders harboring purulent fluid was discovered during physical examination. RESULTS: The patient underwent exploration and two rear-tip extenders were removed. He later underwent redo prosthesis insertion and the device remains fully functional and infection free at follow-up. CONCLUSION: This case conveys the importance of a thorough physical examination and raises the index of suspicion for retained prosthesis fragments in patients with recurrent penile prosthesis infections.

Aged↗

Preliminary investigation of a novel controlled stiffness proximal femoral prosthesis.

Previous studies have suggested that a controlled stiffness prosthesis is required to address the conflicting requirements of minimizing stress shielding and micromotion. The design for a controlled stiffness prosthesis is proposed and a preliminary analytical investigation performed to assess its predicted performance before fabrication of a prototype component. The novel prosthesis consisted of a cobalt-chrome core and a flexible composite outer layer. Varying the composite layer thickness allowed the prosthesis stiffness to be controlled. Three variants of the controlled stiffness prosthesis were critically assessed using the finite element method and their predicted performance compared with those of conventional prosthesis designs. The potential for stress shielding was assessed by examining the periosteal strain energy and the potential for migration assessed by examining the endosteal minimum principal cancellous bone stresses. Both the conventional and controlled stiffness implants performed poorly as press-fit prostheses. All the press-fit prostheses generated high cancellous bone stresses, suggesting that excessive migration of these implants would be likely. The controlled stiffness implants performed better than the conventional implants when bonded to the surrounding bone. Although the controlled stiffness implants did not eliminate stress shielding of the calcar, they produced higher strain energies than the conventional designs. The findings of this study are that osseointegrated controlled stiffness implants may perform better than current osseointegrated cementless prostheses and therefore it is worth while progressing to the next stage, of prototyping an implant.

Biocompatible Materials↗

Cardiopulmonary exercise testing in patients with 21mm St. Jude Medical aortic prosthesis.

BACKGROUND AND AIM OF THE STUDY: Small-sized prostheses may be associated with high transprosthetic gradients, particularly in patients with a body surface area (BSA) >1.70m2, affecting left ventricular mass regression, symptom improvement and long-term survival. However, the influence of such gradients on exercise tolerance has not been clearly defined. The study aim was to verify the utility of cardiopulmonary exercise testing (CPX) in detecting patient-prosthesis mismatch, and to identify the clinical and echocardiographic data that predict exercise tolerance at CPX in patients with a 21mm St. Jude Medical (SJM) aortic prosthesis. METHODS: Twenty patients (one male, 19 females; mean age 66 +/- 9 years) with a 21 mm SJM prosthesis were evaluated by means of 2D echocardiography and CPX at 36 +/- 10 months after operation. Patients were divided into groups on the basis of a BSA of <1.70 m2 (group 1, n = 12) or > or =1.70 m2 (group 2, n = 8). RESULTS: At echocardiography, left ventricular mass reduction was 16 +/- 10% versus 9 +/- 6% in groups 1 and 2, respectively, mean gradient (MG) was 15 +/- 6 versus 17 +/- 4 mmHg (p = NS), effective orifice area index (EOAi) 0.86 +/- 0.10 versus 0.79 +/- 0.09 cm2/m2 (p = 0.05). At CPX, group 2 patients showed a significantly lower exercise duration (p = 0.02), maximum workload (p = 0.02), peak O2 uptake (p = 0.01), anaerobic threshold (AT) (p = 0.03), ventilatory equivalent for CO2 at AT (p = 0.007), and O2 cost of work (p = 0.03). Group 1 patients showed a ventilatory origin for their effort dyspnea, while group 2 patients showed a significant circulatory component. At multivariate analysis, BSA, age, EOAi and MG were independent predictors of CPX results. CONCLUSIONS: In patients with a 21 mm aortic SJM prosthesis and a BSA > or =1.70m2, CPX allows detection of patient-prosthesis mismatch, in terms of impaired exercise tolerance due to circulatory causes. CPX results can be anticipated on the basis of the patient's BSA, age, EOAi and MG. In these patients, technical solutions allowing implantation of a larger prosthesis should be considered whenever an active lifestyle is anticipated after aortic valve replacement.

Aged↗

[A new self-retaining titanium-gold stapes prosthesis].

