SEARCH · Search PubMed
Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
A very rare case of traumatic basilar impression is reported. The patient, a 57-year-old man, was hit on the head vertically in the parietal region. X ray of the cervical spine and computed tomography (CT) scans showed intracranial indentation of the atlas and the odontoid process with a depressed fracture around the foramen magnum. There are no previous reports about this type of fracture.
Clinical and neuroradiological features of two cases with unilateral pedicle fractures of C2 were presented and the literature of this rare traumatic fracture was reviewed. Both 37- and 57-year-old woman had traffic accident and were admitted in our institute. Both patients were neurologically free except for neck pain. Plain X-ray of cervical spine did not show abnormal findings. Computerized tomography (CT) with bone window showed the location and extension of the traumatic fracture in C2 pedicle. The fracture was located in the portion between the lateral border of the odontoid process and pars interarticularis. Fractures of the C2 pedicle are rarely seen in acute traumatic fractures. They can be overlooked because there is confusion in the describing of anatomical location of C2 pedicle in some medical literature. For proper diagnosis of pedicle fracture of the axis, understanding of the anatomy of C2 and CT findings with bone window are important.
Cervical spine involvement is common but usually delayed in patients with psoriatic arthritis. We report two cases with early and predominant involvement of the upper cervical spine. Synovitis of the atlanto-odontoid joint and fusion of multiple facet joints were noted in one patient. In the other patient, the main finding was atlanto-axial subluxation with erosions of the odontoid process and anterior arch of C1. No abnormalities were noted in the peripheral joints, sacroiliac joints, or thoracolumbar spine. Analgesics and conventional antiinflammatory agents were only minimally effective. TNFalpha antagonist therapy (infliximab followed by etanercept) in one patient and phenylbutazone therapy in the other improved the symptoms and led to shrinkage of the pannus.
OBJECTIVE: To discuss a case of occipital-atlantoaxial rotatory subluxation successfully treated with manipulation under general anesthesia. CLINICAL FEATURES: A 4-year-old girl presented to the Taichung Veterans General Hospital with acute torticollis and neck stiffness for 1 week after she had fallen. Although some nonsteroidal anti-inflammatory drugs had been prescribed for her, her neck still tilted to the right side and her chin inclined to the left side. There were no neurological signs, no significant pain if she did not move her neck and head, and no muscular hypertonocity. There was painful guarding in the right sternocleidomatoid muscle when manipulation was attempted. Three-dimensional computer tomography revealed uneven joint space between the C1 anterior arch and odontoid process and confirmed a type II atlantoaxial rotatory subluxation. INTERVENTION AND OUTCOME: Manipulation under anesthesia was performed by a medical doctor trained in manual therapy. The low-velocity, right rotational manipulation applied to the occiput included axial traction. The neck symptoms were relieved immediately after treatment. CONCLUSION: Under general anesthesia, manipulation may be a good method for treating noncomplicated type II atlantoaxial rotatory subluxation. Additional investigations may be necessary to evaluate the treatment effect.
BACKGROUND: Chiari I malformation, accompanied by superposed bony anomaly of the craniovertebral junction, is comparatively rare. We report a case of Chiari I malformation accompanied by assimilation of the atlas, Klippel-Feil syndrome, and syringomyelia. CASE DESCRIPTION: The patient was a 61-year-old woman demonstrating numbness of the extremities, sensory impairment, muscular weakness, and tendon hyper-reflexia. X-ray images and CT scans demonstrated assimilation of the atlas to the occipital bone, C2 and C3 fusion, abnormal passage of the vertebral arteries, and an anomalous bony mass on the right lateral mass of the atlas protruding into the spinal column. The odontoid process was also deviated to the left. Magnetic resonance images demonstrated bilateral descent of the cerebellar tonsils and syringomyelia extending from C6 to T8. Computed tomographic scans with the head rotated to the right demonstrated increased narrowing of the vertebral column caused by the right lateral mass of the atlas, and MR images confirmed exaggerated deformation of the spinal cord at the same region. This deformation manifested no neurologic symptoms, and we therefore performed foramen magnum decompression and duraplasty using Gore-Tex (W.L. Gore & Associates, Inc., Flagstaff, AZ). In the early postoperative period, neurologic symptoms improved. CONCLUSION: We believe it is important that a treatment plan for Chiari I malformation accompanied by bony anomaly of the craniovertebral junction be determined based on morphologic investigation of the region supplemented by dynamic imaging-based evaluation of instability, or a careful inspection for atypical passage of the vertebral arteries, a frequent site of complication.
