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PubMed1995

Effect of single and combined altered auditory feedback on stuttering frequency at two speech rates.

The purpose of this study was to determine if combining delayed auditory feedback (DAF) and frequency altered feedback (FAF) would enhance fluency more than either DAF or FAF alone. Ten stutterers read at normal and fast speech rates under nonaltered auditory feedback (NAF), DAF (i.e., a 50 ms delay), FAF (i.e., a one half octave downward shift), and a combination of DAF and FAF [(COMBO), i.e., a 50 ms delay plus a one half octave downward shift]. Results indicated that stuttering frequency was significantly reduced under all altered auditory conditions at high speech rates relative to the NAF condition. There were, however, no significant differences between the altered auditory feedback conditions (i.e., DAF, FAF, and COMBO). It is suggested that further studies be undertaken to explore the combination of altered auditory feedback conditions, as it may be the case that a floor effect was demonstrated with the singular presentations of DAF and FAF and further improvements in fluency enhancement could not be exhibited in the combined condition. Finally, these findings support the notion that a slowed rate of speech is not necessary for fluency enhancement under conditions of altered auditory feedback.

Adult↗
PubMed1987

Feedback regulation of rRNA synthesis in Escherichia coli. Requirement for initiation factor IF2.

It has been shown that the transcription of rRNA in Escherichia coli is feedback-regulated by its own transcription products through a negative feedback loop which appears to require the assembly of rRNA into complete ribosomes. In order to examine whether the feedback loop involves the ribosomes' main function, translation, we have constructed a strain in which the chromosomal copy of infB, encoding IF2, was placed under lac promoter/operator control, and the effects of limitation of translation initiation factor IF2 on the regulation were examined. By varying the concentration of a lac operon inducer, isopropyl thiogalactoside (IPTG), it was possible to vary the cellular concentration of IF2. Under the growth conditions used, decreasing the concentration of IF2 about twofold affected the growth rate only slightly, but further deprivation of IF2 resulted in a significant decrease in growth rate, an increase in RNA content and a large accumulation of non-translating ribosomes. These accumulated ribosomes were apparently unable to cause feedback regulation of rRNA synthesis in the absence of sufficient IF2. When a higher concentration of IPTG was added to these IF2-deficient cells, a rapid increase in the IF2 level and a significant decrease in the rate of RNA accumulation were observed before the new steady-state growth was attained. These results indicate that IF2 apparently is necessary for feedback regulation of stable RNA and imply that ribosomes must enter translation for feedback regulation to occur.

Centrifugation, Density Gradient↗
PubMedDate not supplied

Event-related covariances during a bimanual visuomotor task. II. Preparation and feedback.

Event-related covariance (ERC) patterns were computed from pre-stimulus and feedback intervals of a bimanual, visuomotor judgment task performed by 7 right-handed men. Late contingent negative variation (CNV) ERC patterns that preceded subsequently accurate right- or left-hand responses differed from patterns that preceded subsequently inaccurate responses. Recordings from electrodes placed at left frontal, midline antero-central, and appropriately contralateral central and parietal sites were prominent in ERC patterns of subsequently accurate performances. This suggests that a distributed cortical 'preparatory network,' composed of distinct cognitive, integrative motor, somesthetic, and motor components, is essential for accurate visuomotor performance. ERC patterns related to feedback about accurate and inaccurate responses were similar to each other in the interval immediately after feedback onset, but began to differ in an interval spanning an early P300 peak. The difference became even greater in an interval spanning a late P300 peak. For both early and late P300 peaks, ERC patterns following feedback about inaccurate performance involved more frontal sites than did those following feedback about accurate performance. Together with the stimulus- and response-locked results presented in part I, results of this study on the preparatory and feedback periods suggest that ERCs show salient features of the rapidly shifting, functional cortical networks that are responsible for simple cognitive tasks. ERCs thus provide a new perspective on information processing in the human brain in relation to behavior--a perspective that supplements conventional EEG and ERP procedures.

