Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “HEMOSTATICS”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 469 records · Page 26Linked to original sources
PubMed2004

[Hemostatic and analgesic effect of Gonghuan Zhixue Tablet on mice].

OBJECTIVE: To explore the hemostatic and analgesic effect of Gonghuan Zhixue Tablet (GHZXT) on mice and to produce experimental evidence for exploiting new drug for endometrorrhagia caused by Cu-intrauterine contraceptive device (Cu-IUD). METHODS: Compared with 6-aminocaproic acid and notoginseng, the effects of GHZXT on clotting and bleeding time of mice with capillary method and severed tail were investigated; and compared with aspirin, the analgesic effects of GHZXT on mice were investigated with hot plate and torsive body method. RESULTS: The clotting time of mice was remarkably shortened with a rising of the dosage of GHZXT and the difference between each therapeutic group and distilled water group was remarkable. As compared with distilled water group, the bleeding time of each dosage group of GHZXT was obviously shortened; and each dosage of GHZXT could prolong the time of pain reaction to hot plate and decrease the degree of torsive body of the mice. CONCLUSION: Pharmacological experiment has proved that GHZXT has evident hemostatic and analgesic function.

Analgesics↗
PubMed2004

The effects of initial hemostatic period on the mechanical strength and transformation of apatite cement.

It is well known that apatite cement causes inflammatory response if it is exposed to blood before setting. In this respect, the hemostatic procedure is very important. However, it has not been clarified how initial hemostasis affects the other basic properties of apatite cement. In the present study, the effect of initial hemostasis on the setting reaction was simulated by allowing the apatite cement paste to be hardened in an incubator for 1 to 30 minutes and then immersed in saline up to 7 days. We found faster transformation of apatite cement to apatitic mineral and higher mechanical strength of the set mass when the cement paste underwent a longer pre-hardening period. We also found that earlier exposure of apatite cement to saline resulted in a set mass with larger porosity. It is thought that the larger porosity of the cement is caused by the penetration of liquid into the cement paste, thus leading to lower mechanical strength and slower transformation of the apatite cement to apatitic mineral. We concluded, therefore, that hemostatic procedure is important not only to prevent inflammatory response but also to obtain a set mass with higher mechanical strength and faster transformation to apatitic mineral.

Analysis of Variance↗
PubMed2005

Hemorrhage control in the battlefield: role of new hemostatic agents.

Uncontrolled hemorrhage is the leading cause of preventable combat-related deaths. The vast majority of these deaths occur in the field before the injured can be transported to a treatment facility. Early control of hemorrhage remains the most effective strategy for treating combat casualties. A number of hemostatic agents have recently been deployed to the warfront that can be used to arrest bleeding before surgical control of the source. The purpose of this article is to summarize the background information regarding these hemostatic agents, indications and rationale for their use, and characteristics of these products that may impact effectiveness.

Acetylglucosamine↗
PubMed1999

Hemostatic agents and their safety.

The pharmacologic management of hemostasis in patients undergoing cardiopulmonary bypass may be accompanied by adverse responses. Evaluating the safety profile of hemostatic agents (eg, lysine analogs, aprotinin, protamine, or even donor blood) should be done objectively. Subsequent to early anecdotal reports, the safety profile of aprotinin, a broad-spectrum serine protease inhibitor, has been thoroughly evaluated in multiple double-blind, placebo-controlled, multicenter studies. Although associated with decreased fibrinolysis, aprotinin has not been associated with an increased risk of post-cardiopulmonary bypass myocardial infarction, graft closure, stroke, or increased risk of renal dysfunction from US studies. As with any polypeptide, there is a risk of anaphylaxis, which is influenced not only by prior exposure but also by time since prior exposure. In a similar fashion, after early anecdotal reports, evaluations involving large numbers of patients have helped define adverse reactions to protamine. Adverse reactions to blood products also must be considered in any safety comparisons involving hemostatic agents.

Aminocaproic Acid↗
PubMed1999

[Efficacy of hemostatic puncture closing device for hemostasis and early ambulation after coronary angiography and angioplasty: results of a multicenter trial].

