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Results for “IATROGENIC DISEASE”

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At least 469 records · Page 26Linked to original sources
PubMed1986

[Iatrogenic pathology in coronary intensive care units. Results of a prospective survey on 802 patients].

Iatrogenic disease in the coronary care unit was detected and analysed using a grid over a 17.5 month period (16.09.82 to 25.02.84). The cases of 802 patients, mean age 65.8 years, predominantly male (56.6%) were examined. Minor or minimal pathology in which the causal relationship was conditional or doubtful according to Karch's criteria was excluded. Only those conditions, moderate, severe or even lethal, specific or not to this type of unit, requiring specialised hospital care and in which the causal relationship could be adequately established were retained. Iatrogenic pathology was common: 11.84% of admissions. This group of 95 patients did not differ significantly from a control group with respect to age [average 4 years older (NS)] or mortality. However, there was a clear cut female predominance (68%, p. less than 0.01) and a different distribution of the organic pathology (p less than 0.001). The iatrogenic disease developed before hospital admission in 40% of patients and during hospitalisation in 60% of patients. It increased the duration of the patient's stay by half (2.77 days). Nearly a quarter of these patients had two or more types of iatrogenic disease. The undesirable effects of drugs were mainly bradycardia (44 cases), tachycardia (11 cases), haemodynamic changes, vascular, renal, gastrointestinal, metabolic and endocrine complications. Twenty-one complications of medical procedures and 13 of surgical procedures were also noted. This study, the first to have been performed in a Coronary Care Unit to the author's knowledge, confirms the high incidence of iatrogenic pathology. This fact should be born in mind before taking any therapeutic decision or before performing invasive diagnostic investigations.

Adult↗
PubMed1991

Iatrogenic liver disease from vitamin A.

In a retrospective case series, 41 patients developed severe liver disease after prolonged administration of vitamin A originally recommended for the treatment of medically benign conditions, mostly dermatologic. Six patients died of liver failure during follow-up.

Chemical and Drug Induced Liver Injury↗
PubMed2004

[Iatrogenic rheumatic diseases].

This article reviews, through illustrative cases, five rheumatic diseases associated with drug treatments: statins and myopathy, quinolones and tendinopathy, viscosupplementation and pseudoseptic arthritis, diuretics and gout, barbiturates and adhesive capsulitis. Due to the rarity of such cases, we lack validated therapeutic recommendations. Announcement to the adverse drug reaction reporting system is the best way to enhance our knowledge and to improve the public health.

Aged↗
PubMed1995

[Drug-induced iatrogenic arterial diseases].

Several drugs have been shown to cause vasomotor troubles such as Raynaud's phenomenon, erythromelalgia, vasculitis, livedo reticularis, or acrocyanosis. Vascular symptoms may develop a few weeks or more after drug initiation, particularly when other drugs are associated than can potentiate vascular side effects. In this review, the authors described the main characteristics of drug-induced vasculopathy, particularly those associated with ergotamine derivates, beta blocking agents or antineoplastic chemotherapy.

Arteries↗
PubMed1999

[Brief history of transmissible spongiform encephalopathies].

Transmissible spongiform encephalopathies have a long and still unfinished history replete with spectacular discoveries and equally spectacular failures. The story begins in the 18th century with the first descriptions of scrapie, a naturally contagious disease of sheep that was not experimentally proven to be a transmissible infection until 1936. This discovery permitted veterinarian investigators to begin to explore aspects of pathogenesis and the nature of the infectious agent. The additional discovery, in the 1960's, that scrapie was similar to the human diseases kuru and Creutzfeldt-Jakob vastly widened what had been a comparatively restricted field of research, and led to rapid advances in molecular characterization of the disease agents, culminating in the proposal that they are self-replicating abnormally configured host proteins, or "prions". Despite these advances, we have seen in recent years 3 potentially preventable outbreaks of disease: iatrogenic Creutzfeldt-Jakob disease due to contaminated pituitary hormone extracts and dura mater grafts, and a new variant of the disease (Will-Ironside syndrome) linked to consumption of beef contaminated by the agent of bovine spongiform encephalopathy, underscoring the disparity between fundamental knowledge and its practical application.

Disease Outbreaks↗
PubMed2005

[Anaerobic deep abscesses with unusual location: report of 5 cases].

OBJECTIVE: Anaerobic deep abscesses are rare and may have unusual location leading to severe outcome due to delayed diagnosis and treatment. In order to improve their diagnosis, we report and analyse 5 new cases. METHODS: Patients were seen from 1999 to 2003 in a single department of internal medicine of the university hospital of Marseille. RESULTS: Five new cases were diagnosed consisting in 3 females and 2 males with a medium age of 56,8 years, with unusual location in 4 cases: epidural (2), psoas (1) and sub-diaphragmatic (1) or circumstances in one case of pulmonary abscess unrelated to inhalation. Predisposing conditions thought to compromise resistance to infection were found in all cases: social poverty (4/5), alcoholism (3/5), smoking (4/5), teeth and periodontal disease (4/5), neoplasia (2/5), iatrogenic disease (2/5). Symptoms were insidious (5/5) and unspecific but were always related to the abscess location. Abscesses were frequently found distant from the initial focus of infection because of frequent hematogenous spread (4/5). Drainage of the collection led to bacterial identification in all cases (4/4), although blood cultures could be positive (3/5) and helpful in one case in which drainage was not possible (1/5). The isolated organisms always corresponded to the suspected initial focus (oropharynx 4/5 and digestive 1/5). Finally, combination of surgical drainage and double prolonged antibiotherapy (penicillin+metronidazole) was the elected treatment. CONCLUSION: Since hematogenous diffusion is frequent, anaerobic infection should be suspected in any case of deep abscess affecting patients with predisposing conditions such as poverty, severe teeth disease or iatrogenic procedure.

Abscess↗