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PubMed1991

Pattern of retinotectal projection in the megachiropteran bat Rousettus aegyptiacus.

The retinotopic organisation of the superior colliculus (SC) in the megachiropteran bat Rousettus aegyptiacus was examined with single and multi-unit recordings and by tracing the retrograde and anterograde transport of horseradish peroxidase (HRP) between the retina and the SC. The pattern of projection of the visual field onto the SC in Rousettus resembles the pattern found in most mammals. The whole of the contralateral visual field is represented and, in addition, a region of the ipsilateral visual field extending 25 degrees beyond the vertical 0 degree meridian. The ipsilateral visual field is represented binocularly in the most anterior 300-500 microns of the rostral pole of the SC. The contralateral visual field up to 25 degrees from the vertical meridian is represented through both eyes for the next 500-800 microns. The peripheral part of the contralateral visual field, 25 degrees-110 degrees from the vertical meridian is seen only by the nasal retina (the monocular crescent) of the contralateral eye and is represented in the caudal part of the SC. Following multiple injections of HRP into one SC, ganglion cells were labeled in both the nasal and temporal hemiretina of the contralateral eye. In the retina ipsilateral to the injection site, labeled cells were restricted to the temporal hemiretina. After injections of HRP into one eye, labeled terminals were found all over the contralateral SC, but in the ipsilateral SC they were restricted to a band that begins 300-500 microns caudal from the rostral pole and extends to the middle of the SC. These results suggest that in Rousettus, unlike the megachiropteran bats described by Pettigrew, Jamieson, Robson, Hall, McAnally, and Cooper (Philosophical Transactions of the Royal Society of London Series B 325:489-559, 1989), the retinotopic organisation of the SC is not primate-like, but follows the general mammalian scheme. As the retinotopic organisation of the SC is not consistent among the megachiropteran bats, the pattern of this projection may not be a useful indicator of their phylogenetic origins.

Animals↗
PubMed1995

Visual areas in the dorsal and medial extrastriate cortices of the marmoset.

To define the number and limits of the visual areas in the primate extrastriate cortex, the visuotopy of the dorsal convexity and medial wall was studied by electrophysiological recordings in five marmosets anaesthetised with sufentanil and nitrous oxide and paralysed with pancuronium bromide. We identified five visuotopic representations in and around the densely myelinated zone between visual area 2 (V2) and the posterior parietal cortex. Most of the densely myelinated zone is formed by the homologue of the owl monkey's dorsomedial area (DM); thus, we also termed this area DM in the marmoset. Within DM, the lower quadrant representation is continuous, with central vision represented laterally, peripheral vision medially, the horizontal meridian caudally, and the vertical meridian rostrally. In contrast, the upper quadrant representation is split, with the central portion represented at the lateral edge of DM on the dorsal surface, and the periphery along the midline. Two other visual field representations, corresponding to the dorsointermediate area (DI) and to a new subdivision termed the dorsoanterior area (DA), are also densely myelinated but can be distinguished from DM based on the separation of the bands of Baillarger and visual topography. In addition, a homologue of the medial visual area (M) was identified. Our results reveal a highly complex visuotopy in primate cortex, with local discontinuities in representation and borders between areas that are often not coincident with either the horizontal or the vertical meridian. The topography of the dorsal extrastriate cortex in the marmoset strongly suggests that both visual area 3 (V3) and the parietooccipital area (PO) of other primates are portions of a single visuotopic representation, DM, and calls into question the existence of visual areas with partial or quadrantic representations of the visual field.

Animals↗
PubMed1986

How the mirror-image pattern specified by a janus mutation of Tetrahymena thermophila comes to expression.