To assess the efficacy and safety of a hemostatic puncture closing device for reducing patient immobilization after cardiac catheterization from a percutaneous femoral artery approach, we conducted a prospective, randomized trial at 4 participating centers. A total of 240 patients (183 men, 57 women, mean age 61 +/- 10 yr; 157 patients underwent diagnostic angiography, 83 patients underwent coronary angioplasty) were randomized to either the device group (n = 120) or the manual compression group (n = 120). There were no statistical differences in age, gender, weight or sheath size between the 2 groups. A 7, 8F sheath was used in 53 patients of the device group and in 43 patients of the manual compression group. One hundred and two patients (85%) in the device group and 96 patients (80%) in the manual compression group received heparin. Protamine was used in one patient of the device group and 23 patients of the manual compression group. Activated clotting time just prior to sheath removal was 206 +/- 64 sec in the device group and 170 +/- 47 sec in the manual compression group (p < 0.01). Successful placement of the device was achieved in 118 of 120 patients (98%). Time to hemostasis was significantly shorter in the device group (0.8 +/- 3.2 vs 12.2 +/- 5.3 min, p < 0.01). Time to ambulation could be reduced in the device group (5.3 +/- 3.7 vs 10.9 +/- 5.1 hr, p < 0.01). The following complication rates occurred in the device group as compared with the manual compression group: hematoma, 16% vs 10%; bleeding, 8% vs 3%; pseudoaneurysm, 0% vs 1%, respectively. None of these differences was statistically significant. These results indicate that early ambulation using a hemostatic puncture closing device is feasible without significantly increasing the risk of peripheral vascular complications.

Adult↗
PubMed1999

Evaluation of the hemostatic function of stored platelet concentrates using the platelet function analyzer (PFA-100 ).

BACKGROUND AND OBJECTIVE: Progressive functional impairment is known to occur in platelet concentrates through the storage period. Standardized methods providing direct measurement of residual platelet function in stored platelets are lacking. The purpose of this study was to determine whether a new platelet function analyzer (PFA-100 ) could provide standardized methods for assessing the hemostatic capacity of stored platelets. DESIGN AND METHODS: The PFA-100 was used to evaluate platelet function in stored platelets. The instrument can process citrated whole blood but it is unable to process platelet suspensions. Accordingly, the function of platelet concentrates should be measured following reconstitution of pseudo-whole blood. The analysis of the results included the closure time (sec) and a predictive index, an arithmetical index computed on the basis of the instrument's output data: the flow rate, the flow volume, the closure time. RESULTS: A final hematocrit of 58+/-2 and a final platelet concentration of 230+/-20x10(9)/L were used as standardized operative conditions to measure the function of stored platelet concentrates. The closure time (PFA-CT) and the predictive index (PFA-PI) both resulted to be capable of discriminating platelet concentrates with maintained or impaired function. PFA-PI was more informative than PFA-CT in terms of description of the residual platelet function. Of the two agonists used, epinephrine (EPI) resulted to be particularly sensitive for the detection of initial platelet hyporeactivity, whereas adenosine 5'-diphosphate (ADP) was particularly useful for measuring the residual platelet reactivity. INTERPRETATION AND CONCLUSIONS: PFA-CT and PFA-PI can be standardized; they provide new information about the hemostatic function of stored platelet concentrates and can be used to assess the quality of platelet concentrates.

Blood Platelets↗
PubMed2001

Effects of unfractionated and low molecular weight heparins on plasma levels of hemostatic factors in patients with acute coronary syndromes.

BACKGROUND AND OBJECTIVES: Unfractionated heparin (UFH) and enoxaparin (low molecular weight heparin) constitute fundamental therapies in the treatment of patients with acute coronary syndrome (ACS). Since enoxaparin appears to offer clinical advantages over UFH in managing ACS, markers of thrombin generation, endothelial function and acute phase response could manifest different responses to UFH or enoxaparin. The purpose of the present study was to investigate the effect that treatment with either UFH or enoxaparin has on plasma hemostatic markers in 24 patients with ACS. DESIGN AND METHODS: The patients were randomized to receive 5,000 IU intravenous bolus and continuous infusion of 18 IU/Kg/h UFH (n=11) or 1 mg/kg/12h subcutaneous enoxaparin (n=13). The plasma levels of fibrinogen (Fg), prothrombin fragment 1+2 (F1+2), thrombin antithrombin complex (TAT), von Willebrand factor (vWF), tissue factor (TF) and tissue factor pathway inhibitor (TFPI) were assayed at admission and 6, 12, 24 and 48 hours after heparin treatment. RESULTS: Upon admission, UFH and enoxaparin patients showed a significant increase in all the hemostatic parameters measured with respect to the levels in the control subjects. In comparison with the baseline levels of the UFH- and enoxaparin-treated patients, Fg showed a significant increase at 48 h and TFPI at 6, 12 and 24 hours. However, at 48 hours TFPI levels were not significantly higher than the basal values. There were no significant changes in F1+2, TAT, vWF or TF. INTERPRETATION AND CONCLUSIONS: Markers of thrombin generation, endothelial function and acute-phase reactants manifest a similar response to UFH and enoxaparin. An increase in thrombin generation may be a result of persistently activated inflammatory and endothelial processes, despite UFH and enoxaparin treatment.