Adult↗
PubMed1995

Positive feedback as a general mechanism for sustaining rhythmic and non-rhythmic activity.

Our aim is to reassess our proposal that various states of motor output may be sustained by positive feedback generated within the premotor neural circuitry. The evidence for this proposal came from the Xenopus embryo which when touched can swim for many seconds even after all movement has been prevented by a neuromuscular blocking agent. Experiments showed that even the spinal cord could sustain its own swimming activity for a few seconds after stimulation. We proposed that this was the result of the glutamatergic excitatory spinal interneurons synapsing with each other. Because this excitation is of long duration compared to the swimming cycle period it can sum from cycle to cycle to sustain swimming by a form of positive feedback. We have tested the plausibility of these ideas by making realistic computer simulations of the spinal networks and have shown that positive feedback can sustain stable swimming activity. Pharmacological evidence recently suggested that acetylcholine contributes to the excitation underlying swimming in spinal embryos so we investigated the central synapses made by motoneurons. Recordings from pairs of synergistic motoneurons then showed: a) cholinergic chemical synapses from more rostral motoneurons activate nicotinic receptors and produce excitation; and b) local intrasegmental electrical synapses also lead to mutual excitation. The presence of central motoneuron synapses suggested that they could contribute to excitation during swimming. We therefore used local drug applications to see if spinal neurons received cholinergic or electrical excitation during fictive swimming. The results show that motoneurons received both types of excitation while interneurons received only cholinergic excitation. This evidence suggests that when motoneurons are active during swimming they contribute positive feedback excitation not only to themselves but also to the premotor interneurons of the spinal rhythm generating network. This excitation would sum with that from 'glutamatergic' excitatory interneurons. We conclude that in addition to our original proposal of feedback between excitatory interneurons, there are other forms of positive feedback during swimming in the Xenopus embryo spinal cord. Motoneurons feed excitation back to each other. They may also contribute cholinergic excitation to premotor interneurons which could sum with the excitation from 'glutamatergic' interneurons and help to sustain swimming. If they do this, motoneurons may be a component part of the central pattern generator for swimming. Since central motoneuron synapses are a feature of most vertebrate groups, these results suggest a reevaluation of such synapses in these groups also.

Animals↗
PubMed2006

Effects of feedback and calibration on the verbal estimation of the duration of tones.

Two experiments investigated the effects of feedback (Experiment 1) and calibration (Experiment 2) on verbal estimation of the duration of tones ranging from 77 to 1183 ms in length. In Experiment 1, accurate feedback was provided after half the trials in the feedback condition, and this was contrasted with a no-feedback condition in which feedback was absent. In Experiment 2, in the calibration condition, participants estimated the duration of the second of two tones, after a first tone of a known duration (ranging from 50 to 1200 ms) had been presented. In the no calibration condition the value of the first tone was unknown. Compared with conditions without feedback or calibration, the feedback/calibration operation produced no significant change in group mean estimates, nor coefficients of variation of estimates, but the absolute deviation of estimates from the real stimulus duration, and the absolute deviation of individual estimates from the group mean, were both significantly reduced. The feedback/calibration thus made participants' mean estimates thus more accurate and more similar to one another, but the actual mechanism by which this was done was apparently a subtle process of adjustment, rather than a gross change in mean estimate or estimate variability.

Feedback↗
PubMed2006

Data feedback for quality improvement of stroke care: CAPTURE Stroke experience.

