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At least 469 records · Page 26Linked to original sources
PubMed1993

Massive hemothorax associated with intrathoracic extramedullary hematopoiesis involving the pleura.

Intrathoracic extramedullary hematopoiesis rarely involves the pleura and is usually asymptomatic. We report a 73-year-old woman with myelofibrosis who had pleural involvement with extramedullary hematopoietic tissue that produced a massive hemothorax. Before the diagnosis of extramedullary hematopoietic tissue was established, sclerosis with tetracycline was attempted, which accelerated pleural bleeding and required surgical evacuation. The bleeding was ultimately controlled by low-dose radiation therapy.

Aged↗
PubMed2001

Hypoglycemia induced by secretion of high molecular weight insulin-like growth factor-II from a malignant solitary fibrous tumor of the pleura.

A 49-year-old woman with a malignant solitary fibrous tumor of the pleura presented with hypoglycemia. Most of the serum insulin-like growth factor II (IGF-II) existed as high molecular weight IGF-II. Furthermore, there were larger amounts of high molecular weight IGF-II found in the tumor cystic fluid than in the serum. After surgical resection of the tumor, high molecular weight IGF-II was not detected in the serum and the hypoglycemia resolved. Immunohistochemically, IGF-II was localized in the so-called Golgi area of the tumor cell. These findings suggest that hypoglycemia in this patient was caused by the high molecular weight IGF-II produced by the tumor.

Female↗
PubMed1978

Medial herniation of the parietal pleura: a useful sign of pneumothorax in supine neonates.

In a series of 235 consecutive infants with respiratory distress syndrome, pneumothorax was demonstrated radiographically in 20. On anteroposterior supine chest radiographs of such infants, the intrapleural gas tends to seek an anteromedial position within the involved hemithorax. When the pneumothorax is large, the gas may cause the ipsilateral mediastinal pleura to bulge and herniate across the anterior mediastinum into the contralateral hemithorax. This was seen in 12 or the 14 right pneumothoraces, but only in two of the 10 left ones. The gas-containing sac appeared radiologically as a crescent-shaped lucency medial to the upper thoracic spine which was sharply delineated laterally by the mediastinal pleural layers and the somewhat atelectatic contralateral lung. In some patients treated with a chest tube, the gas disappeared more slowly from the herniated portion of the pleural sac than from elsewhere in the pleural space. Therefore, in addition to being a useful confirmatory sign of pneumothorax, this finding is also important in assessing the completeness of pleural drainage.

Hernia↗
PubMed2001

Asbestos exposure in malignant mesothelioma of the pleura: a survey of 557 cases.

A series of 557 malignant mesotheliomas of the pleura diagnosed in the Trieste-Monfalcone area, Italy, in the period 1968-2000 were reviewed. The series included 492 men and 65 women, aged between 32 and 93 years (median age 69 years). Necropsy findings were available in 456 cases (82%). Occupational histories were obtained from the patients themselves or from their relatives by personal or telephone interviews. Routine lung sections were examined for asbestos bodies in 442 cases. In 109 cases isolation and counting of asbestos bodies were performed. A majority of people had histories of working in the shipyards. Asbestos bodies were observed in lung sections in 67% of the cases. Lung asbestos body burdens after isolation ranged between 20 bodies and about 10 millions of bodies/g dried tissue. Latency periods (time intervals between first exposure to asbestos and death) ranged between 14 and 75 years (mean 48.8 years, median 51.0). Latency periods among insulators and dock workers were shorter than among the other categories. High asbestos consumption occurred in many countries in the 1960s and in the 1970s. The data on latency periods obtained in the present study suggest that a world mesothelioma epidemic has to be expected in the coming decades.

Adult↗
PubMed2002

Concurrent malignant mesothelioma of the pleura and hepatocellular carcinoma in the same patient: a report of five cases.

Five cases are reported in which malignant mesothelioma of the pleura and hepatocellular carcinoma co-existed in the same patient. The group included four men and one woman, aged between 58 and 86 years. The diagnosis was established at necropsy. In one case the association was clinically suspected. All mesotheliomas were asbestos-related. Liver cirrhosis co-existed in four cases, two of them positive for HCV markers. A lot of elements suggest that the above association is not a fortuitous coincidence. In particular, asbestos could favour liver cancerogenesis by inducing immune impairment.

