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[Tolosa-Hunt syndrome (ophthalmoplegia dolorosa recurrens)].

On the basis of clinical manifestations and results of angiographic and phlebographic investigations the author discusses the symptoms of the Tolosa-Hunt syndrome. Angiographic findings, that is narrowing and uneven contour of vascular lumen in the internal carotid artery siphon as a result of infiltration of the arterial wall occur in early stage of the disease and are not observed in the patients in whom angiography is done after several weeks of the disease. The author stresses as a very characteristic feature of the syndrome rapid regression of symptoms, especially pain, after introduction of steroid therapy.

Adult↗

The role of integumental glands in the social and mating behaviour of the hunting dog Lycaon pictus (Temminck, 1820).

The marking and mating behaviour of captive hunting dogs, Lycaon pictus, is described. Urine scent-marking was the most frequent marking behaviour observed, but anal dragging, body-rolling and body-rubbing were also recorded. The mating behaviour was typical of that of Canidae but the copulatory tie in this case was of very short duration. There was a dense accumulation of sebaceous glands in the praeputium and these secretions are probably important in the urine scent-marking. There is no tail gland in L. pictus.

Animal Population Groups↗

[The Tolosa-Hunt syndrome: report of a case with recurrent (9 times) painful ophthalmoplegia (author's transl)].

A 48-year-old woman was referred to the First Dept. of Int. Med., Nagasaki Univ. Sch. Med., in August, 1979, with a six-month history of recurrent episodes of right-sided painful ophthalmoplegia and diplopia. An epidode affected the right eye, lasted one to two weeks, and relapsed every month. On examination she had a complete ptosis on the right side and pain on the right eye. All extraocular muscle supplied by the 3rd nerve were paralysed. The pupils were equal in size both sides, reacting to light completely. Visual acuity was normal except myopia. All the other cranial nerves and the remainder of central nervous system was normal. Results of thyroid function tests and of lumbar puncture were normal. The glucose tolerance test showed a mild diabetic pattern. Blood and CSF cultures for bacteria, fungi, and acid-fast bacillus were negative. The skull, brain CT scan, and carotid angiogram were within normal limits. A tentative diagnosis of Tolosa-Hunt syndrome was made after an unproductive search for a cause for this woman's painful ophthalmoplegia and unsuccessful treatment of ophthalmoplegia with antibiotics or diet therapy for mild hyperglycemia. The patient was given prednisolone 30 mg daily orally when she had the 9th attack of painful ophthalmoplegia Pain, ptosis, and diplopia disappeared in 5 days and she did not show any recurrence of symptoms over the next 7 months.

Female↗

Tolosa-Hunt syndrome.

Ten cases of painful ophthalmoplegia are reported. In all cases pain marked the onset of the disease; the condition was mostly unilateral. Recurrence and dramatic response to steroid therapy were more constant features than angiographic findings which may be completely normal. CAT permitted us to eliminate a tumor of the cavernous sinus in 7 cases, but in one case, which was operated, an aggravation followed surgery. Despite complete investigations of all patients, some questions remain unanswered. Is it an inflammatory or an allergic inflammatory process? (And the presence of antinuclear factor in an only case does not permit it to respond.) Why is the process confined to the superior orbital fissure? Mathew and Chandy tried to find a similarity between this syndrome and Bell's palsy although the 2 syndromes have not been shown to coexist. Is the Tolosa-Hunt syndrome comparable to the pseudotumor of the orbit? Although the dura mater is inserted on the border of the sphenoidal cleft, some patients may altern the 2 syndromes.

Adolescent↗

Soft contact lens bandage for Ramsay Hunt syndrome with facial palsy.

A patient under the primary care of a physician was referred to a military O.D. who subsequently referred the patient to the author as a consulting contact lens specialist. The patient exhibited the Ramsay Hunt Syndrome and was unable to blink or close her right eye. Patching had been attempted but was discontinued due to the neuralgia of the epidermal tissue of the lids. A hydrophilic contact lens was used to bandage the cornea. The patient was thereby able to maintain corneal integrity until the viral problem subsided and she regained her ability to function normally through the interdisciplinary cooperation of the eye care of professionals.