The initial changes of cell-surface organization that occurred as the recessive janA1 (janus) mutation of Tetrahymena thermophila first became expressed were elucidated in a special mating scheme in which old macronuclei homozygous for janA+ were synchronously replaced by new macronuclei homozygous for janA1. During this period of onset of expression, the number, regularity, and asymmetry of the ciliary rows remained unchanged. New normal (primary) oral apparatuses (OAs) continued to be formed posterior to old OAs, as in normal cells. At about four fissions after conjugation, abnormal (secondary) OAs with a partial reversal of asymmetry began to appear nearly opposite to the primary OAs, close to but not at the eventual circumferential position of janA1 secondary OAs. The array of contractile vacuole pores (CVPs), normally located adjacent to two ciliary rows centered near 22% of the cell circumference to the right of the primary oral meridian, underwent a two-step transformation: first, the number of adjacent ciliary rows bearing CVPs increased to 3, 4, and sometimes 5, then "skipped" rows appeared within this broadened CVP-arc to split the single set of CVPs into two separated subsets. The CVP transformations occurred gradually and progressively. They began prior to the expression of secondary OAs but accelerated as secondary OAs appeared. As the CVP arc became broader, its midpoint shifted somewhat to the right, away from the primary oral meridian, but ended up close to halfway between the primary and secondary oral meridians. The data provide a better fit to an intercalation model than to an alternative double-gradient model, suggesting that the janA1 mutation alters the large-scale organization of positional values by preventing the expression of a subset of these values and thus provoking reverse-intercalation of the remainder.

Animals↗
PubMed1985

Visuotopic information conveyed by each eye to the opossum's superior colliculus.

The uniocular visual field representations on the superior colliculus (SC), as estimated from multiunit response field centres about the horizontal meridian, were compared in midpontine pretrigeminal opossums (Didelphis marsupialis aurita Wied 1826). Recordings from the rostral pole (RP) and its caudal neighbour, the direct binocular region (DBR), as defined by Rocha-Miranda et al. (1978), were distinguished by the histological control. The results showed that while the hemifield contralateral to the recording site was well represented on the DBR by both eyes, the ipsilateral hemifield was generously represented at the RP only by the contralateral eye. At the RP the ipsilateral eye usually conveyed information about the vertical meridian, bringing about an expanded representation of the central visual space. Distinct patterns of representation were also recognized on graphs which relate recording sites along the AP axis of the SC with the azimuths of response field centres. The representation of the vertical reference meridian upon this axis on an oculocentric system was estimated from the DBR data and localized in the RP, at about 500 microns from the rostral end, for the ipsilateral eye (Vo') and in the DBR, at about 800 microns for the other eye (Vo). Similarly, plots of the magnification factor against the AP collicular axis indicated different strategies of representation for each eye. At the segment between 500 and 800 microns on this axis the magnification factors of the ipsilateral eye were usually much higher than those of the other eye. Furthermore, horizontal disparities between field centres were shown to have distinct distributions along the AP axis within the RP and DBR regions.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1983

Visual perception fields in the superficial layers of the opossum's superior colliculus: representation of the ipsi and contralateral hemifields by each eye.

Visual receptive fields of single units in the superior colliculus of the opossums were analysed in regions representing the ipsilateral (rostral pole - RP) and the contralateral hemifields (direct binocular region - DBR) close to and including the representation of the horizontal meridian. Of 242 units half had receptive field centres of the contralateral eye at the ipsilateral hemifield and the other half at the contralateral hemifield. The proportion of units driven by the ipsilateral eye was considerably smaller at the RP than at the DBR and the frequency of unit response to this eye diminished within the ipsilateral hemifield with progressively more rostral penetrations in the RP. The midline was unequally represented by the two eyes in RP units: while 24 out of 26 receptive fields of the ipsilateral eye straddled the vertical meridian, only 50 out of 120 of the contralateral eye did so. Furthermore, at the RP receptive fields of units responsive to the contralateral eye extended up to 46.8 degrees into the ipsilateral visual field while those mapped for the ipsilateral eye extended only up to 26 degrees. As a result of this tendency for the receptive fields of the ipsilateral, but not the contralateral eye, to overlap the vertical meridian, progressively more rostral recordings yielded an increase in the binocular convergent disparity as a function of the eccentricity for the receptive field of the contralateral eye. Since the disparity didn't vary with the eccentricity in the DBR units, we suggest that stimuli at the midline and close to the animal might be the natural ones to drive large disparity units present in the RP.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed2002

Neurons with radial receptive fields in monkey area V4A: evidence of a subdivision of prelunate gyrus based on neuronal response properties.

In recordings from two awake, behaving macaque monkeys we found that neurons in the crown of the prelunate gyrus differed in their responsiveness to simple visual stimuli. Neurons in the posterior part of the gyrus (area V4) responded strongly to stationary or moving bars, while neurons in the anterior part (area V4A) responded only weakly to such stimuli. Most receptive fields in area V4A were elongated with long axes oriented radially towards the fovea. These neurons were sensitive to radial movements, especially to sudden shifts of real 3D objects. The border between areas V4 and V4A coincided with the representation of the horizontal meridian. Area V4A extended into the posterior bank of the superior temporal sulcus, where its border corresponded to the representation of the vertical meridian. The sequence of the representations of the horizontal and vertical meridians over the prelunate gyrus suggests the existence of another area between V4A and V4t.

