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A correlation of the endoscopic and pathological changes in subclinical pathology of the horse's larynx.

The larynges of 6 horses were examined endoscopically and the findings correlated with the gross and histological appearance of the intrinsic laryngeal muscles and their nerve supply. In all cases it appeared that the balance between abductor and adductor muscle groups had been lost due to preferential atrophy of individual muscles or groups of muscles. The laryngeal abnormalities recorded were asymmetry of the larynx with asynchronous left sided abduction and fluttering or trembling of the left vocal cord and arytenoid cartilage. It is suggested that these changes represent the early signs of a progressive lesion which may result in left sided laryngeal hemiplegia.

Animals↗

Radiologic-pathologic correlation from the Armed Forces Institute of Pathology. Lymphangiomyomatosis.

The radiologic patterns caused by interstitial lung disease evoke a long list of differential diagnostic possibilities. Though the problem may at first seem insoluble, subdivision into conditions that spare the pulmonary architecture, as opposed to those that lead to an end-stage "honeycomb lung", and consideration of the clinical findings will frequently narrow down the list. Occasionally, key associated findings such as pleural effusion, pneumothorax, and systemic involvement of many organs will help rule out inappropriate diagnoses. Lymphangiomyomatosis is a rare cause of "honeycomb lung" that may result in a very specific combination of radiologic and clinical findings.

Adult↗

Radiologic-pathologic correlation from the Armed Forces Institute of Pathology. Inflammatory fibroid polyp.

The inflammatory fibroid polyp of the stomach, sometimes called eosinophilic granuloma, is a relatively uncommon lesion usually presenting a solitary, benign-appearing filling defect. The differential diagnoses include polypoid adenocarcinoma, hyperplastic mucosal polyp, adenoma, leiomyoma, epitheliod leiomyoma and leiomyosarcoma, and aberrant pancreas. Although difficult to distinguish by gross morphologic features, the inflammatory fibroid polyp shows a distinctive inflammatory response of the mucosal stroma in which eosinophils may be prominent. It is unrelated to the eosinophilic granuloma of lung or bone.

Adenocarcinoma↗

From the archives of the AFIP: superficial gliomas: radiologic-pathologic correlation. Armed Forces Institute of Pathology.

Glial neoplasms that are peripherally located and involve the cortical gray matter are noteworthy because of their predilection to serve as a seizure locus, their amenability to surgical resection, their generally favorable prognosis, and their characteristic imaging features, which facilitate diagnosis before surgery. The smaller lesions include ganglioglioma and dysembryoplastic neuroepithelial tumor. Gangliogliomas contain both neuronal and glial components and occur most commonly in the temporal lobe. Variant forms of gangliogliomas may occur and are related to the different compositions of the underlying cellular population. Gangliocytomas lack glial cells and are located both in the cerebral hemispheres and the cerebellum. Lhermitte-Duclos disease represents a specific type of cerebellar gangliocytoma with dysplastic features and is characterized by a laminar pattern at imaging. Dysembryoplastic neuroepithelial tumors occur predominantly in children and young adults with partial seizures and most commonly arise in the temporal lobe, frequently in combination with cortical dysplasia. Surrounding vasogenic edema is conspicuously absent in both gangliogliomas and dysembryoplastic neuroepithelial tumors. The larger masses in this group include desmoplastic infantile ganglioglioma and pleomorphic xanthoastrocytoma and tend to involve the leptomeninges and cortical territory. Both invoke an intense desmoplastic reaction, which appears as an enhancing soft-tissue component at imaging.

Adolescent↗

From the archives of the AFIP. Benign tumors and tumorlike lesions of the gallbladder and extrahepatic bile ducts: radiologic-pathologic correlation. Armed Forces Institute of Pathology.

A diverse spectrum of benign tumors and tumorlike lesions arises from the gallbladder and bile ducts, and despite their diversity, these lesions share common embryologic origins and histologic characteristics. Although these lesions are relatively uncommon, their importance lies in their ability to mimic malignant lesions in these locations. Benign neoplasms are derived from the epithelial and nonepithelial structures that compose the normal gallbladder and bile ducts. The epithelium gives rise to adenomas, cystadenomas, and the unusual condition of biliary papillomatosis. Granular cell tumors, neurofibromas, ganglioneuromas, paragangliomas, and leiomyomas are examples of benign tumors that may originate from nonepithelial structures. Tumorlike lesions are more commonly found in the gallbladder and include xanthogranulomatous cholecystitis, adenomyomatous hyperplasia, cholesterol polyps, and heterotopias. In the clinical setting of a patient with nonspecific abdominal complaints or symptoms of biliary obstruction, the discovery of a gallbladder or bile duct polyp or mass, gallbladder wall thickening, or biliary stricture is most often indicative of malignancy. However, the differential diagnosis should include benign tumors and tumorlike lesions. The preoperative determination of a benign lesion may significantly alter therapy and patient prognosis.

Bile Duct Diseases↗

[Pathology of the Cervix. Introduction to the focal topic "Pathology of the cervix - future developments"].

The incidence of cervical cancer has decreased distinctly. Since the causal connection between HPV infection and cervical cancer was proved, new diagnostic and therapeutic methods have become available. New diagnostic possibilities, in certain situations the determination of HPV, a new vaccination as well as molecular-bio-logical tests will shape the future. However, it must not be forgotten that the number of participants in cervical cancer screening has a bigger impact on the decreasing incidence of cervical cancer than any special diagnostic methods.

Cervix Uteri↗

Pathology of craniopharyngiomas: clinical import of pathological findings.

Craniopharyngiomas are benign neoplasms, thought to be of maldevelopmental origin, which occur in both children and adults in the sella and suprasellar regions. There are two distinctive histologic patterns, 'adamantinomatous' and 'squamous papillary', but transitional or mixed examples occur. Prior suggestions that squamous papillary tumors are found 'only' in adults, 'never' calcify, do not invade brain, and are associated with a better outcome ('no' recurrences, better clinical status) are partially correct, but rare pediatric examples occur, rare examples have calcification, and in our study of 56 patients with craniopharyngiomas treated at New York University there was no statistically significant difference in brain invasion or recurrence rates for squamous papillary as compared to adamantinomatous types. Brain invasion, commonly seen in craniopharyngioma specimens, is not a predictor of recurrence.

Adult↗