Aged↗
PubMed1990

Solitary fibrous tumor of pleura: expression of cytokeratins.

A case of solitary fibrous tumor of the pleura (SFT) is presented. The histogenesis of this uncommon tumor is debated with most investigators favouring origin in submesothelial fibroblasts. Part of the evidence supporting this has been the persistent negativity of the tumor cells for cytokeratin--a feature militating against origin in mesothelial-lining cells. Our case shows unequivocal focal cytokeratin positivity in tumor cells; we feel that although this indicates mesothelial differentiation it does not militate against origin in submesothelial fibroblasts since, in reactive conditions, these are capable of mesothelial differentiation including expression of cytokeratin. Indeed, it reinforces the hypothesis that SFT is of submesothelial origin. Solitary fibrous tumors can be cellular and atypical. The reactivity of the tumor with cytokeratin, albeit rarely, should be considered in differentiating SFT from sarcomatoid mesothelioma.

Aged↗
PubMed1986

Plasma cell granuloma of lung and pleura.

A report is presented of seven patients with plasma cell granuloma of the lung or pleura. Two were operated on in 1970, three in 1971, one in 1973 and one in 1984. None of the patients had smoked cigarettes. Five had a history of infection. Most of the patients were young, healthy and working. The surgical treatment was lobectomy in four cases, bilobectomy in one case and resection of tumour in two cases. The histology of the tumours was re-evaluated, and was similar in all cases. They were composed mainly of plasma cells, lymphocytes and granulocytes, and small foci of calcification were also seen. No recurrence of tumour was found in observation up to 13 years postoperatively. One patient died of pancreatic carcinoma after 6 years. The others are doing well.

Adolescent↗
PubMed2001

Malignant solitary fibrous tumor of the pleura causing recurrent hypoglycemia; immunohistochemical stain of insulin-like growth factor i receptor in three cases.

We present three cases of malignant solitary fibrous tumors of the pleura (SFTP) that produced recurrent hypoglycemia. Removal of the tumors produced normoglycemia. The tumors were well circumscribed and lobulated, and consisted of firm masses weighing 1,150 g to 1,450 g with the greatest diameter of 15 to 20 cm. The tumors were composed of spindle cells in fascicles or in a haphazard arrangement and were highly cellular and mitotically active (3-8 mitoses/10 high-power fields), showing histologically malignant features. Ultrastructurally, fibroblastic features of the tumor cells were present. Insulin-like growth factors (IGF) have been implicated in the presentation of hypoglycemia. The serum insulin and C-peptide levels were not elevated. Serum IGF-I levels were also low with values of 97.4, 157.1 and 51.9 ng/mL (ref. 125-317 ng/mL), respectively. However, tumor cells were strongly positive for IGF-I receptor on immunohistochemical analysis. It is tempting to speculate that IGF-I contributes to the hypoglycemia, even though the circulating levels were low.

Aged↗
PubMed1976

[Anatomo-clinical calssification of primary tumors of the pleura and possibility of their surgical treatment].

A distinction is drawn between first category includes peduncolates, giant seslocal and diffuse primary tumours of the pleura on anatomopathological grounds. The first category includes peduncolated, giant sessile, and "deceptive" forms; the latter those in which the lung is surrounded by a "pleural" and "serous" mantle. Treatment is discussed and the soundness of surgical management is stressed.

Diagnosis, Differential↗
PubMed1999

[Kallikrein-kinin system in acute empyema of pleura and pyopneumothorax].

In 56 patients with acute empyema of the pleura the level of aggregate kininogen and prekallikrein, free kallikrein and kininase activities in blood plasma and supernatant of pleural exudate were studied. It was established that epsilon-aminocapronic acid, contrykal and gordox suppress free kallikrein activity in the blood plasma and supernatant of pleural exudate. Intravenous and local application of proteolysis inhibitors resulted in improvement of the outcomes of the disease.

Acute Disease↗
PubMed2000

[Malignant solitary fibrous tumor of the pleura: two cases and review of the literature].

We present two cases of malignant solitary fibrous tumor of the pleura (MSFT-P) and review 29 reported cases of MSFT-P. In examining the clinical and morphological features and prognosis of MSFT-P, we found that over 90% of the patients had some symptoms and one-third showed local recurrence. Chest radiographs and CT demonstrated large broad-based masses with necrosis, hemorrhage, and pleural effusion. The maximum diameter of the tumors was greater than 10 cm. Pleural effusion was seen in more than 70% of the patients, but there was only one case of pleural dissemination. All of the cases were well demarcated, and this was the most reliable finding for differentiating MSFT-P and malignant mesothelioma.