Adult↗

[Late results after total gastrectomy and reconstruction by the Hunt-Lawrence-Ròdino method].

The operative technique to perform the jejunal pouch--a stomach substitute--according to Hunt-Lawrence-Rodinò is described. This operation should be employed in all cases in which a radical procedure is under consideration. The quality of life is much better than after simple esophago-jejunostomy. The 5-year survival after gastrectomy for carcinoma being 37% and 50% for Zollinger-Ellison syndrome, respectively, a somewhat longer operation is justified.

Gastrectomy↗

Partial excision of the clavicle for nonunion in National Hunt Jockeys.

National Hunt jockeys suffer a disproportionate number of clavicular fractures and their return to riding may be considerably delayed by refracture and symptomatic nonunion, with obvious implications. We report six such cases in which excision of the clavicular fragment distal to the fracture was associated with an early return to work and no recurrent injury to the shoulder.

Accidents, Occupational↗

Gadopentetate dimeglumine-enhanced MR in the diagnosis of the Tolosa-Hunt syndrome.

A 54-year-old man first was admitted with a right oculomotor nerve palsy that ameliorated spontaneously. Two months later, he was readmitted with right proptosis, ophthalmoplegia, and optic nerve involvement. MR showed an enlarged right cavernous sinus. There was dramatic improvement after high doses of steroids. MR findings 10 months later were normal. Thus, the diagnosis of the Tolosa-Hunt syndrome was established.

Cavernous Sinus↗

Angiographic findings in Tolosa-Hunt syndrome: a case report.

A 71-year-old man suffered from left-side throbbing headache over the region of the fifth cranial nerve first division, followed by left ptosis and ophthalmoplegia. Under tentative diagnosis of Tolosa-Hunt syndrome (THS), oral prednisolone 60 mg was given daily. His headache and ophthalmoplegia dramatically improved within 24 hours. Magnetic resonance (MR) imaging and computed tomography (CT) of the head were negative. However, irregularity in the siphon of the left internal carotid artery was disclosed by angiography. This case illustrates that angiography may be useful in diagnosing THS, when CT and MR imaging are negative.

Aged↗

[Fatal hunting accidents caused by shotguns].

Four fatal hunting accidents by means of firearms are described from the autopsy material of the Institute for Forensic Medicine of Humboldt University in Berlin. Again the main cause was shown to be the firing of guns in insufficient daylight.

Accidents↗

[Neoplastic angioendotheliosis presenting Tolosa-Hunt syndrome, intraspinal invasion and intraorbital tumor].

A 76-year-old woman with painful erythema on legs and right oculomotor disturbance was diagnosed as neoplastic angioendotheliosis (NAE, B cell type) by skin biopsy. Remission was obtained by 2 courses of VEPA regimen. But 3 months later, she relapsed with right oculomotor, optic, trochlear and trigeminal nerve disturbance which suggested that she had Tolosa-Hunt syndrome. Cerebrospinal fluid (CSF) revealed infiltration of lymphoma cells. She developed intraorbital tumor and died of respiratory failure due to tumor emboli. Autopsy revealed infiltration of tumor cells in the small vessels of systemic organs. This rare case presented intracerebrospinal and intraorbital tumor growth in addition to intravascular infiltration of tumor cells.

Aged↗

Isolation and sequencing of insecticidal peptides from the primitive hunting spider, Plectreurys tristis (Simon).

About 50 peptide toxins were purified from venom of the primitive hunting spider, Plectreurys tristis. Bioassay by injection into larval Heliothis virescens (tobacco budworm) allowed selection of nine toxins for analysis of amino acid sequences. Total sequences were determined for six of the more insecticidal peptides (46-49 amino acids) and three contained free carboxyl-terminal amino acids. These toxins (plectoxins) are paralytic and/or lethal when injected into insect pests such as the lepidopterous larvae H. virescens, Spodoptera exigua (beet armyworm), and Manduca sexta (tobacco hornworm). We expect these plectoxins to be useful in insect control after delivery by a suitable agent such as a recombinant baculovirus.