BACKGROUND: Feedback on "quality indicators" collected from chart audit is a widely used quality-improvement strategy. Skeptics argue that temporal change in practice patterns or improvement of documentation as a result of implementation of chart audit can affect change in quality indicators rather than change in practice due to feedback. This study compared the effectiveness in quality improvement for stroke care of chart audit and feedback versus chart audit only. METHODS: Data were examined on quality indicators constructed from the performance measures abstracted from chart audit for 1953 stroke patients admitted to 13 hospitals. Seven of the 13 hospitals were provided with feedback on quality indicators from baseline audit, and 6 hospitals had chart audit only. RESULTS: Least-squares estimation was used to estimate the adjusted mean change in quality indicators between follow-up and baseline audits and differences in mean change between feedback and nonfeedback groups. Differences in adjusted mean change (with 90% confidence interval) were: deep vein thrombosis prophylaxis, 8.46 (-9.46 to 26.38); dysphagia screening, -3.78 (-21.37 to 13.81); antithrombotic therapy within 48 hours of hospitalization, 3.63 (-6.59 to 13.84); discharged on antithrombotic, -0.31 (-6.26 to 5.63); patients with atrial fibrillation discharged on warfarin/coumadin, 44.73 (-13.14 to 102.60); lipid screening, 19.93 (2.99 to 36.86); and smoking counseling, 17.47 (-12.13 to 47.08). CONCLUSIONS: Although not statistically significant, results suggest a potential for improvement with data feedback. There is a need for evaluation of the effectiveness of a multifaceted approach in a community setting.

Acute Disease↗
PubMed2004

The effectiveness of video feedback in the acquisition of orthopedic technical skills.

BACKGROUND: The addition of video feedback to bench model training offers residents the opportunity to see themselves perform a surgical task. Videotaped feedback therefore promotes self-evaluation, a critical learning skill, and also has the potential to influence how a resident executes a skill once they have had the opportunity to see themselves perform the task. METHODS: Twenty-nine surgical residents were video recorded while performing three technical skills. They then were randomly assigned to receive either no feedback, video feedback alone, or video feedback with the help of an expert, an orthopedic surgeon. The surgical task was then repeated. Orthopedic surgeons evaluated the videotapes using the global rating scale and technical checklist form. RESULTS: One-way between-subject analysis of variance comparing the pretest and post-test difference scores on three different measures for each of the three tasks revealed no statistically significant differences. After controlling for rater variance, the global rating scores across the three surgical tasks did not reveal any statistically significant differences. CONCLUSIONS: This study failed to demonstrate an improvement in technical skills based on utilization of video feedback.

Analysis of Variance↗
PubMed2004

Context preexposure influences the effectiveness of feedback stimuli in avoidance learning.

According to the effective reinforcement theory of avoidance learning, there is a positive relationship between the level of context fear and the effectiveness of feedback stimuli. The present research used different preexposure treatments to manipulate context fear and to evaluate the effects of feedback stimuli in two-way avoidance learning. Rat subjects received nonreinforced preexposure either to the nonvisual context cues (avoidance apparatus with the houselights extinguished), to the visual context cues (avoidance apparatus with the houselights on but with a Plexiglas floor covering the grids), or to a neutral box. During subsequent avoidance training conditioned stimulus termination was delayed for 5s after an instrumental response and either a flashing light or darkness was presented as a feedback stimulus. Without preexposure, darkness produced better avoidance performance than did the flashing light. Preexposure to the visual context cues decreased the effectiveness of darkness as a feedback stimulus. However, preexposure to either the visual or to the nonvisual context cues facilitated avoidance performance when a flashing light was used as a feedback stimulus. The results suggest that the effects of a feedback stimulus may be dependent upon the amount and source of context fear.

Animals↗
PubMed2005

Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations.

The cell-cycle oscillator includes an essential negative-feedback loop: Cdc2 activates the anaphase-promoting complex (APC), which leads to cyclin destruction and Cdc2 inactivation. Under some circumstances, a negative-feedback loop is sufficient to generate sustained oscillations. However, the Cdc2/APC system also includes positive-feedback loops, whose functional importance we now assess. We show that short-circuiting positive feedback makes the oscillations in Cdc2 activity faster, less temporally abrupt, and damped. This compromises the activation of cyclin destruction and interferes with mitotic exit and DNA replication. This work demonstrates a systems-level role for positive-feedback loops in the embryonic cell cycle and provides an example of how oscillations can emerge out of combinations of subcircuits whose individual behaviors are not oscillatory. This work also underscores the fundamental similarity of cell-cycle oscillations in embryos to repetitive action potentials in pacemaker neurons, with both systems relying on a combination of negative and positive-feedback loops.

