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PubMed1993

Complex partial epileptic signs as a continuum from normals to epileptics: normative data and clinical populations.

Over a 10-year period, a total of 447 men and 624 women between 18 and 61 years of age were administered an inventory whose items describe experiences that are similar to those evoked by electrical stimulation of the temporal lobes. Empirically determined factors contained experiences of sensory enhancement, affective-dissociation, ego alien intrusions, and literary emphasis. Using this population as a reference, T scores for these clusters were calculated for special normal populations (poets, drama students, false pregnancies) and for clinical groups (post-traumatic stress, anxiety-depersonalization, exotic dissociations, and complex partial epilepsy). Whereas only mild elevations (50 < T < 65) in indicators of temporal lobe signs and symptoms were noted in the special groups, moderate (65 < T < 75) and severe (T > 79) elevations were noted in the clinical populations.

Adult↗

PubMed1983

Ergotism and the Salem witch panic: a critical analysis and an alternative conceptualization.

The controversial hypothesis that the Salem witchcraft panic of 1692 resulted from ergot poisoning was recently defended by Mary Matossian. She argued that (a) weather conditions in Salem were conducive to the growth of ergot, (b) new evidence concerning the age distribution of ergot sufferers is consistent with the ages of those who exhibited symptoms at Salem, and (c) the symptoms displayed and reported at Salem were those of convulsive ergotism. Each of these propositions is critically examined and rejected, and the events purportedly explained by the ergot hypothesis are accounted for within a social psychological framework. This perspective views the Salem crisis as a sociopolitical drama played out in terms of the worldview shared by seventeenth-century Puritans. The symptoms of demonic affliction are conceptualized as role enactments learned in and legitimated by the community, rather than as the results of disease.

Aged↗

PubMed1988

Changing health needs of the ageing population.

The drama unfolding in this century can be viewed in terms of the age at which people are now dying. Most medical needs, attention and costs occur in the last years of life. At the turn of the century about 25% of people survived age 65. In the developed countries at least 70% of the population now survive beyond this age and 30-40% of deaths are at age 80 or over. Entirely different diseases, conditions and social structures are involved when most people survive to these late ages. Increasing longevity raises the issue of net gain in active functional years versus total years of disability and dysfunction. The available evidence gives rise to pessimism: at present for each active functional year gained we add about 3.5 compromised years. The need for long-term care will continue to grow. Improvements in long-term care involve economic considerations, political will and better mechanisms for the delivery and acceptance of this labour-intensive practice. The education and preparation of the ageing population in terms of normal realities and expectations are even more important. Health-care givers, politicians, and other decision makers are increasingly likely to have first-hand exposure to the good and bad realities of an ageing society, and thereby to perceive the realities of ageing more clearly than ever before. A new political will for more creative and equitable responses to the needs of the elderly and their families is rapidly emerging. The greater our familiarity with the problems of old age, the greater the likelihood for us to find means for improvement.

Activities of Daily Living↗

PubMed2003

A systems neuroscience approach to autism: biological, cognitive, and clinical perspectives.

Autism is a behaviorally defined disorder characterized by a broad constellation of symptoms. Numerous studies directed to the biological substrate demonstrate clear effects of neurodevelopmental differences that will likely point to the etiology, course, and long-term outcomes of the disorder. Consistently replicated research on the neural underpinnings of autism is reviewed. In general, results suggest several main conclusions: First, autism is a heterogeneous disorder and is likely to have multiple possible etiologies; second, structural brain studies have indicated a variety of diffuse anatomical differences, reflective of an early developmental change in the growth or pruning of neural tissue, rather than localized lesions; similarly, neurochemical studies suggest early, neuromodulatory discrepancies rather than gross or localized abnormalities; and finally, there are a number of limitations on studies of brain activity that to date preclude definitive answers to questions of how the brain functions differently in autism. The large number of active research programs investigating the cognitive neuroscience of autism spectrum disorders, in combination with the exciting development of new methodologies and tools in this area, indicates the drama and excitement of work in this area.

Autistic Disorder↗

PubMed2005

Developing a game plan for good sportsmanship.