Animals↗
PubMed1998

Visual field defects in optic neuritis and anterior ischemic optic neuropathy: distinctive features.

BACKGROUND: We analyzed the value of visual-field defects in the differential diagnosis of optic neuritis (ON) and non-arteritic anterior ischemic optic neuropathy (AION). METHODS: Ninety-nine consecutive patients with acute-onset optic neuropathy formed the basis for this study. Compressive and vasculitic neuropathies were excluded. Eighty-six patients fulfilled the criteria for either ON (50 patients): < or = 35 years, normal disk, recovery of visual function, or AION (36 patients): > or = 60 years, swelling of the disk, no recovery of visual function. Without knowledge of other clinical data, visual fields obtained by Gold-mann perimetry were classified into five types of defects (forced choice). With the correct diagnosis at hand, fields were reviewed for characteristic features. RESULTS: Forced-choice classification into defect types [%]: Central scotoma ON 68, AION 18; superior altitudinal defect ON 13 AION 7; inferior altitudinal defect ON 8, AION 52; peripheral defect ON 1, AION 5; diffuse defect ON 10, AION 18. Search for pathognomonic defects: a scotoma centered on the fixation point with a sloping border occurred exclusively in ON (25 of 50 patients). An inferior altitudinal defect with a sharp border along the horizontal meridian, particularly in the nasal periphery, occurred only in AION (10 of 36 patients). A steep centrocecal scotoma occurred in 3 of the 36 AION cases and not at all in the ON cases. Scotomas in the center breaking through to the periphery, superior altitudinal defects (with a sloping border along the horizontal meridian) and diffuse depressions verging on blindness occurred in both ON and AION. CONCLUSION: A sctoma centered on the fixation point with a sloping border is highly characteristic of ON, while an inferior altitudinal defect with a sharp border along the horizontal meridian, particularly in the nasal periphery, is highly characteristic of AION. To identify these diagnostic criteria, it can be necessary to examine full fields. With restriction of perimetry to 30 degrees a large central scotoma can be mistaken for a diffuse defect and the border in the nasal periphery can be missed.

Acute Disease↗
PubMed1989

Anatomic study of transsclerally sutured intraocular lens implantation.

We used 21 cadaver eyes to study transsclerally sutured, ciliary sulcus-fixated intraocular lens implantation. Results showed that transscleral sutures should exit the sclera less than 1 mm posterior to the corneoscleral limbus for true ciliary sulcus fixation. The relationship of the ciliary sulcus to the overlying posterior surgical limbus differed in the vertical and horizontal meridians; needles that pierced the ciliary sulcus after being passed perpendicularly through the sclera entered the sclera 0.83 +/- 0.1 mm posterior to the posterior surgical limbus in the vertical meridians and 0.46 +/- 0.1 mm in the horizontal meridians. The major arterial circle of the iris (located in the ciliary body) was avoided as was the entire ciliary body during proper ciliary sulcus fixation. A one-piece, all polymethylmethacrylate, 10-degree vaulted, 13.5-mm haptic spread intraocular lens provides excellent optic centration and haptic stabilization when the haptic structure is placed at the greatest haptic spread and one transscleral suture pass per haptic is made.

Anterior Chamber↗
PubMed1989

Experimental reversal of the normal dorsal-ventral timing of blastopore formation does not reverse axis polarity in Xenopus laevis embryos.

During gastrulation in Xenopus laevis, the dorsal lip of the blastopore normally appears before the ventral lip. Metabolic gradient models propose that the dorsal lip develops from the region of highest metabolic activity and somehow dominates other regions to prevent them from becoming dorsal. To test these ideas, I applied a temperature gradient of 12 degrees C across the embryo. Localized heating of the prospective ventral vegetal region from early in the first cleavage period until gastrulation causes the blastopore lip to form first by 2 hr at the prospective ventral meridian rather than at the prospective dorsal meridian. Despite this reversal of the timing of blastopore formation, gastrulation is completed, and the neural plate forms at its usual position on the prospective dorsal meridian. This demonstrates that the earliest gastrulating regions of the blastopore do not necessarily become dorsal, nor do they inhibit dorsal development by other regions. It is unlikely that axis polarity is based on regional differences in energy metabolism.

