Studies in disorders of muscle. IV. The clinical manifestations and inheritance of childhood progressive muscular dystrophy.
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Using agar-gel electrophoresis a highly statistically significant decrease in the fractions LDH-4 and LDH-5 and a rise in the LDH-1 and LDH-2 fractions were demonstrated in the serum of patients with dystrophy. Analogous shifts in LDH isoenzyme pattern were found in the serum of 80% of mothers confirmed carriers of the dystrophy gene.
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