It is widely believed in the United States that competition is beneficial for youngsters. However, the media are full of examples of players, fans, and coaches whose behavior veers out of control. There have been well-documented examples of youth in livestock competitions illegally medicating show animals to make them appear calmer, officials biasing their rulings toward a team that will take the most fans to a playoff game, and team rivalries that have become so caustic as to be dangerous for competitors and fans. A university extension and its partners created a program called "Great Fans. Great Sports." in order to teach the kinds of behaviors we wish to instill among all who are involved in competitions. It requires entire communities to develop and implement plans for enhancing sportsmanship in music, debate, drama, 4-H, and other arenas, as well as sports. The goal is to make good sportsmanship not the exception but the norm. The authors provide anecdotal evidence that "Great Fans. Great Sports." is having a positive impact on the attitudes and behaviors of competitors, fans, and communities.

Adolescent↗

PubMed2000

SIMPSON: a general simulation program for solid-state NMR spectroscopy.

A computer program for fast and accurate numerical simulation of solid-state NMR experiments is described. The program is designed to emulate a NMR spectrometer by letting the user specify high-level NMR concepts such as spin systems, nuclear spin interactions, RF irradiation, free precession, phase cycling, coherence-order filtering, and implicit/explicit acquisition. These elements are implemented using the Tcl scripting language to ensure a minimum of programming overhead and direct interpretation without the need for compilation, while maintaining the flexibility of a full-featured programming language. Basically, there are no intrinsic limitations to the number of spins, types of interactions, sample conditions (static or spinning, powders, uniaxially oriented molecules, single crystals, or solutions), and the complexity or number of spectral dimensions for the pulse sequence. The applicability ranges from simple 1D experiments to advanced multiple-pulse and multiple-dimensional experiments, series of simulations, parameter scans, complex data manipulation/visualization, and iterative fitting of simulated to experimental spectra. A major effort has been devoted to optimizing the computation speed using state-of-the-art algorithms for the time-consuming parts of the calculations implemented in the core of the program using the C programming language. Modification and maintenance of the program are facilitated by releasing the program as open source software (General Public License) currently at http://nmr.imsb.au.dk. The general features of the program are demonstrated by numerical simulations of various aspects for REDOR, rotational resonance, DRAMA, DRAWS, HORROR, C7, TEDOR, POST-C7, CW decoupling, TPPM, F-SLG, SLF, SEMA-CP, PISEMA, RFDR, QCPMG-MAS, and MQ-MAS experiments.

Algorithms↗

PubMedDate not supplied

An optimal strategy for recovering the deuterium (2H) quadrupolar interaction under magic-angle spinning NMR.

By exploiting the homology in the form of the truncated high-field homonuclear dipole-dipole and quadrupole coupling Hamiltonians, we have previously demonstrated that a simple adaptation of a rotor-synchronized pulse sequence (DRAMA) used for the recovery of dipole-dipole couplings can also be used to resurrect quadrupole couplings (QUADRAMA). In the canonical implementation of these recovery pulse sequences, the couplings are not significantly scaled down from their static sample values. While such minimal scaling is of course desirable in the recovery of typical homonuclear dipolar couplings (< or =2 kHz) and small quadrupole couplings, it is clearly not ideal for the recovery of the much larger quadrupole couplings (20-200 kHz) often encountered in solid-state 2H NMR. In such a case, some prior knowledge of the order of magnitude of the coupling is required to optimize the experimental conditions for QUADRAMA. In order to overcome this drawback, in this study, we have developed a general and optimized strategy for implementing the QUADRAMA technique which does not require any knowledge of the size of the coupling vQ. Experimental tests of the optimized protocol demonstrate that by judicious choices of a combination of scaling factors and recoupling times, 2H quadrupole couplings ranging over an order of magnitude from 3 to 42 kHz can be measured. Since this optimized protocol can reliably be used to recover couplings over a broad range, it expands the range of systems accessible to study by 2H NMR into a realm where static sample NMR and simple MAS NMR may fail.

Journal Article↗

PubMed1984

Enzyme studies of replication of the Escherichia coli chromosome.

