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[Parathyroid adenoma and renal lithiasis. Report of a case].

A case is presented of nephrolithiasis in a patient with no other symptoms than the urological ones and in which considerable hypercalcemia led to a study being carried out on his phospho-calcium metabolism and the diagnosis reached was primary hyperparathyroidism caused by a parathyroid adenoma. Surgical treatment was performed on the lithiasis and the adenoma as a result of which the symptoms completely disappeared and the biochemical readings returned to normal.

Adenoma↗

[Incidence of biliary lithiasis in African urban areas (Abidjan): a little known pathology?].

The rarity of cholelithiasis in black Africa is a very classical concept that must be called in question again. With the exception of pigmentary lithiasis frequently found in patients with an homozygous haemoglobinopathy, genetic as well as environmental (particularly food related) factors explain in part the low frequency of cholelithiasis with cholesterol gallstones in Africa. Yet the true incidence of cholelithiasis is too often unappreciated. Before the use of ultrasonography, only symptomatic cholelithiasis were detected, usually by the surgeon (19 cases admitted during a 6 years period in the Internal Medicine Department at Treichville University Hospital, Abidjan). The practice of ultrasonography will ease the detection of asymptomatic cholelithiasis. Since ultrasonography has been set up at Treichville University Hospital, 30 cholelithiasis of which 21 were asymptomatic have been detected during an 8 months period, a high detection level of course for a so-called rare disease.

Adolescent↗

[Hepaticojejunostomy for intrahepatic lithiasis. Complementary procedures].

Hepatico-jejunostomy for intrahepatic lithiasis can usefully be completed by a double trans-hepatic drainage, which makes it possible to wash the biliary tree and flush out residual stones in the post-operative period, and also by cutaneous jejunostomy, which facilitates endoscopic removal of intrahepatic stones remaining in situ.

Bile Ducts, Intrahepatic↗

[Calcium lithiasis II. Idiopathic or hypophosphatemic hypercalciuria? Vitamin D - metabolism and othophosphate therapy].

Hypophosphateamia in patients with Ca lithiasis leads to the activation of the vitamin D endocrine system: the plasma 1.25(OH)2-D3 concentration is raised. The raised 1,25(OH)2-D3 biosynthesis causes an increase in intestinal Ca absorption, which in its turn explains the hypercalciuria. The syndrome originally presented by Albright and his pupils as "idiopathic hypercalciuria" in fact corresponds to a secondary, reactive D hypervitaminosis. According to the present findings the often wrongly used term "so-called idiopathic calciuria" should be replaced by the pathogenetically correcter term "hypophosphataemic calciuria". Efficient treatment of this syndrome consists in sufficient oral orthophosphate substitution. In the interests of a better understanding as a requirement for suitable treatment of this metabolic disorder, the vitamin D metabolites and their renal key enzymes, 25-OH-Vitamin-D3-1-Hydroxylase and 25-OH-Vitamin -D3-24-Hydroxylase, are described. The hormonal control add the activation and inactivation of the vitamin D endocrine system are explained independently of the individual Ca and phosphate requirement of the organism. The dependence of renal Ca excretion on the rate of glomerular filtration is pointed out once again. The clinical-diagnostic term hypercalciuria must not be applied globally but individually. Indications, counter-indications, dosage, duration and side-effects of the orthophosphate therapy are discussed.

25-Hydroxyvitamin D3 1-alpha-Hydroxylase↗

[Chronic renal failure and lithiasis].

After analyzing 39 cases, the authors go on to describe the virtues of surgical treatment of non-uric lithiasis after correct evaluation (lateral urography, CT scanning, retrograde ureteropyelography). The operative techniques draw considerable benefits from intraoperative radiography and, when necessary, the clamping of the renal pedicle under pharmacological protection. Surgical management offers the only possible means of preventing aggravation of the renal failure.

Humans↗

Triamterene and renal lithiasis: a review.

A small number of patients taking products containing triamterene (TAT) develop renal calculi that contain TAT and its metabolites. Most TAT-containing calculi are composed of various crystalline materials, but a small number consist only of TAT, its metabolites, and a protein matrix. Calculi form as the drug binds to the protein matrix. In patients receiving TAT therapy, the incidence of calculi consisting of TAT and its metabolites ranges from 1 in 1,500 to 1 in 2,000 patients. No clear "dose-effect" relationship between TAT use and renal lithiasis has been established, and no correlation between the duration of TAT therapy and the formation of renal calculi has been found. Patients with a propensity for renal calculi formation, based on previous occurrence or family history, develop calculi at about the same rate in the presence or absence of TAT. Patients who form renal calculi containing TAT do not absorb or excrete abnormal quantities of TAT and do not metabolize the drug abnormally.

Female↗

[Calcium lithiasis: uric acid under question].

