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PubMed1987

A prospective analysis of 142 carotid endarterectomies for occlusive vascular disease, 1979-1985.

Carotid endarterectomy may carry a substantial risk of morbidity and mortality from major stroke, thus offsetting any statistical benefit in reduction of future stroke. Because of the disturbing ranges in the incidence of stroke morbidity and mortality reported from the several institutional series studying carotid endarterectomy, the authors undertook a prospective review of 142 consecutive carotid endarterectomies performed for symptomatic atherosclerotic occlusive vascular disease on the neurosurgical service. The University of Alabama Hospital. Preoperative risk assessment was performed in each case according to the Mayo Clinic classification system. The overall mortality rate was 1.4% and the major stroke morbidity rate was 0.7%, for a combined major morbidity and mortality rate of 2.1%. The incidence of minor neurological morbidity was 1.4%. There was no morbidity or mortality in the Grade I and II (low-risk) patient groups. This low combined major morbidity and mortality rate of 2.1% for carotid endarterectomy causes the surgical stroke-free survival curve to intersect the medical stroke-free survival curve at an earlier point in time, and thus demonstrates the greater reduction in risk of stroke which accrues over time for the surgically treated patient.

Arterial Occlusive Diseases↗
PubMed1988

Low morbidity and mortality of carotid endarterectomy performed with regional anesthesia.

Various anesthetic and surgical techniques have been recommended with or without cerebral function monitoring in attempts to reduce the risk of carotid endarterectomy, but there is no consensus as to the ideal method for performing this procedure. General anesthesia is now the most common anesthetic technique used, but of 337 carotid endarterectomies performed by the author's service from 1981 through 1985, 305 (91%) were conducted with regional anesthesia. This paper presents the morbidity and mortality rates for those patients. There were two perioperative transient ischemic attacks (0.66%), two perioperative strokes (0.66%), and two perioperative deaths (0.66%). No patient in the series suffered a myocardial infarction within 30 days after endarterectomy. This series demonstrates that carotid endarterectomy can be performed with good results using regional anesthesia, which facilitates intraoperative cerebral function monitoring. Regional anesthesia is associated with a very low incidence of postoperative hypertension and perioperative myocardial infarction.

Adult↗
PubMed1990

Risk of late stroke and survival following carotid endarterectomy procedures for symptomatic patients.

The long-term outcome following carotid endarterectomy for neurological symptoms was analyzed using a retrospective life-table approach in 212 patients who had undergone 243 endarterectomy procedures. The postoperative follow-up period averaged 38.9 +/- 2.1 months (mean +/- standard error of the mean). The endpoints of stroke and death were evaluated in these patients. Patient groups with the preoperative symptoms of amaurosis fugax, transient ischemic attack, and prior recovered stroke were similar in terms of life-table outcome over the follow-up period. Sixty-two percent of symptomatic patients were alive and free of stroke at 5 years. The late risk of stroke (after 30 days postoperatively) averaged 1.7% per year based on a linear approximation to the hazard at each life-table interval (1.3% per year for ipsilateral stroke). The trend of late stroke risk was clearly downward, however, and could be fitted more accurately by an exponential decay function with a half-life of 33 months. Thus, the risk of stroke following carotid endarterectomy for neurological symptoms was highest in the perioperative period, slowly declined with time, and occurred predominantly ipsilateral to the procedure. The definition of a prospective medical control group remains crucial for a critical analysis of treatment modalities following the onset of premonitory neurological symptoms. In the absence of an adequate control group for this series, the calculated perioperative and postoperative stroke risk from this study was compared to data obtained from the literature on stroke risk in medically treated symptomatic patients. This uncontrolled comparison of treatment modalities suggests the combined perioperative and postoperative stroke risk associated with carotid endarterectomy to be modestly improved over medical treatment alone.

Carotid Artery Diseases↗
PubMed1993

Anterior communicating artery collateral flow protection against ischemic change during carotid endarterectomy.