Anaphase-Promoting Complex-Cyclosome↗
PubMed2004

Decrease in prefrontal hemoglobin oxygenation during reaching tasks with delayed visual feedback: a near-infrared spectroscopy study.

Visual feedback of hand movement is crucial to accurate reaching. Although previous studies have extensively examined spatial alteration of visual feedback (e.g., prism adaptation), temporal delay of visual feedback has been less explored. In the present study, we investigated the effect of delayed visual feedback of the moving hand in a reaching task. The prefrontal cortical activity was measured by near-infrared spectroscopy (NIRS). Twelve subjects performed reaching tasks under two conditions where visual feedback of their own hand was delayed by 200 ms (delay condition) or 0 ms (normal condition). Introducing the visual feedback delay significantly disrupted the reaching performance, although the subjects gradually adapted to the delay during the experiment. There was a clear tendency to overreach the target in the delay condition, even after the reaching movement had been practiced sufficiently in the normal condition. We observed marked oxy- and total-Hb decreases in the dorsal prefrontal area in the delay conditions. The decrease began shortly after task onset and diminished during the rest period, indicating that the decrease was task-induced. Furthermore, the oxy- and total-Hb decreases were significantly correlated with task performance--the degree of decrease was larger as the subject made more errors. We suggest that the decreases in oxy- and total-Hb at the dorsal prefrontal area are related with the visuomotor recalibration process.

Adult↗
PubMed2006

Modulation of late alpha band oscillations by feedback in a hypothesis testing paradigm.

We used the electroencephalogram (EEG) to investigate whether positive and negative performance feedbacks differentially modulate late time-locked oscillatory brain activity in hypothesis testing. Ten college students serially tested hypotheses concerning a hidden rule by judging its presence or absence in triplets of digits, and revised them on the basis of an exogenous performance feedback. The EEG signal was convolved with a family of complex wavelets and induced brain potentials were extracted in the alpha range (8-13 Hz). The time-varying modulation of alpha activity time-locked to positive and negative feedback was analyzed in the 350-700 ms time-window. The results showed differential feedback-induced modulations of upper-alpha rhythms (> or =10 Hz) between 450 and 700 ms in parieto-occipital and central regions, and of lower-alpha rhythms (<10 Hz) between 350 and 450 ms in central regions. These results were interpreted in terms of differential functional roles of feedback in short-term memory and active inhibition/disinhibition of resources for subsequent hypothesis testing. Some implications for cognitive models of feedback are discussed.

Adult↗
PubMed2006

Effect of reducing frequency of augmented feedback on manual dexterity training and its retention.

OBJECTIVE: The study addressed the impact of the frequency of tutorial-enriched augmented visual feedback, provided by a virtual simulation system (DentSim), on the skill acquisition for a cavity preparation task in novice dental students. METHODS: Thirty-six subjects were assigned to two training groups and a control group. The task consisted of a geometrical cross preparation on the lower left first molar. All subjects performed a pre-test to assess their basic skill level. The training groups received simulation feedback, enriched with tutorial information, across acquisition. One group trained under continuous augmented feedback, while a second group trained under an intermittent (66% of the time) feedback. At both 1-day and 4-month interval, subjects performed a retention test to explore learning specific effects. Two transfer tests were added to assess the extrapolation of the learned skills to an adjacent molar. All tests were performed in the absence of feedback. A control group performed all the tests, without preceding training. All preparations were graded by the simulation system. RESULTS: The training groups performed similarly across acquisition and improved with practice (ANOVA, P<0.001). After 1 day and 4 months of no practice, the training groups outperformed the control group on a retention test (ANOVA, P<0.001) and transfer test (ANOVA, P<0.001). CONCLUSIONS: Performance and learning of a cavity preparation task on a simulation unit was independent of the frequency of tutorial-enriched augmented visual feedback within the range tested. Training sessions on a simulation unit could be alternated with training sessions in the traditional phantom head laboratory.

Adolescent↗
PubMed2005

Kinematic and EMG characteristics of simple shoulder movements with proprioception and visual feedback.