A case of long standing atlanto-axial subluxation following relatively minor trauma is reported. Progressive development of pain and spastic quadriparesis led to clinical and radiological investigation at Groote Schuur Hospital which revealed a spontaneous fusion of C1 and C2 with marked compromise of the spinal cord. The possibility of a pre-existing unfused odontoid process (os odontoideum) is discussed. A brief review of the literature is presented.
BACKGROUND: We treated 20 cases of craniovertebral junction lesions via a transoral approach. Developmental abnormalities of the craniovertebral junction accounted for 15 cases; there were 3 cases of tumor, 1 case of osteomyelitis, and 1 case of rheumatoid arthritis. METHODS: The transoral transpharyngeal approach was used in all cases. In 17 non-tumoral patients the anterior margin of the atlas and the odontoid process were resected. In one patient with a ventral clivus chordoma, both a transoral and a transnasal transsphenoidal approach was used for partial resection of the tumor mass. In two cases the median transpharyngeal approach was combined with a jaw-facial incision. In one case a metastatic adenocarcinoma, and in another a neurinoma of the accessory nerve straddling the posterior fossa and the pharyngeal region were removed. RESULTS: After operation four cases developed craniovertebral joint instability and required posterior cervical fusion or external fixation with a halo brace. Follow-up ranged from 2 to 44 months. In most patients neurologic function slowly improved. One worsened, and one died of respiratory failure after operation. Two patients with malignant tumors died during the follow-up period. CONCLUSION: In patients with developmental malformations, transoral decompression will result in some neurologic improvement and arrest the progress of symptoms. Patients with tumors are likely to show a good neurologic outcome when transoral surgery is performed in the early stage of the condition.
Asymmetry of the interspaces between the odontoid process and the lateral masses of the atlas is a finding occasionally noted on anteroposterior open-mouth radiographs obtained following trauma. Controversy exists as to the clinical significance of this finding in minimally symptomatic patients. Some believe this asymmetry is a normal variant, while others suggest that pathological rotation of the atlas on the axis may be present. This condition has been termed atlantoaxial rotatory subluxation (ARS), and when not corrected by 15 degrees head rotation, is said to be "fixed." Recent experience has shown that some patients with radiographic findings of ARS do not exhibit clinical signs or symptoms, leading us to question the significance of the radiographic diagnosis. A study was performed to evaluate the incidence of atlantoaxial asymmetry in normal subjects, the effect of rotation on the atlantoaxial relationship, and the ability to correct asymmetry by rotation. Eleven normal volunteers were evaluated with the following anteroposterior open-mouth views: without tilt or rotation (neutral); 15 degrees rotation in each direction; 15 degrees head and neck tilt to the right; right rotation with right tilt; and left rotation with right tilt. Six normals (54%) demonstrated atlantoaxial asymmetry in the neutral position despite proper positioning. No predictable change in the atlantoaxial relationship was produced by any of the manipulations described. Two normal subjects fulfilled the radiographic criterion for fixed atlantoaxial subluxation (asymmetry not corrected by rotation). We conclude that the radiographic finding of atlantoaxial asymmetry is common and not in itself abnormal.(ABSTRACT TRUNCATED AT 250 WORDS)
The authors report the case of a girl with achondroplasia suffering from a progressively worsening hypotonic quadriparesis. CT scan showed slight dilatation of ventricular and subarachnoid spaces, with well-defined evidence of cortical sulci and gyri. This aspect was compatible with the diagnosis of macrocrania and megalencephaly (CP being 51 cm). The foramen magnum was narrowed, the transverse diameter measuring 15 mm and the 50th percentile being, for age, 26 mm. Somatosensory evoked potentials (SEPs) revealed bilaterally prolonged interpeak latencies Erb-N13, slowing of central conduction time N13-N20 from right median nerve stimulation, and block from left median nerve. The suspicion of cervicomedullary compression was confirmed by MRI, showing a very marked stenosis with compression exerted by the odontoid process. Further, a stenotic cervical canal and optic nerves verticalization were manifest. The patient underwent neurosurgical decompression by suboccipital craniectomy and cervical-C1 laminectomy. In spite of treatment, both neurologic and respiratory problems (rapid, shallow and almost abdominal breathing) were unchanged. The girl died 4 1/2 months later. The authors emphasize the important role of SEPs in detection of cervicomedullary compression in achondroplastic children and also stress the necessity of an early surgical treatment as the only condition for possible clinical improvement and/or full recovery.