The purpose of this study was to determine whether preoperative angiographic patterns of collateral cerebral blood flow correlate with protection against intraoperative electroencephalographic (EEG) evidence of cerebral ischemia caused by carotid artery cross-clamping during carotid endarterectomy. Previous studies have shown that contralateral carotid artery occlusion and intracranial stenoses are associated with cerebral ischemia during carotid endarterectomy; however, the angiographic collateral flow patterns associated with cerebral ischemia have not been identified. This paper reports a retrospective study of 67 patients who underwent two- to four-vessel cerebral angiography followed by carotid endarterectomy with 16-channel EEG monitoring. The angiograms were reviewed for extracranial occlusive disease and collateral flow patterns, and the EEG recordings were analyzed for ischemic changes during carotid artery cross-clamping. Statistical analysis was by Fisher's exact test. Cross-filling of the anterior and middle cerebral arteries from the contralateral carotid artery through the anterior communicating artery correlated with a decreased incidence of EEG ischemic changes. Only 21% of patients with this collateral flow pattern showed ischemic changes compared to 50% of patients without this pattern (p < 0.03). Three angiographic findings occurring in combination on the side contralateral to surgery correlated with EEG ischemia: 1) occlusion of the contralateral internal carotid artery (five of seven or 71%, p < 0.03); 2) collateral flow from the external carotid circulation to the internal carotid circulation via the ophthalmic artery; and 3) collateral flow from the posterior circulation to the contralateral anterior circulation via the posterior communicating artery. The data presented here corroborate the correlation between contralateral carotid artery occlusion and cerebral ischemia during carotid endarterectomy. They also demonstrate that cross-filling of the anterior and middle cerebral arteries by the contralateral carotid artery protects against such ischemia. This collateral flow may serve as an indicator of tolerance to carotid artery cross-clamping.

Aged↗
PubMed2002

Intraoperative lidocaine injection into the carotid sinus during endarterectomy.

OBJECT: Many surgeons inject a local anesthetic agent into the carotid sinus before carotid endarterectomy in an attempt to ameliorate perioperative hemodynamic instability. The purpose of this study is to analyze the effect of carotid sinus injection with lidocaine on perioperative hemodynamics and complications. METHODS: The authors prospectively studied 92 patients in whom 100 consecutive carotid endarterectomies were performed by a single surgeon (eight procedures were bilateral). Patients were randomly assigned to one of two groups, in which either 0.5 ml of 1% lidocaine was injected into the carotid sinus nerve or no injection of lidocaine was administered before the arteriotomy. All patients were treated postoperatively according to a standard endarterectomy protocol. There were no significant differences between the two groups in the incidence of hypertension, hypotension, or the use of vasoactive medications in the operating room following restoration of carotid artery (CA) blood flow, in the recovery room, or in the intensive care unit. CONCLUSIONS: Injection of lidocaine into the carotid sinus at the time of endarterectomy is not associated with a significant improvement in any hemodynamic factor, from the time of restoration of CA blood flow to postoperative Day 1.

Aged↗
PubMed1989

Carotid endarterectomy: why question it now?

Carotid endarterectomy has been accepted widely as an important stroke-prevention tool since the 1950s, in spite of the lack of any proof of its efficacy in randomized, controlled clinical trials in either symptomatic or asymptomatic patients. While surgery for asymptomatic carotid disease always has been controversial, the indications and benefits of carotid endarterectomy in symptomatic patients now are being questioned also, although the available evidence suggests that the operation, when performed in expert hands, reduces the incidence of subsequent strokes in patients with minor, carotid-territorial ischaemic events and significant ipsilateral carotid disease. (A morbidity and mortality rate of more than 3% is unacceptable, and hence the procedure should be undertaken only by those who are skilled in its performance). For each patient, a decision has to be made as to whether the potential reduction of the risk of stroke outweighs the immediate surgical risk of stroke or death. Some large, expensive and important randomized clinical trials are either proposed or under way in North America and Europe to evaluate the precise role of carotid endarterectomy in the prevention of strokes. The basis for the current questioning of carotid endarterectomy and the rationale for these trials are addressed in this review.

Carotid Arteries↗
PubMed2000

Carotid endarterectomy using the eversion technique.