The objective of this study was to determine if simple, shoulder movements use the dual control hypothesis strategy, previously demonstrated with elbow movements, and to see if this strategy also applies in the absence of visual feedback. Twenty subjects were seated with their right arm abducted to 90 degrees and externally rotated in the scapular plane. Subjects internally rotated to a target position using a custom shoulder wheel at three different speeds with and without visual feedback. Kinematics were collected with a motion analysis system and electromyographic (EMG) recordings of the pectoralis major (PECT), infraspinatus (INFRA), anterior and posterior (ADELT, PDELT) deltoid muscles were used to evaluate muscle activity patterns during movements. Kinematics changed as movement speed increased with less accuracy (p<0.01). Greater EMG activity was observed in the PECT, PDELT, and INFRA with shorter durations for the ADELT, PDELT and INFRA. Movements with only kinesthetic feedback were less accurate (p<0.01) and performed faster (p<0.01) than movements with visual feedback. EMG activity suggests no major difference in CNS control strategies in movements with and without visual feedback. Greater resolution with visual feedback enables the implementation of a dual control strategy, allowing greater movement velocity while maintaining accuracy.

Adult↗
PubMed2006

Impact of surgeon-specific feedback on surgical site infection rates in Thailand.

Data on surgeon-specific feedback on surgical site infection (SSI) rates are not currently available in Thailand. The authors conducted a before and after study among patients undergoing surgery in seven Thai hospitals to examine whether a feedback system to surgeons could reduce SSI rates. After a six-month surveillance period, surgeons were provided with their own SSI rates and standardized infection ratios (SIRs). The criteria of the National Nosocomial Infection Surveillance (NNIS) system were used to determine SSI rates, and the SSI rates were compared with the NNIS report in terms of the SIR. To compare the SIR before and after intervention, the SIR ratio was calculated and logistic regression analysis was used to estimate the relative impact of surgeon-specific feedback, adjusting for patient sex, patient age, degree of wound contamination, American Society of Anesthesiologists' score, duration of operation, type of operation, use and duration of antibiotic prophylaxis, and length of pre-operative stay. After confidential feedback to surgeons for six months, SSI rates and the SIR remained unchanged. The SSI rate in the pre-intervention period was 1.7 infections/100 operations and the corresponding SIR was 0.8 [95% confidence intervals (CI)=0.6-0.9]. In the post-intervention period, the SSI rate was 1.8 infections/100 operations, with a corresponding SIR of 0.8 (95%CI=0.7-0.9). The SIR ratio was 1.0. The relative risk of SSI after surgeon-specific feedback suggested that this intervention had no effect (adjusted relative risk=1.02, 95%CI=0.77-1.35). Feedback to surgeons on their SSI rates did not reduce the rates of such infections in Thailand.

Adolescent↗
PubMed2006

Programming of GnRH feedback controls timing puberty and adult reproductive activity.

The timing of puberty generally differs between sexes, and this may be due to sex differences in the organization of steroid feedback systems. We propose that the reproductive neuroendocrine default sex is female. If the individual is male, the feedback control of GnRH secretion is programmed early in development, and the pubertal GnRH rise is either advanced or delayed depending upon species. This developmental programming is by androgens. Early programming also reorganizes adult reproductive neuroendocrine function to change a pattern of cyclic gamete release (periodic ovulations) requiring multiple feedback systems to that of a continuous one (spermatogenesis) requiring only the negative feedback control. The multiple feedback systems underlying the complex ovulatory cycle are innate, and in the male the unnecessary feedbacks are abolished or rendered less sensitive during development by the estrogenic, as well as the androgenic metabolites of testosterone.

Animals↗
PubMed2005

The effect of changed visual feedback on intention tremor in multiple sclerosis.