Progress of the replication forks of the Escherichia coli chromosome depends on a multisubunit DNA polymerase (for chain elongation) and a primosome (for chain initiations), together comprising about 30 polypeptides with a mass in excess of 10(6) daltons. Integration of their actions with those of helicases and DNA binding proteins suggest a more complex and integrated replisome assembly with novel possibilities for concurrent replication of both parental strands. Initiation of a new cycle of chromosome replication at its unique 245-bp (oriC) is being studied in a soluble enzyme system with plasmids, autonomous replication of which depends on the oriC sequence. Required proteins include RNA polymerase, DNA gyrase, dnaA protein (with 4 strong binding sites in oriC), HU protein, and additional proteins (e.g., topoisomerase I and ribonuclease H) that confer oriC specificity by suppressing initiation of replication elsewhere on the duplex DNA. Clarification of the biochemical mechanisms of replication is fundamental for understanding cell growth and development. Knowledge of the biochemistry of initiating a cycle of chromosome replication opens the way toward exploring the regulation of the cell cycle. I remain faithful to the conviction that anything a cell can do, a biochemist should be able to do. He should do it even better, being freed from the constraints of substrate and enzyme concentrations, pH, ionic strength, and temperature, and by having the license to introduce novel reagents to drive or restrain a reaction. Put another way, one can be creative more easily with a reconstituted system. One can grapple directly with the molecules instead of trying by remote means to manipulate their structures or levels in the intact cell. Enzyme purification carries many dangers beyond the well-known exposure of the fragile enzyme to the hostilities of an unfamiliar environment, high dilution, glass containers and a denaturable investigator. But the rewards of enzyme purification have justified the effort. The polymerases, nucleases, ligases purified out of curiosity about the mechanisms of replication, repair and recombination have supplied the cast of actors responsible for the current drama of genetic engineering. Beyond the uses of these enzymes as reagents, understanding the mechanisms of DNA metabolism will have practical value in manipulating the replication of plasmids and viruses and the expression of their genes and, beyond that, in obtaining a more secure grasp of chromosome structure and function.

Bacterial Proteins↗

PubMed2002

Satisfaction of life and late psycho-social outcome after severe brain injury: a nine-year follow-up study in Aquitaine.

In view of assessing their late outcome and satisfaction of life, 79 out of 158 severe traumatic brain injury (STBI) patients who received inpatient rehabilitation in Aquitaine in 1993 were followed by phone interview. Results showed that 9 years on average after their injury, 65 to 85% of these patients were independent for daily living, whereas 35 to 55% only were independent in social life. Most of the patients were satisfied with their autonomy (67%), family life (66%) and financial status (41%), but they were dissatisfied with leisures (36%), vocational adjustment (28%) and sexual life (32%). Satisfaction of life was mostly related to age, gender, physical autonomy, need of help because of cognitive impairment and functional outcome as assessed by the Glasgow Outcome Scale. Severe traumatic brain injury (STBI) stands in industrialised countries as a major Public Health problem and a dreadful human drama for the patients, their families and the community [2]. A great number of STBI patients survive with severe disability, most of them being young adults. The most severely impaired may live only with their parents or in high-cost nursing homes. From a psychological point of view, STBI causes a total and sudden breakdown of the mental states, personality and conditions of life. Life plans and projects are definitively disrupted, satisfaction of life is deeply changed. Rehabilitation aims at improving functional outcome of persons with STBI, and at improving their overall quality of life. Planning for rehabilitation and re-entry into community of STBI patients need to be provided with precise data on their late outcome and disability level. Despite that the concepts of quality and satisfaction of life are difficult to define and moreover to assess, these are also major factors to take into account. The aims of the present study were to assess the late psycho-social outcome of patients hospitalized in Aquitaine for rehabilitation of a STBI 7 to 10 years after their injury, and to ask for their satisfaction of life and subjective feeling of quality of life.

Activities of Daily Living↗

PubMed1990

The therapist and the source of healing among the Yaka of Zaire.

The Yaka of southwestern Zaire and the capital, Kinshasa, practise some ten major healing cults with initiatory treatments. These follow the model of rites de passage and lead the patient to resituate him/herself in the group, while partially redramatizing the cosmology and the fundamental values of the society. The body-self is the source and scene of the healing. The therapeutic drama offers a space-time stage upon which metaphoric correspondents of organs, affects, energies and bodily functions are constituted and manipulated. Acting as the patient's maternal uncle, as trapper-hunter, and as demiurge and weaver, the healer aims at fighting the illness by turning it back against itself autodestructively. The initiate is 'reborn' thanks to the emergence of the vital flow, particularly through trance, leading her or him to take up a transformed presence in the world and the group: this is "the weaving of the vital flow."

Cross-Cultural Comparison↗

PubMed1987

Healing spirits of South Kanara.