OBJECTIVE: To evaluate normal patterns of enhancement of signal intensity in and about the atlantoaxial joints following intravenous administration of a gadolinium-containing contrast agent. METHODS AND MATERIAL: Fat-suppressed axial T1 weighted SE images were obtained in 12 patients without evidence of inflammmatory arthritis before and immediately after intravenous administration of a gadolinium-containing contrast agent. Patterns of enhancement of signal intensity in and about the atlantoaxial joints were evaluated qualitatively. RESULTS: Four different MR imaging patterns were observed: no enhancement of signal intensity, enhancement in the form of a single punctate region, enhancement in a confluent pattern, and bandlike enhancement. CONCLUSION: Enhancement occurs around the odontoid process in patients without evidence of rheumatoid arthritis (RA). The dividing line between early synovitis and normal enhancement seems broader than expected. The reasons remain unclear and warant further studies.
A follow-up of 332 consecutive cervical spine injury patients is described. Treatment was with collars (47%), operation (6%), skull traction (24%) and Halo vest (23%). There was a large number of cervical spine injuries at the C2 level, and odontoid process fractures constituted 35% of all cervical spine injuries. The bad reputation of cervical spine injuries with high mortality rates, high non-union rates, and a high incidence of severe neurological impairment could not be confirmed. Traffic accidents affected the younger age categories, and injuries from falls the older ages. The accidents occurred in 95% during leisure, and at least 22% of the patients were under the influence of drugs and/or alcohol. Halo vest treatment gave a low complication rate, a low use of hospital bed days, sick leave and disability pension, compared with operations and skull traction treatment. The complication rate associated with the skull traction and operative treatment was unacceptably high.
It has hitherto been assumed without exception that A-P films of acute torticollis demonstrate neither malposture nor subluxation or (worse still) luxation of the atlas. In contrast, there is ventral subluxation of the atlas in all cases, although in about one-half of them this only become manifest in ventral flexion, with a tendency to form an angle between the odontoid process and the first cervical vertebra. In conformity with the head posture in acute torticollis, X-ray findings in the head joints are normal on A-P films. Fundamental to acute torticollis is that when the head is held in certain positions -- lateral inclination with rotation, sometimes combined with tilting of the head -- spontaneous, occasionally gradual obstruction of rotation of the atlas (and more rarely of the axis) occur; as a result, the head has to be held in these positions by force. In attempts to equalize head posture temporarily, lateral shifting of the atlas quite frequently occurs; depending on atlas rotation and the statics of the cervical spine, it may be either physiological or pathologic.
A 2 1/2-year-old female with a sphenooccipital-vertebral chordoma presented with neck pain, torticollis, fever, a lytic lesion of C2 vertebra, and bilateral nodular infiltrates in the lung. The lung biopsy revealed multiple tumor emboli by an enigmatic epithelioid-appearing neoplasm with immunohistochemical staining for vimentin, cytokeratin, and epithelial membrane antigen. A thorough roentgenographic evaluation disclosed a destructive, prepontine mass in the region of the clivus, erosion of the odontoid process, and compression of the cervical spinal cord. The patient died after a clinical course of 3 months. We identified 16 additional cases of metastasizing chordomas in the pediatric-age population; this case is the first to our knowledge with pathologically documented pulmonary metastasis at presentation.