Various aspects of stapes surgery have been improved since its introduction in 1958 by Shea. However, fixation of the prosthesis on the long process of the incus remains difficult. Furthermore, the functional result of crimping cannot be predicted. Necrosis of the lenticular process still occurs. A new stapes prosthesis has been developed with the Kurz Co. The use of titanium allowed an innovative design: titanium has a shape memory, and a clip was constructed which uses this memory for fixation on the incus. Two new instruments were also developed to facilitate application of the prosthesis: a prosthesis inserter and a prosthesis crimper. The clip does not strangulate the incus; it is attached only to the superior and inferior surface of the incus, which are the crucial locations for mechanical transmission of the piston-like movements of the ossicular chain. Avoidance of circumferential attachment should reduce the risk of incus necrosis. Once the clip is pushed onto the incus no further crimping is necessary. The piston is of pure gold, as in this company's gold piston which has been in use for many years. In future the prosthesis may be all-titanium.

Gold↗

[The use of Bicontact hip prosthesis in treatment of coxarthrosis].

The issue of a stabile, long lasting bone-implant interface is still very valid. One of the new models of uncemented hip prosthesis is the Bicontact prosthesis made by Aesculap. This four-part endoprosthesis offers two types of cups: threaded München type and spherical Plasmacup type. The prosthesis stem is a wedged type stem, porous in the proximal type. The aim of this paper was to evaluate the value of Bicontact prosthesis in treatment of coxarthrosis. Our material consisted of 69 patients (38 female and 31 male) with 72 operated hips. Average age of the patients was 50.8 years. The mean follow-up was 24.5 months. Clinical and radiological evaluation according to Merle d'Aubine-Postel classification with Charnley's modification yielded 88% very good and good results. In 11 hips a similar complication was noted--fracture of the femur during final hammering of the prosthesis stem into the medullary canal. This was immediately repaired by circular wire fixation without any influence on the final result. This complication was observed during the first procedures. The learning curve of surgical technique allowed us to avoid this complication during subsequent procedures. We concluded that type of hip prosthesis was is very useful in in treatment of coxarthrosis.

Adult↗

[Mechanical complications of total shoulder inverted prosthesis].

Our series of inverted prosthesis included 5 patients with a mean age of 73 +/- 6 years. In 4 cases, the implant was performed as a surgical revision. The follow up was 81 +/- 15 months. Three shoulders were pain free whereas two caused a dull pain after a free interval due to mechanical complications. The mean active elevation was 72 degrees while external rotation was - 2 degrees. The adjusted Constant score passed from 32 to 60. In case of complications, the score dropped to 32. Mechanical complications were important with in one case, an unscrening of the glenosphere and in two cases, a loosening of the glenoid prosthesis. This last and major complication occurred 6 years after surgery and was promoted by the occurrence of a progressive bone erosion in the scapula. This gap represented an attempt to accomodate the medial part of the humeral prosthesis under the scapula when the arm is at rest or in adduction. The concept of an inverted prosthesis is attractive and this implant remains one of the options in cuff-tear arthropathy. Our results were not as good as those reported by others but most of ours patients had been already operated before. The occurrence of an osseous gap on pilar of scapula may lead to failure of this prosthesis. This gap remains a threath as it can progress and as such warrants a design alteration of the prosthesis.

Activities of Daily Living↗

[GUEPAR radial head prosthesis for recent and old fractures: a series of 22 cases].

PURPOSE OF THE STUDY: We reviewed retrospectively outcome in 22 patients with recent or old fractures of the radial head treated with a GUEPAR radial head prosthesis. This prosthesis, derived from the GUEPAR sliding total elbow prosthesis, has a cemented mobile metal cup. MATERIAL AND METHODS: Eighteen patients underwent emergency surgery, four deferred surgery. Mean age at surgery was 41 years and mean follow-up was 18 months. The Mayo Clinic score was calculated to assess clinical outcome. Static and dynamic x-rays of the elbows and wrists were analyzed. All of the fractures were total or displaced head fractures and 72% involved elbow dislocation. The coronoid process was fixed in one patient, the olecranon in one and the medial ligaments were repaired in 5. The quality of the cartilage of the humeral condyle was checked before insertion of the prosthesis. Proper position and height of the prosthesis were carefully controlled. RESULTS: There were no complications. Outcome was good in the patients who underwent emergency surgery with a mean Mayo Clinic score of 83/100, mean force 75%, good joint motion (77 degrees pronation, 79 degrees supination), stable elbow, and no wrist problems. Outcome was not as good in patients who underwent deferred implantation, particularly for joint motion (pronation 44 degrees, supination 54 degrees ). The distal radio-ulnar ratio was not perfectly restored. Finally 4 patients required arthrolysis for limited flexion/extension, proportionally more among the deferred patients. DISCUSSION: Resection of the radial head is an alternative in case of complex fractures. There are two drawbacks. The first is an unstable elbow in valgus if the medial ligaments are damaged. The second is an ascension of the radius if the interosseous membrane is damaged. Osteosynthesis is another alternative which is difficult to achieve and does not give good results (in our experience in comparison with 20 equivalent fractures, and in the literature). The GUEPAR radial head prosthesis appears to be a good solution. It stabilizes the elbow, prevents ascension of the radius, allows early rehabilitation, and provides good subjective results, particularly after emergency surgery.