Carotid endarterectomy by the eversion technique allows for all of the benefits of conventional endarterectomy but obviates the need for a distal suture line on the smaller internal carotid artery, and thus batching. Carotid artery reanastomosis onto the bifurcation can be quickly and simply performed with almost no risk of closure-related restenosis, given the anastomosis is on the larger of 2 arteries. In our experience of over 3,000 eversion carotid artery endarterectomies, the restenosis rate has been less than 1% judged by rigorous duplex follow-up. In this article, the technique and utility of eversion carotid endarterectomy is discussed.

Carotid Stenosis↗
PubMed2000

[Eversion endarterectomy--out?].

Carotid eversion endarterectomy has become a well established alternative to conventional carotid endarterectomy. Similar perioperative morbidity and mortality results have been documented in several large clinical series. Our experience with carotid reconstructive surgery consists of 12,596 operations between 8/84 and 12/97, some 60% of which were performed using the eversion technique. Transient or permanent neurologic deficit was observed in 2.0%; 0.8% died after the procedure. Eversion endarterectomy should only be performed under suitable anatomic conditions. It is a challenging technique which requires advanced surgical skills and sound clinical judgement. The long-term rate of restenosis seems to be influenced favourably after eversion endarterectomy.

Blood Vessel Prosthesis Implantation↗
PubMed1999

Carotid endarterectomy without protective measures in patients with occluded and non occluded contralateral carotid artery.

BACKGROUND: Comparison of carotid endarterectomy in patients with and without occluded contralateral carotid artery. METHODS DESIGN: evaluation of results without using shunt or patch. SETTING: < > Hospital, Medical School, University of Athens. SUBJECTS: 235 patients, divided into group I of 40 patients with and group II of 195 patients without occluded contralateral carotid artery. INTERVENTION: carotid endarterectomy under general anesthesia. MAIN OUTCOME MEASURES: heparin administration, stable hemodynamic status during clamping, short duration monitoring postoperatively. RESULTS: Postoperative morbidity of both groups was 2.5% (6/235) and mortality 1.7% (4/235). Group I: mortality rate was 2.5% (1/40) major and minor stroke each 2.5% (1/40) and group I: 1.5% (3/195) and 1% (2/195) respectively (NS). Four to 108 months later, 30% (12/40) of group I and 21% (41/195) of group II died. CONCLUSIONS: Endarterectomy of the carotid artery under general anesthesia without use of shunt and patch in patients with or without occlusion of the contralateral carotid artery presented the same comparative results. Candidates for carotid endarterectomy should be screened systematically for coronary disease preoperatively and annual stress testing postoperatively, tactics which may improve early and late mortality rate after carotid surgery.

Aged↗
PubMed2000

Carotid endarterectomy reoperations in a regional medical center.

Large, randomized prospective clinical trials have not addressed the safety of reoperation for recurrent carotid disease. Our purpose was to determine whether outcomes for carotid endarterectomy for recurrent disease were different from those for primary or contralateral carotid endarterectomy. We reviewed all carotid endarterectomies done in our regional medical center hospital from 1979 through 1997. We analyzed 1656 primary procedures, 377 contralateral carotid procedures, and 63 reoperations. Operation for recurrent disease was done in 3 per cent of those having primary operations. Patients in the three groups did not differ significantly with regard to age, race, or sex. Seventy per cent of patients were symptomatic with transient ischemic attacks, amaurosis, and reversible ischemic neurological deficit being most prominent. There were no deaths and three strokes in the reoperation group for a combined stroke and death rate of 4.8 per cent. This was not significantly different from that of 3.2 per cent for the stroke and death rate for the primary group and 3.5 per cent for the contralateral group. Carotid endarterectomy is a safe treatment for recurrent carotid artery disease.

Aged↗
PubMed2000

[Results and role of carotid endarterectomy].