In patients with multiple sclerosis (MS), intention tremor amplitude is enhanced during the visually guided compared to the memory guided motor tasks. In the present study, the effect of visual feedback on intention tremor was investigated during visually guided wrist step-tracking tasks. Specifically, visual feedback of the hand was provided either instantly or averaged over different time windows. Thirteen MS patients with intention tremor and 14 healthy controls performed the wrist step-tracking task, while the visual representation of the actual hand position was displayed instantly or averaged over time windows of 150, 250 and 350 ms. It has been found in the patient group that, in association with a decreased initial error and decreased tremor amplitude on the screen, the amplitude of the actual performed tremor also decreased when visual feedback was changed. The tremor reduction was not different between conditions with manipulated feedback, although delays in presenting visual feedback of the hand position increased when the time window was larger. The reduction in overall tremor amplitude was unlikely related to other factors, such as eye fixation deficits or the speed of the primary hand movement. These results suggest that hand tremor severity is dependent on the visual feedback of position and movement errors.

Adult↗
PubMed2006

Neural correlates of developmental differences in risk estimation and feedback processing.

The primary aim of this study was to compare the neural substrates of decision-making in middle-aged children and adults. To this end, we collected fMRI data while 9-12-year-olds and 18-26-year-olds performed a simple gambling task. The task was designed to tap two important aspects of decision-making: risk estimation and feedback processing. We examined how orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and dorsolateral prefrontal cortex (DLPFC) contributed to risk estimation, and how ventrolateral and medial prefrontal cortices (VLPFC and medial PFC) contributed to negative feedback processing in children and adults. Region of interest analyses revealed differences in brain activation between children and adults for ACC and lateral OFC. ACC was recruited more for high-risk than for low-risk trials, and this difference was larger for children than for adults. In contrast, children and adults did not differ in activation for OFC or DLPFC. These data suggest that children's decision-making under uncertainty is associated with a high degree of response conflict. Both age groups exhibited bilateral VLPFC (BA 47) and medial PFC/ACC (BA 6/ BA 32 (dorsal) and 24 (ventral)) activation associated with negative feedback processing. Relative to adults, children engaged lateral OFC more strongly for negative relative to positive feedback. These results indicate that children may find negative feedback more aversive than adults do. In summary, children aged 9-12 years and adults recruit similar brain regions during risk-estimation and feedback processing, but some key differences between the groups provide insight into the factors contributing to developmental changes in decision-making.

Adolescent↗
PubMed2006

Learning spinal manipulation: the importance of augmented feedback relating to various kinetic parameters.

BACKGROUND CONTEXT: Spinal manipulation is a widely accepted therapeutic approach in the treatment of back pain. In standard training programs, feedback on student performances is provided by an instructor based on teaching and clinical experience. Systematic study of the type of augmented feedback provided and skill learning is lacking in the literature. PURPOSE: The goal of this investigation is to compare the performance of two groups of chiropractic students, one receiving traditional training from experienced instructors, and the other, augmented feedback on specific biomechanical aspects of spinal manipulation therapy using an instrumented manikin. STUDY DESIGN: Randomized controlled study. PATIENT SAMPLE: Thirty-one fourth-year students from the Department of Chiropractic of Université du Québec à Trois-Rivières participated in this study. OUTCOME MEASURES: Kinetic parameters (force-time curves) of spinal manipulation were evaluated. METHODS: Spinal manipulation parameters were measured before and after a 5-week training period in which one group received standard chiropractic training while a second group received augmented feedback about specific biomechanical parameters of spinal manipulation. For both groups, practice scheduling and time duration were similar and consisted of a weekly practice session of 90 minutes for five consecutive weeks. Both groups had to practice thoracic spine manipulation throughout the training period. RESULTS: Both groups showed a decrease in peak force applied, with a diminution in the number of trials where a downward incisural point was present in preload force. Participants in the feedback training group significantly reduced their peak force variability and significantly increased their preload force. No significant difference was observed for time to peak force. CONCLUSIONS: The results of this study highlight the merits of practicing with an instrumented manikin or other instrumented training aids. Such a device can provide specific feedback on specific parameters of the task during learning; it can also serve as a tool to assess the progress of students and eliminate the risks relating to repetitive spinal manipulative therapy practice on student colleagues.

Adult↗