Acute Disease↗
PubMedDate not supplied

Hemostatic technique. Using a splint in oral bleeding.

Controlling hemorrhage from dental treatment in bleeding disorder patients is one of the most serious procedures encountered by the dentist. Local hemostatic techniques combined with replacement therapy are the usual management. A polyurethane stent as an adjunct therapy is beneficial in controlling hemorrhage. The hemostatic stent provides pressure at the surgical site and adequate protection.

Blood Coagulation Disorders↗
PubMed1999

[A study on hemostatic and immunological actions of fresh and dry Dihuang].

OBJECTIVE: To investigate the difference between fresh and dry Dihuang (Radix Rehmanniae) in hemostatic and immunological actions. METHODS: The hemostatic action was assessed in aspirin-treated mice; immunological action was assessed by phagocytosis of macrophages in dexamethasone-treated mice; and Con A-induced mitogenesis and LPS-induced alkaline phosphatase activity of splenocytes were determined in thyroxin-treated mice. RESULT: The blood clotting in mice induced by aspirin was inhibited by oral administrations of juice decoction of fresh Dihuang or decoction of dry Dihuang alike. The action of fresh Dihuang juice was stronger than that of dry Dihuang decoction. Oral administrarion of fresh Dihuang juice or decoction for 10 days enhanced LPS-induced alkaline phosphatase activity of splenocytes in thyroxin-treated mice. The juice also enhanced Con A-induced splenocyte mitogenesis. The action of dry Dihuang decoction was weaker than that of fresh juice in increasing LPS-induced alkaline phosphatase activity. CONCLUSION: It is recommended to follow the tradition of using fresh Dihuang juice or decoction to treat some diseases such as hemorrhagenic troubles.

Animals↗
PubMed2002

[Saving surgical time with great hemostatic safety and efficiency using the LIGA-SURE system in complete pelvic urologic surgery].

OBJECTIVE: To achieve an effective, safe and fast hemostasis. To translate it into a great diminution of operating time, avoiding multiple ligatures that are time consuming and being merely a mechanical, repetitive act do not add any element of quality to surgery in general and to urologic pelvic procedures in particular. METHODS: A new hemostatic system has been experimented in pelvic urologic open surgery, specifically in radical cystectomy (RC) (with orthotopic substitution or urinary diversion) and radical prostatectomy (RP). It achieves vascular sealing by means of tissue collagen precipitation when applied in previously dissected vascular pedicles during radical cystectomy and neuro-vascular bundles during radical prostatectomy. RESULTS: It has been noted a complete efficacy in the coagulation of all vascular pedicles as well as a significant decrease in operating time (around 25%) because the use of ligatures is completely avoided. It has also been noted a great decrease in blood loss, with reductions in transfusion needs down to 50% of the cases. CONCLUSIONS: The new hemostatic system by tissue collagen coagulation allows a fast, effective and safe hemostasis in complex urological pelvic surgery, which translates into operative time savings and minimal blood loss.

Adenocarcinoma↗
PubMed1998

[Collagen sponge and its hemostatic properties].

Soluble collagen was extracted from bovine tendon in acid solution. Collagen sponge hemostatics were prepared by means of lyophibization. The amino acid and UV spectrum analyses were made to confirm the composition of the soluble collagen. The results of experiments on rabbits indicated the collagen sponge prepared in the authors' lab had excellent hemostatic and adhesive properties in vivo surgical tests.

Amino Acids↗
PubMed1992

Development of medicated aerosol dressings of chlorhexidine acetate with hemostatics.

Aerosol formulations to act as medicated aerosol dressings have been prepared with an aim of forming a protective film over the wound after spraying combining the properties of antiseptics and hemostatics. Chlorhexidine acetate along with three hemostatics namely zinc acetate, methyl cellulose and Calendula tincture were used for the formulations. The formulations were found to be satisfactory in their performance and purpose.

Aerosols↗
PubMedDate not supplied

[Use of "NovoSeven" (rFVIIa) hemostatic in patients operated with extracorporeal blood circulation].