In South Kanara, India (formerly the kingdom of Tulunadu), and area stretching some 150 miles along the Arabian Sea and 25 to 50 miles inland, ancient forms of rural pageantry in honor of particular local Spirits are enacted yearly. These ritualized performances include elements of masked folk drama and epic recitation and serve a valued social role as a form of healing and counselling within village communities. Contemporary practitioner-patient interactions are part of an intricate tapestry partaking of customs occurring since times long past, such as the kinship structure (aliya-santana or nephew inheritance), the geopolitical milieu and the myths of Tulunadu. The power of these healing Spirits lies in their ability to reproduce social form through the cultural idiom of therapeutic efficacy.

Ceremonial Behavior↗

PubMed1992

Genetic concepts in Greek literature from the eighth to the fourth century B.C.

A review of the concepts of genetics found in epic, historical and dramatic ancient Greek writings from the eighth to the fourth centuries B.C., is presented. The derived data suggest that the development of genetical concepts and ideas started with the praise of the heroes' divine or noble origin in Homer's epic poems (eighth century B.C.). It continued in the tracing of the descent and vicissitudes of the families of the Greek gods and the common ancestry of the Greek tribes as described in Hesiod's genealogical poems (around 700 B.C.), in the statement of descent and dual parenthood of leaders and kings in the books of Herodotus and Xenophon (fifth and fourth centuries B.C.), and in the concern about the lineage of the tragic figures in Greek drama (fifth century B.C.). The genetical concepts expressed in these writings most probably reflected popular notions of that time. They must, therefore, have been the basis of the perceptions and theories on heredity and procreation expressed by the ancient physicians and philosophers in the fifth and fourth centuries B.C., which in turn influenced the development of genetics for many centuries.

Child↗

PubMed1991

How to identify psychogenic disorders of stance and gait. A video study in 37 patients.

Thirty-seven patients with psychogenic disorders of stance and gait were clinically evaluated, recorded on video, and analysed with regard to clinical phenomenology. Characteristic, suggestive and unspecific features were identified. Six characteristic features proved most valuable for diagnosis of psychogenesis, as they occurred alone or in combination in 97% of patients: (1) momentary fluctuations of stance and gait, often in response to suggestion; (2) excessive slowness or hesitation of locomotion incompatible with neurological disease; (3) "psychogenic" Romberg test with a build-up of sway amplitudes after a silent latency or with improvement by distraction; (4) uneconomic postures with wastage of muscular energy; (5) the "walking on ice" gait pattern, which is characterized by small cautious steps with fixed ankle joints; (6) sudden buckling of the knees, usually without falls. Seventy-three percent of patients had additional suggestive features. Classification into characteristic subtypes was not found useful because predominant features varied from patient to patient and occurred in various combinations. Factitious impairment of stance and gait was studied in 13 healthy drama students. Simulated gait dysfunction appeared less conspicuous and more difficult to diagnose than the clinical psychogenic disorders.

Adult↗

PubMed1994

Menstrual cycle variation of women's interest in erotica.

Female respondents were given the opportunity to choose feature films for viewing. Choices were made on the basis of synopses and promotional videos. These materials projected (i) a focus on erotic, sexual events, (ii) romantic themes, (iii) action-packed violent drama, and (iv) hilarious comedy. Additionally, respondents evaluated the appeal of the projected films. Respondents' position in the menstrual cycle was then determined, with placement into one of seven 4-day phases. Measured in both choices and evaluations, a postmenstrual surge in erotic interest was evident. Erotic interest was also pronounced prior to and during menses. In contrast, it was at a minimum during the first half of the luteal phase. The choice of romantic films was not appreciably influenced by cycle position. However, in evaluating films with romantic themes, premenstrual women expressed particularly little interest in this genre.

Analysis of Variance↗

PubMedDate not supplied

A qualitative analysis of emotional effector patterns and their feedback.

This paper is devoted to the study of the relationship between the subjective component (feelings) and the behavioral aspect of emotions. The following emotions were studied: fear-anxiety, anger-aggression, joy-laughter, love-eroticism, love-tenderness, and sadness-tears. The observations were performed with three different groups of people: patients with anxiety neurosis, students under hypnosis, and drama students. Each emotion was characterized by a specific set of reactions in the respiratory pattern, heart activity, muscular activity, and facial expression. The feelings were correlated with the behavioral patterns and each time the behavioral patterns were interfered with a concomitant modification of the subjectivity component was observed. The direct performance of the behavioral emotional patterns in the absence of the emotogenic stimulus produced the feeling corresponding to the mimicked emotion. If the subjects were stimulated with an emotogenic stimulus during the direct performance of the behavioral patterns of another emotion, they confessed to have the feeling corresponding to the mimicked emotion, and not to the emotion belonging to the emotogenic stimulus. The role played by the feedback from the effector organs in the determination of the subjective emotional states is discussed.