Usually calcium nephrolithiasis is due to "idiopathic" hypercalciuria associated with failure of the compensatory mechanisms (dissolving substances and crystallisation inhibitors. Classically a sufficient diuresis, a low calcium diet, the phosphate ion or (and) the thiazidic diuretics manage to reduce the hypercalciuria and to decrease the chances of relapse. This aim may be differently reached when hyperuricosuria is associated with hypercalciuria. The use of uric acid synthesis inhibitors (allopurinol, thiopurinol) brings the frequency of the recurring stone formation down and... the calciuria often. Series dealing with 141 calcium lithiasis with hyperuricosuria.

Allopurinol↗

[Long-term clinical experiences with the cation exchanger UJOLYT as a metaphylactic in absorptive hypercalciuria and chronic recurring calcium oxalate lithiasis].

The UJOLYT cation exchange was checked in a clinically controlled study over a long period using 6 male test persons with chronically recidive calcium oxalate lithiasis and absorptive hypercalciuria. The PAK calcium load test proved clinically valuable in the differentiation of idiopathic hypercalciuria. The paraclinical findings revealed an average reduction of urinary calcium excretion by 40% and an increase of urinary magnesium excretion by 11.7% compared to the initial situation. The recidive frequency was clearly reduced. No serious side-effects were observed in the patients presented.

Adult↗

[Common bile duct lithiasis. Reflections apropos of 1000 cases].

One thousand case reports of patients treated in eleven French surgical departments for stones in the common bile duct between 1975 and 1982 were analyzed. One in three cases were asymptomatic and detected by peroperative radiology during treatment of a simple or complicated gallstone, most forms were painful, with jaundice in 9 p. cent, an angiocholitis in 12 p. cent, and biliary pancreatitis in 2 p. cent. The most reliable exploratory procedure for gallstones is ultrasound imaging, as positive results were obtained in 90 p. cent of cases, but it enabled the diagnosis of choledocholithiasis in only one out of five patients. Intravenous cholangiography is a useful diagnostic tod for painful forms (60 p. cent). The failure of these two methods to establish the diagnosis in forms complicated by jaundice, pancreatitis, or angiocholitis has to be compared with the good results (85 p. cent) observed with endoscopic retrograde cholangiography. Treatment was surgical in 99 p. cent of patients, peroperative radiology being performed in 95 p. cent of these cases and endoscopy in 30 p. cent. In one out of two cases a single large stone was present while multiple stones were present in 8 p. cent. A "ideal" choledochotomy was carried out in 77 patients (7,7 p. cent) without mortality. External biliary drainage in 702 cases resulted in a 1.7 p. cent mortality rate, this increasing to 8 p. cent after 192 biliodigestive shunt operations, and 7 p. cent after 146 sphincterotomies, including 18 under endoscopic control. Unrecognized lithiasis, detected during follow-up radiography two weeks after external biliary drainage, accounted for 2-8 p. cent of cases. Of the 30 patients with residual stones and open biliary pathways, 6 were treated by mechanical removal, 6 by endoscopic sphincterotomy, and the others by repeat surgery.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

[Oxalate lithiasis associated bith abetalipoproteinemia. Report of a case].

A case of oxalate lithiasis associated with Abetalipoproteinemia is reported. The excessive absorption of dietary oxalate in this patient with fat malabsorption occurs because unabsorbed fatty acids in the bowel lumen combine with calcium ions which would otherwise impair oxalate absorption by forming insoluble calcium oxalate crystals. The medical management include dietary fat restriction and supplements of the fat soluble vitamins A, E and K. The prognostic is poor particularly in the neurological and retinal component of this disease.

Abetalipoproteinemia↗

[Value of echotomography for the diagnosis of lithiasis of the common bile duct].

The accuracy of ultrasonography (US) for the diagnosis of cholelithiasis and for dilatation of the intra- and extra-hepatic biliary tree is well known. However, the value of US for the diagnosis of common bile duct stones remains poorly defined. We performed a prospective study in 100 patients who were referred for endoscopic retrograde cholangiopancreatography (ERCP); all the examinations were carried out by the same sonographist in the 24 h preceding the ERCP. Fifty patients had choledocholithiasis, 20 patients had obstruction of the bile ducts without lithiasis and the common bile duct (CBD) was free in 30 patients. The sensitivity of US for the diagnosis of choledocholithiasis was 40 p. 100, the specificity 90 p. 100. The positive and negative predictive values of the "CBD stone" sign was 80 p. 100 and 60 p. 100 respectively. In a total of 30 false negatives, the CBD could not be explored in 4 cases, dilatation of the CBD was missed in one case, and obstruction of the CBD by an other disease was diagnosed in 2; in all the other cases, US was able to appreciate the CBD size as well as the ERCP. In the 20 patients with an obstructed CBD but without choledocholithiasis, US diagnosed a stone in 5 cases. Age, serum bilirubin, existence of a previous cholecystectomy, technical difficulties, stone size were comparable in patients with true positive tests and in patients with false negative tests. However the diagnosis of choledocholithiasis was more frequently achieved in patients with dilated CBD over 10 mm (p less than 0.05) and in patients with multiple stones.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

[Stenosis of the left hepatic duct with intrahepatic lithiasis: treatment by the percutaneous transhepatic approach].