Animals↗
PubMed1987

Natural boundaries for the spatial spread of directed visual attention.

The spatial characteristics of directed attention were studied using spatial precues in a suprathreshold luminance detection task. Visual response times to probe flashes presented at various distances from the presumed focus of attention provided the dependent measure. The variation in response times with distance from the attentional focus was used to create spatial maps of the expectancy effect. The results indicate that, in an uncluttered visual field, the effects of precuing are widely distributed, and that the principal transitions in performance tend to occur either at the horizontal meridian, the vertical meridian, or both meridians, depending on the locus of the observers' expectancy.

Attention↗
PubMed1992

Directional acuity for drifting plaids.

Orientation discrimination thresholds were estimated for symmetrical "plaids", constructed by the super-imposition of two, independent drifting sine-wave gratings of 2.5 c/deg. Experiments were conducted when the apparent direction of drift was on the two principal meridians (vertical and horizontal), and when the apparent direction of drift was at the two oblique orientations (45 and 135 deg). Acuity for the direction of drift for these stimuli is of the same order of precision as orientation acuity for static or drifting gratings, and exhibits a meridional anisotropy that favours the principal meridians. This anisotropy follows a pattern that is determined by the apparent direction of drift, and not the orientation of the underlying elements. Acuity for orientation is lowest for oblique drift directions, even though both of the elements are oriented on the principal meridians. This finding was confirmed when the orientation of the underlying elements was subject to a random variation. The results are not easily accommodated by models that propose that the individual elements of the plaid are analysed separately. Second, the data are incompatible with models of the oblique effect of orientation discrimination that are based on an axis dependent, differential sampling of the retinal image.

Discrimination, Psychological↗
PubMed1992

The two-dimensional shape of spatial interaction zones in the parafovea.

The spatial analysis of a target may be strongly degraded by the simultaneous presentation of nearby pattern elements. The present study investigated the shape and extent of the region of interaction as a function of retinal location. The stimuli consisted of 3 collinear [symbol: see text] s which were randomly oriented up ([symbol: see text]) or down ([symbol: see text]). The task was to discriminate the orientation of the middle [symbol: see text]. The retinal locations studied were at 0, 2.5, 5 and 10 degrees, on the lower vertical meridian and on the nasal halves of both the horizontal and the 45 degrees diagonal visual field meridians. The extent of the interaction region was defined as the separation between the midpoint of two adjacent [symbol: see text] s that resulted in 75% correct discrimination. The shape of the interaction region was determined by using several orientations (horizontal, vertical, left diagonal and right diagonal) for the virtual line joining the 3. [symbol: see text] s. Our results show that the size of the interaction regions varies linearly with eccentricity as does the size of a just resolved individual [symbol: see text]. However, the size of the interaction region varies much more rapidly than does the resolution threshold for an individual [symbol: see text]. The spatial interaction zones appear to be elongated radially, so that they have an elliptical shape. The size of the major axis is about 2-3 times the size of the minor axis. The major axis is along the meridian through the central visual field (i.e. it is oriented radially) while the minor axis is oriented tangentially (i.e. isoeccentrically).

Adult↗
PubMed1996

Cyclopean discrimination thresholds for the direction and speed of motion in depth.

We measured just-noticeable differences in the direction and speed of motion in depth of cyclopean and monocularly visible targets. Our stimulus set comprised different combinations of (d phi/dt)/(d delta/ dt), d delta/dt, d phi/dt and delta delta, where d phi/dt was the angular frontal plane speed of the binocularly-fused target, d delta/dt was its rate of change of disparity and delta delta was its disparity displacement. Our three subjects based their direction discriminations entirely on the task-relevant variable (d phi/dt)/(d delta/dt), and based their speed discriminations entirely on the task-relevant variable d delta/dt. They ignored all task-irrelevant variables in both tasks. Performance on both tasks was the same for motion within the horizontal and vertical meridians. Direction discrimination threshold rose significantly as the reference direction grew more oblique with respect to a line passing midway between the eyes and perpendicular to the frontal plane. Performance on the direction discrimination task was significantly better for the noncyclopean than for the cyclopean target, but the difference was not great. For the cyclopean target, the lowest value of the direction discrimination threshold was 0.70 deg (mean of three observers and two meridians). The Weber fraction for discriminating speed was not significantly different for the cyclopean and monocularly visible targets, and did not depend on the direction of motion in depth. The lowest values (mean of three observers and two meridians) were 0.12 (cyclopean) and 0.10 (noncyclopean). Findings did not scale for viewing distance. We propose that the human visual pathway contains: (a) a cyclopean mechanism sensitive to variations in the ratio (d phi/dt)/(d delta/dt) that is comparatively insensitive to both d phi/dt and d delta/dt; and (b) a speed-sensitive cyclopean mechanism that responds to variations in the value of d delta/dt, but is comparatively insensitive to d phi/dt. We also propose that a single speed-sensitive mechanism determines speed discrimination thresholds for both cyclopean and monocularly visible targets.