Adolescent↗

PubMed1994

Narrative scripts: composing a life with ambition and desire.

The "formative and deformative narratives" and the psychodynamics of male-female relations permeate us all, and are revealed in theme and variations in our consulting rooms. Conventional narrative forms are largely androcentric, action-oriented, and point single-mindedly toward a goal (Van Buren, 1991), whereas women's stories and their identities--digressive and complex weavings--are built around the significant relationships in their lives (Gilligan, 1982; Kaplan, 1984; Bernay, 1986). As clinicians, we must be mindful of derangements of our own desire, shaped by our biological mothers and fathers, our psychoanalytic fathers, Freud, and his early followers, and sometimes our own analysts. We must attend to the voice of our own ambition and trace its flourishes and derailments, understanding female ambition from a woman's point of view in order to assist our patients in reconstructing deformative narratives into healthier and more enabling ones. We need to take responsibility for our own ambition, stilling the disabling voices of the characters in our own intrapsychic dramas, maintaining consciousness of the deformative voices in the culture at large, and attunement to voices of support for ambition integrated with nurturance and aggression.

Assertiveness↗

PubMedDate not supplied

Mimetic muscles and emotions: Hans Memling's fifteenth century masterpiece, "Last judgment," as a study for aesthetic surgery.

As the most recognizable part of the body, the face has always interested, not only artists, but doctors as well. Each has had their own perception of facial beauty. The task for plastic and aesthetic surgery regarding the face is to reconstruct, not only traumatic lesions, but also to prevent the effects of facial tissue aging. It is also important to preserve the aesthetic values of the face in different emotional conditions. Those conditions are partially represented by mimetic or facial muscles. One might suggest that the perception of human beings portrayed by the artists could be very helpful in the realm of plastic and aesthetic surgery. Take, for example, Hans Memling, a fifteenth century Flemish artist whose masterpiece "Last Judgment" is exhibited at Gdańsk National Museum in Poland. The fortunate individuals on the left side of the painting are queuing at heaven's gate to receive their reward. Their faces are smooth with smiles, displaying blessings and happiness. The right-hand side of the painting exemplifies the expression of fear and the drama of the situation. These sinners have been damned and sentenced to hell by evil creatures. The fear, pain, and tragedy of condemnation fill their faces. For plastic and cosmetic surgeons, studying the works of great artists has not been as valuable as using the emotionless and intangible figures of an anatomy book. Undoubtedly, the only useful paintings and sculptures are those that are full of expression with the face displaying a plethora of emotions. In all surgical approaches where mimetic muscles are concerned, one has to remember and be conscious of the fact that the face is a very significant part of our body.

Belgium↗

PubMed2004

Television, disordered eating, and young women in Fiji: negotiating body image and identity during rapid social change.

Although the relationship between media exposure and risk behavior among youth is established at a population level, the specific psychological and social mechanisms mediating the adverse effects of media on youth remain poorly understood. This study reports on an investigation of the impact of the introduction of television to a rural community in Western Fiji on adolescent ethnic Fijian girls in a setting of rapid social and economic change. Narrative data were collected from 30 purposively selected ethnic Fijian secondary school girls via semi-structured, open-ended interviews. Interviews were conducted in 1998, 3 years after television was first broadcast to this region of Fiji. Narrative data were analyzed for content relating to response to television and mechanisms that mediate self and body image in Fijian adolescents. Data in this sample suggest that media imagery is used in both creative and destructive ways by adolescent Fijian girls to navigate opportunities and conflicts posed by the rapidly changing social environment. Study respondents indicated their explicit modeling of the perceived positive attributes of characters presented in television dramas, but also the beginnings of weight and body shape preoccupation, purging behavior to control weight, and body disparagement. Response to television appeared to be shaped by a desire for competitive social positioning during a period of rapid social transition. Understanding vulnerability to images and values imported with media will be critical to preventing disordered eating and, potentially, other youth risk behaviors in this population, as well as other populations at risk.

Adolescent↗