BACKGROUND: The indications for carotid endarterectomy have been defined on the basis of several large prospective randomised trials. Today this operation is widely performed as primary and secondary stroke prevention in patients with high grade carotid artery stenosis. Permanent quality control of the surgical results is mandatory to ensure optimal stroke prevention and further reduce perioperative complications. METHODS: In this retrospective study we analyse the surgical results of 272 consecutive carotid endarterectomies performed in 260 patients with special emphasis on the prevention of intraoperative brain ischaemia. Patients were operated on in general anaesthesia and moderate hypothermia. Before clamping the arteries at the neck, a fast-acting barbiturate or propofol was administered intravenously to obtain burst suppression on the EEG. Transcranial Doppler sonography allowed continuous intraoperative monitoring of brain perfusion and detection of emboli. Intraoperative shunting was performed only when the collateral circulation was insufficient. RESULTS: The postoperative course was uneventful in 249 endarterectomies (91.5%). The internal carotid artery was sonographically recanalised at hospital discharge and at 6-week follow-up in all 249 cases. Ischaemic cerebral complications were observed in 7 patients (2.6%): minor reversible brain ischaemia in 4 (1.5%), and major brain ischaemia with infarction in 3 (1.1%). Three patients died in the perioperative period, representing a mortality rate of 1.1% in this series. The overall combined stroke and death rate was 3.7%. The combined major stroke and death rate was 2.2%. Various non cerebral complications occurred in 13 patients (4.8%). CONCLUSIONS: These results confirm that endarterectomy is a safe and efficient treatment for atherosclerotic carotid stenosis at the neck. Very low complication rates can be attained by non-invasive diagnostic methods combined with intraoperative monitoring of cerebral blood flow velocity. New upcoming endovascular therapies such as percutaneous angioplasty and stenting need to be compared with these current surgical results with regard not only to perioperative morbidity and mortality but also patency rate, restenosis, and intracerebral blood flow restoration.

Adult↗
PubMed2000

Combined carotid endarterectomy with transluminal angioplasty and primary stenting of the supra-aortic vessels.

BACKGROUND: Carotid endarterectomy (CEA) is the standard of care for patients with high-grade carotid artery stenosis who are acceptable surgical candidates. Focal occlusive lesions of the origin of aortic arch vessels can be effectively and safely treated with balloon angioplasty and primary stenting. The purpose of this study was to retrospectively review results of carotid endarterectomy for high-grade carotid bifurcation stenosis combined with intraoperative retrograde transluminal angioplasty and primary stenting of a hemodynamically significant stenosis at the origin of a proximal ipsilateral aortic arch vessel. METHODS: Between October 1994 and August 1998, 592 patients underwent CEA. Six patients were found to have hemodynamically significant tandem lesions affecting one of the aortic arch vessels and the ipsilateral ICA for an overall incidence of 1%. Age ranged from 63 to 78 years (mean 74.7). Four of 6 (67%) patients had asymptomatic lesions, and 2 of 6 (33%) had symptoms of cerebral ischemia. Five patients had tandem lesions affecting the proximal left common carotid artery and the left ICA. One patient had a tandem lesion affecting the innominate artery and the right ICA. Carotid duplex imaging and arch and cerebral arteriography was performed in all six patients. Arteriography confirmed high-grade stenoses in both the ICA and ipsilateral proximal aortic arch vessel. The range of stenoses in the ICA was 70 to 95% (mean 80.8%) measured arteriographically. The range of stenoses at the origin of the aortic arch vessels was 75-90% (mean 79.2%). All six patients underwent combined retrograde transluminal balloon angioplasty and primary stenting of the ipsilateral CCA or innominate artery with temporary occlusion of the ICA for cerebral protection. The endovascular procedure was then followed with standard surgical endarterectomy using an inline shunt. RESULTS: All six procedures were successfully completed. There were no periprocedural strokes or other morbidities. Follow-up ranged from 6 to 43 months (mean 23.6) and showed no evidence of recurrent stenosis by carotid duplex imaging. No TIAs or strokes related to the surgically corrected lesions were noted during the follow-up period. One patient suffered a right hemispheric stroke secondary to a high-grade right carotid stenosis which occurred two months after her procedure surgically correcting tandem lesions on the opposite side. CONCLUSIONS: Carotid endarterectomy with balloon angioplasty and primary stenting of an ipsilateral hemodynamically significant aortic arch trunk vessel stenosis can be safely and successfully accomplished and avoids the need for an intra/extrathoracic bypass procedure.