The "NovoSeven" drug was used in 25 patients (male - 18, female - 7) operated on the heart and main vessels including with artificial extracorporeal circulation (AEC). Patients did not have any clinically significant impairment in blood circulation before surgery. Perioperatively, all of them and, immediately after surgery, 4 them had uncontrollable hemorrhages at 10-25 ml/min in spite of extensive hemostatic therapy, including freshly frozen plasma, cryoprecipitate, thromboconcentrate, trasilol and ?-amine acid. Yet in 30 min after "NovoSeven" administration, hemorrhages seized virtually in all patients irrespective of a surgical intervention. It normalized the hemostasis by it differential action on an impairment depending on an activated or suppressed coagulation. Thus, the conclusion is that the "NovoSeven" (rFVIIa) is an effective hemostatic ensuring the correction of massive intra- and postoperative blood losses in cardiosurgery patients. The drug cuts the need in using the donor-blood components, thus, diminishing the risk of multi organ failure that can develop immediately after surgery.

Blood Coagulation↗
PubMed2005

Evaluation of vasopressin mediated effects on hemostatic mechanisms: relationship with aquaporins and caveolin proteins.

With a view to evaluate the role of AQP-1 and caveolin proteins in the hemostatic actions of vasopressin, hemostasis was evaluated by bleeding and clotting time respectively. Groups of mice and guinea pigs were treated with arginine vasopressin (AVP) and 1-deamino-8D-AVP (DDAVP) to evaluate their effects on the hemostasis. DDAVP and AVP were able to appreciably reduce the bleeding and clotting time after sodium thiopentone, but not effectively after TEA treatment. Animal groups were pretreated with aquaporin-1 (AQP-1) blockers or water deprived to enhance the expression of AQP-1 water channels. Another group of animals were treated with caveolin protein modulators, cholera toxin (CTX) and the effect of vasopressin analogues evaluated. The results suggest that AQP-1 water channels and caveolin proteins contribute to modulate the hemostatic mechanisms of vasopressin.

Animals↗
PubMedDate not supplied

[Ferakril--a local-action hemostatic].

The data of the preclinical and clinical study of feracryl, a local hemostatic, are presented. The drug's hemostatic activity, acute, subacute and chronic toxicity, anesthetic effect as well as antibacterial and antifungal activities were studied. The results of the clinical trial of the drug are given.

Acrylic Resins↗
PubMed1990

[Use of polymer hemostatic cotton and plate in surgery of the lungs and pleura].

The article discusses the efficacy of using polymeric hemostatic wool and plate in operations on the lungs and pleura in experiments. From the results of experimental studies the authors concluded that a biodegradable polyamide based on hexamethylenediamine and derivatives of amino acids in a model of parenchymatous-capillary bleeding from the lungs and pleura is an effective hemostatic. The authors recommend these polymers for use in the clinic.

Animals↗
PubMed1990

[Progression of regressor tumor cells by host reactive cells to such foreign bodies as plastic plate and hemostatic spongel].

I examined the effects of host cells reactive to foreign bodies such as plastic plate or hemostatic spongel on the progression of tumor cells. QR tumor cells spontaneously regressed in normal C57BL/6 mice apparently associated with a reduction in production of PGE2 by the tumor cells. I have observed that such regressor tumor cells are able to grow lethally when implanted in mice after having been attached to plastic plate. The clones which were derived from these plastic plate-derived tumors in normal mice maintained their growth potential when they were injected into other normal mice. Furthermore the arising tumors produce much higher levels of PGE2 than the original QR tumor cells. Interestingly, I could not observe acquisition of tumorigenicity or a higher level of PGE2-production in the clones obtained from the arising tumors which were grown in 10Gy-irradiated mice. Moreover, QR tumor cells are able to grow in mice when they are injected at the site where plastic plate had been implanted about 30 days previously. These results indicate that the restoration of tumorigenicity of QR tumor cells is not only due to attachment to plastic plate, but also mediated by radiation-sensitive host cells reactive to plastic plate which enhance the progression of tumor cells. Similar results are also obtained by coinoculation of QR tumor cells with host reactive cells which had been induced by implantation of hemostatic spongels into the peritoneal cavity of mice. Greater amounts of PGE2-production by QR tumor cells were observed when the tumor cells were cocultured with spongel reactive cells. This PGE2-production was markedly inhibited by the presence of radical scavengers (Catalase, Mannitol, SOD + Catalase) in the coculture medium(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