Aged↗
PubMed2001

T cell extranodal lymphoma case involving pleura and pericardium in a renal transplant patient.

Application of immunosuppressive treatment for a long period after organ transplantations suppresses immune system in organ receivers and increases the risk of development of neoplastic diseases along with infections. Among the complications developing after transplantation, post-transplant lymphoproliferative diseases are not rare. Although the disease is generally of B cell origin, cases of rare post-transplant lymphoproliferative disease of T cell origin have been reported. Post-transplant lymphoproliferative disease often occurs after Epstein-Barr virus (EBV) infection. In our case an extranodal T cell lymphoma originating from the pleura and pericardium in a renal transplant patient has been diagnosed with cytology.

Heart Neoplasms↗
PubMed2001

[Malignant primary fibrous histiocytoma of the pleura].

UNLABELLED: Malignant fibrous histiocytoma (MFH) is a uncommon primary sarcoma, occurring exceptionally in the thoracic site. We report a case of malignant fibrous histiocytoma of the pleura in a 23-year-old man. The tumour was revealed by chest pain and alteration of the general state. A complete resection of the tumour histologically diagnosed as a malignant fibrous histiocytoma, with a right upper lobectomy was performed. No adjuvant treatment was proposed. The patient died 4 months after operation with cerebral metastasis. CONCLUSION: MFH should be treated by wide surgical resection if technically feasible, the role of adjuvant treatment is not defined.

Adult↗
PubMed1975

[Mesotheliomas of the pleura].

The materials concerning 19 patients with pleural mesotheliomas are analysed. The patients were subdivided into three groups according to the clinico-roentgenological picture and course of the affection: 1) four patients in whom pleural mesothelioma proceeded without exudate accumulation; 2) seven patients in whom exudate accumulation in the pleural cavity was the main sign of the tumor; 3) 8 subjects in whom the tumor developed on the side of an artificial pneumothorax many years following its cessation. Among 19 patients only in 5 cases the tumor was suspected soon after their admission to the hospital. A needle biopsy of the pleura is felt to be the most effective method of diagnosis of pleural mesotheliomas, whereas in failure of the former -- pleuroscopy.

Adult↗
PubMed2002

Small cell carcinoma of the pleura.

We describe a patient with small cell carcinoma of the pleura who survived more than 4 years despite no response to chemotherapy. The natural history of pleural small cell carcinoma is unknown, and similar cases in the medical experience will shed light on possible treatment.

Carcinoma, Small Cell↗
PubMed2002

[A case of diffuse malignant mesothelioma of the pleura with bilateral chylothorax].

We describe a case of bilateral chylothorax with malignant pleural mesothelioma. A 41-year-old woman was admitted to our hospital because of dyspnea. She had no history of exposure to asbestos. A chest radiograph and chest computed tomogram (CT) on admission revealed massive bilateral pleural effusion and a large tumor with pleural thickening in the left lateral and anterior parts of the pleura and mediastinum. Biochemical tests of pleural fluid revealed chyle. Two years before, she had been diagnosed through histological and histochemical examinations as having diffuse malignant pleural mesothelioma of the epithelial type. Chest-tube drainage was performed, and pleurodesis was induced by the intrathoracic injection of OK-432 at 10 KE per dose. The chylothorax disappeared after pleurodesis. To date, reports of malignant mesothelioma with nontraumatic chylothorax have been rare.

Adult↗
PubMed2002

[Surgery in the treatment of metastatic lesions of the lung and pleura].

An experience with treatment of 53 patients with intrapulmonary metastases of malignant tumors of different nature included 65 surgical interventions, among them there were bilateral operations and reoperations. During the postoperative period complications took place in 5 cases (9.1%). After the operations there were no lethal outcomes. Long-term results of the surgical treatment of intrapulmonary metastases insignificantly differed from those of surgical treatment of primary lung cancer. The surgical treatment is thought to be an expedient method of treatment of intrapulmonary metastases in patients without recurrent tumors, late metastasis of another localization, satisfactory condition of the patient. High effectiveness of thoracoscopic methods for treatment of metastatic lesions of pleura is also noted.

Adenocarcinoma↗