Adult↗
PubMed1996

The heliolongitudinal distribution of solar flares associated with solar proton events.

We find that the heliolongitudinal distribution of solar flares associated with earth-observed solar proton events is a function of the particle measurement energy. For solar proton events containing fluxes with energies exceeding 1 GeV, we find a Gaussian distribution about the probable root of the Archimedean spiral favorable propagation path leading from the earth to the sun. This distribution is modified as the detection threshold is lowered. For > 100 MeV solar proton events with fluxes > or = 10 protons (cm2-sec-ster)-1 we find the distribution becomes wider with a secondary peak near the solar central meridian. When the threshold is lowered to 10 MeV the distribution further evolves. For > 10 MeV solar proton events having a flux threshold at 10 protons (cm2-sec-ster)-1 the distribution can be considered to be a composite of two Gaussians. One distribution is centered about the probable root of the Archimedean spiral favorable propagation path leading from the earth to the sun, and the other is centered about the solar central meridian. For large flux solar proton events, those with flux threshold of 1000 (cm2-sec-ster)-1 at energies > 10 MeV, we find the distribution is rather flat for about 40 degrees either side of central meridian.

Earth, Planet↗
PubMed2005

Limbal relaxing incisions versus on-axis incisions to reduce corneal astigmatism at the time of cataract surgery.

PURPOSE: To compare limbal relaxing incisions (LRIs) with placement of the corneal cataract incision on the steepest keratometric axis for the reduction of preexisting corneal astigmatism at the time of cataract surgery. SETTING: The Queen Elizabeth Hospital, Adelaide, South Australia, Australia. METHODS: In a prospective single center study, patients having 1.5 diopters (D) or more of keratometric astigmatism were randomly assigned to 2 surgical techniques: on-axis incisions (OAIs) consisting of a single clear corneal cataract incision centered on the steepest corneal meridian or LRIs consisting of 2 arcuate incisions straddling the steepest corneal meridian and a temporal clear corneal incision. Vector analysis of the target axis flattening effect was used to assess the efficacy of treatment. RESULTS: Seventy-one eyes of 71 patients were evaluated, 33 in the OAI group and 38 in the LRI group. Six weeks postoperatively, the flattening effect was 0.41 D (median and interquartile range 0.15 to 0.78 D) in the OAI group and 1.21 D (range 0.43 to 2.25 D) in the LRI group (P = .002). After 6 months, the flattening effect was 0.35 D (range 0.00 to 0.96 D) and 1.10 D (range 0.25 to 1.79 D), respectively (P = .004). CONCLUSION: The amount of astigmatism reduction achieved at the intended meridian was significantly more favorable with the LRI technique, which remained consistent throughout the follow-up period.

Aged↗
PubMed2006

Local corneal thickness changes after small-incision cataract surgery.

PURPOSE: To assess whether a temporal limbal-corneal incision approach for phacoemulsification cataract surgery induces a gradient in corneal thickening along the horizontal meridian. SETTING: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. METHODS: Corneal thickness in 21 eyes of 21 patients was measured preoperatively as well as 1 day, 1 week, and 1 and 3 months after phacoemulsification through a temporal limbal-corneal incision. Measurements were performed using partial coherence interferometry (PCI) with a commercial instrument, the ACMaster (Carl Zeiss Meditec, Jena). Measurements were taken along the horizontal meridian centrally along the visual axis at 1.5 mm, 3.0 mm, and 4.5 mm eccentricity. RESULTS: Preoperatively, there were slight nasal-temporal differences in corneal thickness at all eccentricities. The mean thickness was 522 microm +/- 34 (SD) at 1.5 mm nasally and 513 +/- 36 microm at 1.5 mm temporally (P<.01). On day 1, there was a significant mean increase in corneal thickness (38 +/- 43 microm) along all locations. The thickening was slightly more pronounced in the periphery than in the center, a difference not reaching statistical significance. At 1 week, corneal thickness returned almost to baseline at all locations except for 3.0 mm temporally, where it was slightly, but not significantly, thicker (mean 8 +/- 14 mum). At 1 month, corneal thickness at the 3.0 mm temporal location returned to baseline. CONCLUSIONS: A nasal-temporal difference in corneal thickness was found preoperatively in all patients. Phacoemulsification through a temporal limbal-corneal incision caused an increase in corneal thickness along the horizontal meridian 1 day after surgery. The prolonged corneal thickening at 3.0 mm eccentricity temporally could be a result of the proximity to the incision site.