The authors report the case of a 78-year-old woman suffering from cholangitis secondary to intrahepatic biliary stricture and intrahepatic lithiasis. Successful management consisted of successive percutaneous transhepatic internal-external biliary drainage, balloon dilatation of the stricture and gallstone mobilisation and removal through the stricture. No complications were noted.

Aged↗

[Recurrence and prevention of recurrence after dissolution of gallbladder lithiasis by chenodeoxycholic acid in 22 patients].

Dissolution of gallstones was observed 33 times in 22 patients. For 11 of them a recurrent lithiasis was dissolved by means of a second or third medical treatment. 21 patients have been followed for 3 to 6 years (median over 4 years). Without longstanding treatment the recurrence rate was 50 p. 100 in 3 years and 87.5 p. 100 in 6 years. Most of the patients should have relapsed in less than 9 years. Recurrences were always successfully treated with the same treatment but relapsed if the treatment was stopped (21 recurrences in 14 patients). A-1 month every 4 months-long standing treatment did not prevent recurrences in 8 patients whereas treatment every other month prevented recurrences in 5. It is therefore suggested to give long treatment after dissolution of gallstones to avoid recurrences. Its duration should be undefinite. Alternatives might include: 1) repeated dissolving treatments in case of recurrences, if relapses occur lately; 2) or longstanding treatment in case of early recurrences.

Adult↗

[Echographic aspects of biliary lithiasis and its complications].

Ultrasonic appearances of various types of gallbladder stones are described and findings on ultrasonic imaging of the main complications of biliary lithiasis analyzed. New possibilities for examination of the principal biliary pathway are being opened up by progress in improving resolution of the ultrasonoscope and by advances in knowledge of ultrasonic anatomy of the biliary tracts.

Biliary Fistula↗

[Surgery of ureterocele with lithiasis].

We present 7 cases of ureterocele with secondary lithiasis, which constitute 15% of all our cases of ureterocele. From the clinical point of view, the symptoms are not different from those of these two separate pathologies. Nephroureteral colics associated with a low ureteral syndrome were the most frequent cause of the patients' visiting the doctor. Obstruction of the vesical neck is characteristic of ectopic or large ureteroceles. The diagnostic is radiographic and endoscopic. The results of the surgical treatment are much more superior with the transvesical approach followed by antireflux plastia to the transureteral approach, in which postoperative reflux is common, although it is usually well tolerated by adult patients.

Female↗

[Biliary lithiasis in patients over 75. 100 cases operated upon (author's transl)].

This is a retrospective study of 100 elderly patients (36 men and 64 women aged 75 years or more) operated upon for biliary tract calculi. Thirty-one patients had one or several underlying visceral diseases and 5 had associated carcinoma of the digestive tract. Calculi of the common bile duct were present in 48 cases, and 41 patients had acute infection, including cholecystitis (14) and cholangitis (27). Surgery included cholecystectomy in every case and opening of the common bile duct in 49 cases with either choledocho-duodenal anastomosis (31 cases) or external biliary drainage (18 cases). Only one patient with gastric carcinoma died. The morbidity rate was low (11 post-operative complications) and each group of patients spent about the same time in hospital. Neither mortality nor morbidity were aggravated by the presence of calculi in the common bile duct and/or acute infection. In uncomplicated lithiasis the surgical indications mainly depend upon the severity of underlying visceral diseases. Early intervention seems desirable in most patients with acute cholecystitis or cholangitis. Surgery of the biliary tract is basically the same in elderly and in young patients, but the operation must be simple and, if possible, complete. The quality of medical surveillance and nursing has considerable influence on the results.

Aged↗

[Ursodeoxycholic acid in the treatment of gallbladder lithiasis].

22 patients with radiolucid stones and functioning gallbladder were grouped to establish ursodeoxycholic acid efficacy (i.e. gallstones dissolution) and innocuousness for gallbladder lithiasis. Methodological aspects were detailed, the dose determined (8 and 10 mg/k/d.) and the patients evaluated after a six months' treatment. 11 patients received "day-time" doses and the other 11 "overnight" dose. Only 7 subjects turned out to be evaluated for the study of biliary lipids, to the other 15 the development of their gallstones was followed up. Successful gallstone dissolution was achieved in 8 patients (53,3%), 2 reduced size and number. 5 out of these 8 patients received "day-time" doses and the other 3 "overnight" doses. From an attendance point of view, we do not consider biliary lipids study (bile cholesterol saturation rate) to be necessary.

Cholelithiasis↗