Aged↗
PubMed1999

Endarterectomy for preventing stroke in symptomatic and asymptomatic carotid stenosis. Review of clinical trials and recommendations for surgical therapy.

BACKGROUND: Multicenter, randomized trials have demonstrated advantages for surgery over medical therapy in both symptomatic and asymptomatic carotid stenosis of greater than 70%. Controversial interpretations of these trials are debated between medical and surgical camps. The goal of this review is to summarize the current state of knowledge in carotid stenosis and the role of surgery and several advances in operative management. METHODS: Summaries of seven major controlled trials of carotid endarterectomy versus medical therapy are presented along with supportive data from over 90 related publications. Criticisms, deficiencies as well as strengths are offered. RESULTS: All studies in which trial design, clinical variables, case selection, complication definition, and patient follow-up were well conceived and performed showed statistically significant advantages for surgical therapy within a remarkable short interval of follow-up (less than 3 years). Carotid endarterectomy demonstrated a two to four fold reduction in the late incidence of stroke when compared to optimum medical management (risk factor reduction and initiation of antiplatelet therapy). Reduction in stroke risk over time remains stable in surgically treated patients whereas medically treated patients clearly show progression of stenosis and evolution of new neurologic events with time. Several studies indicate that diabetes is a risk factor for stroke with medical therapy that is eliminated by surgical therapy. Advantages were more clearly demonstrated when symptomatic patients (TIAs, stroke, or amaurosis) were studied, but asymptomatic patients received significant benefit as well. The degree of benefit measured was in direct balance to the perioperative risk. Perioperative stroke and death rates must be low (less than 3% combined for asymptomatic patients) in order for statistically significant differences to be detected. However, most centers now can perform carotid endarterectomy within these outcome parameters. CONCLUSIONS: Randomized trials support the safety and efficacy of carotid endarterectomy for stenosis greater than 70% (with or without symptoms). Advantages of surgery over medical therapy were found in less than three years and there is ample evidence to suggest that the differences between these groups would have been even more pronounced had longer follow-up been obtained. Thus for patients who face many years of risk after diagnosis of a carotid lesion, early surgery is the most important and effective intervention for preventing stroke. The results of these trials raised initial concern over increasing health care expenditures from rising surgical case volumes. However, studies of cost effectiveness confirmed that surgery saves health care dollars when compared to the long term care of stroke victims.

Carotid Stenosis↗
PubMedDate not supplied

[Endarterectomy and carotid angioplasty: surgical perspective].

INTRODUCTION: Carotid endarterectomy (CE) is a well-established operation, although recently it has been challenged by newer, less invasive procedures such as carotid angioplasty with or without insertion of a stent. DEVELOPMENT: In this article the author gives his views on the use of CE in patients with carotid stenosis, both those with and those without symptoms, and also those in whom no definite indication has yet been established. In symptomatic carotid stenosis it had been clearly shown that CE is an effective procedure for the prevention of strokes and death from strokes in patients with carotid stenosis of over 70%, provided that the patients have reasonable general health and life expectation. There is only minor benefit from surgery in patients with asymptomatic disease of the carotid arteries and much less than in those with symptomatic carotid disease. Therefore endarterectomy is recommended when there is obvious progression of the degree of stenosis, especially when the stenosis has reached 70% or the patient begins to complain of symptoms. One of the most serious complications of CE is acute myocardial infarction. CONCLUSION: It is a good time to design careful randomised studies to compare endarterectomy with angioplasty, probably with stenting, in a selected group of patients at greater risk than those accepted for endarterectomy.

Angioplasty↗
PubMed2001

Current practice--routine use of shunting in carotid endarterectomy. Cost reduction and surgical training.