Amino Acid Sequence↗

[A case of Tolosa Hunt syndrome].

The authors review the clinical signs, results of investigations and clinical course under treatment of the Tolosa-Hunt syndrome; they illustrate their case presentation with a complete sequence of the imaging and the clinical and radiological findings of a case which fits the classical description found in the literature. They insist on the term of syndrome rather than disease because of the obvious diversity of anomalies encountered in this condition.

Adult↗

Ramsay Hunt syndrome with aseptic meningitis.

A case of Ramsay Hunt Syndrome with characteristic vesicles on the lateral aspect of the left pinna, evidence of infranuclear palsy of the left 7th cranial nerve, associated with same sided loss of taste sensation in the presulcal area of the tongue and perceptive deafness without vestibular disturbances is reported here. The patient had evidence of aseptic meningitis.

Adult↗

Application of DNA fingerprinting to enforcement of hunting regulations in Ontario.

DNA fingerprinting has been used in investigations of 40 cases of infractions of hunting regulations involving white-tailed deer (Odocoileus virginianus) and moose (Alces alces) in Ontario. In most of these cases, individual-specific DNA fingerprints obtained with the Jeffrey's 33.15 multilocus probe were used to link the animal remains found at the illegal kill site to blood and tissue samples of the dead animal associated with a suspect. DNA fingerprints from 27 white-tailed deer and 19 moose were obtained in order to establish the level of band-sharing in DNA fingerprints among unrelated individuals in each species. We also determined the levels of band-sharing among animals from the same region and calculated the probability of two individuals sharing the same DNA fingerprint. Details are presented from cases in which the evidence was presented and accepted by Ontario courts.

Animals↗

[Tolosa Hunt syndrome and autoimmune polyglandular syndrome. A rare case report].

The authors refer to a case report in which two rare clinical syndromes, the Tolosa Hunt Syndrome (THS) and the polyglandular auto-immune syndrome (PGA) co-exist in the same patient and make a detailed analysis of the literature regarding this kind of diseases. The THS is a rare clinical condition characterized by a painful ophthalmoplegia due to an involvement of the cranial nerves and of the sympathetic nerve-fibres going through the cavernous sinus and the superior orbit cavity. Nowadays the diagnosis of TSH is made by high resolution computerized tomography aimed at the cavernous sinus and the upper orbital cavity. This method allows to notice if at the basis of this syndrome there are vascular, neoplastic or inflammatory diseases or if, as in e case here presented, by exclusion, we must think of an inflammatory process with unknown pathogenesis. In this case report the patient under observation process to be affected by THS and also by auto-immune polyglandular syndrome type III, as she was affected by diabetes type I, Basedow disease and alopecia. The authors believe that an auto-immune mechanism can be at basis of the THS, and this fact has already been pointed out in the literature in two previous works. An important feature of this case report has been the definitive improvement of the symptoms by an antithyroid effect and, also, by an immune suppressor activity. The Authors hope that there will be reported a greater number of cases pointing to the coexistence of the THS with autoimmune diseases.

Adult↗

[Recent molecular histochemistry and its application from localization to gene hunting].

In situ hybridization histochemistry is established as a method in molecular histochemistry. Although various methods were initially examined, the variation tends to converge into a few popular methods. Current methods in in situ hybridization histochemistry are introduced in this review. In addition, future aspects in the field of molecular histochemistry are discussed. A visualization of DNA binding molecules and an imaging of various phenomena in living tissue would substantially expand the potentiality of histochemistry. Furthermore, a molecular histochemical technique could be used, not only for a localization of molecule but also for a molecular biological method, such as, a screening process in the differential display, which is a sophisticated method, to hunt a specific gene. These advanced methods in molecular histochemistry could be quite useful in the field of thoracic diseases.

Animals↗