Adult↗

[Tripolar arthroplasty for recurrent total hip prosthesis dislocation].

PURPOSE OF THE STUDY: The purpose of this study was to assess the results of revision surgery for recurrent total hip prosthesis dislocation using a tripolar prosthesis composed of a conventional stem with a mobile head of an intermediary prosthesis measuring more than 40 mm and a modified cup. This technique was used in two centers in Rouen France and Los Angeles USA. MATERIAL AND METHODS: Twenty-one hips in 21 patients were operated on. The mobile heads measured 40 to 47 mm. Mean patient age was 70 years (range 29-92). The indication for the tripolar prosthesis was reserved for extremely unstable hips in patients with major risk factors for recurrent dislocation. These 21 patients had experienced 95 dislocations. The acetabular cup was custom-made for the large-diameter heads. A cemented polyethylene cup was used in 14 cases and a press-fit metal-backed around a polyethylene insert in 7. The polyethylene thickness varied from 6.5 to 16 mm for the cemented cups and 4 to 5 mm for the press-fit cups. Fourteen femoral stems were left in place as were two press-fit cups where only the inserts were changed. Mean follow-up was 5.4 years (range 3-11.8). RESULTS: There has been no recurrent dislocation for 20 hips. One patient experienced a dislocation one week after surgery which required a second revision procedure to reposition the acetabular implant. Final outcome was good at 7.6 years for this hip. One patient who had not had any recurrent dislocation died 4 years after the revision surgery due to a cause unrelated to the prosthesis. Two patients were lost to follow-up at 3.7 and 6 years, both were pain free and had no radiological anomalies. Infection occurred in one patient undergoing chemotherapy for a myeloma; the head and neck had to be resected. For the 20 other patients, functional outcome, assessed with the UCLA score, showed improvement in pain (5.8 preoperatively, 9.2 at last follow-up), walking (4.8 and 8 respectively), function (4 and 6 respectively), and daily activities (3.3 and 5.2 respectively). A revision procedure was necessary for one patient during the 4(th) year because of a fracture of the polyethylene insert on a metal-back cup; the insert alone was changed. Excepting the patient with infection, there were no cases of certain or probable loosening during the follow-up. DISCUSSION: The tripolar prosthesis with a mobile cup and a large-diameter head appears to be a reliable solution for these severely unstable hips. The procedure can often be limited to the acetabular component, reducing morbidity. The thickness of the polyethylene cup is a limitation which may affect long-term survival. Search for a highly wear-resistant couple continues.

Adult↗

[Changes in the physiologic pattern of mitral prosthesis regurgitation in the presence of a prosthetic dysfunction].

AIM OF STUDY: Evaluation by transesophageal echocardiography of the effect on the characteristics of physiological regurgitant jets (JF) resulting from prosthetic disfunction due to pathologic regurgitation (JF). PATIENTS AND METHODS: We studied 69 consecutive patients with the diagnosis of prosthesis in mitral position using transesophageal echocardiography and color doppler codification. The patients were divided in two groups (N and D groups) according to the presence of prosthesis disfunction by pathologic regurgitation. In each patient we determined planimetric areas and atrial peak depth of each JF and also the sum of JF planimetric areas of each mitral prosthesis. When pathological regurgitation was present we calculated the highest planimetric area, severity degree and atrial peak depth in each JP. RESULTS: The planimetric area in each JF of group N was 330 +/- 167 mm2 and in group D 117 +/- 116 mm2 (p less than 0.001). The sum of the areas of JF in group N was 474 +/- 204 mm2 and in group D 254 +/- 176 mm2 (p less than 0.01). The atrial depth of JF in group was 32 +/- 15 mm and in group D 26 +/- 18 mm (p less than 0.01). In group D 29% of the patients had mild pathological regurgitation, 10% moderate and 61% severe. The maximum planimetric area of JP in group D was 1078 +/- 1007 mm2 with atrial depth of 37 +/- 28 mm. CONCLUSION: The pathological regurgitation in disfunction prosthesis in mitral position has a significant reduction effect in the dimension of prosthesis physiologic regurgitation jets. This transesophageal echocardiographic observation makes it possible to characterize and clarify more precisely the different types of mitral prosthesis jets.