A biomechanical study was undertaken to quantitate the immediate postoperative stability of the atlantoaxial articulation after stabilization by simple midline wiring, as well as the Gallie and Brooks procedures. Fresh adult cadaveric cervical spines were mounted for testing such that only the C1-2 motion segment and the load deflection curves generated in flexion, extension, and torsion moved. Spines were tested after the creation of a fracture at the base of the odontoid process with transection of the transverse ligament and after stabilization by each of the surgical techniques. Mean apparent stiffness values evaluated the biomechanical properties of these three commonly performed procedures. Although all tested procedures restored supraphysiologic mechanical properties in all modes tested (p less than 0.001), the Brooks technique was stiffer than the other two methods (p less than 0.001). Although many factors must be considered when selecting a particular surgical technique, the biomechanical data obtained in this study may be of assistance to the surgeon in choosing the type of construct for upper cervical stabilization and arthrodesis.
OBJECTIVE AND IMPORTANCE: This case report illustrates the importance of obtaining tissue from a destructive lesion of the dens in a patient with systemic sarcoidosis. Although sarcoidosis can involve the axial skeleton, tissue obtained at the time of C1-C2 fusion demonstrated unsuspected pathological features, which dramatically altered the subsequent medical treatment. The technique of open posterior biopsy of the dens is illustrated, and the advantages of the approach are discussed. CLINICAL PRESENTATION: A 40-year-old woman with systemic sarcoidosis developed neck pain and atlantoaxial instability. Imaging revealed multiple thoracic and cervical vertebral abnormalities, including a destructive enhancing lesion involving the base of the dens. INTERVENTION: At the time of posterior C1-C2 fusion, we elected to perform an open biopsy of the base of the dens. A 16-gauge biopsy needle was introduced along the medial portion of the left C2 pars, aiming medially toward the base of the odontoid process. This procedure was performed under direct observation, with fluoroscopic guidance. The biopsy specimen contained caseating granulomas, and cultures were positive for Mycobacterium tuberculosis. CONCLUSION: The unusual presentation, the technique, and the importance of obtaining tissue to confirm the diagnosis of tuberculous involvement of the dens are emphasized. The relationship between sarcoidosis and tuberculosis reported in the literature is reviewed. In the current case, cell wall-positive tuberculous bacteria were cultured, confirming the presence of two separate diseases in the same patient.
CT examination of rheumatoid dislocation in the C1-C2 region was performed in 20 patients with advanced disease. The patients were classified in three grades according to the degree of medullary compression caused by the odontoid process in the extended position of the neck. Five patients showed no dural or medullary compression (grade 1), nine dural compression (grade 2), and six medullary compression (grade 3). CT grading was found to correlate best with long tract symptoms. These were present in 4/6 grade 3 and 0/5 grade 1 patients, while 3/9 grade 2 patients had long tract symptoms. Tissue attenuation values over the anterior atlanto-axial joint indicated interposing firm connective tissue in patients showing no reduction of the subluxation on extension of the neck.
Posterior cervical fusion was performed in 34 patients with advanced rheumatoid atlanto-axial subluxation. Atraumatic surgical technique was used with local anesthesia and without skull traction. Intractable occipital rhizopathy and long-tract signs were the main indications. Anterior atlanto-axial subluxation in 28 patients was operated on with posterior fusion of C1-C2. Superior migration of the odontoid process into the foramen magnum in six patients was treated with posterior fusion of occiput C1-C2. Immediate mobilization in a plastic brace followed surgery. Average follow-up was 3 years. All patients became symptom-free, except for three who had remaining long-tract signs. Bony fusion was achieved in 17 patients; stable fibrous fusion, in 8 patients; and pseudoarthrosis, in 4 patients. There were no major postoperative complications. Five deaths occurred after 1-2 years from unrelated causes.
Median nerve somatosensory-evoked potential (SEP) examinations were performed in 24 consecutive patients with rheumatoid arthritis who had symptomatic cervical spine instability. Eighteen patients had C1-C2 instability: in ten, the subluxation was completely reducible, and in eight, the subluxation was irreducible, with or without superior migration of the odontoid process. Four patients had superior migration alone, and two had subaxial subluxation alone. Abnormal SEPs were found in seven patients overall. However, 58% of those patients with irreducible atlanto-axial subluxation and/or superior migration of the dens demonstrated abnormal cervical cord conduction latencies. Patients with these radiographic findings may be at a higher risk for the development of overt myelopathy.