Aged↗
PubMed2006

Torque and flattening effects of clear corneal temporal and on-axis incisions for phacoemulsification.

PURPOSE: To compare the torque and flattening effect induced by temporal or on-axis clear corneal incisions (CCIs) for phacoemulsification. SETTING: Moorfields Eye Hospital, London, United Kingdom. METHODS: Randomized controlled clinical trial on 62 eyes with cataract and mild to moderate corneal astigmatism (<2.60 diopters [D]) having phacoemulsification with a temporal CCI (temporal group) or on-axis CCI (on-axis group). Corneal astigmatism was assessed by corneal topography preoperatively and 3 weeks after surgery. The meridian of the incisions was marked on the cornea before local anesthesia was given to avoid anesthesia-related cyclotorsion. The surgically induced astigmatism (SIA) vector, torque, flattening effect, and accuracy of incision placement were analyzed in the 2 groups and compared with a paired t test. RESULTS: Three weeks after surgery, the on-axis CCI induced slightly more flattening of the meridian of the incision (mean -0.63 +/- 0.57 D [SD]) than the temporal CCI (mean -0.50 +/- 0.44 D); however, the differences were not statistically significant (P = .31). Simple algebraic difference showed a mean increase in astigmatism magnitude of 0.12 +/- 0.52 D in the temporal group and a mean reduction of 0.21 +/- 0.53 D in the on-axis group (P = .02). The mean absolute torque was 0.28 +/- 0.27 D and 0.53 +/- 0.37 D, respectively (P<.005). The absolute angle of error of incision placement (alpha) was greater after on-axis CCIs (mean 25.9 +/- 20.1 degrees) than after temporal CCIs (mean 14.5 +/- 14.3 degrees) (P = .01). CONCLUSIONS: In eyes with preoperative astigmatism less than 2.60 D, on-axis CCI phacoemulsification induced slightly more flattening along the incision meridian than temporal CCI phacoemulsification, although the differences were not significant. The on-axis CCI was associated with significantly greater absolute torque and angle of error than the temporal CCI. These factors could limit the benefit of placing the incision on axis when the aim is to reduce preoperative astigmatism in phacoemulsification.

Aged↗
PubMed1996

Kinetic disposition of an aqueous formulation of alphacypermethrin applied to the dorsal mid-line of sheep with long wool and its effect on lice.

A group of 5 adult Merino sheep with fleeces about 70 mm long (7-months growth of wool) was treated with a topical formulation of the synthetic pyrethroid insecticide, alphacypermethrin, applied to the dorsal mid-line. Insecticide concentrations at the tip, middle and base of wool staples collected from meridians along the back, upper and lower flanks were measured at intervals from 1 to 98 days after treatment. Some movement of the alphacypermethrin from the back to the lower body occurred within 24h after treatment, but despite careful application of the insecticide there was wide variation in the concentration between and within meridians. The majority of the alphacypermethrin remained close to the dorsal mid-line and near the tip of the staple. There were significant differences in the concentration between the tip, middle and base segments of the staples in the back and lower flank meridians (P < 0.05). Despite exposure of the sheep to normal weathering, there was no significant difference in the concentration of alphacypermethrin between samples collected at day 1 or day 98 after treatment (P > 0.05). Numbers of pyrethroid-susceptible lice surviving exposure in vitro for 20 h differed significantly between samples collected at different times after treatment, lice survived for 20 h in wool taken from parts of the fleece that contained high (P < 0.05). The numbers of lice surviving in samples collected within 28 days after treatment tended to be lower than in those collected from 28 to 98 days but, in some samples, regardless of time after treatment, concentrations of alphacypermethrin.

Administration, Topical↗