BACKGROUND: Sophisticated methods of determining cerebral blood flow have reduced the use of shunting in carotid endarterectomy in 6-25% of cases. However teaching university hospitals still have to provide their young vascular surgeons with experience in the shunting procedure. Since complications of shunting have been related to the surgeon's experience in the technique, our study aimed to evaluate a policy of the routine use of shunting in carotid endarterectomy by vascular surgeons in training. In addition to concluding how this policy would affect the optimum outcome of our patients. The probable reduction of hospital charges was also evaluated. METHODS: A prospective audit of the results of 423 consecutive carotid endarterectomies performed by a senior vascular surgeon (the first 97 cases) and a vascular surgeon in training under the supervision of a senior vascular surgeon (326 cases), with routine use of an indwelling intraluminal shunt, in a university hospital in Athens. RESULTS: During the study period, 337 patients admitted to our department were managed surgically independently of any demanding surgery due to the anatomy and the extension of internal carotid artery disease. The perioperative stroke/death rate at 30 days was 0.47%, but the stroke rate alone was 0%. Minor complications amounted to 5.4%, with an increased but not significant difference in patients presenting contralateral internal carotid occlusion. There was no difference in complication rates when a young surgeon performed the shunting procedure compared with the experienced senior surgeon's results, but this was achieved after training in the method in the first 97 cases. The reduction of the total cost was related to avoidance of cost of the devices necessary for determination of the cerebral circulation during carotid clamping and the cost of specially trained personnel. Our policy resulted in only eight patients having to be treated in the intensive care unit for a total of 13 days. CONCLUSIONS: Experience in a large number of shunting procedures are required for a young vascular surgeon's training, in order to achieve optimum results. This can be done in teaching hospitals by using the method more frequently than required. Moreover in the contest of continuing changes in the practice of carotid endarterectomy and the economic restrictions on health expenditure, the routine use of shunting resulted in cost saving without jeopardizing the patients' outcome.

Aged↗
PubMed2002

[Combined carotid endarterectomy and off-pump coronary artery bypass grafting].

Patients with angina undergoing carotid endarterectomy have a high mortality. A 74-yaer-old man who has severe carotid stenosis was performed combined carotid endarterectomy and off-pump coronary artery bypass grafting successfully. At first, carotid endarterectomy was performed with Jamieson's specially designed dissector, which allow simultaneous dissection and removal blood from the surgical field. Secondly, then off-pump CABG was performed. Skeletonized internal mammary artery was harvested with ultrasound dissector. The advantage of that the dissected artery is not only long and greater blood flow, but also less damage to sternal blood flow which prevent infection and complications. Then internal mammary artery was anastomosed to left anterior discending artery with Octopus II stabilizer. After the operation, he recovered uneventfully without neurological complication. Combined single staged carotid endarterectomy and off-pump CABG appears to be a safe method.

Aged↗
PubMed2003

Carotid stenting for irradiation-associated carotid stenosis 3 years after previous carotid endarterectomy.

Extracranial carotid stenosis is a known complication of external irradiation to the head and neck region. We report on a patient with previous carotid endarterectomy for irradiation-associated carotid stenosis. This patient developed symptomatic carotid stenosis over the ipsilateral common carotid artery proximal to the previous endarterectomy site 3 years later, and was successfully treated with carotid angioplasty and stenting. This case illustrates the importance of Duplex scan surveillance after carotid endarterectomy for patients with irradiation-associated carotid stenosis. The complimentary role of carotid endarterectomy and carotid angioplasty for managing such a patient is highlighted.

Angioplasty, Balloon↗
PubMed1992

Transcranial Doppler measurement before and after carotid endarterectomy.

Carotid endarterectomy not only removes a source of emboli but significantly increases flow up the internal carotid artery (ICA). ICA flow and middle cerebral artery velocity (Vmca) measurements were made before, during and after endarterectomy in 40 consecutive patients. Mean ICA flow increased from 207 ml/min (95% confidence interval (CI) 136-259) to 388 ml/min (95% CI 348-428) (P < 0.001, Mann-Whitney U test) following endarterectomy. Despite this, Vmca did not rise significantly at the end of the procedure. By the first postoperative day Vmca rose to 55.3 cm/s (95% CI 47.6-62.4) (P < 0.025, ANOVA) only to fall preoperative values (46.0 cm/s (95% CI 40.0-52.1)) by 6 weeks. These results suggest that cerebral autoregulation takes time to adapt to the increased flow and pressure following endarterectomy, but has stabilized by 6 weeks.

Aged↗