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Results for “MANDIBULAR CONDYLE”

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At least 469 records · Page 26Linked to original sources
PubMed1985

Morphometric study of the mandibular condyle of the rat during postnatal development.

A morphometric technique for the use of the temporomandibular joint (TMJ) of the rat as an experimental model was developed to study TMJ growth from birth to 120 days of age. Experimental conditions for the reduction and embedding of the specimen, as well as for data collection were standardized. Morphometric data were obtained from projected drawings and the areas occupied by the various structures were determined by counting points with a specially constructed integration grid. The areas occupied by the layers making up the mandibular condyle remained relatively constant, forming an architectural pattern from the 30th postnatal day on. Between the 10th and 30th day they underwent modifications interpreted to be functional adaptations conditioned by changes in the animal's feeding habits.

Aging↗
PubMed2002

Immunohistochemical localization and distribution of proliferating cell nuclear antigen in the rabbit mandibular condyle following experimental induction of anterior disk displacement.

The purpose of the present study was to identify proliferating cells in control versus experimental condyles two weeks following experimental induction of anterior disk displacement (ADD) in the rabbit craniomandibular joint (CMJ). The right joint of 15 rabbits was exposed surgically and all diskal attachments were severed except for the posterior attachment. The disk was then repositioned anteriorly and sutured to the zygomatic arch. The left joint served as a sham-operated control. Ten additional joints were used as nonoperated controls. Mandibular condyles were excised two weeks following surgery and processed for proliferating cell nuclear antigen (PCNA) immunostaining. In control and sham operated condyles, PCNA was localized in the nuclei of chondroblasts of the reserve cell layer, chondrocytes of the upper hypertrophic layer and bone marrow cells of the subchondral bone. In contrast to control joints, the PCNA positive cells of the experimental joints were located throughout the osteoarthritic condylar cartilage. In addition, the percentage of PCNA positive cells of the osteoarthritic condylar cartilage was statistically significantly higher when compared to the control group, p < 0.05. It was concluded that surgical induction of ADD in the rabbit CMJ leads to an increase in mitosis of chondrocytes, which lead to cell proliferation and subsequent hyperplasia of the condylar cartilage.

Analysis of Variance↗
PubMed2001

The osseointegration of Mitek mini anchors in the mandibular condyle.

PURPOSE: This study examined the histomorphology of the bone around the Mitek mini anchors (Mitek Inc, Norwood, MA) after 3 to 59 months of implantation. MATERIALS AND METHODS: Thirteen condylar specimens from 8 patients were evaluated. Each of these patients had had previously placed Mitek mini anchors and braided polyester sutures for temporomandibular joint (TMJ) articular disc stabilization. Histologic evaluation of each specimen was performed to determine the degree of osseointegration. Each specimen was also evaluated for anchor configuration, fracture, and particulation and the presence or absence of intervening fibrous connective tissue or an inflammatory cell infiltrate. RESULTS: All anchors became osseointegrated without evidence of associated inflammation or fibrous connective tissue formation along the surface. There was no evidence of anchor fracture or particulation. CONCLUSIONS: The Mitek mini anchor can osseointegrate in the mandibular condyle. These suture anchors remain intact and biocompatible for as long as 59 months, the longest interval examined in this study.

Adolescent↗
PubMed2000

Ultrastructural characterization of the rabbit mandibular condyle following experimental induction of anterior disk displacement.

Previous studies in our laboratory have shown that surgical induction of anterior disk displacement (ADD) in the rabbit craniomandibular joint (CMJ) leads to cellular and extracellular alterations consistent with osteoarthritis. Similar findings were also reported in human ADD as well as osteoarthritis of other joints. The purpose of this study was to further characterize these histopathological findings at the ultrastructural level. The right joint of 15 rabbits was exposed surgically and all discal attachments were severed except for the posterior attachment. The disk was then repositioned anteriorly and sutured to the zygomatic arch. The left joint served as a sham-operated control. Ten additional joints were used as nonoperated controls. Mandibular condyles were excised 2 weeks following surgery and processed for transmission electron microscopy. Experimental condyles showed neovascularization, fibrillation and vacuolation of the extracellular matrix and an increase in the number of apoptotic cells compared to controls. In addition, chondrocytes in osteoarthritic cartilage showed an increase in the amounts of rough endoplasmic reticulum and Golgi complex suggesting an increase in protein synthesis. The presence of thick collagen fibers in osteoarthritic cartilage supports our previous immunohistochemical results of the presence of type I collagen instead of normally existing type II collagen. It was concluded that surgical induction of ADD in the rabbit CMJ leads to ultrastructural changes in the mandibular condylar cartilage consistent with degenerative alterations known to occur in osteoarthritis.

Animals↗
PubMed1994

An ultrastructural study of extracellular fibrillar components of developing mouse mandibular condyle with special reference to type VI collagen.

The localization of type VI collagen was examined from birth to 8 weeks of age. Immunohistochemical staining with anti-type VI collagen antibody was strongly positive in the hypertrophic zone and moderately positive in the fibrous zone and the outer periphery of the proliferative zone, but negative in the inner area of the proliferative zone and mature zone. After ATP treatment, type VI collagen periodic fibrils with about 80-nm intervals were frequently observed but only in the fibrous zone. They occurred mainly in the superficial area of this zone, where striated collagen fibrils were sparse, while a few were noted in the inner area, where bundles of collagen fibrils were abundant. From these distributional differences of both components, a subzonation of the fibrous zone into superficial and inner area is suggested. Moreover, with ATP treatment there were fewer type VI collagen periodic fibrils formed with increasing age (8 weeks). Testicular hyaluronidase digestion before ATP treatment facilitated the formation of periodic fibrils, in all the ages examined, in the intercellular space and around the fibroblastic cells. The interaction of type VI collagen with other components such as collagen fibrils, glycosaminoglycans or proteoglycans may play a part in maintaining the structural integrity of extracellular matrix in the mouse mandibular condyle.

Adenosine Triphosphate↗