Adult↗

[Revision hip arthroplasty after prosthesis removal in septic loosening].

The author presents the therapeutic protocol in "hanging hip" after prosthesis removal in septic loosening, basing on a series of 11 patients--7 females and 4 males--age ranging from 31 to 67 years. On average the primary prosthesis was removed 2.5 years after implantation, while patients remained with a "hanging hip" for an average period of 2.2 years (limb shortening before revision arthroplasty was on average 4.5cm). When qualifying patients for revision arthroplasty the following parameters were taken into account: sedimentation rate, CRP reactive protein levels, bacteriological blood culture results, cultures from the hip punctate, every-day life activity and post-op patient compliance with the therapy. Acetabular roof defects were managed according to Zuk's method. Clinical assessment of the patients was performed 6 weeks, 3, 6 and 12 months using Merle-d'Aubigne and Postel classification, while X-rays were used to assess proper prosthesis implantation. During follow-up proper prosthesis implantation was found in all cases, while no signs of re-infection, nor radiological and clinical signs of implant loosening were noted. Clinical assessment of the patients yielded 1 very good result, 7 good results and 3 satisfactory. The presented material indicates that good results can be obtained in prosthesis reimplantation after removal of the primary prosthesis because of its septic loosening.

Adult↗

[Factors that affect in situ lifetime of Provox voice prosthesis].

OBJECTIVES: We evaluated the effect of age, radiotherapy, insertion time of prosthesis, the period between radiotherapy and insertion time on in situ lifetime of Provox, voice quality and complications. PATIENTS AND METHODS: The study included the use of 62 Provox voice prosthesis in 50 total laryngectomy patients (46 males, 4 females; mean age 61 years; range 43 to 77 years). The patients visited our clinic regularly every three months for the first year after insertion and every six months in subsequent years. The ease of use and complications of prothesis and voice quality of the patients were evaluated. RESULTS: The mean in situ lifetime was 24 months (range 1 to 49 months). Age, radiotherapy, insertion time of the prosthesis, the period between radiotherapy and the insertion time had no influence on the in situ lifetime of Provox. These variables were not associated with the complications of the prosthesis. A statistically significant good voice quality was found in nonirradiated patients and those in whom the prosthesis was inserted between 6 and 24 months after laryngectomy. The use of Provox was easier in nonirradiated patients than irradiated patients (p<0.001). CONCLUSION: In situ lifetime of Provox was not influenced by age, radiotherapy, insertion time, and the period between radiotherapy and insertion time of prosthesis. We believe that the patient factor is the most important factor that affect the in situ lifetime of Provox.

Adult↗

Short-term patency of 1 mm diameter PTFE prosthesis: an angiographic, Doppler-flowmetric and morphological experimental study.

Expanded polytetrafluoroethylene (PTFE) prostheses may be used in peripheral vascular surgery. Due to contradictory results on patency rate and neointimal formation, the effectiveness of this kind of prosthesis in small caliber artery reconstruction is still under discussion. In order to evaluate the effectiveness of this technique 1 mm internal diameter PTFE prosthesis (fibril length 35 microm) interposed in rabbit femoral artery, for 15 and 30 days, were studied functionally and morphologically. Doppler was performed during surgery, at day 2, 15 and 30. Arteriography was carried out at day 1. Light microscopy and scanning electron microscopy were performed on prosthesis sampled at day 15 and 30. Doppler flowmetry showed the full patency in all PTFE prosthesis. Angiography confirmed that all PTFE grafts were patent after 24 h. Doppler flowmetry, performed after 15 and 30 days, showed a reducing patency rate respectively at 70% (21 grafts) and 60% (18 grafts). Morphological studies showed that endothelial lining was not present at 15 day. After 30 days proliferation of blood cells occurred in the graft wall. Lumina presented a fibrous lining and did not show significant endothelial cell growths. These results confirm that PTFE prosthesis represents a suitable alternative to biological graft for the repair of small caliber artery when the latter are not available. Autologous vein is the vascular substitute of choice for peripheral vascular reconstruction, and PTFE prosthesis may be quite successfully used as a secondary choice, when multiple reconstruction are needed and biological grafts are not sufficient.

Angiography↗

Selection of femoral prosthesis in total hip replacement for ankylosing spondylitis.

OBJECTIVE: To investigate the implication of morphological changes of the proximal femur in femoral prosthesis selection in total hip replacement for treatment of ankylosing spondylitis (AS). METHODS: Twenty-four patients (36 hips) admitted for cementless total hip replacement (THR) because of AS were enrolled in this study along with the control group of 30 patients (45 hips) without AS. Measurement of the Singh index, canal flare index, morphological index of the cortex, cortical index and stem-canal fit was performed in the two groups on the basis of roentgenograms. RESULTS: The AS patients had more serious osteoporosis in their proximal femur. There were significant differences between the two groups in Singh index, canal flare index, morphological index of the cortex and stem-canal fit (P<0.05), but not in the cortical index (P>0.05). The AS patients were found to have severe osteoporosis in the upper femur and massive spongy bone loss, so that the morphology of the canal was almost orthostatic in the upper femur because of the thinned femoral cortex. CONCLUSION: Cemented prosthesis is recommended for AS patients with severe osteoporosis, who should be treated with revised THR to ensure good fit of the prosthesis to the canal. Cementless prosthesis, however, can still achieve good therapeutic effect in AS patients without significant morphologic changes in the proximal femurs. Computer-aided design and manufacture of individualized prosthesis better suits the AS patients than the currently available prosthesis.

Adult↗

[Clinical study of implant-retained facial prosthesis].

OBJECTIVE: To evaluate clinical results and technical characteristics of implant-retained facial prosthesis. METHODS: Six patients with facial defects underwent implant retained prosthesis treatment, of which 3 orbita defects (including upper and lower eyelids, eyeball) in 3 cases, 2 ears defects in 2 cases, and a nose defect in one case. Under local anaesthesia 21 extra-oral implant were placed, facial prosthesis were individually made six month postoperatively. Follow up ranged from 6 month to 6 years. RESULTS: All 21 implants osseointegrated well, implant lost and peri implantitis was not found. All 6 cases had individual facial prosthesis and were satisfied with the prosthesis. CONCLUSIONS: Extra oral implants provided excellent retainment for facial prosthesis; result of current silicon with individual color shade is encouragable.

Dental Prosthesis, Implant-Supported↗

Outcome after aortic valve replacement in young adults: is patient profile more important than prosthesis type?

BACKGROUND AND AIM OF THE STUDY: The optimal prosthesis choice in young adults requiring aortic valve replacement (AVR) remains controversial. The study aim was to determine whether implanted prosthesis type is an important determinant of outcome after AVR in young adults. METHODS: Between 1991 and 2001, 414 young adults (mean age 40 +/- 11 years; range: 16-55 years) underwent a total of 438 consecutive AVRs using 204 mechanical prostheses (MP), three bioprostheses (BP), 150 allografts (AL), and 81 autografts (AU). The perioperative characteristics, early and late mortality, occurrence of valve-related events and predictors of adverse outcome and prosthesis selection, were evaluated. RESULTS: Mean patient ages were 45 years for MP, 50 years for BP, 39 years for AL, and 31 years for AU. MP selection was associated with older age, impaired left ventricular function (LVF) and concomitant mitral valve surgery (concMVS); AL selection with ascending aortic aneurysm, active endocarditis, and Marfan's disease; and AU selection with younger age, prior balloon valvuloplasty and isolated valve disease. Hospital mortality was 2.3% (n = 10). During follow up (97% complete) 30 patients died. Ten-year survival was better for AU (96 +/- 2%) compared to MP (84 +/- 4%) and AL (92 +/- 2%). Prosthesis type was not predictive of late mortality; rather, predictors of increased late mortality were prior aortic valve surgery, impaired LVF, concMVS, and older patient age. Ten-year freedom from bleeding and thromboembolism was 89 +/- 3% for MP versus 94 +/- 3% for AL and 99 +/- 1% for AU (p = 0.054). Ten-year freedom from reoperation was 95 +/- 2% for MP versus 79 +/- 5% for AL and 87 +/- 5% for AU (p = 0.003). CONCLUSION: Survival after AVR in young adults in Rotterdam was mainly determined by patient-related factors, and not by prosthesis type. A randomized controlled trial is necessary to determine whether valve prosthesis type indeed plays a crucial role in improving survival in young adult patients.

Adolescent↗

[Long-term results of mitral valve prosthetics depending on the prosthesis model (ball, disk)].

The authors conducted a comparative analysis of patients of 2 groups--with a MK4 model ball prosthesis and an folding disc prosthesis. It was found that the number of late-term (repeated) thromboembolic complications was significantly less in patients with a disc prosthesis (3.95 cases per 100 patient-years) and 4.28 cases among patients with a ball prostheses. No fatal outcomes associated with thromboembolism occurred among patients with a disc prosthesis, the lethality among those with a ball prosthesis was 27.5%. The advantages of a disc prosthesis in indices of physical activity and increased survival were also established.

Adult↗